JP2022515318A5 - - Google Patents
Info
- Publication number
- JP2022515318A5 JP2022515318A5 JP2021528872A JP2021528872A JP2022515318A5 JP 2022515318 A5 JP2022515318 A5 JP 2022515318A5 JP 2021528872 A JP2021528872 A JP 2021528872A JP 2021528872 A JP2021528872 A JP 2021528872A JP 2022515318 A5 JP2022515318 A5 JP 2022515318A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- cdr
- indicated
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811617535 | 2018-12-28 | ||
| CN201811617535.8 | 2018-12-28 | ||
| PCT/CN2019/126495 WO2020135201A1 (zh) | 2018-12-28 | 2019-12-19 | 一种抗体及其用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022515318A JP2022515318A (ja) | 2022-02-18 |
| JP2022515318A5 true JP2022515318A5 (enExample) | 2023-07-28 |
| JP7562528B2 JP7562528B2 (ja) | 2024-10-07 |
Family
ID=71126071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021528872A Active JP7562528B2 (ja) | 2018-12-28 | 2019-12-19 | 抗体及びその用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12297265B2 (enExample) |
| EP (1) | EP3904386A4 (enExample) |
| JP (1) | JP7562528B2 (enExample) |
| KR (1) | KR20210109520A (enExample) |
| CN (2) | CN119350498A (enExample) |
| WO (1) | WO2020135201A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119350498A (zh) | 2018-12-28 | 2025-01-24 | 四川科伦博泰生物医药股份有限公司 | 一种抗体及其用途 |
| SG11202108398YA (en) | 2019-02-01 | 2021-08-30 | Novarock Biotherapeutics Ltd | Anti-claudin 18 antibodies and methods of use thereof |
| CN115715202B (zh) * | 2020-05-15 | 2025-11-04 | 四川科伦博泰生物医药股份有限公司 | 抗体药物缀合物及其制备方法和用途 |
| CN113754780A (zh) * | 2020-06-04 | 2021-12-07 | 四川科伦博泰生物医药股份有限公司 | 靶向cldn18.2的嵌合抗原受体、其组合物及用途 |
| CN111704669B (zh) * | 2020-07-13 | 2022-05-13 | 北京凯因科技股份有限公司 | 一种用于治疗晚期胃癌的抗cldn18全人源化抗体 |
| CA3196930A1 (en) * | 2020-09-28 | 2022-03-31 | Elpiscience (Suzhou) Biopharma, Ltd. | Novel anti-claudin18 antibodies |
| CN114437221B (zh) * | 2020-11-05 | 2023-08-01 | 北京天广实生物技术股份有限公司 | 一种癌症检测抗体及其用途 |
| WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| CN114617961B (zh) * | 2020-12-10 | 2022-12-02 | 北京东方百泰生物科技股份有限公司 | 一种抗lag-3单克隆抗体的注射制剂 |
| TW202241519A (zh) | 2020-12-23 | 2022-11-01 | 捷克商舒迪安生物技術公司 | 腫瘤特異性密連蛋白１８﹒２抗體藥物結合物 |
| CN115109154A (zh) * | 2021-03-17 | 2022-09-27 | 三优生物医药(上海)有限公司 | 一种靶向cldn18.2的抗体或其抗原结合片段及其应用 |
| AU2022275043B2 (en) * | 2021-05-08 | 2025-11-20 | Remegen Co., Ltd. | Anti-Claudin 18.2 antibody and antibody-drug conjugate thereof |
| CN115611983A (zh) * | 2021-07-14 | 2023-01-17 | 三优生物医药(上海)有限公司 | Cldn18.2结合分子及其用途 |
| CN113801231B (zh) * | 2021-08-20 | 2022-09-02 | 四川大学华西医院 | 抗dog-1抗体或其抗原结合片段及其用途 |
| CN113687085A (zh) * | 2021-08-27 | 2021-11-23 | 复旦大学附属中山医院 | 一种评估实体肿瘤Claudin18.2蛋白表达的方法和应用 |
| AU2022371521A1 (en) * | 2021-10-19 | 2024-05-02 | Biosion Inc. | Antibodies binding cldn18.2 and uses thereof |
| CN115991784A (zh) * | 2021-10-19 | 2023-04-21 | 宝船生物医药科技(上海)有限公司 | 抗cd47-cldn18.2双特异性抗体及其用途 |
| JP7796230B2 (ja) * | 2021-12-17 | 2026-01-08 | フォートビタ バイオロジクス（シンガポール）プライベート リミティド | Ｃｌａｕｄｉｎ１８．２を標的とする抗体―薬物複合体 |
| KR102809807B1 (ko) * | 2021-12-21 | 2025-05-16 | 한림대학교 산학협력단 | 항-cldn18.2를 포함하는 키메릭 항원 수용체를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 및 이의 제조 방법 |
| CN117229398A (zh) * | 2022-06-15 | 2023-12-15 | 中山康方生物医药有限公司 | 抗cldn18.2抗体、其药物组合物及用途 |
| CN116284387B (zh) * | 2022-07-15 | 2025-10-03 | 台州恩泽医疗中心(集团) | 一种抗hla-g2及hla-g6分子的单克隆抗体及用途 |
| EP4558518A2 (en) * | 2022-07-22 | 2025-05-28 | The Government of The United States, as represented by The Secretary of The Army | Monoclonal antibodies that interfere with iron uptake |
| CN117777288A (zh) * | 2022-09-29 | 2024-03-29 | 南京博望医药科技有限公司 | 抗密蛋白18.2的抗体 |
| WO2024074145A1 (zh) * | 2022-10-08 | 2024-04-11 | 盛禾(中国)生物制药有限公司 | 一种结合baffr和cd3的双特异性抗体及其应用 |
| CN115947851B (zh) * | 2022-12-19 | 2024-02-13 | 华润生物医药有限公司 | 结合cldn18.2的抗体及其用途 |
| TW202434307A (zh) | 2023-01-18 | 2024-09-01 | 大陸商泰勵生物科技（上海）有限公司 | 抗體偶聯藥物及其用途 |
| CN116813782B (zh) * | 2023-08-10 | 2024-01-23 | 北京百普赛斯生物科技股份有限公司 | 一种Claudin-18.2特异性抗体及其应用 |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| CN117106081B (zh) * | 2023-09-28 | 2024-05-07 | 北京凯祥弘康生物科技有限公司 | 一种抗nfl蛋白的捕获抗体 |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025078686A1 (en) | 2023-10-12 | 2025-04-17 | Sotio Biotech A.S. | Combination therapy involving antibody-drug conjugates against claudin18.2 and pd1/pd-l axis inhibitors for treatment of cancer |
| CN117736329B (zh) * | 2023-12-25 | 2024-11-12 | 华润生物医药有限公司 | 抗pd-1抗体及其用途 |
| CN118184782A (zh) * | 2024-03-13 | 2024-06-14 | 河北森朗生物科技有限公司 | 抗cldn18.2的纳米抗体、嵌合抗原受体及其应用 |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| CA2430013C (en) | 2000-11-30 | 2011-11-22 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| EP1997832A1 (en) | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
| US9056092B2 (en) | 2011-12-02 | 2015-06-16 | Ethicon, Inc. | Hemostatic bioabsorbable device with polyethylene glycol binder |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| WO2013174404A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2013174403A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014075697A1 (en) | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| JP6499079B2 (ja) | 2012-11-13 | 2019-04-10 | バイオエヌテック アーゲーＢｉｏＮＴｅｃｈ ＡＧ | クローディンを発現するガン疾患を処置するための剤 |
| WO2014146672A1 (en) * | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
| KR102236367B1 (ko) | 2013-07-26 | 2021-04-05 | 삼성전자주식회사 | DARPin을 포함하는 이중 특이 키메라 단백질 |
| CA2942546C (en) | 2014-03-17 | 2022-11-22 | Mitsubishi Tanabe Pharma Corporation | Antibody-fynomer conjugates |
| WO2016165762A1 (en) * | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
| WO2017059900A1 (en) * | 2015-10-07 | 2017-04-13 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
| ES2979068T3 (es) * | 2016-07-08 | 2024-09-24 | Crage Medical Co Ltd | Anticuerpos para anti-claudina 18A2 y utilización de los mismos |
| WO2018054484A1 (en) | 2016-09-23 | 2018-03-29 | Biontech Ag | Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases |
| CN119241554A (zh) | 2017-12-15 | 2025-01-03 | 四川科伦博泰生物医药股份有限公司 | 生物活性物偶联物及其制备方法和用途 |
| WO2019149116A1 (zh) | 2018-01-30 | 2019-08-08 | 四川科伦博泰生物医药股份有限公司 | 制备偶联物的方法 |
| WO2019154120A1 (zh) | 2018-02-11 | 2019-08-15 | 四川科伦博泰生物医药股份有限公司 | 细胞毒性剂及其偶联物、其制备方法及用途 |
| EP3765522A4 (en) | 2018-03-14 | 2022-05-18 | Beijing Xuanyi Pharmasciences Co., Ltd. | ANTI-CLAUDIN 18.2 ANTIBODIES |
| US11059887B2 (en) | 2018-05-18 | 2021-07-13 | Lanova Medicines Limited Company | Anti-claudin 18.2 antibodies and uses thereof |
| WO2019242505A1 (zh) * | 2018-06-17 | 2019-12-26 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用 |
| CN111110862A (zh) | 2018-11-01 | 2020-05-08 | 上海健信生物医药科技有限公司 | 抗cldn18．2抗体的药物偶联体及其制备方法和用途 |
| US12054543B2 (en) | 2018-07-25 | 2024-08-06 | Accurus Biosciences, Inc. | CLDN 18.2-specific monoclonal antibodies and methods of use thereof |
| BR112021011014A2 (pt) | 2018-12-07 | 2021-08-31 | Zlip Holding Limited | Anticorpos anti-claudina e usos destes |
| CN119350498A (zh) | 2018-12-28 | 2025-01-24 | 四川科伦博泰生物医药股份有限公司 | 一种抗体及其用途 |
-
2019
- 2019-12-19 CN CN202411323934.9A patent/CN119350498A/zh active Pending
- 2019-12-19 CN CN201980076474.5A patent/CN113166246B/zh active Active
- 2019-12-19 JP JP2021528872A patent/JP7562528B2/ja active Active
- 2019-12-19 EP EP19903546.0A patent/EP3904386A4/en active Pending
- 2019-12-19 KR KR1020217015188A patent/KR20210109520A/ko not_active Ceased
- 2019-12-19 US US17/295,603 patent/US12297265B2/en active Active
- 2019-12-19 WO PCT/CN2019/126495 patent/WO2020135201A1/zh not_active Ceased
-
2025
- 2025-04-02 US US19/097,908 patent/US20250340630A1/en active Pending
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