MX366701B - Métodos mejorados para la acilación del maitansinol. - Google Patents

Métodos mejorados para la acilación del maitansinol.

Info

Publication number
MX366701B
MX366701B MX2015003745A MX2015003745A MX366701B MX 366701 B MX366701 B MX 366701B MX 2015003745 A MX2015003745 A MX 2015003745A MX 2015003745 A MX2015003745 A MX 2015003745A MX 366701 B MX366701 B MX 366701B
Authority
MX
Mexico
Prior art keywords
maytansinol
amino acid
acylation
improved methods
carboxyanhydride
Prior art date
Application number
MX2015003745A
Other languages
English (en)
Other versions
MX2015003745A (es
Inventor
Yongxin Zhao Robert
C Widdison Wayne
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of MX2015003745A publication Critical patent/MX2015003745A/es
Publication of MX366701B publication Critical patent/MX366701B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
    • H01R12/50—Fixed connections
    • H01R12/51—Fixed connections for rigid printed circuits or like structures
    • H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
    • H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
    • H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
    • H05K1/0203—Cooling of mounted components
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/11—Printed elements for providing electric connections to or between printed circuits
    • H05K1/115—Via connections; Lands around holes or via connections
    • H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/18—Printed circuits structurally associated with non-printed electric components
    • H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components

Abstract

Se proporciona un método para preparar un éster de aminoácidos de maitansinol representado por la siguiente fórmula al hacer reaccionar maitansinol con un N carboxianhídrido de un aminoácido (NCA) en presencia de un agente de secado. También se proporciona un método mejorado para preparar un éster de aminoácido de maitansinol en el cual se agrega un nucleófilo a la mezcla de reacción después de completar la reacción entre maitansinol y un N-carboxianhídrido de un aminoácido. (ver Fórmula).
MX2015003745A 2012-09-26 2013-09-26 Métodos mejorados para la acilación del maitansinol. MX366701B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261705731P 2012-09-26 2012-09-26
PCT/US2013/061839 WO2014052537A1 (en) 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol

Publications (2)

Publication Number Publication Date
MX2015003745A MX2015003745A (es) 2015-06-24
MX366701B true MX366701B (es) 2019-07-22

Family

ID=49328648

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015003745A MX366701B (es) 2012-09-26 2013-09-26 Métodos mejorados para la acilación del maitansinol.
MX2019008652A MX2019008652A (es) 2012-09-26 2015-03-24 Metodos mejorados para la acilacion del maitansinol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019008652A MX2019008652A (es) 2012-09-26 2015-03-24 Metodos mejorados para la acilacion del maitansinol.

Country Status (27)

Country Link
US (6) US9012629B2 (es)
EP (3) EP3904358A1 (es)
JP (6) JP6517693B2 (es)
CN (2) CN108586487B (es)
AU (4) AU2013323572B2 (es)
BR (2) BR122021022582B1 (es)
CA (2) CA2884873C (es)
CY (2) CY1121415T1 (es)
DK (2) DK2900676T3 (es)
ES (2) ES2716561T3 (es)
HK (1) HK1212341A1 (es)
HR (2) HRP20190473T1 (es)
HU (2) HUE055443T2 (es)
IL (2) IL237899A (es)
LT (2) LT2900676T (es)
MX (2) MX366701B (es)
MY (1) MY169250A (es)
NZ (2) NZ739573A (es)
PL (2) PL3486248T3 (es)
PT (2) PT3486248T (es)
RS (2) RS58493B1 (es)
RU (2) RU2648992C2 (es)
SG (1) SG11201501918UA (es)
SI (2) SI3486248T1 (es)
TR (1) TR201903625T4 (es)
WO (1) WO2014052537A1 (es)
ZA (1) ZA201501898B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2884873C (en) * 2012-09-26 2021-11-23 Immunogen, Inc. Improved methods for the acylation of maytansinol
CN105585579A (zh) * 2014-10-24 2016-05-18 南京联宁生物制药有限公司 一种化合物及其制备方法以及美登素dm1的制备方法
EP3271339B1 (en) * 2015-03-17 2021-11-24 Regeneron Pharmaceuticals, Inc. Amino acid acylation reagents and methods of using the same
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US20230030526A1 (en) 2019-11-29 2023-02-02 Microbiopharm Japan Co., Ltd. Method for enzymatically producing maytansinol

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JP3054741B2 (ja) * 1989-09-29 2000-06-19 武田薬品工業株式会社 Ｔａｎ―１３１３およびそのアシル誘導体
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TWI298067B (en) * 2002-01-31 2008-06-21 Daiso Co Ltd New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof
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Also Published As

Publication number Publication date
PL2900676T3 (pl) 2019-06-28
RS58493B1 (sr) 2019-04-30
US20170137440A1 (en) 2017-05-18
RS62075B1 (sr) 2021-07-30
AU2018201392B2 (en) 2020-03-12
RU2015111635A (ru) 2016-11-20
CN104768955A (zh) 2015-07-08
CN108586487B (zh) 2021-11-05
RU2765072C2 (ru) 2022-01-25
AU2020203823A1 (en) 2020-07-02
JP2022068367A (ja) 2022-05-09
AU2022201557A1 (en) 2022-03-31
JP2020180150A (ja) 2020-11-05
US9796731B2 (en) 2017-10-24
US10100062B2 (en) 2018-10-16
CY1124337T1 (el) 2022-07-22
HUE043285T2 (hu) 2019-08-28
BR112015006505B1 (pt) 2022-03-15
IL253988B (en) 2019-02-28
EP3486248B1 (en) 2021-04-07
SI3486248T1 (sl) 2021-10-29
RU2648992C2 (ru) 2018-03-29
WO2014052537A1 (en) 2014-04-03
AU2020203823B2 (en) 2021-12-09
US9012629B2 (en) 2015-04-21
CA3133906A1 (en) 2014-04-03
JP2024010055A (ja) 2024-01-23
MX2019008652A (es) 2019-09-13
US10944190B2 (en) 2021-03-09
US10461449B2 (en) 2019-10-29
MY169250A (en) 2019-03-19
AU2018201392A1 (en) 2018-03-15
RU2018109295A3 (es) 2021-06-24
PL3486248T3 (pl) 2021-10-25
JP6735000B1 (ja) 2020-08-05
HUE055443T2 (hu) 2021-11-29
PT3486248T (pt) 2021-07-12
AU2013323572A1 (en) 2015-04-02
DK2900676T3 (en) 2019-04-08
CN108586487A (zh) 2018-09-28
HRP20211030T1 (hr) 2021-10-01
US20190013604A1 (en) 2019-01-10
DK3486248T3 (da) 2021-07-12
IL253988A0 (en) 2017-10-31
NZ706019A (en) 2018-03-23
AU2013323572B2 (en) 2017-12-07
MX2015003745A (es) 2015-06-24
SI2900676T1 (sl) 2019-04-30
ZA201501898B (en) 2019-06-26
LT3486248T (lt) 2021-08-25
LT2900676T (lt) 2019-03-25
HRP20190473T1 (hr) 2019-05-03
JP6517693B2 (ja) 2019-05-22
ES2880754T3 (es) 2021-11-25
EP2900676B1 (en) 2018-12-19
NZ739573A (en) 2019-11-29
US20150191488A1 (en) 2015-07-09
US9469655B2 (en) 2016-10-18
BR112015006505A2 (pt) 2017-07-04
CA2884873C (en) 2021-11-23
CA3133906C (en) 2023-05-02
RU2018109295A (ru) 2019-02-26
CY1121415T1 (el) 2020-05-29
JP2016500657A (ja) 2016-01-14
EP2900676A1 (en) 2015-08-05
HK1212341A1 (en) 2016-06-10
CN104768955B (zh) 2018-04-27
CA2884873A1 (en) 2014-04-03
EP3904358A1 (en) 2021-11-03
ES2716561T3 (es) 2019-06-13
TR201903625T4 (tr) 2019-04-22
PT2900676T (pt) 2019-03-29
JP2020117527A (ja) 2020-08-06
US20140142297A1 (en) 2014-05-22
EP3486248A1 (en) 2019-05-22
BR122021022582B1 (pt) 2023-01-10
SG11201501918UA (en) 2015-05-28
US20200153130A1 (en) 2020-05-14
JP2018109044A (ja) 2018-07-12
IL237899A (en) 2017-08-31
US20180099980A1 (en) 2018-04-12

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