HUE061695T2 - Diaszteroszelektív eljárás tiol-vagy diszulfid-tartalmú maytansinoid-észterek elõállítására és köztitermékeik - Google Patents
Diaszteroszelektív eljárás tiol-vagy diszulfid-tartalmú maytansinoid-észterek elõállítására és köztitermékeikInfo
- Publication number
- HUE061695T2 HUE061695T2 HUE20719160A HUE20719160A HUE061695T2 HU E061695 T2 HUE061695 T2 HU E061695T2 HU E20719160 A HUE20719160 A HU E20719160A HU E20719160 A HUE20719160 A HU E20719160A HU E061695 T2 HUE061695 T2 HU E061695T2
- Authority
- HU
- Hungary
- Prior art keywords
- diasteroselective
- thiol
- intermediates
- disulfide
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19170052 | 2019-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE061695T2 true HUE061695T2 (hu) | 2023-08-28 |
Family
ID=66396993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE20719160A HUE061695T2 (hu) | 2019-04-18 | 2020-04-09 | Diaszteroszelektív eljárás tiol-vagy diszulfid-tartalmú maytansinoid-észterek elõállítására és köztitermékeik |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11420981B2 (hu) |
| EP (1) | EP3956332B1 (hu) |
| JP (1) | JP7568644B2 (hu) |
| CN (1) | CN113710674B (hu) |
| DK (1) | DK3956332T3 (hu) |
| ES (1) | ES2942915T3 (hu) |
| FI (1) | FI3956332T3 (hu) |
| HU (1) | HUE061695T2 (hu) |
| PL (1) | PL3956332T3 (hu) |
| PT (1) | PT3956332T (hu) |
| SI (1) | SI3956332T1 (hu) |
| WO (1) | WO2020212256A1 (hu) |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4162940A (en) | 1977-03-31 | 1979-07-31 | Takeda Chemical Industries, Ltd. | Method for producing Antibiotic C-15003 by culturing nocardia |
| JPS56102793A (en) | 1979-12-28 | 1981-08-17 | Takeda Chem Ind Ltd | Preparation of antibiotic c-15003 p-3 |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6573074B2 (en) | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| AR030612A1 (es) * | 2000-09-12 | 2003-08-27 | Smithkline Beecham Corp | Procedimiento e intermedios |
| US6790954B2 (en) | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| WO2004103272A2 (en) * | 2003-05-20 | 2004-12-02 | Immunogen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
| US7301019B2 (en) | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| CA2617953C (en) | 2005-08-09 | 2013-12-17 | Millennium Pharmaceuticals, Inc. | Method of acylating maytansinol with chiral amino acids |
| PL1945647T3 (pl) | 2005-11-08 | 2012-04-30 | Immunogen Inc | Procesy wytwarzania maytansinolu |
| ES2716561T3 (es) | 2012-09-26 | 2019-06-13 | Immunogen Inc | Métodos mejorados para la acilación de maitansinol |
| CN103254213B (zh) * | 2012-12-21 | 2015-02-25 | 百奥泰生物科技(广州)有限公司 | 类美登素酯的制备方法及用于所述方法的组合物 |
| CN105585579A (zh) * | 2014-10-24 | 2016-05-18 | 南京联宁生物制药有限公司 | 一种化合物及其制备方法以及美登素dm1的制备方法 |
-
2020
- 2020-04-09 PL PL20719160.2T patent/PL3956332T3/pl unknown
- 2020-04-09 ES ES20719160T patent/ES2942915T3/es active Active
- 2020-04-09 WO PCT/EP2020/060214 patent/WO2020212256A1/en active Application Filing
- 2020-04-09 JP JP2021561939A patent/JP7568644B2/ja active Active
- 2020-04-09 FI FIEP20719160.2T patent/FI3956332T3/fi active
- 2020-04-09 PT PT207191602T patent/PT3956332T/pt unknown
- 2020-04-09 US US17/603,533 patent/US11420981B2/en active Active
- 2020-04-09 CN CN202080029053.XA patent/CN113710674B/zh active Active
- 2020-04-09 EP EP20719160.2A patent/EP3956332B1/en active Active
- 2020-04-09 SI SI202030178T patent/SI3956332T1/sl unknown
- 2020-04-09 HU HUE20719160A patent/HUE061695T2/hu unknown
- 2020-04-09 DK DK20719160.2T patent/DK3956332T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3956332B1 (en) | 2023-02-22 |
| CN113710674B (zh) | 2024-03-15 |
| JP2022529064A (ja) | 2022-06-16 |
| PT3956332T (pt) | 2023-04-24 |
| JP7568644B2 (ja) | 2024-10-16 |
| WO2020212256A1 (en) | 2020-10-22 |
| FI3956332T3 (fi) | 2023-05-09 |
| DK3956332T3 (da) | 2023-05-01 |
| PL3956332T3 (pl) | 2023-05-29 |
| ES2942915T3 (es) | 2023-06-07 |
| CN113710674A (zh) | 2021-11-26 |
| SI3956332T1 (sl) | 2023-05-31 |
| US11420981B2 (en) | 2022-08-23 |
| EP3956332A1 (en) | 2022-02-23 |
| US20220119408A1 (en) | 2022-04-21 |
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