JP2021531764A5 - - Google Patents
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- JP2021531764A5 JP2021531764A5 JP2021502881A JP2021502881A JP2021531764A5 JP 2021531764 A5 JP2021531764 A5 JP 2021531764A5 JP 2021502881 A JP2021502881 A JP 2021502881A JP 2021502881 A JP2021502881 A JP 2021502881A JP 2021531764 A5 JP2021531764 A5 JP 2021531764A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 206
- 239000005557 antagonist Substances 0.000 claims description 22
- 239000012634 fragment Substances 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 238000006467 substitution reaction Methods 0.000 claims description 11
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 7
- 102100035488 Nectin-2 Human genes 0.000 claims description 7
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 7
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 7
- 101001102797 Homo sapiens Transmembrane protein PVRIG Proteins 0.000 claims description 6
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 5
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 5
- 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 claims description 5
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 5
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 5
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 5
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 4
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 4
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims description 4
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 4
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims description 4
- 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 claims description 3
- 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 claims description 3
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 3
- 101001023712 Homo sapiens Nectin-3 Proteins 0.000 claims description 3
- 108010066979 Interleukin-27 Proteins 0.000 claims description 3
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 3
- 102100031789 Myeloid-derived growth factor Human genes 0.000 claims description 3
- 101150065403 NECTIN2 gene Proteins 0.000 claims description 3
- 102000002356 Nectin Human genes 0.000 claims description 3
- 108060005251 Nectin Proteins 0.000 claims description 3
- 102100035487 Nectin-3 Human genes 0.000 claims description 3
- 102100035486 Nectin-4 Human genes 0.000 claims description 3
- 108091059809 PVRL4 Proteins 0.000 claims description 3
- 102100029740 Poliovirus receptor Human genes 0.000 claims description 3
- 229940044665 STING agonist Drugs 0.000 claims description 3
- 102100039630 Transmembrane protein PVRIG Human genes 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 102000045804 human PVRIG Human genes 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 108010048507 poliovirus receptor Proteins 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
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- 239000003814 drug Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
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- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 4
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- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
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- 206010030155 Oesophageal carcinoma Diseases 0.000 description 2
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- 230000004614 tumor growth Effects 0.000 description 2
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- 206010046766 uterine cancer Diseases 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 229940119179 CD96 antagonist Drugs 0.000 description 1
- 206010025654 Malignant melanoma of sites other than skin Diseases 0.000 description 1
- 201000007552 Pituitary carcinoma Diseases 0.000 description 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 1
- 229940123803 TIM3 antagonist Drugs 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- -1 or TIM-3 antagonist Proteins 0.000 description 1
- 208000011866 pituitary adenocarcinoma Diseases 0.000 description 1
- 201000002511 pituitary cancer Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 description 1
- 210000004085 squamous epithelial cell Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022023855A JP7633193B2 (ja) | 2018-07-20 | 2022-02-18 | 抗ｃｄ１１２ｒ組成物及び方法 |
| JP2024091126A JP7738129B2 (ja) | 2018-07-20 | 2024-06-05 | 抗ｃｄ１１２ｒ組成物及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862701065P | 2018-07-20 | 2018-07-20 | |
| US62/701,065 | 2018-07-20 | ||
| US201962844958P | 2019-05-08 | 2019-05-08 | |
| US62/844,958 | 2019-05-08 | ||
| PCT/US2019/042545 WO2020018879A1 (en) | 2018-07-20 | 2019-07-19 | Anti-cd112r compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022023855A Division JP7633193B2 (ja) | 2018-07-20 | 2022-02-18 | 抗ｃｄ１１２ｒ組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021531764A JP2021531764A (ja) | 2021-11-25 |
| JP2021531764A5 true JP2021531764A5 (enExample) | 2022-01-06 |
| JP7072715B2 JP7072715B2 (ja) | 2022-05-20 |
Family
ID=69164765
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502881A Active JP7072715B2 (ja) | 2018-07-20 | 2019-07-19 | 抗ｃｄ１１２ｒ組成物及び方法 |
| JP2022023855A Active JP7633193B2 (ja) | 2018-07-20 | 2022-02-18 | 抗ｃｄ１１２ｒ組成物及び方法 |
| JP2024091126A Active JP7738129B2 (ja) | 2018-07-20 | 2024-06-05 | 抗ｃｄ１１２ｒ組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022023855A Active JP7633193B2 (ja) | 2018-07-20 | 2022-02-18 | 抗ｃｄ１１２ｒ組成物及び方法 |
| JP2024091126A Active JP7738129B2 (ja) | 2018-07-20 | 2024-06-05 | 抗ｃｄ１１２ｒ組成物及び方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US11214619B2 (enExample) |
| EP (1) | EP3823673A4 (enExample) |
| JP (3) | JP7072715B2 (enExample) |
| KR (1) | KR20210032488A (enExample) |
| CN (1) | CN112584865A (enExample) |
| AU (1) | AU2019306628B2 (enExample) |
| BR (1) | BR112021000727A2 (enExample) |
| CA (1) | CA3106114A1 (enExample) |
| CL (1) | CL2021000149A1 (enExample) |
| CO (1) | CO2021001912A2 (enExample) |
| IL (1) | IL280134A (enExample) |
| MX (2) | MX2021000745A (enExample) |
| MY (1) | MY204773A (enExample) |
| PH (1) | PH12021550152A1 (enExample) |
| SG (1) | SG11202100373VA (enExample) |
| TW (1) | TWI841577B (enExample) |
| WO (1) | WO2020018879A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7072715B2 (ja) | 2018-07-20 | 2022-05-20 | サーフィス オンコロジー インコーポレイテッド | 抗ｃｄ１１２ｒ組成物及び方法 |
| US20240279342A1 (en) * | 2019-11-15 | 2024-08-22 | Surface Oncology, Inc. | Compositions and methods for immunotherapy |
| WO2021113831A1 (en) | 2019-12-05 | 2021-06-10 | Compugen Ltd. | Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing |
| TW202216778A (zh) * | 2020-07-15 | 2022-05-01 | 美商安進公司 | Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| IL303269A (en) | 2020-12-03 | 2023-07-01 | Century Therapeutics Inc | Genetically engineered cells and uses thereof |
| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| WO2022165266A1 (en) | 2021-01-28 | 2022-08-04 | Compugen Ltd. | Anti-pvrig antibodies formulations and uses thereof |
| US20240076373A1 (en) | 2021-01-28 | 2024-03-07 | Compugen Ltd. | Combination therapy with anti-pvrig antibodies formulations and anti-pd-1 antibodies |
| CA3207791A1 (en) * | 2021-02-09 | 2022-08-18 | Shanghai Junshi Biosciences Co., Ltd. | Anti-cd112r antibody and use thereof |
| KR20230159823A (ko) * | 2021-02-11 | 2023-11-22 | 넥틴 테라퓨틱스 리미티드 | Cd112r에 대한 항체 및 이의 용도 |
| EP4314060A1 (en) | 2021-03-31 | 2024-02-07 | GlaxoSmithKline Intellectual Property Development Limited | Antigen binding proteins and combinations thereof |
| US20240343803A1 (en) * | 2021-07-30 | 2024-10-17 | Shandong Simcere Biopharmaceutical Co., Ltd. | Anti-Pvrig/Anti-Tigit Bispecific Antibodies And Applications Thereof |
| JP2024535793A (ja) | 2021-09-15 | 2024-10-02 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | Ｐｄ－１に特異的に結合するタンパク質及びその医薬的使用 |
| CA3259975A1 (en) | 2022-03-15 | 2023-09-21 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
| CN116925222A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗pvrig抗体、其药物组合物及用途 |
| CN116925233A (zh) | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗tigit-抗pvrig双特异性抗体、其药物组合物及用途 |
| US20260035460A1 (en) | 2022-07-28 | 2026-02-05 | Adeboye Henry ADEWOYE, MD | Combination therapy with anti-pvrig antibodies formulations and anti-pd-1 antibodies |
| WO2024027824A1 (zh) * | 2022-08-05 | 2024-02-08 | 上海君实生物医药科技股份有限公司 | 抗cd112r抗体药物组合物及其用途 |
| US20260116967A1 (en) | 2022-08-31 | 2026-04-30 | CSPC Megalith Biopharmaceutical Co., Ltd. | Anti-pvrig antibody and application thereof |
| CN120187755A (zh) * | 2022-11-10 | 2025-06-20 | 华辉安健（北京）生物科技有限公司 | 抗cd112r抗体及其用途 |
| CN121591902A (zh) * | 2022-12-30 | 2026-03-03 | 杭州中美华东制药有限公司 | 一种靶向cd112r的抗体或其抗原结合片段及其应用 |
| EP4681729A4 (en) | 2023-03-15 | 2026-07-15 | Shanghai Mabgen Biotech Ltd | PHARMACEUTICAL COMPOSITION CONTAINING A PD-1/PVRIG/TIGIT BINDING PROTEIN AND ITS MEDICAL USE |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
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