JP2019523630A5 - - Google Patents
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- JP2019523630A5 JP2019523630A5 JP2018555198A JP2018555198A JP2019523630A5 JP 2019523630 A5 JP2019523630 A5 JP 2019523630A5 JP 2018555198 A JP2018555198 A JP 2018555198A JP 2018555198 A JP2018555198 A JP 2018555198A JP 2019523630 A5 JP2019523630 A5 JP 2019523630A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 229920001184 polypeptide Polymers 0.000 claims 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 6
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- 208000014829 head and neck neoplasm Diseases 0.000 claims 6
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- 210000004881 tumor cell Anatomy 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 4
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- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 1
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- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 108010055196 EphA2 Receptor Proteins 0.000 claims 1
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- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
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- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 1
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- 230000004988 N-glycosylation Effects 0.000 claims 1
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- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
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- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 102100033579 Trophoblast glycoprotein Human genes 0.000 claims 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 claims 1
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- 108091008605 VEGF receptors Proteins 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021192091A JP2022058338A (ja) | 2016-04-22 | 2021-11-26 | Ｃｄ１３７に対する新規の二重特異性ポリペプチド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201607046 | 2016-04-22 | ||
| GB1607046.8 | 2016-04-22 | ||
| PCT/EP2017/059656 WO2017182672A1 (en) | 2016-04-22 | 2017-04-24 | Novel bispecific polypeptides against cd137 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021192091A Division JP2022058338A (ja) | 2016-04-22 | 2021-11-26 | Ｃｄ１３７に対する新規の二重特異性ポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019523630A JP2019523630A (ja) | 2019-08-29 |
| JP2019523630A5 true JP2019523630A5 (enExample) | 2020-05-21 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555198A Pending JP2019523630A (ja) | 2016-04-22 | 2017-04-24 | Ｃｄ１３７に対する新規の二重特異性ポリペプチド |
| JP2021192091A Pending JP2022058338A (ja) | 2016-04-22 | 2021-11-26 | Ｃｄ１３７に対する新規の二重特異性ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021192091A Pending JP2022058338A (ja) | 2016-04-22 | 2021-11-26 | Ｃｄ１３７に対する新規の二重特異性ポリペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20190169308A1 (enExample) |
| EP (1) | EP3445788B1 (enExample) |
| JP (2) | JP2019523630A (enExample) |
| KR (1) | KR102426765B1 (enExample) |
| CN (1) | CN109195994A (enExample) |
| AU (1) | AU2017252233A1 (enExample) |
| BR (1) | BR112018071612A2 (enExample) |
| CA (1) | CA3021618A1 (enExample) |
| DK (1) | DK3445788T3 (enExample) |
| ES (1) | ES2910365T3 (enExample) |
| IL (1) | IL262482A (enExample) |
| MX (1) | MX2018012897A (enExample) |
| RU (1) | RU2018139339A (enExample) |
| WO (1) | WO2017182672A1 (enExample) |
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| US10532106B2 (en) | 2014-10-29 | 2020-01-14 | Bicyclerd Limited | Bicyclic peptide ligands specific for MT1-MMP |
| CA3025345A1 (en) | 2016-05-27 | 2017-11-30 | Abbvie Biotherapeutics Inc. | Bispecific binding proteins binding an immunomodulatory protein and a tumor antigen |
| US11214618B2 (en) | 2016-06-20 | 2022-01-04 | F-Star Therapeutics Limited | LAG-3 binding members |
| US11214620B2 (en) | 2016-06-20 | 2022-01-04 | F-Star Therapeutics Limited | Binding molecules binding PD-L1 and LAG-3 |
| UA128304C2 (uk) | 2016-07-14 | 2024-06-05 | Ґенмаб А/С | Мультиспецифічне антитіло до cd40 і cd137 |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| CN117510643A (zh) * | 2016-09-23 | 2024-02-06 | 美勒斯公司 | 调节细胞表达的生物活性的结合分子 |
| MY200973A (en) | 2017-04-11 | 2024-01-26 | Inhibrx Inc | Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same |
| BR112019017241A2 (pt) | 2017-04-13 | 2020-04-14 | Agenus Inc | anticorpos anti-cd137 e métodos de uso dos mesmos |
| CA3070272A1 (en) | 2017-07-20 | 2019-01-24 | Aptevo Research And Development Llc | Antigen binding proteins binding to 5t4 and 4-1bb and related compositions and methods |
| JP7290013B2 (ja) | 2017-08-04 | 2023-06-13 | ジェンマブ エー／エス | Ｐｄ－ｌ１およびｃｄ１３７に結合する結合物質ならびにその使用 |
| CN111183147B (zh) | 2017-08-04 | 2024-07-05 | 拜斯科技术开发有限公司 | Cd137特异性的双环肽配体 |
| CN111683968B (zh) | 2017-11-13 | 2024-07-05 | 克雷森多生物制剂有限公司 | 结合至cd137和psma的分子 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| CN111741976B (zh) | 2017-12-19 | 2024-09-17 | 英沃克斯制药有限公司 | 包括pd-l1抗原结合位点的fc结合片段 |
| CN109970865B (zh) * | 2017-12-28 | 2022-10-04 | 上海细胞治疗研究院 | 一种cd137双向激活共刺激分子受体及其用途 |
| JP2021514953A (ja) | 2018-02-23 | 2021-06-17 | バイスクルテクス・リミテッド | 多量体二環式ペプチドリガンド |
| EP3765493A2 (en) | 2018-03-12 | 2021-01-20 | Genmab A/S | Antibodies |
| KR20200139236A (ko) * | 2018-04-04 | 2020-12-11 | 바이사이클티엑스 리미티드 | 헤테로탠덤 비사이클릭 펩티드 복합체 |
| IL323061A (en) | 2018-04-11 | 2025-10-01 | Inhibrx Biosciences Inc | Multispecific polypeptide constructs with forced CD3 binding and related methods and uses |
| US12168691B2 (en) | 2018-05-31 | 2024-12-17 | Board Of Regents, The University Of Texas System | VHS format bi-specific antibodies specific for HER2 and VEGF and use thereof |
| JP7557377B2 (ja) | 2018-06-06 | 2024-09-27 | レアダルティス、ソシエダッド リミターダ | 三量体ポリペプチド複合体およびその使用 |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| CA3106048A1 (en) | 2018-07-12 | 2020-01-16 | F-Star Beta Limited | Antibody molecules that bind cd137 and ox40 |
| GB201811450D0 (en) * | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| GB201811415D0 (en) * | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| CN112423845B (zh) | 2018-07-12 | 2024-07-30 | F-星治疗有限公司 | 结合pd-l1和cd137的抗体分子 |
| GB201811404D0 (en) * | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| CN112789294A (zh) | 2018-07-24 | 2021-05-11 | 印希比股份有限公司 | 含有受限cd3结合结构域和受体结合区的多特异性多肽构建体及其使用方法 |
| CA3113539A1 (en) * | 2018-10-10 | 2020-04-16 | Zymeworks Inc. | Antibody constructs binding 4-1bb and tumor-associated antigens and uses thereof |
| TW202506736A (zh) * | 2018-10-11 | 2025-02-16 | 美商因荷布瑞克斯生物科學公司 | 5t4單域抗體及其治療性組合物 |
| WO2020083277A1 (zh) * | 2018-10-22 | 2020-04-30 | 上海一宸医药科技有限公司 | 一种双特异性抗体 |
| BR112021010402A2 (pt) | 2018-11-30 | 2021-08-24 | Abl Bio Inc. | Anticorpos biespecíficos anti-pd-l1/anti-4-1bb e uso dos mesmos |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
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| US20220064325A1 (en) * | 2018-12-17 | 2022-03-03 | Alligator Bioscience Ab | Novel polypeptides |
| EP3897725A4 (en) * | 2018-12-21 | 2022-11-30 | Actinium Pharmaceuticals, Inc. | COMBINATION OF RADIOIMMUNOTHERAPY AND IMMUNOTHERAPY IN THE TREATMENT OF CANCER |
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| TWI793395B (zh) * | 2019-01-25 | 2023-02-21 | 大陸商信達生物製藥（蘇州）有限公司 | 結合ｐｄ-ｌ１和ｏｘ４０的雙特異性抗體 |
| GB201905100D0 (en) * | 2019-04-10 | 2019-05-22 | Antibody Innovation Ltd | Polypeptides and methods of use |
| CN113811541A (zh) | 2019-05-09 | 2021-12-17 | 拜斯科技术开发有限公司 | Ox40特异性的双环肽配体 |
| CN114450306B (zh) * | 2019-07-26 | 2024-04-05 | Abl生物公司 | 抗egfr/抗4-1bb双特异性抗体及其用途 |
| WO2021020846A1 (en) | 2019-07-26 | 2021-02-04 | Abl Bio Inc. | Anti-her2/anti-4-1bb bispecific antibody and use thereof |
| TWI862640B (zh) | 2019-07-30 | 2024-11-21 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| CN112592404B (zh) * | 2019-09-20 | 2023-07-25 | 上海交通大学医学院 | 抗体活性改造及其筛选方法 |
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- 2017-04-24 WO PCT/EP2017/059656 patent/WO2017182672A1/en not_active Ceased
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