JP2020507571A5 - - Google Patents
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- JP2020507571A5 JP2020507571A5 JP2019543051A JP2019543051A JP2020507571A5 JP 2020507571 A5 JP2020507571 A5 JP 2020507571A5 JP 2019543051 A JP2019543051 A JP 2019543051A JP 2019543051 A JP2019543051 A JP 2019543051A JP 2020507571 A5 JP2020507571 A5 JP 2020507571A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- seq
- inhibitor
- lag3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims description 57
- 102000036639 antigens Human genes 0.000 claims description 57
- 108091007433 antigens Proteins 0.000 claims description 57
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- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 17
- 101100510618 Homo sapiens LAG3 gene Proteins 0.000 claims description 16
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 16
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims description 16
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- 229940127121 immunoconjugate Drugs 0.000 claims description 13
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 4
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- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762457287P | 2017-02-10 | 2017-02-10 | |
| US62/457,287 | 2017-02-10 | ||
| PCT/US2018/017525 WO2018148476A1 (en) | 2017-02-10 | 2018-02-09 | Radiolabeled anti-lag3 antibodies for immuno-pet imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020507571A JP2020507571A (ja) | 2020-03-12 |
| JP2020507571A5 true JP2020507571A5 (enExample) | 2021-03-25 |
| JP7167041B2 JP7167041B2 (ja) | 2022-11-08 |
Family
ID=61244834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543051A Active JP7167041B2 (ja) | 2017-02-10 | 2018-02-09 | 免疫ｐｅｔイメージングのための放射標識抗ｌａｇ３抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10905784B2 (enExample) |
| EP (1) | EP3580238A1 (enExample) |
| JP (1) | JP7167041B2 (enExample) |
| KR (2) | KR102660715B1 (enExample) |
| CN (2) | CN118557758A (enExample) |
| AU (2) | AU2018219909B2 (enExample) |
| BR (1) | BR112019016336A2 (enExample) |
| CA (1) | CA3053348A1 (enExample) |
| CL (1) | CL2019002264A1 (enExample) |
| CO (1) | CO2019008675A2 (enExample) |
| EA (1) | EA201991673A1 (enExample) |
| IL (2) | IL268667B2 (enExample) |
| MA (2) | MA46814B2 (enExample) |
| MX (2) | MX2019009565A (enExample) |
| MY (1) | MY200034A (enExample) |
| PH (1) | PH12019501837A1 (enExample) |
| SG (1) | SG11201907208XA (enExample) |
| WO (1) | WO2018148476A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI756187B (zh) * | 2015-10-09 | 2022-03-01 | 美商再生元醫藥公司 | 抗ｌａｇ３抗體及其用途 |
| RS67792B1 (sr) | 2016-12-01 | 2026-03-31 | Regeneron Pharma | Radio-obeležena anti-pd-l1 antitela za imuno-pet snimanje |
| BR112019016336A2 (pt) | 2017-02-10 | 2020-03-31 | Regeneron Pharmaceuticals, Inc. | Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto. |
| WO2018222718A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3136568A1 (en) | 2019-05-13 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer |
| PE20240329A1 (es) | 2019-06-05 | 2024-02-27 | Regeneron Pharma | Dispositivos y metodos para administracion de dosis de precision |
| CN114340684B (zh) | 2019-09-16 | 2025-09-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| KR20220152555A (ko) * | 2020-03-12 | 2022-11-16 | 비온드 바이오로직스 엘티디 | 증가된 안정성을 가진 쉐딩 차단제 |
| EP4168451A2 (en) | 2020-06-22 | 2023-04-26 | NGM Biopharmaceuticals, Inc. | Lair-1-binding agents and methods of use thereof |
| CA3196496A1 (en) | 2020-10-23 | 2022-04-28 | Laurence David TOMS | Lag-3 antagonist therapy for lung cancer |
| US12447218B1 (en) * | 2021-02-09 | 2025-10-21 | Actinium Pharmaceuticals, Inc. | Radioconjugates directed to MHC-complexed antigens in cancer |
| US12649031B2 (en) | 2021-09-08 | 2026-06-09 | Regeneron Pharmaceuticals, Inc. | Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation |
| US20230398242A1 (en) * | 2022-06-10 | 2023-12-14 | Wisconsin Alumni Research Foundation | Fibroblast Activation ImmunoPET for Detection of Fibrosis Activity |
| CN115337413B (zh) * | 2022-08-08 | 2023-08-22 | 中国科学院近代物理研究所 | 一种针对非小细胞肺癌诊断的放射性分子探针的制备及应用 |
| KR102759386B1 (ko) * | 2022-08-11 | 2025-01-24 | 성균관대학교산학협력단 | 89Zr 표지된 항-CD25 항체를 이용한 immuno-PET |
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