MX352470B - Disales de acido malonico y metodo para preparar dihaluros de malonilo. - Google Patents

Disales de acido malonico y metodo para preparar dihaluros de malonilo.

Info

Publication number
MX352470B
MX352470B MX2014006992A MX2014006992A MX352470B MX 352470 B MX352470 B MX 352470B MX 2014006992 A MX2014006992 A MX 2014006992A MX 2014006992 A MX2014006992 A MX 2014006992A MX 352470 B MX352470 B MX 352470B
Authority
MX
Mexico
Prior art keywords
compound
formula
preparing
salts
malonic acid
Prior art date
Application number
MX2014006992A
Other languages
English (en)
Other versions
MX2014006992A (es
Inventor
Zhang Wenming
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of MX2014006992A publication Critical patent/MX2014006992A/es
Publication of MX352470B publication Critical patent/MX352470B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/36—Acyl halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
    • C07C57/36—Phenymalonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención describe un compuesto de la Fórmula 2, (ver Fórmula) en donde R1, MA y MB son como se definen en la descripción. Se describe, además, un método para preparar un compuesto de la Fórmula 1 (ver Fórmula) en donde R1 y X son como se definen en la descripción; el método comprende poner en contacto un compuesto de la Fórmula 2 con un agente halogenante. Se describe, además, un método para preparar un compuesto de la Fórmula 4 (ver Fórmulas) en donde R1, R3 y R4 son como se definen en la descripción; el método comprende hacer reaccionar un compuesto de la Fórmula 5, en donde R3 y R4 son como se define en la descripción, con un compuesto de la Fórmula 1, con un compuesto de la Fórmula 1; el proceso de preparación del compuesto de la Fórmula 4 incluye la etapa de preparar el compuesto de la Fórmula 1 a partir del compuesto de la Fórmula 2 mediante el método descrito anteriormente. Se describe, además, un compuesto que es 3,5- diclorobencenoetanimidato de metilo, 3,5- diclorobencenoetanimidato de metilo o 3,5- diclorobencenoetanimidato de etilo o sales de estos.
MX2014006992A 2011-12-15 2012-12-13 Disales de acido malonico y metodo para preparar dihaluros de malonilo. MX352470B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161570962P 2011-12-15 2011-12-15
PCT/US2012/069468 WO2013090547A1 (en) 2011-12-15 2012-12-13 Malonic acid di-salts and a method for preparing malonyl dihalides

Publications (2)

Publication Number Publication Date
MX2014006992A MX2014006992A (es) 2014-08-01
MX352470B true MX352470B (es) 2017-11-27

Family

ID=47459174

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006992A MX352470B (es) 2011-12-15 2012-12-13 Disales de acido malonico y metodo para preparar dihaluros de malonilo.

Country Status (17)

Country Link
US (1) US9108965B2 (es)
EP (1) EP2791107B1 (es)
JP (2) JP2015501841A (es)
KR (1) KR102066682B1 (es)
CN (1) CN104066713B (es)
AR (1) AR089221A1 (es)
AU (1) AU2012352256B2 (es)
BR (1) BR112014014232B1 (es)
CA (1) CA2857333A1 (es)
CO (1) CO7121339A2 (es)
HU (1) HUE044394T2 (es)
IL (1) IL232632A (es)
MX (1) MX352470B (es)
RU (1) RU2636942C2 (es)
TW (1) TWI572587B (es)
WO (1) WO2013090547A1 (es)
ZA (1) ZA201403383B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI528899B (zh) * 2010-12-29 2016-04-11 杜邦股份有限公司 中離子性殺蟲劑
MX352976B (es) 2012-06-21 2017-12-15 Du Pont Formas solidas de una sal interna de pirido-pirimidinio.
CN105254515A (zh) * 2015-11-13 2016-01-20 浙江汇能生物股份有限公司 一种氯化琥珀胆碱的制备方法
TW201738229A (zh) 2016-04-26 2017-11-01 杜邦股份有限公司 製備ｎ－［（５－嘧啶基）甲基］－２－吡啶胺之方法
WO2018105492A1 (ja) * 2016-12-06 2018-06-14 日本化薬株式会社 ３－（ピリジル－２－アミノ）プロピオニトリル及びその類縁体の製造方法
JP6916161B2 (ja) * 2018-02-20 2021-08-11 インディアン オイル コーポレーション リミテッド ポリオレフィンポリマー用添加剤および熱可塑性組成物
US20210051958A1 (en) * 2018-03-05 2021-02-25 E. I. Du Pont De Nemours And Company Process and intermidiates for the preparation of certain mesoionic pesticides
CN108373468B (zh) * 2018-05-18 2019-12-17 武汉工程大学 一种n-2-吡啶-5-嘧啶甲胺的制备方法
CN109020952A (zh) * 2018-11-01 2018-12-18 雅本化学股份有限公司 一种n-2-吡啶基-5-嘧啶甲胺的制备方法
WO2023086802A1 (en) 2021-11-10 2023-05-19 Corteva Agriscience Llc Processes for the preparation of certain mesoionic pesticides
WO2024040111A1 (en) 2022-08-18 2024-02-22 Corteva Agriscience Llc Process for the preparation and isolation of intermediates of certain mesoionic pesticides
CN116003253A (zh) * 2022-12-31 2023-04-25 上海试四化学品有限公司 一种三氟苯嘧啶中间体2-[3-(三氟甲基)苯基]丙二酸二甲酯的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2290412A1 (fr) * 1974-11-09 1976-06-04 Gema Sa Procede pour la preparation de chlorures d'acide a partir d'esters silyliques
US5358924A (en) 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
WO1997036868A1 (de) * 1996-04-02 1997-10-09 Bayer Aktiengesellschaft Substituierte phenylketoenole als schädlingsbekämpfungsmittel und herbizide
DE19649665A1 (de) * 1996-04-02 1997-10-09 Bayer Ag Neue substituierte Phenylketoenole
US6297400B1 (en) * 1999-07-02 2001-10-02 The Clorox Company Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
JP3824483B2 (ja) * 2000-10-31 2006-09-20 住友ベークライト株式会社 芳香族カルボン酸とその酸塩化物、および合成法
JP4644957B2 (ja) * 2001-03-09 2011-03-09 住友ベークライト株式会社 芳香族カルボン酸及びその酸塩化物誘導体、並びにそれらの合成法
US6806380B2 (en) * 2001-10-02 2004-10-19 Lexicon Pharmaceuticals, Inc. Modified safe and efficient process for the environmentally friendly synthesis of imidoesters
US7060818B2 (en) 2003-02-21 2006-06-13 Carnegie Mellon University Synthesis of macrocyclic tetraamido compounds and new metal insertion process
JP2004292393A (ja) * 2003-03-27 2004-10-21 Sumitomo Bakelite Co Ltd 芳香族カルボン酸及びその酸塩化物誘導体の合成法
JP2005187368A (ja) * 2003-12-25 2005-07-14 Sumitomo Chemical Co Ltd カルボン酸クロリドの製造方法
CN100402520C (zh) 2006-07-28 2008-07-16 马启明 2-取代丙二酸钙盐的制备方法及钙盐的用途
RU2373182C2 (ru) * 2007-12-19 2009-11-20 Государственное образовательное учреждение высшего профессионального образования "Курский государственный технический университет" (КурскГТУ) Способ получения малоната и сукцината марганца (ii)
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
IN2012DN00838A (es) 2009-08-05 2015-06-26 Du Pont
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
EP2461684A2 (en) * 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionic pesticides
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
WO2011091532A1 (en) * 2010-01-28 2011-08-04 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
TWI528899B (zh) 2010-12-29 2016-04-11 杜邦股份有限公司 中離子性殺蟲劑
WO2012106495A1 (en) * 2011-02-03 2012-08-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides

Also Published As

Publication number Publication date
CO7121339A2 (es) 2014-11-20
ZA201403383B (en) 2015-12-23
BR112014014232A2 (pt) 2018-05-22
AU2012352256B2 (en) 2017-05-25
US9108965B2 (en) 2015-08-18
KR20140107420A (ko) 2014-09-04
JP6579399B2 (ja) 2019-09-25
MX2014006992A (es) 2014-08-01
EP2791107B1 (en) 2019-03-13
BR112014014232B1 (pt) 2020-01-28
TW201329037A (zh) 2013-07-16
EP2791107A1 (en) 2014-10-22
CA2857333A1 (en) 2013-06-20
AR089221A1 (es) 2014-08-06
IL232632A (en) 2017-04-30
WO2013090547A1 (en) 2013-06-20
CN104066713B (zh) 2016-08-24
KR102066682B1 (ko) 2020-01-16
RU2636942C2 (ru) 2017-11-29
CN104066713A (zh) 2014-09-24
JP2015501841A (ja) 2015-01-19
IL232632A0 (en) 2014-06-30
HUE044394T2 (hu) 2019-10-28
AU2012352256A1 (en) 2014-05-29
JP2018058840A (ja) 2018-04-12
US20140343284A1 (en) 2014-11-20
RU2014128826A (ru) 2016-02-10
TWI572587B (zh) 2017-03-01

Similar Documents

Publication Publication Date Title
MX352470B (es) Disales de acido malonico y metodo para preparar dihaluros de malonilo.
NZ600119A (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
NZ707389A (en) Process for preparing bile acid derivatives
PH12015501226A1 (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing the same
WO2012138147A3 (en) 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid crystalline form and the producing method thereof
AU2016237099B2 (en) Method for producing novel nitrogen-containing compound or salt thereof, and production intermediate of same
NZ601805A (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
IN2015DN02424A (es)
TW201129550A (en) Method for producing diepoxy compound
EA201490998A1 (ru) Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)-уксусной кислоты
MX363986B (es) Metodo para producir carboxamidas.
WO2011102640A3 (en) Method for preparing sitagliptin and amine salt intermediates used therein
MX2014003638A (es) Cristal de hidrato 5-hidroxi-1h-imidazol-4-carboxamida-3/4, metodo para producir el mismo y cristal de hidrato de 5-hidroxi-1h-imidazol-4-carboxamida.
PH12016501704B1 (en) Method for producing 2-acyliminopyridine derivative
MX337997B (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
MX2010009926A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexancarboxilico.
TN2014000329A1 (en) Method for preparing compound by novel michael addition reaction using water or various acids as additive
GB2523674A (en) Compounds as inhibitor of DNA double-strand break repair, methods and applications thereof
JO3189B1 (ar) طريقة جديدة لتخليق (e2) -3- (3, 4- داي ميثوكسي فينيل)بروب-2 - يننيتريل واستخدامها لتخليق ايفابرادين والاملاح المضافة منها مع حمض مقبول صيدلانيا
UA102091C2 (ru) Способ получения сульфонилпиролов как ингибиторов hdac
UA111329C2 (uk) Спосіб синтезу івабрадину і його адитивних солей з фармацевтично прийнятною кислотою
EA201300100A2 (ru) Способ ферментативного синтеза (7s)-3,4-диметоксибицикло[4.2.0]окта-1,3,5-триен-7-карбоновой кислоты или ее сложных эфиров и применение для синтеза ивабрадина и его соли
MX2014008995A (es) Compuesto novedoso de ester de acido acetico o una sal del mismo.
GEP20156369B (en) New process for synthesis of ivabradine and addition salts therewith pharmaceutically acceptable acid
GEP20156245B (en) New process for synthesis of ivabradine and addition salts thereof with pharmaceutically acceptable acid

Legal Events

Date Code Title Description
FG Grant or registration