JP2017500057A5 - - Google Patents
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- JP2017500057A5 JP2017500057A5 JP2016553248A JP2016553248A JP2017500057A5 JP 2017500057 A5 JP2017500057 A5 JP 2017500057A5 JP 2016553248 A JP2016553248 A JP 2016553248A JP 2016553248 A JP2016553248 A JP 2016553248A JP 2017500057 A5 JP2017500057 A5 JP 2017500057A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 164
- 239000000427 antigen Substances 0.000 claims description 79
- 102000036639 antigens Human genes 0.000 claims description 79
- 108091007433 antigens Proteins 0.000 claims description 79
- 238000000034 method Methods 0.000 claims description 47
- 210000004027 cell Anatomy 0.000 claims description 40
- 206010028980 Neoplasm Diseases 0.000 claims description 38
- 230000005867 T cell response Effects 0.000 claims description 31
- 239000012642 immune effector Substances 0.000 claims description 21
- 229940121354 immunomodulator Drugs 0.000 claims description 21
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 14
- 230000004936 stimulating effect Effects 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 12
- 210000003162 effector t lymphocyte Anatomy 0.000 claims description 12
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 12
- 210000004986 primary T-cell Anatomy 0.000 claims description 12
- 231100000433 cytotoxic Toxicity 0.000 claims description 9
- 230000001472 cytotoxic effect Effects 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 101710160107 Outer membrane protein A Proteins 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 206010000830 Acute leukaemia Diseases 0.000 claims description 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 3
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 3
- 102000003735 Mesothelin Human genes 0.000 claims description 3
- 108090000015 Mesothelin Proteins 0.000 claims description 3
- 206010027406 Mesothelioma Diseases 0.000 claims description 3
- 208000034578 Multiple myelomas Diseases 0.000 claims description 3
- 101100346932 Mus musculus Muc1 gene Proteins 0.000 claims description 3
- 101100155997 Mus musculus Vmn1r51 gene Proteins 0.000 claims description 3
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 101150109474 TMEM37 gene Proteins 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 208000024207 chronic leukemia Diseases 0.000 claims description 3
- 208000005017 glioblastoma Diseases 0.000 claims description 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 230000000139 costimulatory effect Effects 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 210000002540 macrophage Anatomy 0.000 claims description 2
- 210000000952 spleen Anatomy 0.000 claims description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- -1 Tert Proteins 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361901310P | 2013-11-07 | 2013-11-07 | |
| US61/901,310 | 2013-11-07 | ||
| US201462037875P | 2014-08-15 | 2014-08-15 | |
| US62/037,875 | 2014-08-15 | ||
| PCT/US2014/064621 WO2015070061A1 (en) | 2013-11-07 | 2014-11-07 | Anti-wt1/hla bi-specific antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500057A JP2017500057A (ja) | 2017-01-05 |
| JP2017500057A5 true JP2017500057A5 (enExample) | 2018-05-10 |
| JP6553069B2 JP6553069B2 (ja) | 2019-07-31 |
Family
ID=51987482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553248A Expired - Fee Related JP6553069B2 (ja) | 2013-11-07 | 2014-11-07 | 抗ｗｔ１／ｈｌａ二重特異性抗体 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3066130B1 (enExample) |
| JP (1) | JP6553069B2 (enExample) |
| CN (1) | CN106414500B (enExample) |
| ES (1) | ES2742224T3 (enExample) |
| WO (1) | WO2015070061A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| EP3359565A1 (en) | 2015-10-09 | 2018-08-15 | Immatics Biotechnologies GmbH | Anti-wt1/hla-specific antibodies |
| JP7316042B2 (ja) | 2015-10-23 | 2023-07-27 | ユーリカ セラピューティックス， インコーポレイテッド | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
| US11505599B2 (en) | 2016-01-14 | 2022-11-22 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for Foxp3-derived peptides |
| CA3053010A1 (en) | 2017-02-08 | 2018-08-16 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| JP7685821B2 (ja) | 2017-02-20 | 2025-05-30 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｈｅｒ２、ＮＫＧ２ＤおよびＣＤ１６に結合するタンパク質 |
| CA3059753A1 (en) | 2017-04-26 | 2018-11-01 | Eureka Therapeutics, Inc. | Chimeric antibody/t-cell receptor constructs and uses thereof |
| US12178830B2 (en) | 2017-06-30 | 2024-12-31 | Memorial Sloan Kettering Cancer Center | Compositions and methods for adoptive cell therapy for cancer |
| JP7072792B2 (ja) * | 2017-12-11 | 2022-05-23 | 国立大学法人神戸大学 | 二重特異性抗体 |
| WO2019122052A2 (en) | 2017-12-21 | 2019-06-27 | F. Hoffmann-La Roche Ag | Antibodies binding to hla-a2/wt1 |
| US11884733B2 (en) | 2018-02-08 | 2024-01-30 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
| CA3090236A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| CN112041432A (zh) | 2018-02-15 | 2020-12-04 | 纪念斯隆-凯特林癌症中心 | Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法 |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| JP2021526365A (ja) * | 2018-05-18 | 2021-10-07 | チルドレンズ ナショナル メディカル センターＣｈｉｌｄｒｅｎ’Ｓ Ｎａｔｉｏｎａｌ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 改善された標的化ｔ細胞療法 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| MA53284A (fr) | 2018-08-08 | 2022-01-26 | Dragonfly Therapeutics Inc | Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur |
| AU2019318083A1 (en) | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use |
| US20240383999A1 (en) * | 2020-04-02 | 2024-11-21 | The Board Of Regents Of The University Of Texas System | Cd5l-binding antibodies and uses for the same |
| IL297922A (en) | 2020-05-06 | 2023-01-01 | Dragonfly Therapeutics Inc | Proteins binding nkg2d, cd16 and clec12a |
| CA3193478A1 (en) * | 2020-09-24 | 2022-03-31 | F. Hoffmann-La Roche Ag | Prevention or mitigation of t-cell bispecific antibody-related adverse effects |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| CN117222663A (zh) | 2021-03-03 | 2023-12-12 | 蜻蜓疗法股份有限公司 | 使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法 |
| CA3246381A1 (en) * | 2022-03-22 | 2023-09-28 | Morphosys Ag | CD3-SPECIFIC DEIMMUNEIZED ANTIBODIES |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| SI1673398T1 (sl) * | 2003-10-16 | 2011-05-31 | Micromet Ag | Multispecifiäśne deimunizirajoäśe cd3 povezovalne molekule |
| CN101426521A (zh) * | 2005-12-21 | 2009-05-06 | 医疗免疫有限责任公司 | EPHA2 BiTE分子及其应用 |
| EA201391449A1 (ru) * | 2011-04-01 | 2014-03-31 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Антитела против пептидов цитозоля |
-
2014
- 2014-11-07 JP JP2016553248A patent/JP6553069B2/ja not_active Expired - Fee Related
- 2014-11-07 WO PCT/US2014/064621 patent/WO2015070061A1/en not_active Ceased
- 2014-11-07 ES ES14803300T patent/ES2742224T3/es active Active
- 2014-11-07 EP EP14803300.4A patent/EP3066130B1/en active Active
- 2014-11-07 CN CN201480061156.9A patent/CN106414500B/zh not_active Expired - Fee Related