MX354498B - Cristal de hidrato 5-hidroxi-1h-imidazol-4-carboxamida-3/4, metodo para producir el mismo y cristal de hidrato de 5-hidroxi-1h-imidazol-4-carboxamida. - Google Patents

Cristal de hidrato 5-hidroxi-1h-imidazol-4-carboxamida-3/4, metodo para producir el mismo y cristal de hidrato de 5-hidroxi-1h-imidazol-4-carboxamida.

Info

Publication number
MX354498B
MX354498B MX2014003638A MX2014003638A MX354498B MX 354498 B MX354498 B MX 354498B MX 2014003638 A MX2014003638 A MX 2014003638A MX 2014003638 A MX2014003638 A MX 2014003638A MX 354498 B MX354498 B MX 354498B
Authority
MX
Mexico
Prior art keywords
imidazole
hydroxy
carboxamide
hydrate
crystal
Prior art date
Application number
MX2014003638A
Other languages
English (en)
Other versions
MX2014003638A (es
Inventor
Fujimoto Taisuke
Hashimoto Tomohiro
Hayashi Katsuyuki
Tanaka Tomoyuki
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of MX2014003638A publication Critical patent/MX2014003638A/es
Publication of MX354498B publication Critical patent/MX354498B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporciona un método para producir hidrato de 5-hidroxi-1H-imidazol-4-carboxamida•3/4, que comprende: un paso en donde 2-aminomalonamida es reaccionada con un compuesto representado por la fórmula general (1) (en donde cada R representa independientemente un grupo alquilo C1-3) en la presencia de un ácido carboxílico para obtener 5-hidroxi-1H-imidazol-4-carboxamida; un paso en donde la 5-hidroxi-1H-imidazol-4-carboxamida así obtenida es reaccionada con un compuesto ácido para obtener una sal de ácido 5-hidroxi-1H-imidazol-4-carboxamida o un hidrato de la misma; y un paso en donde la sal de ácido 5-hidroxi-1H-imidazol-4-carboxami da así obtenida o un hidrato de la misma es reaccionada con una sal en la presencia de un solvente ácido.
MX2014003638A 2011-09-28 2012-09-28 Cristal de hidrato 5-hidroxi-1h-imidazol-4-carboxamida-3/4, metodo para producir el mismo y cristal de hidrato de 5-hidroxi-1h-imidazol-4-carboxamida. MX354498B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011213501 2011-09-28
JP2011213500 2011-09-28
PCT/JP2012/075106 WO2013047758A1 (ja) 2011-09-28 2012-09-28 ５－ヒドロキシ－１ｈ－イミダゾール－４－カルボキサミド水和物の結晶及び５－ヒドロキシ－１ｈ－イミダゾール－４－カルボキサミド・３／４水和物の結晶及びその製造方法

Publications (2)

Publication Number Publication Date
MX2014003638A MX2014003638A (es) 2014-05-21
MX354498B true MX354498B (es) 2018-03-08

Family

ID=47995783

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003638A MX354498B (es) 2011-09-28 2012-09-28 Cristal de hidrato 5-hidroxi-1h-imidazol-4-carboxamida-3/4, metodo para producir el mismo y cristal de hidrato de 5-hidroxi-1h-imidazol-4-carboxamida.

Country Status (14)

Country Link
US (2) US9108928B2 (es)
EP (1) EP2762469B1 (es)
KR (1) KR101970509B1 (es)
CN (1) CN103827093B (es)
AU (1) AU2012317424B2 (es)
BR (1) BR112014007436A2 (es)
CA (1) CA2850196A1 (es)
HK (1) HK1197406A1 (es)
IL (2) IL231677A (es)
IN (1) IN2014CN02346A (es)
MX (1) MX354498B (es)
RU (2) RU2672560C1 (es)
SG (1) SG11201400974VA (es)
WO (1) WO2013047758A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2672560C1 (ru) 2011-09-28 2018-11-16 Фуджифилм Корпорэйшн Кристалл гидрата 5-гидрокси-1Н-имидазол-4-карбоксамида и фармацевтическая композиция на его основе
WO2014112529A1 (ja) * 2013-01-15 2014-07-24 富士フイルム株式会社 ５－ヒドロキシ－１ｈ－イミダゾール－４－カルボキサミドの硫酸塩
AU2015205151B2 (en) * 2014-01-10 2018-02-01 Fujifilm Corporation 5-hydroxy-1H-imidazole-4-carboxamide effective-dose/sensitivity prediction method and prediction device, xanthosine-monophosphate-amount measurement method, and myelodysplastic-syndrome treatment agent and treatment method
EP3513791B1 (en) * 2016-09-13 2021-07-28 FUJIFILM Corporation Medicinal drug, method, use, and compound for preventing or curing leukemia associated with mll
WO2019082898A1 (ja) 2017-10-27 2019-05-02 富士フイルム株式会社 ５－ヒドロキシ－１ｈ－イミダゾール－４－カルボキサミド・３／４水和物の製造方法

Family Cites Families (15)

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US4181731A (en) * 1976-09-07 1980-01-01 Sumitomo Chemical Company, Limited Novel therapeutic application of 4-carbamoyl-5-hydroxyimidazole
JPS5625165A (en) * 1979-08-08 1981-03-10 Sumitomo Chem Co Ltd Novel imidazole derivative
JPS5824569A (ja) 1981-08-05 1983-02-14 Sumitomo Chem Co Ltd イミダゾ−ル誘導体の精製方法
US4503235A (en) * 1983-03-11 1985-03-05 Warner-Lambert Company Process for producing 4-carbamoyl-1H-imidazolium-5-olate
JPS60185727A (ja) * 1984-03-05 1985-09-21 Sumitomo Chem Co Ltd ４−カルバモイルイミダゾリウム−５−オレ−ト製剤の安定化法
CA2152863A1 (en) 1994-07-26 1996-01-27 Yeun-Kwei Han Preparation of acyclovir
US5567816A (en) 1994-07-26 1996-10-22 Syntex (U.S.A.) Inc. Preparation of acyclovir using 1,3 dioxolane
US7002023B2 (en) 2000-09-29 2006-02-21 Basf Aktiengesellschaft Method for producing 1 substituted 5-chloro-4 methly pyrazoles
JP2002265601A (ja) 2001-03-07 2002-09-18 Rikogaku Shinkokai イミド樹脂
AU2006215567B2 (en) * 2005-02-16 2011-05-12 Abbott Healthcare Products B.V. 1H-imidazole derivatives as cannabinoid CB2 receptor modulators
CN101395141A (zh) * 2006-02-24 2009-03-25 莱西肯医药有限公司 咪唑基化合物，包含其的组合物和它们的使用方法
JP5266010B2 (ja) * 2007-09-14 2013-08-21 富士フイルム株式会社 ４−カルバモイル−５−ヒドロキシ−イミダゾール誘導体のスルホン酸塩化合物
KR100982720B1 (ko) * 2008-02-04 2010-09-17 주식회사 파마코스텍 4-카르바모일-1-β-Ｄ-리보푸라노실이미다졸륨-5-올레이트의 생산을 위한 중간체로서의 2-아미노말론아미드의제조방법
RU2672560C1 (ru) 2011-09-28 2018-11-16 Фуджифилм Корпорэйшн Кристалл гидрата 5-гидрокси-1Н-имидазол-4-карбоксамида и фармацевтическая композиция на его основе
TWI594988B (zh) 2011-09-28 2017-08-11 富士軟片股份有限公司 ５－羥基－１ｈ－咪唑－４－甲醯胺．３／４水合物及其結晶之製造方法

Also Published As

Publication number Publication date
AU2012317424B2 (en) 2017-05-18
EP2762469B1 (en) 2016-11-23
IL231677A0 (en) 2014-05-28
NZ622928A (en) 2015-04-24
IL231677A (en) 2017-01-31
IN2014CN02346A (es) 2015-06-19
US20150315156A1 (en) 2015-11-05
CN103827093A (zh) 2014-05-28
KR101970509B1 (ko) 2019-04-19
BR112014007436A2 (pt) 2017-04-04
CN103827093B (zh) 2016-06-15
MX2014003638A (es) 2014-05-21
SG11201400974VA (en) 2014-09-26
HK1197406A1 (zh) 2015-01-16
EP2762469A1 (en) 2014-08-06
EP2762469A4 (en) 2015-01-14
KR20140069052A (ko) 2014-06-09
US9567303B2 (en) 2017-02-14
WO2013047758A1 (ja) 2013-04-04
IL246754A (en) 2017-08-31
CA2850196A1 (en) 2013-04-04
RU2630682C2 (ru) 2017-09-12
AU2012317424A8 (en) 2014-07-03
RU2014111810A (ru) 2015-11-10
AU2012317424A1 (en) 2014-04-17
RU2672560C1 (ru) 2018-11-16
US20140275568A1 (en) 2014-09-18
US9108928B2 (en) 2015-08-18

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