JP2020510422A5 - - Google Patents

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Publication number
JP2020510422A5
JP2020510422A5 JP2019546327A JP2019546327A JP2020510422A5 JP 2020510422 A5 JP2020510422 A5 JP 2020510422A5 JP 2019546327 A JP2019546327 A JP 2019546327A JP 2019546327 A JP2019546327 A JP 2019546327A JP 2020510422 A5 JP2020510422 A5 JP 2020510422A5
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JP
Japan
Prior art keywords
seq
antibody
amino acid
cancer
variable region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2019546327A
Other languages
English (en)
Japanese (ja)
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JP2020510422A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/020239 external-priority patent/WO2018160704A1/en
Publication of JP2020510422A publication Critical patent/JP2020510422A/ja
Publication of JP2020510422A5 publication Critical patent/JP2020510422A5/ja
Priority to JP2022118823A priority Critical patent/JP2022141910A/ja
Priority to JP2024026609A priority patent/JP2024057038A/ja
Withdrawn legal-status Critical Current

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JP2019546327A 2017-02-28 2018-02-28 抗tigit抗体 Withdrawn JP2020510422A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022118823A JP2022141910A (ja) 2017-02-28 2022-07-26 抗tigit抗体
JP2024026609A JP2024057038A (ja) 2017-02-28 2024-02-26 抗tigit抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762464529P 2017-02-28 2017-02-28
US62/464,529 2017-02-28
US201862616779P 2018-01-12 2018-01-12
US62/616,779 2018-01-12
PCT/US2018/020239 WO2018160704A1 (en) 2017-02-28 2018-02-28 Anti-tigit antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022118823A Division JP2022141910A (ja) 2017-02-28 2022-07-26 抗tigit抗体

Publications (2)

Publication Number Publication Date
JP2020510422A JP2020510422A (ja) 2020-04-09
JP2020510422A5 true JP2020510422A5 (enExample) 2021-04-08

Family

ID=63370305

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019546327A Withdrawn JP2020510422A (ja) 2017-02-28 2018-02-28 抗tigit抗体
JP2022118823A Pending JP2022141910A (ja) 2017-02-28 2022-07-26 抗tigit抗体
JP2024026609A Pending JP2024057038A (ja) 2017-02-28 2024-02-26 抗tigit抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022118823A Pending JP2022141910A (ja) 2017-02-28 2022-07-26 抗tigit抗体
JP2024026609A Pending JP2024057038A (ja) 2017-02-28 2024-02-26 抗tigit抗体

Country Status (13)

Country Link
US (3) US20200040082A1 (enExample)
EP (1) EP3589313A4 (enExample)
JP (3) JP2020510422A (enExample)
KR (1) KR20190123749A (enExample)
CN (1) CN111050788A (enExample)
AU (2) AU2018227489B2 (enExample)
BR (1) BR112019017550A2 (enExample)
CA (1) CA3053486A1 (enExample)
IL (1) IL268517A (enExample)
MA (1) MA47694A (enExample)
MX (2) MX2019010206A (enExample)
SG (2) SG10202103227YA (enExample)
WO (1) WO2018160704A1 (enExample)

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MA40835A (fr) 2014-10-23 2017-08-29 Biogen Ma Inc Anticorps anti-gpiib/iiia et leurs utilisations
MA40861A (fr) * 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
EP3458485B1 (en) 2016-05-19 2021-12-29 The General Hospital Corporation Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity
CA3044664C (en) 2016-11-30 2022-11-22 Oncomed Pharmaceuticals, Inc. Methods for treatment of cancer comprising tigit-binding agents
US11021537B2 (en) 2017-05-01 2021-06-01 Agenus Inc. Anti-TIGIT antibodies and methods of use thereof
IL272227B2 (en) * 2017-07-27 2025-09-01 iTeos Belgium SA Anti-tigit antibodies
TW202023625A (zh) 2018-08-23 2020-07-01 美商西雅圖遺傳學公司 抗tigit抗體
US11376255B2 (en) 2018-09-11 2022-07-05 iTeos Belgium SA Thiocarbamate derivatives as A2A inhibitors, pharmaceutical composition thereof and combinations with anticancer agents
CN113226324B (zh) 2018-09-11 2024-12-31 Iteos比利时公司 作为a2a抑制剂的硫代氨基甲酸酯衍生物、其药物组合物以及与抗癌剂的组合
EP3898677A1 (en) 2018-12-21 2021-10-27 OSE Immunotherapeutics Bifunctional anti-pd-1/il-7 molecule
WO2020165374A1 (en) 2019-02-14 2020-08-20 Ose Immunotherapeutics Bifunctional molecule comprising il-15ra
US20200318200A1 (en) 2019-04-02 2020-10-08 The Brigham And Women's Hospital, Inc. Methods for Identifying Progression of a Primary Melanoma
AU2020290916A1 (en) * 2019-06-13 2021-11-04 Green Cross Corporation Antibody to TIGIT and use thereof
CN114729040A (zh) * 2019-06-21 2022-07-08 单细胞技术股份有限公司 抗tigit抗体
IL292757A (en) * 2019-11-05 2022-07-01 Merck Patent Gmbh Anti-tigit antibodies and uses thereof
WO2021122866A1 (en) 2019-12-17 2021-06-24 Ose Immunotherapeutics Bifunctional molecules comprising an il-7 variant
CN112409450B (zh) * 2020-03-29 2023-01-24 郑州大学 TIGIT-IgV的亲和剂及其应用
CN113563470B (zh) * 2020-04-29 2023-02-10 广州昂科免疫生物技术有限公司 结合tigit抗原的抗体及其制备方法与应用
EP4147053B1 (en) 2020-05-07 2026-01-28 Institut Curie Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy
CN114507284B (zh) * 2020-05-09 2023-05-26 华博生物医药技术(上海)有限公司 抗tigit的抗体、其制备方法和应用
CR20220611A (es) 2020-06-02 2023-06-07 Arcus Biosciences Inc Anticuerpos anti-tigit
IL298946A (en) 2020-06-18 2023-02-01 Genentech Inc Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
WO2021258337A1 (en) * 2020-06-24 2021-12-30 Huahui Health Ltd. Human monoclonal antibodies against tigit for immune related diseases
CN111718415B (zh) * 2020-07-03 2021-02-23 上海洛启生物医药技术有限公司 一种抗tigit纳米抗体及其应用
TW202216778A (zh) 2020-07-15 2022-05-01 美商安進公司 Tigit及cd112r阻斷
US20230265187A1 (en) * 2020-08-05 2023-08-24 Crystal Bioscience Inc. Anti-tigit antibody and methods of use thereof
AU2021357841A1 (en) 2020-10-08 2023-06-15 Affimed Gmbh Trispecific binders
WO2022112198A1 (en) 2020-11-24 2022-06-02 Worldwide Innovative Network Method to select the optimal immune checkpoint therapies
WO2022148781A1 (en) 2021-01-05 2022-07-14 Institut Curie Combination of mcoln activators and immune checkpoint inhibitors
EP4294948A1 (en) 2021-02-17 2023-12-27 iTeos Belgium SA Compounds, compositions and methods of treatment thereof
CA3213917A1 (en) 2021-04-09 2022-10-13 Nicolas Poirier New scaffold for bifunctional molecules with improved properties
WO2022214652A1 (en) 2021-04-09 2022-10-13 Ose Immunotherapeutics Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
TW202304965A (zh) 2021-05-04 2023-02-01 美商艾吉納斯公司 抗tigit抗體、抗cd96抗體及其使用方法
JP2024527049A (ja) 2021-07-28 2024-07-19 ジェネンテック, インコーポレイテッド がんを治療するための方法及び組成物
JP2024529381A (ja) 2021-07-30 2024-08-06 アフィメド ゲーエムベーハー デュプレックスボディ
WO2023056403A1 (en) 2021-09-30 2023-04-06 Genentech, Inc. Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
US20250179176A1 (en) 2022-05-02 2025-06-05 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
IL317449A (en) 2022-06-07 2025-02-01 Genentech Inc Method for determining the efficacy of a lung cancer treatment comprising an anti-PD-L1 antagonist and an anti-TIGIT antibody-antagonist
WO2024003360A1 (en) 2022-07-01 2024-01-04 Institut Curie Biomarkers and uses thereof for the treatment of neuroblastoma
JP2025525886A (ja) 2022-08-02 2025-08-07 オーエスイー・イミュノセラピューティクス Cd28に対する多機能性分子
EP4687990A1 (en) 2023-03-30 2026-02-11 Ose Immunotherapeutics Method of synthesis of targeted lipid nanoparticle and uses thereof
WO2024200823A1 (en) 2023-03-30 2024-10-03 Ose Immunotherapeutics Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof
WO2025068461A1 (en) 2023-09-29 2025-04-03 Negio Therapeutics Guanfacine derivatives and their use in treating cancer
WO2025068452A1 (en) 2023-09-29 2025-04-03 Negio Therapeutics Guanfacine derivatives and their use in treating cancer
WO2025132831A1 (en) 2023-12-19 2025-06-26 Universite D'aix-Marseille N-heteroaryl derivatives and uses thereof for treating cancer
WO2025242836A1 (en) 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders
WO2025242835A1 (en) 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of cancer
WO2025255297A1 (en) * 2024-06-05 2025-12-11 Agilent Technologies, Inc. Anti-human tigit antibodies for in vitro diagnostics
WO2025262250A1 (en) 2024-06-20 2025-12-26 Negio Therapeutics Guanfacine derivatives and their uses

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Publication number Priority date Publication date Assignee Title
AU2014290069B2 (en) * 2013-07-16 2019-01-03 Genentech, Inc. Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors
WO2015073682A1 (en) * 2013-11-13 2015-05-21 Oregon Health And Science University Methods of detecting cells latently infected with hiv
AR103268A1 (es) * 2014-12-23 2017-04-26 Bristol Myers Squibb Co Anticuerpos contra tigit
TWI715587B (zh) * 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit結合劑和彼之用途
WO2017030823A2 (en) * 2015-08-14 2017-02-23 Merck Sharp & Dohme Corp. Anti-tigit antibodies
KR20250021613A (ko) * 2015-09-25 2025-02-13 제넨테크, 인크. 항-tigit 항체 및 이의 이용 방법

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