JP2018522888A5 - - Google Patents
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- Publication number
- JP2018522888A5 JP2018522888A5 JP2018501345A JP2018501345A JP2018522888A5 JP 2018522888 A5 JP2018522888 A5 JP 2018522888A5 JP 2018501345 A JP2018501345 A JP 2018501345A JP 2018501345 A JP2018501345 A JP 2018501345A JP 2018522888 A5 JP2018522888 A5 JP 2018522888A5
- Authority
- JP
- Japan
- Prior art keywords
- isolated polypeptide
- seq
- nos
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562193309P | 2015-07-16 | 2015-07-16 | |
| US62/193,309 | 2015-07-16 | ||
| PCT/US2016/042862 WO2017011837A2 (en) | 2015-07-16 | 2016-07-18 | Multivalent and multispecific dr5-binding fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020196358A Division JP7244938B2 (ja) | 2015-07-16 | 2020-11-26 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522888A JP2018522888A (ja) | 2018-08-16 |
| JP2018522888A5 true JP2018522888A5 (enExample) | 2019-07-04 |
| JP6807606B2 JP6807606B2 (ja) | 2021-01-06 |
Family
ID=57757772
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501345A Active JP6807606B2 (ja) | 2015-07-16 | 2016-07-18 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
| JP2020196358A Active JP7244938B2 (ja) | 2015-07-16 | 2020-11-26 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
| JP2022191038A Pending JP2023022214A (ja) | 2015-07-16 | 2022-11-30 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
| JP2025032594A Pending JP2025084923A (ja) | 2015-07-16 | 2025-03-03 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020196358A Active JP7244938B2 (ja) | 2015-07-16 | 2020-11-26 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
| JP2022191038A Pending JP2023022214A (ja) | 2015-07-16 | 2022-11-30 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
| JP2025032594A Pending JP2025084923A (ja) | 2015-07-16 | 2025-03-03 | 多価及び多重特異性ｄｒ５結合融合タンパク質 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10308720B2 (enExample) |
| EP (2) | EP3322734B1 (enExample) |
| JP (4) | JP6807606B2 (enExample) |
| KR (2) | KR102760380B1 (enExample) |
| CN (2) | CN114106178A (enExample) |
| AU (3) | AU2016291701B2 (enExample) |
| CY (1) | CY1123615T1 (enExample) |
| DK (1) | DK3322734T3 (enExample) |
| ES (1) | ES2833773T3 (enExample) |
| HR (1) | HRP20201785T1 (enExample) |
| HU (1) | HUE051896T2 (enExample) |
| IL (3) | IL307994A (enExample) |
| LT (1) | LT3322734T (enExample) |
| MX (2) | MX2018000523A (enExample) |
| NZ (1) | NZ777930A (enExample) |
| PL (1) | PL3322734T3 (enExample) |
| PT (1) | PT3322734T (enExample) |
| RS (1) | RS61062B1 (enExample) |
| RU (2) | RU2021111382A (enExample) |
| SG (1) | SG10201912410TA (enExample) |
| SI (1) | SI3322734T1 (enExample) |
| SM (1) | SMT202100066T1 (enExample) |
| WO (1) | WO2017011837A2 (enExample) |
| ZA (1) | ZA201800238B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201909160WA (en) | 2017-04-11 | 2019-10-30 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
| US20210079106A1 (en) * | 2017-12-28 | 2021-03-18 | Julius-Maximilians-Universität Würzburg | TUMOR NECROSIS FACTOR (TNF) RECEPTOR SUPERFAMILY (TNFRSF) RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY (TNFRSF RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY; TRAAFFIAA) |
| CN110305210B (zh) * | 2018-03-27 | 2023-02-28 | 信达生物制药(苏州)有限公司 | 新型抗体分子、其制备方法及其用途 |
| WO2019200022A1 (en) | 2018-04-11 | 2019-10-17 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| WO2020047705A1 (zh) * | 2018-09-03 | 2020-03-12 | 安菲尼生命科技有限公司 | Dr5单域抗体及其用途 |
| GB201903767D0 (en) * | 2019-03-19 | 2019-05-01 | Quadrucept Bio Ltd | Multimers, tetramers & octamers |
| KR20220070215A (ko) * | 2019-10-01 | 2022-05-30 | 엡실로겐 리미티드 | 하이브리드 항체 |
| US20230287143A1 (en) * | 2020-06-30 | 2023-09-14 | Harbour Biomed (Shanghai) Co., Ltd | Binding protein in fab-hcab structure |
| EP4545569A3 (en) * | 2020-06-30 | 2025-10-08 | Harbour Biomed (Shanghai) Co., Ltd | Binding protein having h2l2 and hcab structures |
| CA3208641A1 (en) * | 2021-02-19 | 2022-08-25 | Ashraf AMANULLAH | Formulations of dr5 binding polypeptides |
| US20250215101A1 (en) * | 2022-04-08 | 2025-07-03 | Inhibrx Biosciences, Inc. | DR5 Agonist and PLK1 Inhibitor or CDK Inhibitor Combination Therapy |
| WO2023230432A1 (en) * | 2022-05-23 | 2023-11-30 | Inhibrx, Inc. | Dr5 agonist and iap antagonist combination therapy |
| CN117285644A (zh) * | 2022-06-16 | 2023-12-26 | 清华大学 | 一种相变调节元件及其用途 |
| US20260036590A1 (en) | 2022-09-28 | 2026-02-05 | Valink Therapeutics Ltd | Multivalent proteins and screening methods |
| TW202515917A (zh) * | 2023-06-29 | 2025-04-16 | 美商奧迪希治療公司 | 抗trailr2抗原結合蛋白及其用途 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ241119A (en) * | 1990-12-20 | 1993-06-25 | Ixsys Inc | Manipulating nucleic acid to optimize the binding characteristics of the encoded binding protein |
| US20020147140A1 (en) * | 2000-01-31 | 2002-10-10 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| KR20070010046A (ko) | 2004-04-06 | 2007-01-19 | 제넨테크, 인크. | Ｄｒ5 항체 및 그의 용도 |
| CN101120021A (zh) | 2004-12-31 | 2008-02-06 | 基因技术公司 | 结合br3的多肽及其用途 |
| JP2008532014A (ja) | 2005-02-24 | 2008-08-14 | セマインズ，インコーポレイティド | 生物試料を分類するための組成物及び方法 |
| US8124076B2 (en) | 2005-08-18 | 2012-02-28 | Ramot At Tel Aviv University Ltd. | Single chain antibodies against β-amyloid peptide |
| JP2009518024A (ja) | 2005-12-06 | 2009-05-07 | ドマンティス リミテッド | Ｅｇｆｒおよび／またはｖｅｇｆに対して結合特異性を有するリガンドおよびその使用法 |
| CA2638912A1 (en) | 2006-02-20 | 2007-08-30 | Phylogica Limited | Method of constructing and screening libraries of peptide structures |
| JP2008133206A (ja) | 2006-11-28 | 2008-06-12 | Yokohama City Univ | 緑膿菌に対して感染防御能を誘導できる医薬組成物 |
| CA2706732A1 (en) | 2007-11-30 | 2009-06-11 | Kalobios Pharmaceuticals, Inc. | Antibodies to the pcrv antigen of pseudomonas aeruginosa |
| ES2713864T3 (es) * | 2008-06-05 | 2019-05-24 | Ablynx Nv | Secuencias de aminoácidos dirigidas contra proteínas de la envuelta de un virus y polipéptidos que comprenden las mismas para el tratamiento de enfermedades virales |
| US20110166076A1 (en) * | 2008-09-10 | 2011-07-07 | Bac Ip B.V. | Antigen-binding proteins that inhibit superantigens for the treatment of skin diseases |
| EP2408475B1 (en) | 2009-03-18 | 2017-11-15 | Wake Forest University Health Sciences | Flagellin fusion proteins and use thereof to induce immune responses against pseudomonas aeruginosa |
| WO2010115141A2 (en) | 2009-04-02 | 2010-10-07 | New York University | System and uses for generating databases of protein secondary structures involved in inter-chain protein interactions |
| CN101717775B (zh) * | 2009-11-13 | 2012-01-04 | 厦门大学 | 抗人死亡受体5的单链抗体基因 |
| RS67588B1 (sr) | 2009-12-14 | 2026-01-30 | Ablynx Nv | Antitela sa pojedinačnim varijabilnim domenom imunoglobulina protiv ox40l, konstrukti i njihova terapijska upotreba |
| US9120855B2 (en) * | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| WO2011134060A1 (en) | 2010-04-27 | 2011-11-03 | National Research Council Of Canada | Anti-icam-1 single domain antibody and uses thereof |
| CN103118706B (zh) * | 2010-09-27 | 2016-05-18 | 莫佛塞斯公司 | 抗cd38抗体与来那度胺或硼替佐米用于治疗多发性骨髓瘤和nhl |
| US9771416B2 (en) | 2010-10-25 | 2017-09-26 | National Research Council Of Canada | Clostridium difficile-specific antibodies and uses thereof |
| CN103270047A (zh) | 2010-12-23 | 2013-08-28 | 因特塞尔奥地利股份公司 | Oprf/i剂及其在住院患者和其他患者中的用途 |
| PH12014500380A1 (en) | 2011-08-17 | 2022-05-02 | Glaxo Group Ltd | Modified proteins and peptides |
| SMT202000091T1 (it) | 2011-10-13 | 2020-05-08 | Bristol Myers Squibb Co | Polipeptidi anticorpali che antagonizzano cd40l |
| EP2776061B1 (en) | 2011-11-07 | 2019-08-14 | MedImmune, LLC | Multispecific and multivalent binding proteins and uses thereof |
| US9879093B2 (en) | 2011-12-20 | 2018-01-30 | Adaerata, Limited Partnershp | Single domain antibodies as inhibitors of PCSK9 |
| EP2820043B1 (en) | 2012-03-02 | 2020-01-15 | Ablynx N.V. | Biparatopic pseudomonas aeruginosa pcrv binding single variable domain antibodies |
| WO2013167883A1 (en) | 2012-05-07 | 2013-11-14 | The University Court Of The University Of Aberdeen | Single domain binding molecule |
| EP2684896A1 (en) * | 2012-07-09 | 2014-01-15 | International-Drug-Development-Biotech | Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof |
| JP2015531350A (ja) | 2012-09-13 | 2015-11-02 | ノバルティス アーゲー | 末端修飾を有する抗原結合分子 |
| KR20150082367A (ko) | 2012-11-06 | 2015-07-15 | 메디뮨 엘엘씨 | 항슈도모나스 ｐｓｌ 및 ｐｃｒｖ 결합 분자를 이용한 병용 요법 |
| CN102924600B (zh) * | 2012-11-14 | 2013-10-30 | 河南大学 | 死亡受体5激动性多价抗体及其在制备抗肿瘤药物中的应用 |
| WO2014111550A1 (en) | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
| US9862777B2 (en) | 2013-05-28 | 2018-01-09 | Vib Vzw | Single domain antibodies against SOD1 and their use in medicine |
| KR20160103007A (ko) * | 2014-01-10 | 2016-08-31 | 각코호진 데이쿄 헤이세이 다이가쿠 | 재조합 편성 혐기성 그램 양성균 |
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2016
- 2016-07-18 EP EP16825315.1A patent/EP3322734B1/en active Active
- 2016-07-18 PT PT168253151T patent/PT3322734T/pt unknown
- 2016-07-18 JP JP2018501345A patent/JP6807606B2/ja active Active
- 2016-07-18 KR KR1020187000975A patent/KR102760380B1/ko active Active
- 2016-07-18 AU AU2016291701A patent/AU2016291701B2/en active Active
- 2016-07-18 IL IL307994A patent/IL307994A/en unknown
- 2016-07-18 SM SM20210066T patent/SMT202100066T1/it unknown
- 2016-07-18 SI SI201631005T patent/SI3322734T1/sl unknown
- 2016-07-18 LT LTEP16825315.1T patent/LT3322734T/lt unknown
- 2016-07-18 CN CN202111039963.9A patent/CN114106178A/zh active Pending
- 2016-07-18 SG SG10201912410TA patent/SG10201912410TA/en unknown
- 2016-07-18 MX MX2018000523A patent/MX2018000523A/es unknown
- 2016-07-18 US US15/213,296 patent/US10308720B2/en active Active
- 2016-07-18 DK DK16825315.1T patent/DK3322734T3/da active
- 2016-07-18 RS RS20201315A patent/RS61062B1/sr unknown
- 2016-07-18 RU RU2021111382A patent/RU2021111382A/ru unknown
- 2016-07-18 WO PCT/US2016/042862 patent/WO2017011837A2/en not_active Ceased
- 2016-07-18 CN CN201680041274.2A patent/CN107922491B/zh active Active
- 2016-07-18 IL IL292037A patent/IL292037A/en unknown
- 2016-07-18 EP EP20189995.2A patent/EP3798232A1/en active Pending
- 2016-07-18 ES ES16825315T patent/ES2833773T3/es active Active
- 2016-07-18 RU RU2018102803A patent/RU2748620C2/ru active
- 2016-07-18 HU HUE16825315A patent/HUE051896T2/hu unknown
- 2016-07-18 KR KR1020257002277A patent/KR20250017305A/ko active Pending
- 2016-07-18 PL PL16825315T patent/PL3322734T3/pl unknown
- 2016-07-18 NZ NZ777930A patent/NZ777930A/en unknown
- 2016-07-18 HR HRP20201785TT patent/HRP20201785T1/hr unknown
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2018
- 2018-01-07 IL IL256772A patent/IL256772B/en unknown
- 2018-01-12 ZA ZA2018/00238A patent/ZA201800238B/en unknown
- 2018-01-12 MX MX2023002379A patent/MX2023002379A/es unknown
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2019
- 2019-04-18 US US16/387,754 patent/US11117973B2/en active Active
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2020
- 2020-11-16 CY CY20201101085T patent/CY1123615T1/el unknown
- 2020-11-26 JP JP2020196358A patent/JP7244938B2/ja active Active
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2021
- 2021-08-05 US US17/394,900 patent/US11976126B2/en active Active
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2022
- 2022-11-30 JP JP2022191038A patent/JP2023022214A/ja active Pending
- 2022-12-21 AU AU2022291498A patent/AU2022291498A1/en active Pending
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2024
- 2024-04-04 US US18/626,699 patent/US20240376220A1/en active Pending
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2025
- 2025-03-03 JP JP2025032594A patent/JP2025084923A/ja active Pending
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2026
- 2026-01-16 AU AU2026200317A patent/AU2026200317A1/en active Pending