WO2011110198A8 - A process for making voriconazole - Google Patents
A process for making voriconazole Download PDFInfo
- Publication number
- WO2011110198A8 WO2011110198A8 PCT/EP2010/001607 EP2010001607W WO2011110198A8 WO 2011110198 A8 WO2011110198 A8 WO 2011110198A8 EP 2010001607 W EP2010001607 W EP 2010001607W WO 2011110198 A8 WO2011110198 A8 WO 2011110198A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- making
- voriconazole
- compound
- formula
- diastereomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The present invention relates to a process of making a pair of trans-diastereomers of a compound of formula (I) comprising the step of reacting the compound of formula (VI) with an acid or a carboxylate salt thereof of formula (X) wherein M is hydrogen or an equivalent of a metal cation, in the presence of a metal salt in a solvent, and to the use of the compound (X) in making voriconazole.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2010/001607 WO2011110198A1 (en) | 2010-03-10 | 2010-03-10 | A process for making voriconazole |
EP10708939A EP2545039A1 (en) | 2010-03-10 | 2010-03-10 | A process for making voriconazole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2010/001607 WO2011110198A1 (en) | 2010-03-10 | 2010-03-10 | A process for making voriconazole |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011110198A1 WO2011110198A1 (en) | 2011-09-15 |
WO2011110198A8 true WO2011110198A8 (en) | 2012-08-16 |
Family
ID=43127257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/001607 WO2011110198A1 (en) | 2010-03-10 | 2010-03-10 | A process for making voriconazole |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2545039A1 (en) |
WO (1) | WO2011110198A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6262972B2 (en) * | 2013-09-17 | 2018-01-17 | 公益財団法人微生物化学研究会 | Compound, method for producing the same, and method for producing voriconazole |
CN107827876A (en) * | 2017-10-27 | 2018-03-23 | 江苏理工学院 | A kind of preparation method of voriconazole raceme |
CN113929660B (en) * | 2021-10-18 | 2022-10-04 | 深圳市海滨制药有限公司 | Ring opening method of ethylene oxide derivative |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8819308D0 (en) | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
GB9002375D0 (en) | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
GB9516121D0 (en) | 1995-08-05 | 1995-10-04 | Pfizer Ltd | Organometallic addition to ketones |
CN1473825A (en) | 2002-08-07 | 2004-02-11 | 张文祥 | Process for preparing voriconazole |
CN1488630A (en) | 2002-10-08 | 2004-04-14 | 张文更 | Method for preparing triazole antifungal agent |
CN100579977C (en) | 2002-10-08 | 2010-01-13 | 许永翔 | Method for producing antifungal drug in triazole class |
US20080194820A1 (en) | 2004-12-14 | 2008-08-14 | Venkataraman Sundaram | Process For Preparing Voriconazole |
CN1810806A (en) | 2005-01-28 | 2006-08-02 | 江苏豪森药业股份有限公司 | Prepn process and intermediate for voriconazole |
EP1899327A1 (en) | 2005-06-30 | 2008-03-19 | MSN Laboratories Limited | Improved process for the preparation of 2r, 3s-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol (voriconazole) |
CN1847243A (en) | 2005-07-08 | 2006-10-18 | 北京博尔达生物技术开发有限公司 | Prepn process and prepn of new soluble voriconazole salt |
CN1814597A (en) | 2005-12-09 | 2006-08-09 | 北京丰德医药科技有限公司 | New method for preparing voriconazole |
CA2640922A1 (en) | 2006-02-01 | 2007-11-22 | Medichem, S.A. | Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof |
AR061889A1 (en) | 2006-07-13 | 2008-10-01 | Medichem Sa | IMPROVED PROCESS FOR THE PREPARATION OF VORICONAZOL |
CN1919846B (en) | 2006-09-14 | 2013-01-02 | 大道隆达(北京)医药科技发展有限公司 | Novel oriented synthesis method of voriconazole, medicinal salt and intermediate thereof |
CN100478341C (en) | 2006-12-31 | 2009-04-15 | 中国医学科学院医药生物技术研究所 | Voriconazole derivate and preparation process thereof |
KR100889937B1 (en) | 2007-08-06 | 2009-03-20 | 한미약품 주식회사 | Process for preparing voriconazole |
WO2009084029A2 (en) | 2007-12-03 | 2009-07-09 | Neuland Laboratories Ltd | Improved process for the preparation of (2r,3s)-2-(2,4- difluqrophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol |
-
2010
- 2010-03-10 EP EP10708939A patent/EP2545039A1/en not_active Withdrawn
- 2010-03-10 WO PCT/EP2010/001607 patent/WO2011110198A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2011110198A1 (en) | 2011-09-15 |
EP2545039A1 (en) | 2013-01-16 |
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