PL1945647T3 - Procesy wytwarzania maytansinolu - Google Patents

Procesy wytwarzania maytansinolu

Info

Publication number
PL1945647T3
PL1945647T3 PL06844315T PL06844315T PL1945647T3 PL 1945647 T3 PL1945647 T3 PL 1945647T3 PL 06844315 T PL06844315 T PL 06844315T PL 06844315 T PL06844315 T PL 06844315T PL 1945647 T3 PL1945647 T3 PL 1945647T3
Authority
PL
Poland
Prior art keywords
maytansinol
preparation
processes
bridged
scaleable
Prior art date
Application number
PL06844315T
Other languages
English (en)
Inventor
Ravi V J Chari
Wayne C Widdison
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of PL1945647T3 publication Critical patent/PL1945647T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL06844315T 2005-11-08 2006-11-08 Procesy wytwarzania maytansinolu PL1945647T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73433005P 2005-11-08 2005-11-08
EP06844315A EP1945647B9 (en) 2005-11-08 2006-11-08 Processes for preparation of maytansinol
PCT/US2006/043718 WO2007056550A2 (en) 2005-11-08 2006-11-08 Processes for preparation of maytansinol

Publications (1)

Publication Number Publication Date
PL1945647T3 true PL1945647T3 (pl) 2012-04-30

Family

ID=38024003

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06844315T PL1945647T3 (pl) 2005-11-08 2006-11-08 Procesy wytwarzania maytansinolu

Country Status (10)

Country Link
US (1) US7411063B2 (pl)
EP (1) EP1945647B9 (pl)
JP (1) JP5117390B2 (pl)
AT (1) ATE540956T1 (pl)
AU (1) AU2006311485B2 (pl)
CA (1) CA2625867C (pl)
DK (1) DK1945647T3 (pl)
ES (1) ES2380687T3 (pl)
PL (1) PL1945647T3 (pl)
WO (1) WO2007056550A2 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
CA2447139C (en) 2001-05-11 2013-11-19 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
CN104013956B (zh) 2007-01-25 2018-12-18 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
JP5618549B2 (ja) 2007-03-15 2014-11-05 ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
ES2609915T3 (es) 2007-08-14 2017-04-25 Ludwig Institute For Cancer Research Ltd. Anticuerpo monoclonal 175 direccionado al receptor de EGF y derivados y usos del mismo
FR2949469A1 (fr) * 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
ES2544608T3 (es) 2010-11-17 2015-09-02 Genentech, Inc. Conjugados de anticuerpo y de alaninil-maitansinol
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
TWI541022B (zh) 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
ES2960619T3 (es) 2014-02-28 2024-03-05 Hangzhou Dac Biotech Co Ltd Enlazadores cargados y sus usos para la conjugación
TW201711702A (zh) 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN110099682B (zh) 2016-11-14 2023-03-31 杭州多禧生物科技有限公司 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
EP3931198B1 (en) 2019-03-01 2023-04-19 Celgene Corporation Preparation of maytansinol
PL3956332T3 (pl) 2019-04-18 2023-05-29 Indena S.P.A. Diastereoselektywny sposób wytwarzania estrów majtanzynoidowych zawierających tiol lub dwusiarczek i ich produkty pośrednie
TW202116778A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩二號公司 作為治療劑之細胞毒素之肽結合物
EP3996749A1 (en) 2019-07-10 2022-05-18 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics
JPWO2021107133A1 (pl) 2019-11-29 2021-06-03

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5566586A (en) * 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US6333410B1 (en) * 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
EP1507781A4 (en) * 2002-05-13 2006-03-15 Smithkline Beecham Corp METHOD OF PREPARING MAYTANSINOL

Also Published As

Publication number Publication date
WO2007056550A2 (en) 2007-05-18
EP1945647A2 (en) 2008-07-23
JP2009514978A (ja) 2009-04-09
EP1945647B9 (en) 2012-11-14
US7411063B2 (en) 2008-08-12
JP5117390B2 (ja) 2013-01-16
EP1945647B1 (en) 2012-01-11
WO2007056550A3 (en) 2007-12-06
US20070112188A1 (en) 2007-05-17
CA2625867C (en) 2014-12-23
AU2006311485B2 (en) 2012-09-27
AU2006311485A1 (en) 2007-05-18
CA2625867A1 (en) 2007-05-18
EP1945647A4 (en) 2010-10-20
ATE540956T1 (de) 2012-01-15
ES2380687T3 (es) 2012-05-17
DK1945647T3 (da) 2012-05-07

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