JP2014522850A5 - - Google Patents
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- JP2014522850A5 JP2014522850A5 JP2014519224A JP2014519224A JP2014522850A5 JP 2014522850 A5 JP2014522850 A5 JP 2014522850A5 JP 2014519224 A JP2014519224 A JP 2014519224A JP 2014519224 A JP2014519224 A JP 2014519224A JP 2014522850 A5 JP2014522850 A5 JP 2014522850A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- variable region
- cdr2
- cdr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 53
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 46
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 24
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 24
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 3
- 229940127121 immunoconjugate Drugs 0.000 claims description 3
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 11
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161504633P | 2011-07-05 | 2011-07-05 | |
| US61/504,633 | 2011-07-05 | ||
| US201161558945P | 2011-11-11 | 2011-11-11 | |
| US61/558,945 | 2011-11-11 | ||
| PCT/US2012/045235 WO2013006547A2 (en) | 2011-07-05 | 2012-07-02 | Antibodies against epidermal growth factor receptor (egfr) and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017223241A Division JP2018070622A (ja) | 2011-07-05 | 2017-11-21 | 上皮成長因子受容体（ｅｇｆｒ）に対する抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014522850A JP2014522850A (ja) | 2014-09-08 |
| JP2014522850A5 true JP2014522850A5 (enExample) | 2015-08-13 |
| JP6249945B2 JP6249945B2 (ja) | 2017-12-20 |
Family
ID=46682898
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519224A Expired - Fee Related JP6249945B2 (ja) | 2011-07-05 | 2012-07-02 | 上皮成長因子受容体（ｅｇｆｒ）に対する抗体及びその使用 |
| JP2017223241A Withdrawn JP2018070622A (ja) | 2011-07-05 | 2017-11-21 | 上皮成長因子受容体（ｅｇｆｒ）に対する抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017223241A Withdrawn JP2018070622A (ja) | 2011-07-05 | 2017-11-21 | 上皮成長因子受容体（ｅｇｆｒ）に対する抗体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (9) | US8691231B2 (enExample) |
| EP (2) | EP2729172B1 (enExample) |
| JP (2) | JP6249945B2 (enExample) |
| KR (1) | KR20140048230A (enExample) |
| CN (1) | CN103781494B (enExample) |
| AU (1) | AU2012279132B2 (enExample) |
| BR (1) | BR112014000158A8 (enExample) |
| CA (1) | CA2840088A1 (enExample) |
| HK (1) | HK1197071A1 (enExample) |
| IL (1) | IL229951B (enExample) |
| MX (1) | MX350861B (enExample) |
| TW (1) | TWI583700B (enExample) |
| WO (1) | WO2013006547A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2566512A1 (en) | 2010-05-04 | 2013-03-13 | Merrimack Pharmaceuticals, Inc. | Antibodies against epidermal growth factor receptor (egfr) and uses thereof |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| WO2013173255A2 (en) | 2012-05-17 | 2013-11-21 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind egfr |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| JP6324381B2 (ja) | 2012-07-31 | 2018-05-16 | クラウン バイオサイエンス インコーポレイテッド（タイカン） | 抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー |
| KR101854003B1 (ko) | 2013-07-02 | 2018-06-14 | 경희대학교 산학협력단 | 복수의 레이어를 포함하는 영상의 부호화 및 복호화 방법 |
| MA39599A (fr) | 2014-05-14 | 2016-10-05 | Merrimack Pharmaceuticals Inc | Dosage et administration d'agents thérapeutiques anti-egfr |
| EP2955522A1 (en) * | 2014-06-13 | 2015-12-16 | Fundació Privada Institut d'Investigació Oncològica de Vall Hebron | A method for monitoring the treatment of patients with tumors expressing EGFR |
| AU2016252877A1 (en) * | 2015-04-24 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Methods of treating patients having mutations in the extracellular domain of epidermal growth factor receptor (EGFR) with a combination of three fully human monoclonal anti-EGFR antibodies |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| PL3337467T3 (pl) | 2015-08-20 | 2021-06-14 | Ipsen Biopharm Ltd. | Terapia skojarzona z zastosowaniem liposomalnego irynotekanu i inhibitora parp do leczenia nowotworu |
| IL257149B2 (en) | 2015-08-21 | 2024-11-01 | Ipsen Biopharm Ltd | Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin |
| WO2017035482A1 (en) * | 2015-08-27 | 2017-03-02 | Merrimack Pharmaceuticals, Inc | Combination therapies for treatment of heregulin positive cancers |
| MX382522B (es) | 2015-10-16 | 2025-03-13 | Ipsen Biopharm Ltd | Composiciones farmaceuticas estabilizantes de camptotecina. |
| WO2017070456A1 (en) * | 2015-10-22 | 2017-04-27 | Merrimack Pharmaceuticals, Inc. | Methods of treating cancer by administering a bispecific antibody antagonist of igf-ir and erbb3 and a combination of anti-egfr antibodies |
| WO2017070475A1 (en) * | 2015-10-22 | 2017-04-27 | Merrimack Pharmaceuticals, Inc. | Methods of treating cancer by administering a mek inhibitor and a combination of anti-egfr antibodies |
| WO2017070356A1 (en) * | 2015-10-23 | 2017-04-27 | Merrimack Pharmaceuticals, Inc. | DOSAGE AND ADMINISTRATION OF ANTI-c-MET, ANTI-EpCAM BISPECIFIC ANTIBODIES, USES THEREOF AND MENTHODS OF TREATMENT THEREWITH |
| US20180271998A1 (en) | 2015-12-04 | 2018-09-27 | Merrimack Pharmaceuticals, Inc. | Disulfide-stabilized fabs |
| BR112018069318A2 (pt) * | 2016-03-28 | 2019-01-22 | Toray Industries | composição farmacêutica para tratamento e/ou prevenção de um câncer, anticorpo ou fragmento do mesmo, combinação farmacêutica para tratamento e/ou prevenção de um câncer e método para tratar e/ou prevenir um câncer |
| US20170336392A1 (en) * | 2016-05-02 | 2017-11-23 | Emmanuel A. Theodorakis | Imaging methods to assess the efficacy of anticancer drugs in vitro cancer using spontaneously- forming spheroids |
| CN108472371B (zh) * | 2016-07-05 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | Egfr抗体-药物偶联物及其在医药上的应用 |
| EP3535026A1 (en) | 2016-11-02 | 2019-09-11 | Ipsen Biopharm Limited | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
| EP3585814B1 (en) * | 2017-02-22 | 2025-12-10 | University of Saskatchewan | Egfr-binding agents and uses thereof |
| WO2018169953A1 (en) | 2017-03-17 | 2018-09-20 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| KR102905526B1 (ko) | 2017-06-27 | 2025-12-30 | 주식회사 뉴라클사이언스 | 항-fam19a5 항체 및 이의 용도 |
| CN109402063B (zh) * | 2017-08-18 | 2020-11-24 | 河北省科学院生物研究所 | 抗猪血红蛋白杂交瘤细胞株及其单克隆抗体与应用 |
| US20200347140A1 (en) | 2017-08-30 | 2020-11-05 | Symphogen A/S | Compositions and methods for treating cancer with anti-egfr antibodies |
| CU24558B1 (es) * | 2017-11-28 | 2021-12-08 | Ct Inmunologia Molecular | Anticuerpos monoclonales que reconocen al receptor del factor de crecimiento epidérmico y sus fragmentos derivados |
| US12258378B2 (en) | 2018-03-14 | 2025-03-25 | Dana-Farber Cancer Institute, Inc. | Engineered cells, T cell immune modulating antibodies and methods for using the same |
| KR20200118913A (ko) | 2018-04-24 | 2020-10-16 | 주식회사 뉴라클사이언스 | 신경병성 통증의 치료를 위한 서열 유사성 19, 멤버 a5 항체를 갖는 항-패밀리의 용도 |
| IL281344B2 (en) | 2018-09-10 | 2025-09-01 | Mirati Therapeutics Inc | Combination of adagrasib and cetuximab for cancer treatment |
| SG11202106990PA (en) | 2018-12-28 | 2021-07-29 | Kyowa Kirin Co Ltd | BISPECIFIC ANTIBODY BINDING TO TfR |
| CN110812479A (zh) * | 2019-11-18 | 2020-02-21 | 青海晨菲制药有限公司 | 没食子酸和egfr靶点抗体组合物及其在肺癌上应用 |
| WO2022240757A1 (en) | 2021-05-10 | 2022-11-17 | Entrada Therapeutics, Inc. | Antigen-binding and antigen degradation constructs |
| TW202530270A (zh) * | 2022-08-31 | 2025-08-01 | 中國醫藥大學 | 抗meEGFR抗體、其抗原結合片段及其用途 |
| CN120005727B (zh) * | 2025-01-03 | 2025-10-31 | 华南理工大学 | 一种用于研究胶质瘤car-t疗法的动态微流控芯片装置、制备方法及其应用 |
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| US20150231238A1 (en) | 2011-03-15 | 2015-08-20 | Merrimack Pharmaceuticals, Inc. | Overcoming resistance to erbb pathway inhibitors |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| US20170314079A1 (en) | 2011-07-05 | 2017-11-02 | Merrimack Pharmaceuticals, Inc. | Antibodies against epidermal growth factor receptor (egfr) and uses thereof |
| EP2554551A1 (en) | 2011-08-03 | 2013-02-06 | Fundacio Institut mar d'Investigacions Médiques (IMIM) | Mutations in the epidermal growth factor receptor gene |
| US9273143B2 (en) | 2011-09-30 | 2016-03-01 | Regeneron Pharmaceuticals, Inc. | Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody |
| WO2013138371A1 (en) | 2012-03-12 | 2013-09-19 | Merrimack Pharmaceuticals, Inc. | Methods for treating pancreatic cancer using combination therapies comprising an anti-erbb3 antibody |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| MA39599A (fr) | 2014-05-14 | 2016-10-05 | Merrimack Pharmaceuticals Inc | Dosage et administration d'agents thérapeutiques anti-egfr |
| AU2016252877A1 (en) | 2015-04-24 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Methods of treating patients having mutations in the extracellular domain of epidermal growth factor receptor (EGFR) with a combination of three fully human monoclonal anti-EGFR antibodies |
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2012
- 2012-06-04 US US13/488,270 patent/US8691231B2/en not_active Expired - Fee Related
- 2012-07-02 HK HK14109561.4A patent/HK1197071A1/xx unknown
- 2012-07-02 KR KR1020147002877A patent/KR20140048230A/ko not_active Ceased
- 2012-07-02 CA CA2840088A patent/CA2840088A1/en not_active Abandoned
- 2012-07-02 JP JP2014519224A patent/JP6249945B2/ja not_active Expired - Fee Related
- 2012-07-02 EP EP12748078.8A patent/EP2729172B1/en not_active Not-in-force
- 2012-07-02 BR BR112014000158A patent/BR112014000158A8/pt not_active IP Right Cessation
- 2012-07-02 EP EP16173573.3A patent/EP3090759A1/en not_active Withdrawn
- 2012-07-02 WO PCT/US2012/045235 patent/WO2013006547A2/en not_active Ceased
- 2012-07-02 MX MX2014000270A patent/MX350861B/es active IP Right Grant
- 2012-07-02 AU AU2012279132A patent/AU2012279132B2/en not_active Ceased
- 2012-07-02 CN CN201280040289.9A patent/CN103781494B/zh not_active Expired - Fee Related
- 2012-07-04 TW TW101123962A patent/TWI583700B/zh not_active IP Right Cessation
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2013
- 2013-12-17 IL IL229951A patent/IL229951B/en not_active IP Right Cessation
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2014
- 2014-01-03 US US14/147,331 patent/US9226964B2/en not_active Expired - Fee Related
- 2014-02-14 US US14/181,307 patent/US20140170668A1/en not_active Abandoned
- 2014-04-30 US US14/266,387 patent/US20140234314A1/en not_active Abandoned
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2015
- 2015-08-24 US US14/833,834 patent/US20160083800A1/en not_active Abandoned
- 2015-09-08 US US14/847,297 patent/US10072299B2/en not_active Expired - Fee Related
- 2015-09-08 US US14/847,291 patent/US9902999B2/en not_active Expired - Fee Related
- 2015-09-08 US US14/847,304 patent/US9885087B2/en not_active Expired - Fee Related
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2017
- 2017-03-17 US US15/462,738 patent/US20170356049A1/en not_active Abandoned
- 2017-11-21 JP JP2017223241A patent/JP2018070622A/ja not_active Withdrawn
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