JP2018523493A5 - - Google Patents
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- JP2018523493A5 JP2018523493A5 JP2018523387A JP2018523387A JP2018523493A5 JP 2018523493 A5 JP2018523493 A5 JP 2018523493A5 JP 2018523387 A JP2018523387 A JP 2018523387A JP 2018523387 A JP2018523387 A JP 2018523387A JP 2018523493 A5 JP2018523493 A5 JP 2018523493A5
- Authority
- JP
- Japan
- Prior art keywords
- gitr
- isolated polypeptide
- amino acid
- cancer
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 110
- 229920001184 polypeptide Polymers 0.000 claims description 107
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 107
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 60
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 52
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 201000011510 cancer Diseases 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 6
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 6
- 108020001507 fusion proteins Proteins 0.000 claims description 5
- 102000037865 fusion proteins Human genes 0.000 claims description 5
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims description 4
- 101710204410 Scaffold protein Proteins 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 230000001603 reducing effect Effects 0.000 claims description 4
- 230000004614 tumor growth Effects 0.000 claims description 4
- 230000006044 T cell activation Effects 0.000 claims description 3
- 230000006052 T cell proliferation Effects 0.000 claims description 3
- 241000251468 Actinopterygii Species 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010005949 Bone cancer Diseases 0.000 claims description 2
- 208000018084 Bone neoplasm Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 102000019298 Lipocalin Human genes 0.000 claims description 2
- 108050006654 Lipocalin Proteins 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038111 Recurrent cancer Diseases 0.000 claims description 2
- 206010070308 Refractory cancer Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 101000677856 Stenotrophomonas maltophilia (strain K279a) Actin-binding protein Smlt3054 Proteins 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 108010068032 caltractin Proteins 0.000 claims description 2
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 2
- 208000025997 central nervous system neoplasm Diseases 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 201000003115 germ cell cancer Diseases 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 238000005734 heterodimerization reaction Methods 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 208000037819 metastatic cancer Diseases 0.000 claims description 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 230000004083 survival effect Effects 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000004471 Glycine Chemical group 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- 208000037062 Polyps Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195822P | 2015-07-23 | 2015-07-23 | |
| US62/195,822 | 2015-07-23 | ||
| PCT/US2016/043717 WO2017015623A2 (en) | 2015-07-23 | 2016-07-22 | Multivalent and multispecific gitr-binding fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523493A JP2018523493A (ja) | 2018-08-23 |
| JP2018523493A5 true JP2018523493A5 (enExample) | 2019-08-29 |
| JP6913682B2 JP6913682B2 (ja) | 2021-08-04 |
Family
ID=57835278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018523387A Expired - Fee Related JP6913682B2 (ja) | 2015-07-23 | 2016-07-22 | 多価および多重特異性ｇｉｔｒ結合融合タンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10093742B2 (enExample) |
| EP (1) | EP3325512B1 (enExample) |
| JP (1) | JP6913682B2 (enExample) |
| KR (1) | KR20180031728A (enExample) |
| CN (1) | CN108650886B (enExample) |
| AR (1) | AR105767A1 (enExample) |
| AU (1) | AU2016297249B2 (enExample) |
| BR (1) | BR112018001161A2 (enExample) |
| CA (1) | CA2992298A1 (enExample) |
| IL (1) | IL257030B2 (enExample) |
| MX (1) | MX2018000948A (enExample) |
| RU (1) | RU2753439C2 (enExample) |
| SG (1) | SG10201913807QA (enExample) |
| TW (1) | TWI745296B (enExample) |
| WO (1) | WO2017015623A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
| RU2753439C2 (ru) | 2015-07-23 | 2021-08-16 | Инхибркс, Инк. | Поливалетные и полиспецифичные gitr-связывающие слитые белки |
| JP7084870B2 (ja) | 2015-10-22 | 2022-06-15 | アブリンクス エン．ヴェー． | Ｇｉｔｒアゴニスト |
| EP3478721A1 (en) | 2016-07-01 | 2019-05-08 | Five Prime Therapeutics, Inc. | Combined anti tumor therapy with a gitr agonist and cpg |
| CN110709420A (zh) * | 2017-03-31 | 2020-01-17 | 戊瑞治疗有限公司 | 使用抗gitr抗体的癌症组合疗法 |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| TW202515920A (zh) | 2017-04-11 | 2025-04-16 | 美商因荷布瑞克斯生物科學公司 | 具有經受限cd3結合的多重特異性多肽構築體及使用其之方法 |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| KR20200006115A (ko) | 2017-05-16 | 2020-01-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-gitr 효능제 항체에 의한 암의 치료 |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
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| WO2018234879A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Il-1beta binding antibodies for use in treating cancer |
| JP2020525483A (ja) | 2017-06-27 | 2020-08-27 | ノバルティス アーゲー | 抗ｔｉｍ−３抗体のための投与レジメンおよびその使用 |
| CN111163798A (zh) | 2017-07-20 | 2020-05-15 | 诺华股份有限公司 | 用于抗lag-3抗体的给药方案及其用途 |
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2016
- 2016-07-22 RU RU2018106452A patent/RU2753439C2/ru active
- 2016-07-22 EP EP16828658.1A patent/EP3325512B1/en active Active
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2017
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2018
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