|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US4968607A
(en)
|
1987-11-25 |
1990-11-06 |
Immunex Corporation |
Interleukin-1 receptors
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
AU643427B2
(en)
|
1988-10-31 |
1993-11-18 |
Immunex Corporation |
Interleukin-4 receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
ATE210680T1
(de)
|
1990-03-17 |
2001-12-15 |
Takeda Chemical Industries Ltd |
Antikörper gegen hypophysäre adenylatzyklase aktivierende peptid-pacap, hybridome und bestimmung von pacap
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AU651596B2
(en)
|
1990-06-05 |
1994-07-28 |
Immunex Corporation |
Type II interleukin-1 receptors
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
CA2111348A1
(en)
|
1991-06-14 |
1992-12-23 |
John S. Logan |
Production of human hemoglobin in transgenic pigs
|
|
JPH06508880A
(ja)
|
1991-07-08 |
1994-10-06 |
ユニバーシティ オブ マサチューセッツ アット アムハースト |
サーモトロピック液晶セグメント化ブロックコポリマー
|
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
|
CA2130173A1
(en)
|
1992-03-17 |
1993-09-30 |
Norman Hardman |
Genetically engineered antibodies
|
|
JPH07509137A
(ja)
|
1992-07-24 |
1995-10-12 |
セル ジェネシス，インク． |
異種抗体の生産
|
|
EP0618291A3
(en)
|
1993-02-26 |
1997-12-03 |
Takeda Chemical Industries, Ltd. |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
US6399316B1
(en)
|
1994-02-25 |
2002-06-04 |
Takeda Chemical Industries, Ltd. |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
ATE265466T1
(de)
|
1994-08-16 |
2004-05-15 |
Human Genome Sciences Inc |
Calcitoninrezeptor
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
EP0822830B1
(en)
|
1995-04-27 |
2008-04-02 |
Amgen Fremont Inc. |
Human anti-IL-8 antibodies, derived from immunized xenomice
|
|
US6462016B1
(en)
|
1995-10-06 |
2002-10-08 |
Shiseido Company, Ltd. |
Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method
|
|
AU728657B2
(en)
|
1996-03-18 |
2001-01-18 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6017533A
(en)
|
1996-04-25 |
2000-01-25 |
Shiseido Company, Ltd. |
Peptides having specific affinity to pituitary adenylate cyclase activating polypeptide type 1 receptors
|
|
AU6596096A
(en)
|
1996-07-23 |
1998-02-10 |
Smithkline Beecham Corporation |
Calcitonin gene-related peptide receptor component factor (houdc44)
|
|
US6255455B1
(en)
|
1996-10-11 |
2001-07-03 |
The Trustees Of The University Of Pennsylvania |
Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
|
|
EP2305027B1
(en)
|
1996-12-03 |
2014-07-02 |
Amgen Fremont Inc. |
Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
CA2335341A1
(en)
|
1998-07-20 |
2000-02-03 |
Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R |
Peptide analogues of pacap
|
|
US6242563B1
(en)
|
1998-07-20 |
2001-06-05 |
Societe De Conseils De Recherches Et D'applications Scientifiques, Sas |
Peptide analogues
|
|
US6210924B1
(en)
|
1998-08-11 |
2001-04-03 |
Amgen Inc. |
Overexpressing cyclin D 1 in a eukaryotic cell line
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US20020155533A1
(en)
|
1998-11-30 |
2002-10-24 |
Takeda Chemical |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
US20020182729A1
(en)
|
2001-01-11 |
2002-12-05 |
Dicicco-Bloom Emanuel |
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
FR2821080B1
(fr)
|
2001-02-20 |
2003-12-19 |
Sanofi Synthelabo |
Anticorps specifique de l'adrenomedulline humaine, composition pharmaceutique le contenant, ses applications therapeutiques
|
|
WO2003009817A2
(en)
|
2001-07-25 |
2003-02-06 |
Protein Design Labs, Inc. |
Stable lyophilized pharmaceutical formulation of igg antibodies
|
|
EP1433793A4
(en)
|
2001-09-13 |
2006-01-25 |
Inst Antibodies Co Ltd |
METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY
|
|
JP4603261B2
(ja)
|
2001-09-27 |
2010-12-22 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ヒト化カルシトニン遺伝子関連ペプチド受容体をコードする単離ｄｎａ分子、関連する非ヒトトランスジェニック動物及びアッセイ方法
|
|
US7658924B2
(en)
|
2001-10-11 |
2010-02-09 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20040110170A1
(en)
|
2002-05-18 |
2004-06-10 |
The Regents Of The University Of California |
Cloning and characterization of calcitonin gene related peptide receptors
|
|
WO2005056606A2
(en)
|
2003-12-03 |
2005-06-23 |
Xencor, Inc |
Optimized antibodies that target the epidermal growth factor receptor
|
|
PL375536A1
(en)
|
2002-08-12 |
2005-11-28 |
Birkir Sveinsson |
Use of cgrp antagonist compounds for treatment of psoriasis
|
|
US20040176577A1
(en)
|
2002-09-10 |
2004-09-09 |
Eva Rojer |
Immunoassays for specific determination of SCCA isoforms
|
|
WO2004062684A2
(en)
|
2003-01-16 |
2004-07-29 |
D. Collen Research Foundation Vzw Onderwijs En Navorsing Campus Gasthuisberg K.U. Leuven |
Treatment of thrombocytopenia with inhibitors of pacap
|
|
WO2004097421A2
(en)
|
2003-04-29 |
2004-11-11 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl)
|
|
US20050129687A1
(en)
|
2003-11-03 |
2005-06-16 |
University Of Vermont And State Agricultural College |
Use of inhibitors of PACAP receptor activity for treatment of overactive bladder and pelvic floor pain syndrome
|
|
CA2554735A1
(en)
|
2004-01-30 |
2005-08-11 |
Peplin Biolipids Pty Ltd |
Therapeutic and carrier molecules
|
|
BRPI0507594A
(pt)
|
2004-02-11 |
2007-07-03 |
Amylin Pharmaceuticals Inc |
polipetìdeos hìbridos com propriedades selecionáveis
|
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
|
WO2006068953A2
(en)
|
2004-12-21 |
2006-06-29 |
Astrazeneca Ab |
Antibodies directed to angiopoietin-2 and uses thereof
|
|
TWI671403B
(zh)
|
2005-03-31 |
2019-09-11 |
中外製藥股份有限公司 |
控制組裝之多肽的製造方法
|
|
US9072777B2
(en)
|
2005-06-16 |
2015-07-07 |
Takayuki Shindo |
Method for screening substance having proangiogenic effect
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
CA2620364A1
(en)
|
2005-08-26 |
2007-03-01 |
David C. Yeomans |
Methods for treatment of headaches by administration of oxytocin
|
|
GB0521139D0
(en)
|
2005-10-18 |
2005-11-23 |
Univ Sheffield |
Therapeutic agent
|
|
US8168592B2
(en)
|
2005-10-21 |
2012-05-01 |
Amgen Inc. |
CGRP peptide antagonists and conjugates
|
|
JP5123197B2
(ja)
*
|
2005-11-14 |
2013-01-16 |
ライナット ニューロサイエンス コーポレイション |
カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体およびその使用方法
|
|
WO2007076336A1
(en)
*
|
2005-12-22 |
2007-07-05 |
Eli Lilly And Company |
Treatment of migraine with anti-cgrp antibodies
|
|
GEP20135917B
(en)
|
2006-03-17 |
2013-09-10 |
Biogen Idec Inc |
Stabilized polypeptide compositions
|
|
EP2064244B1
(en)
|
2006-08-03 |
2019-06-05 |
MedImmune Limited |
ANTIBODIES DIRECTED TO alphaVbeta6 AND USES THEREOF
|
|
CA2660330A1
(en)
|
2006-08-08 |
2008-02-14 |
Kyoto University |
Novel monoclonal antibody and use of the same
|
|
JP5622397B2
(ja)
|
2007-03-12 |
2014-11-12 |
エスバテック− ア ノバルティス カンパニー エルエルシー |
一本鎖抗体の配列に基づく操作および最適化
|
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
|
US8793074B2
(en)
|
2007-06-21 |
2014-07-29 |
Saint Louis University |
Sequence covariance networks, methods and uses therefor
|
|
DK2158315T3
(en)
|
2007-06-25 |
2016-06-06 |
Esbatech Alcon Biomed Res Unit |
Methods of modifying antibodies and modified antibodies with improved functional properties
|
|
WO2009033489A2
(en)
|
2007-09-11 |
2009-03-19 |
Glostrup Hospital |
Selective pacl inhibitors for use in the treatment of migraine and headaches
|
|
SI2235064T1
(sl)
|
2008-01-07 |
2016-04-29 |
Amgen Inc. |
Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
|
|
DK2265288T3
(en)
|
2008-03-04 |
2016-06-06 |
Labrys Biologics Inc |
Methods for the treatment of inflammatory pain
|
|
FR2934597B1
(fr)
|
2008-07-31 |
2013-04-19 |
Univ Aix Marseille Ii |
Anticorps se liant aux recepteurs de l'adrenomedulline et leurs utilisations comme medicament.
|
|
CN101434649B
(zh)
|
2008-12-12 |
2012-04-25 |
余榕捷 |
一种环七肽及其制备方法和应用
|
|
JO3382B1
(ar)
|
2008-12-23 |
2019-03-13 |
Amgen Inc |
أجسام مضادة ترتبط مع مستقبل cgrp بشري
|
|
US9676845B2
(en)
*
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
AU2010281436B2
(en)
|
2009-07-27 |
2016-03-24 |
Tonix Pharma Limited. |
Methods for treatment of pain
|
|
KR101519192B1
(ko)
|
2009-08-28 |
2015-05-11 |
리나트 뉴로사이언스 코프. |
칼시토닌 유전자-관련된 펩티드에 대해 지시된 길항제 항체의 투여에 의한 내장 통증의 치료 방법
|
|
JP2013514795A
(ja)
|
2009-12-22 |
2013-05-02 |
ノバルティス アーゲー |
治療における使用のための四価ｃｄ４７抗体定常領域融合タンパク質
|
|
EP2686682A4
(en)
|
2011-03-11 |
2015-03-11 |
Amgen Inc |
METHOD FOR CORRELATED MUTATION ANALYSIS TO IMPROVE THERAPEUTIC ANTIBODIES
|
|
ES2668895T3
(es)
|
2011-03-16 |
2018-05-23 |
Amgen Inc. |
Variantes de Fc
|
|
NZ732970A
(en)
*
|
2011-05-20 |
2022-08-26 |
H Lundbeck As |
Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
|
|
JP2015502397A
(ja)
|
2011-12-23 |
2015-01-22 |
ファイザー・インク |
部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
|
|
AU2013266611B2
(en)
|
2012-05-21 |
2016-08-11 |
Genentech, Inc. |
Methods for improving safety of blood-brain barrier transport
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
US9546203B2
(en)
|
2013-03-14 |
2017-01-17 |
Amgen Inc. |
Aglycosylated Fc-containing polypeptides with cysteine substitutions
|
|
TWI636064B
(zh)
*
|
2013-03-15 |
2018-09-21 |
安美基公司 |
人類ｐａｃ１抗體
|