HUE058259T2 - Eljárás lubiproszton és annak intermedierei elkészítésére - Google Patents
Eljárás lubiproszton és annak intermedierei elkészítéséreInfo
- Publication number
- HUE058259T2 HUE058259T2 HUE19185543A HUE19185543A HUE058259T2 HU E058259 T2 HUE058259 T2 HU E058259T2 HU E19185543 A HUE19185543 A HU E19185543A HU E19185543 A HUE19185543 A HU E19185543A HU E058259 T2 HUE058259 T2 HU E058259T2
- Authority
- HU
- Hungary
- Prior art keywords
- lubiprostone
- intermediates
- preparation
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- WGFOBBZOWHGYQH-MXHNKVEKSA-N lubiprostone Chemical compound O1[C@](C(F)(F)CCCC)(O)CC[C@@H]2[C@@H](CCCCCCC(O)=O)C(=O)C[C@H]21 WGFOBBZOWHGYQH-MXHNKVEKSA-N 0.000 title 1
- 229960000345 lubiprostone Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/34—Halogenated alcohols
- C07C31/38—Halogenated alcohols containing only fluorine as halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/34—Halogenated alcohols
- C07C31/40—Halogenated alcohols perhalogenated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
- C07C59/215—Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/034,598 US10457623B1 (en) | 2018-07-13 | 2018-07-13 | Process for the preparation of Lubiprostone and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE058259T2 true HUE058259T2 (hu) | 2022-07-28 |
Family
ID=67296975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE19185543A HUE058259T2 (hu) | 2018-07-13 | 2019-07-10 | Eljárás lubiproszton és annak intermedierei elkészítésére |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10457623B1 (hu) |
| EP (1) | EP3594201B1 (hu) |
| JP (1) | JP6872583B2 (hu) |
| KR (1) | KR102203107B1 (hu) |
| CN (1) | CN110713477B (hu) |
| HU (1) | HUE058259T2 (hu) |
| TW (1) | TWI710550B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10253011B1 (en) * | 2018-07-13 | 2019-04-09 | Chirogate International Inc. | Lubiprostone crystals and methods for preparing the same |
| JP7024943B1 (ja) | 2021-04-14 | 2022-02-24 | 一幸 森 | 歌唱者、吹奏者又は発話者の呼気中の飛沫及びエアロゾルを、局所排気装置の動力を用いて強制的に及び個人毎に吸引及び捕集する装置及び方法。 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256696A (en) * | 1989-11-22 | 1993-10-26 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds |
| CA2030346C (en) | 1989-11-22 | 2000-04-11 | Ryuji Ueno | Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds |
| JPH11302251A (ja) * | 1998-04-16 | 1999-11-02 | Asahi Glass Co Ltd | プロスタグランジン誘導体およびその製造方法 |
| KR100867295B1 (ko) * | 2001-05-18 | 2008-11-06 | 수캄포 아게 | 하제 조성물 |
| NZ531503A (en) * | 2001-08-31 | 2006-01-27 | Sucampo Ag | Prostaglandin analogs as chloride channel opener |
| US7511168B2 (en) * | 2006-01-18 | 2009-03-31 | Shih-Yi Wei | Processes and intermediates for the preparations of prostaglandins |
| WO2007091697A2 (en) * | 2006-02-07 | 2007-08-16 | R-Tech Ueno, Ltd. | Method for preparing prostaglandin derivative |
| CA2639240A1 (en) * | 2008-08-29 | 2010-02-28 | Alphora Research Inc. | Prostaglandin synthesis and intermediates for use therein |
| US9382272B2 (en) * | 2009-01-22 | 2016-07-05 | Apotex Pharmachem Inc. | Methods of making lubiprostone and intermediates thereof |
| WO2012048447A1 (en) * | 2010-10-15 | 2012-04-19 | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. | Processes for preparation of lubiprostone |
| CN103787942B (zh) * | 2012-11-02 | 2017-02-15 | 上海源力生物技术有限公司 | 一种制备鲁比前列酮的中间体、其制备方法以及通过其制备鲁比前列酮的方法 |
| CN104140410B (zh) * | 2013-05-09 | 2017-12-15 | 江苏豪森药业集团有限公司 | 鲁比前列酮的制备方法 |
| KR102311896B1 (ko) * | 2013-09-30 | 2021-10-14 | 패턴 에이피아이 서비시즈 인코포레이티드 | 복분해를 사용하는 프로스타글란딘 및 프로스타글란딘 중간체의 합성 경로 |
| CN105254657B (zh) * | 2014-07-10 | 2018-06-15 | 台湾神隆股份有限公司 | 金属催化不对称1,4-共轭加成反应产生前列腺素和前列腺素类似物 |
| JP2015120693A (ja) * | 2014-12-19 | 2015-07-02 | サイノファーム （クンシャン） バイオケミカル テクノロジ カンパニー リミテッド | ルビプロストンの調製方法 |
| CN104557845B (zh) * | 2015-01-13 | 2020-12-22 | 齐鲁制药有限公司 | 一种鲁比前列酮化合物的制备方法 |
-
2018
- 2018-07-13 US US16/034,598 patent/US10457623B1/en active Active
-
2019
- 2019-07-10 CN CN201910618884.XA patent/CN110713477B/zh active Active
- 2019-07-10 TW TW108124386A patent/TWI710550B/zh active
- 2019-07-10 EP EP19185543.6A patent/EP3594201B1/en active Active
- 2019-07-10 JP JP2019128093A patent/JP6872583B2/ja active Active
- 2019-07-10 KR KR1020190083154A patent/KR102203107B1/ko active IP Right Grant
- 2019-07-10 HU HUE19185543A patent/HUE058259T2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3594201B1 (en) | 2022-02-16 |
| TW202019865A (zh) | 2020-06-01 |
| JP2020045334A (ja) | 2020-03-26 |
| CN110713477B (zh) | 2023-06-02 |
| KR102203107B1 (ko) | 2021-01-15 |
| TWI710550B (zh) | 2020-11-21 |
| US10457623B1 (en) | 2019-10-29 |
| CN110713477A (zh) | 2020-01-21 |
| KR20200007691A (ko) | 2020-01-22 |
| JP6872583B2 (ja) | 2021-05-19 |
| EP3594201A1 (en) | 2020-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL276917A (en) | A process for the preparation of alubixivet | |
| IL287140A (en) | A process for the preparation of polyethylene glycol-converted pharmaceutical binders and their intermediates | |
| IL292648A (en) | A process for the preparation of glucuronide-drug binders and their intermediates | |
| ZA202101214B (en) | Process and intermediates for the preparation of bilastine | |
| ZA202003590B (en) | Process for the preparation of opicapone and intermediates thereof | |
| EP3717456A4 (en) | PROCESS FOR PREPARING ROXADUSTAT AND ITS INTERMEDIARIES | |
| HUE062956T2 (hu) | Eljárások niraparib és köztitermékei elõállítására | |
| PL3765440T3 (pl) | Sposób wytwarzania n-alkilonitratoetylonitroamin | |
| HUE058259T2 (hu) | Eljárás lubiproszton és annak intermedierei elkészítésére | |
| IL281254A (en) | A process for the preparation of lanbatinib | |
| IL276773A (en) | Process and intermediates for the preparation of certain toxic pesticides | |
| PL3737685T3 (pl) | Sposób wytwarzania kryzaborolu i jego związków pośrednich | |
| GB201915447D0 (en) | Polymorphs of avapritinib and methods of preparing the polymorphs | |
| ZA202107053B (en) | Novel process for the preparation of filgotinib and intermediates thereof | |
| IL290169A (en) | Method and intermediates for the preparation of pyroxulfone | |
| IL272837A (en) | A process for preparing tubolysins and their intermediates | |
| EP3877361C0 (en) | PROCESS FOR PREPARING ARYLSULFONYLPROPENENITRILE | |
| PL3599256T3 (pl) | Sposób wytwarzania poliorganosiloksanów | |
| PT3969459T (pt) | Processo e intermediários para a preparação de eldecalcitol | |
| IL281090A (en) | Alternative processes for the preparation of tubolysins and their intermediates | |
| RS65238B1 (sr) | Proces i međuproizvod za izradu oksetan-2-ilmetanamina | |
| PL3704100T3 (pl) | Nowy sposób wytwarzania tawaborolu i jego związków pośrednich | |
| HUP1800278A2 (en) | Process for the preparation of boc-linagliptin |