|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US4968607A
(en)
|
1987-11-25 |
1990-11-06 |
Immunex Corporation |
Interleukin-1 receptors
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1990005183A1
(en)
|
1988-10-31 |
1990-05-17 |
Immunex Corporation |
Interleukin-4 receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
ES2284161T3
(es)
|
1990-01-12 |
2007-11-01 |
Amgen Fremont Inc. |
Generacion de anticuerpos xenogenicos.
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
JP3107225B2
(ja)
|
1990-03-17 |
2000-11-06 |
武田薬品工業株式会社 |
Ｐａｃａｐに対する抗体およびその用途
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
WO1991018982A1
(en)
|
1990-06-05 |
1991-12-12 |
Immunex Corporation |
Type ii interleukin-1 receptors
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
WO1992022646A1
(en)
|
1991-06-14 |
1992-12-23 |
Dnx Corp. |
Production of human hemoglobin in transgenic pigs
|
|
JPH06508880A
(ja)
|
1991-07-08 |
1994-10-06 |
ユニバーシティ オブ マサチューセッツ アット アムハースト |
サーモトロピック液晶セグメント化ブロックコポリマー
|
|
DE69233528T2
(de)
|
1991-11-25 |
2006-03-16 |
Enzon, Inc. |
Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
|
|
WO1993019180A1
(en)
|
1992-03-17 |
1993-09-30 |
Ciba-Geigy Ag |
Genetically engineered antibodies
|
|
ES2301158T3
(es)
|
1992-07-24 |
2008-06-16 |
Amgen Fremont Inc. |
Produccion de anticuerpos xenogenicos.
|
|
EP0618291A3
(en)
|
1993-02-26 |
1997-12-03 |
Takeda Chemical Industries, Ltd. |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
US6399316B1
(en)
|
1994-02-25 |
2002-06-04 |
Takeda Chemical Industries, Ltd. |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
WO1996005221A1
(en)
|
1994-08-16 |
1996-02-22 |
Human Genome Sciences, Inc. |
Calcitonin receptor
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
EP0822830B1
(en)
|
1995-04-27 |
2008-04-02 |
Amgen Fremont Inc. |
Human anti-IL-8 antibodies, derived from immunized xenomice
|
|
US6462016B1
(en)
|
1995-10-06 |
2002-10-08 |
Shiseido Company, Ltd. |
Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method
|
|
ATE279947T1
(de)
|
1996-03-18 |
2004-11-15 |
Univ Texas |
Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
|
|
US6017533A
(en)
|
1996-04-25 |
2000-01-25 |
Shiseido Company, Ltd. |
Peptides having specific affinity to pituitary adenylate cyclase activating polypeptide type 1 receptors
|
|
AU6596096A
(en)
|
1996-07-23 |
1998-02-10 |
Smithkline Beecham Corporation |
Calcitonin gene-related peptide receptor component factor (houdc44)
|
|
US6255455B1
(en)
|
1996-10-11 |
2001-07-03 |
The Trustees Of The University Of Pennsylvania |
Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
|
|
ATE549918T1
(de)
|
1996-12-03 |
2012-04-15 |
Amgen Fremont Inc |
Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
PL345583A1
(en)
|
1998-07-20 |
2001-12-17 |
Sod Conseils Rech Applic |
Peptide analogues of pacap
|
|
US6242563B1
(en)
|
1998-07-20 |
2001-06-05 |
Societe De Conseils De Recherches Et D'applications Scientifiques, Sas |
Peptide analogues
|
|
US6210924B1
(en)
|
1998-08-11 |
2001-04-03 |
Amgen Inc. |
Overexpressing cyclin D 1 in a eukaryotic cell line
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US20020155533A1
(en)
|
1998-11-30 |
2002-10-24 |
Takeda Chemical |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
US20020182729A1
(en)
|
2001-01-11 |
2002-12-05 |
Dicicco-Bloom Emanuel |
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
FR2821080B1
(fr)
|
2001-02-20 |
2003-12-19 |
Sanofi Synthelabo |
Anticorps specifique de l'adrenomedulline humaine, composition pharmaceutique le contenant, ses applications therapeutiques
|
|
AU2002324556A1
(en)
|
2001-07-25 |
2003-02-17 |
Protein Design Labs, Inc. |
Stable lyophilized pharmaceutical formulation of igg antibodies
|
|
US7371849B2
(en)
|
2001-09-13 |
2008-05-13 |
Institute For Antibodies Co., Ltd. |
Methods of constructing camel antibody libraries
|
|
ATE453661T1
(de)
|
2001-09-27 |
2010-01-15 |
Merck & Co Inc |
Isolierte dna-moleküle, die für einen humanisierten calcitonin gene-related peptide receptor kodieren, damit verwandte, nichthumane transgene tiere und assayverfahren
|
|
US7658924B2
(en)
|
2001-10-11 |
2010-02-09 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20040110170A1
(en)
|
2002-05-18 |
2004-06-10 |
The Regents Of The University Of California |
Cloning and characterization of calcitonin gene related peptide receptors
|
|
SI1556020T1
(sl)
|
2002-08-12 |
2009-08-31 |
Birkir Sveinsson |
Uporaba spojin, ki so antagonisti CGRP, za zdravljenje psoriaze
|
|
US20040176577A1
(en)
|
2002-09-10 |
2004-09-09 |
Eva Rojer |
Immunoassays for specific determination of SCCA isoforms
|
|
EP1583550A2
(en)
|
2003-01-16 |
2005-10-12 |
D. Collen Research Foundation vzw |
Inhibition of pacap signalling for the prevention and treatment of thrombocytopenia
|
|
WO2004097421A2
(en)
|
2003-04-29 |
2004-11-11 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl)
|
|
US20050129687A1
(en)
|
2003-11-03 |
2005-06-16 |
University Of Vermont And State Agricultural College |
Use of inhibitors of PACAP receptor activity for treatment of overactive bladder and pelvic floor pain syndrome
|
|
EP1701979A2
(en)
|
2003-12-03 |
2006-09-20 |
Xencor, Inc. |
Optimized antibodies that target the epidermal growth factor receptor
|
|
WO2005073164A1
(en)
|
2004-01-30 |
2005-08-11 |
Peplin Biolipids Pty Ltd |
Therapeutic and carrier molecules
|
|
US20060094652A1
(en)
|
2004-02-11 |
2006-05-04 |
Levy Odile E |
Hybrid polypeptides with selectable properties
|
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
|
ES2371083T3
(es)
|
2004-12-21 |
2011-12-27 |
Medimmune Limited |
Anticuerpos dirigidos contra la angiopoyetina-2 y usos de los mismos.
|
|
CN101198698B
(zh)
|
2005-03-31 |
2014-03-19 |
中外制药株式会社 |
通过调节多肽缔合制备多肽的方法
|
|
EP1900374B1
(en)
|
2005-06-16 |
2014-03-12 |
Takayuki Shindo |
Angiogenetic agent containing adrenomedulin as the active ingredient
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
WO2007025286A2
(en)
|
2005-08-26 |
2007-03-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Therapy procedure for drug delivery for trigeminal pain
|
|
GB0521139D0
(en)
|
2005-10-18 |
2005-11-23 |
Univ Sheffield |
Therapeutic agent
|
|
US8168592B2
(en)
|
2005-10-21 |
2012-05-01 |
Amgen Inc. |
CGRP peptide antagonists and conjugates
|
|
ES2433251T5
(es)
|
2005-11-14 |
2020-03-13 |
Teva Pharmaceuticals Int Gmbh |
Anticuerpos antagonistas dirigidos contra un péptido relacionado con el gen de la calcitonina y procedimientos que utilizan los mismos
|
|
WO2007076336A1
(en)
*
|
2005-12-22 |
2007-07-05 |
Eli Lilly And Company |
Treatment of migraine with anti-cgrp antibodies
|
|
CN103073639A
(zh)
|
2006-03-17 |
2013-05-01 |
比奥根艾迪克Ma公司 |
稳定的多肽组合物
|
|
KR20090039739A
(ko)
|
2006-08-03 |
2009-04-22 |
아스트라제네카 아베 |
αＶβ６에 대해 작용하는 항체 및 그의 용도
|
|
WO2008018472A1
(fr)
*
|
2006-08-08 |
2008-02-14 |
Kyoto University |
Nouvel anticorps monoclonal et son utilisation
|
|
CN103275216B
(zh)
|
2007-03-12 |
2015-05-06 |
艾斯巴技术-诺华有限责任公司 |
单链抗体的基于序列的工程改造和最优化
|
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
|
US8793074B2
(en)
|
2007-06-21 |
2014-07-29 |
Saint Louis University |
Sequence covariance networks, methods and uses therefor
|
|
DK2158315T3
(en)
|
2007-06-25 |
2016-06-06 |
Esbatech Alcon Biomed Res Unit |
Methods of modifying antibodies and modified antibodies with improved functional properties
|
|
WO2009033489A2
(en)
|
2007-09-11 |
2009-03-19 |
Glostrup Hospital |
Selective pacl inhibitors for use in the treatment of migraine and headaches
|
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
|
ES2584907T3
(es)
|
2008-03-04 |
2016-09-30 |
Labrys Biologics Inc. |
Métodos para tratamiento del dolor inflamatorio
|
|
FR2934597B1
(fr)
|
2008-07-31 |
2013-04-19 |
Univ Aix Marseille Ii |
Anticorps se liant aux recepteurs de l'adrenomedulline et leurs utilisations comme medicament.
|
|
CN101434649B
(zh)
|
2008-12-12 |
2012-04-25 |
余榕捷 |
一种环七肽及其制备方法和应用
|
|
JO3382B1
(ar)
*
|
2008-12-23 |
2019-03-13 |
Amgen Inc |
أجسام مضادة ترتبط مع مستقبل cgrp بشري
|
|
US9676845B2
(en)
*
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
KR20180052610A
(ko)
|
2009-07-27 |
2018-05-18 |
노시셉터 엘엘씨 |
통증 치료 방법
|
|
ES2912569T3
(es)
|
2009-08-28 |
2022-05-26 |
Teva Pharmaceuticals Int Gmbh |
Métodos para tratar el dolor visceral administrando anticuerpos antagonistas dirigidos contra el péptido relacionado con el gen de la calcitonina
|
|
JP2013514795A
(ja)
|
2009-12-22 |
2013-05-02 |
ノバルティス アーゲー |
治療における使用のための四価ｃｄ４７抗体定常領域融合タンパク質
|
|
CA2829628A1
(en)
|
2011-03-11 |
2012-09-20 |
Amgen Inc. |
Method of correlated mutational analysis to improve therapeutic antibodies
|
|
MX348071B
(es)
|
2011-03-16 |
2017-05-26 |
Amgen Inc |
Variantes de fc.
|
|
RS66303B1
(sr)
*
|
2011-05-20 |
2025-01-31 |
H Lundbeck As |
Upotreba anti-cgrp antitela i fragmenata antitela za sprečavanje ili inhibiranje fotofobije ili odbojnosti prema svetlu kod subjekata kojima je to potrebno, naročito kod subjekata koji pate od migrene
|
|
EP3539982B1
(en)
|
2011-12-23 |
2025-02-19 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
MX374424B
(es)
|
2012-05-21 |
2025-03-06 |
Genentech Inc |
Metodos para mejorar la seguridad del transporte de la barrera hematoencefalica.
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
US9546203B2
(en)
|
2013-03-14 |
2017-01-17 |
Amgen Inc. |
Aglycosylated Fc-containing polypeptides with cysteine substitutions
|
|
TWI636064B
(zh)
*
|
2013-03-15 |
2018-09-21 |
安美基公司 |
人類ｐａｃ１抗體
|