PL3956332T3 - Diastereoselektywny sposób wytwarzania estrów majtanzynoidowych zawierających tiol lub dwusiarczek i ich produkty pośrednie - Google Patents
Diastereoselektywny sposób wytwarzania estrów majtanzynoidowych zawierających tiol lub dwusiarczek i ich produkty pośrednieInfo
- Publication number
- PL3956332T3 PL3956332T3 PL20719160.2T PL20719160T PL3956332T3 PL 3956332 T3 PL3956332 T3 PL 3956332T3 PL 20719160 T PL20719160 T PL 20719160T PL 3956332 T3 PL3956332 T3 PL 3956332T3
- Authority
- PL
- Poland
- Prior art keywords
- diasteroselective
- thiol
- intermediates
- disulfide
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19170052 | 2019-04-18 | ||
PCT/EP2020/060214 WO2020212256A1 (en) | 2019-04-18 | 2020-04-09 | Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3956332T3 true PL3956332T3 (pl) | 2023-05-29 |
Family
ID=66396993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL20719160.2T PL3956332T3 (pl) | 2019-04-18 | 2020-04-09 | Diastereoselektywny sposób wytwarzania estrów majtanzynoidowych zawierających tiol lub dwusiarczek i ich produkty pośrednie |
Country Status (12)
Country | Link |
---|---|
US (1) | US11420981B2 (pl) |
EP (1) | EP3956332B1 (pl) |
JP (1) | JP2022529064A (pl) |
CN (1) | CN113710674B (pl) |
DK (1) | DK3956332T3 (pl) |
ES (1) | ES2942915T3 (pl) |
FI (1) | FI3956332T3 (pl) |
HU (1) | HUE061695T2 (pl) |
PL (1) | PL3956332T3 (pl) |
PT (1) | PT3956332T (pl) |
SI (1) | SI3956332T1 (pl) |
WO (1) | WO2020212256A1 (pl) |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
US4162940A (en) | 1977-03-31 | 1979-07-31 | Takeda Chemical Industries, Ltd. | Method for producing Antibiotic C-15003 by culturing nocardia |
JPS56102793A (en) | 1979-12-28 | 1981-08-17 | Takeda Chem Ind Ltd | Preparation of antibiotic c-15003 p-3 |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US6573074B2 (en) | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
AR030612A1 (es) * | 2000-09-12 | 2003-08-27 | Smithkline Beecham Corp | Procedimiento e intermedios |
US6790954B2 (en) | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
EP3524611B1 (en) * | 2003-05-20 | 2020-12-30 | ImmunoGen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
EP1913002B9 (en) | 2005-08-09 | 2012-04-25 | Millennium Pharmaceuticals, Inc. | Method of acylating maytansinol with chiral amino acids |
US7411063B2 (en) | 2005-11-08 | 2008-08-12 | Immunogen, Inc. | Process for preparation of maytansinol |
MY169250A (en) * | 2012-09-26 | 2019-03-19 | Immunogen Inc | Improved methods for the acylation of maytansinol |
CN103254213B (zh) * | 2012-12-21 | 2015-02-25 | 百奥泰生物科技(广州)有限公司 | 类美登素酯的制备方法及用于所述方法的组合物 |
CN105585579A (zh) * | 2014-10-24 | 2016-05-18 | 南京联宁生物制药有限公司 | 一种化合物及其制备方法以及美登素dm1的制备方法 |
-
2020
- 2020-04-09 WO PCT/EP2020/060214 patent/WO2020212256A1/en active Application Filing
- 2020-04-09 PT PT207191602T patent/PT3956332T/pt unknown
- 2020-04-09 US US17/603,533 patent/US11420981B2/en active Active
- 2020-04-09 JP JP2021561939A patent/JP2022529064A/ja active Pending
- 2020-04-09 ES ES20719160T patent/ES2942915T3/es active Active
- 2020-04-09 HU HUE20719160A patent/HUE061695T2/hu unknown
- 2020-04-09 EP EP20719160.2A patent/EP3956332B1/en active Active
- 2020-04-09 CN CN202080029053.XA patent/CN113710674B/zh active Active
- 2020-04-09 FI FIEP20719160.2T patent/FI3956332T3/fi active
- 2020-04-09 DK DK20719160.2T patent/DK3956332T3/da active
- 2020-04-09 SI SI202030178T patent/SI3956332T1/sl unknown
- 2020-04-09 PL PL20719160.2T patent/PL3956332T3/pl unknown
Also Published As
Publication number | Publication date |
---|---|
HUE061695T2 (hu) | 2023-08-28 |
CN113710674A (zh) | 2021-11-26 |
PT3956332T (pt) | 2023-04-24 |
DK3956332T3 (da) | 2023-05-01 |
EP3956332B1 (en) | 2023-02-22 |
ES2942915T3 (es) | 2023-06-07 |
EP3956332A1 (en) | 2022-02-23 |
FI3956332T3 (fi) | 2023-05-09 |
CN113710674B (zh) | 2024-03-15 |
US20220119408A1 (en) | 2022-04-21 |
JP2022529064A (ja) | 2022-06-16 |
SI3956332T1 (sl) | 2023-05-31 |
US11420981B2 (en) | 2022-08-23 |
WO2020212256A1 (en) | 2020-10-22 |
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