DK1945647T3 - Fremgangsmåder til fremstilling af maytansinol - Google Patents

Fremgangsmåder til fremstilling af maytansinol

Info

Publication number
DK1945647T3
DK1945647T3 DK06844315.9T DK06844315T DK1945647T3 DK 1945647 T3 DK1945647 T3 DK 1945647T3 DK 06844315 T DK06844315 T DK 06844315T DK 1945647 T3 DK1945647 T3 DK 1945647T3
Authority
DK
Denmark
Prior art keywords
maytansinol
methods
bridged
preparing maytansinol
preparing
Prior art date
Application number
DK06844315.9T
Other languages
English (en)
Inventor
Ravi V J Chari
Wayne C Widdison
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Application granted granted Critical
Publication of DK1945647T3 publication Critical patent/DK1945647T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK06844315.9T 2005-11-08 2006-11-08 Fremgangsmåder til fremstilling af maytansinol DK1945647T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73433005P 2005-11-08 2005-11-08
PCT/US2006/043718 WO2007056550A2 (en) 2005-11-08 2006-11-08 Processes for preparation of maytansinol

Publications (1)

Publication Number Publication Date
DK1945647T3 true DK1945647T3 (da) 2012-05-07

Family

ID=38024003

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06844315.9T DK1945647T3 (da) 2005-11-08 2006-11-08 Fremgangsmåder til fremstilling af maytansinol

Country Status (10)

Country Link
US (1) US7411063B2 (da)
EP (1) EP1945647B9 (da)
JP (1) JP5117390B2 (da)
AT (1) ATE540956T1 (da)
AU (1) AU2006311485B2 (da)
CA (1) CA2625867C (da)
DK (1) DK1945647T3 (da)
ES (1) ES2380687T3 (da)
PL (1) PL1945647T3 (da)
WO (1) WO2007056550A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
EP1392359B2 (en) 2001-05-11 2013-03-13 Ludwig Institute for Cancer Research Ltd. Specific binding proteins and uses thereof
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
US9023356B2 (en) 2007-03-15 2015-05-05 Ludwig Institute For Cancer Research Ltd Treatment method using EGFR antibodies and SRC inhibitors and related formulations
ES2609915T3 (es) 2007-08-14 2017-04-25 Ludwig Institute For Cancer Research Ltd. Anticuerpo monoclonal 175 direccionado al receptor de EGF y derivados y usos del mismo
FR2949469A1 (fr) * 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
JP5889912B2 (ja) 2010-11-17 2016-03-22 ジェネンテック， インコーポレイテッド アラニニルメイタンシノール抗体コンジュゲート
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
TWI541022B (zh) 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
TW201711702A (zh) 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR102459469B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
WO2020180709A1 (en) 2019-03-01 2020-09-10 Celgene Corporation Preparation of maytansinol
HUE061695T2 (hu) 2019-04-18 2023-08-28 Indena Spa Diaszteroszelektív eljárás tiol-vagy diszulfid-tartalmú maytansinoid-észterek elõállítására és köztitermékeik
JP2022541747A (ja) 2019-07-10 2022-09-27 サイブレクサ ３，インコーポレイテッド 治療薬としての微小管標的化剤のペプチドコンジュゲート
KR20220052918A (ko) 2019-07-10 2022-04-28 싸이브렉사 2, 인크. 치료제로서의 사이토톡신의 펩티드 접합체
EP4067497A4 (en) 2019-11-29 2024-03-13 MicroBiopharm Japan Co., Ltd. MAYTANSINOL ENZYMATIC PRODUCTION PROCESS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5566586A (en) * 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US6333410B1 (en) * 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
AU2003228998A1 (en) * 2002-05-13 2003-12-02 Smithkline Beecham Corporation Process for preparing maytansinol

Also Published As

Publication number Publication date
US20070112188A1 (en) 2007-05-17
CA2625867A1 (en) 2007-05-18
WO2007056550A2 (en) 2007-05-18
US7411063B2 (en) 2008-08-12
EP1945647B9 (en) 2012-11-14
ES2380687T3 (es) 2012-05-17
CA2625867C (en) 2014-12-23
EP1945647A2 (en) 2008-07-23
ATE540956T1 (de) 2012-01-15
WO2007056550A3 (en) 2007-12-06
JP2009514978A (ja) 2009-04-09
EP1945647B1 (en) 2012-01-11
EP1945647A4 (en) 2010-10-20
AU2006311485A1 (en) 2007-05-18
AU2006311485B2 (en) 2012-09-27
PL1945647T3 (pl) 2012-04-30
JP5117390B2 (ja) 2013-01-16

Similar Documents

Publication Publication Date Title
DK1945647T3 (da) Fremgangsmåder til fremstilling af maytansinol
DK1633697T3 (da) Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser
ATE427965T1 (de) Antikírper gegen 25-hydroxyvitamin d
ECSP056111A (es) Derivados de 2-acilamino-4-feniltiazol, su preparación y aplicación en terapeutica
EA201300253A1 (ru) Способ получения эпоксида
EA200801560A1 (ru) Бифенилкарбоксамиды
TW200942525A (en) Process for producing epichlorohydrin
CR7728A (es) Nuevas quinazolinas espirocondensadas y su uso como inhibidores de la fosfodiesterasa
NO20066078L (no) Metode for fremstilling av Entecavir og nye mellomprodukter derav via karbon-silisium oksidasjon
SE0300924D0 (sv) A method to provide a triple well in an epitaxially based CMOS or BiCMOS process
ATE483311T1 (de) Prozesskonfiguration in einem netzwerk
WO2005073152A3 (de) Verfahren zur herstellung von polyisobutenylphenolen
DK2089371T3 (da) Fremstillingsmåde til fremstilling af hexahydrofuro[2,3-b]furan-3-OL
EA200602169A1 (ru) Способ получения производных 2-оксо-1-пирролидина внутримолекулярным аллилированием
TW200619205A (en) A method for preparing irbesartan and intermediates thereof
SG170081A1 (en) Method of patterning and product(s) obtained therefrom
EA200600485A1 (ru) Способ получения производных 2-оксо-1-пирролидина
HRP20051005A2 (en) Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
EA200801573A1 (ru) Способ получения кристаллических форм орлистата
DK1410382T3 (da) Fremgangsmåde til støjreduktion i et høreapparat til implementering af en sådan fremgangsmåde
AP2277A (en) Process for production of 1,2,2,2-tertafluoro ethyl difluoro methyl ether.
EA201001872A1 (ru) Новые способы получения производных циклопропиламида
EA200801404A1 (ru) Новый способ получения 5-амино-3н-тиазоло[4,5-d]пиримидин-2-она
EA200801239A1 (ru) Новые способы получения пиперазинильных и диазепанильных производных бензамина