JP2009521496A5 - - Google Patents

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Publication number
JP2009521496A5
JP2009521496A5 JP2008547744A JP2008547744A JP2009521496A5 JP 2009521496 A5 JP2009521496 A5 JP 2009521496A5 JP 2008547744 A JP2008547744 A JP 2008547744A JP 2008547744 A JP2008547744 A JP 2008547744A JP 2009521496 A5 JP2009521496 A5 JP 2009521496A5
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
set forth
lcvr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2008547744A
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English (en)
Japanese (ja)
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JP2009521496A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/062397 external-priority patent/WO2007076391A1/en
Publication of JP2009521496A publication Critical patent/JP2009521496A/ja
Publication of JP2009521496A5 publication Critical patent/JP2009521496A5/ja
Ceased legal-status Critical Current

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JP2008547744A 2005-12-23 2006-12-20 TGF−β結合組成物 Ceased JP2009521496A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75395605P 2005-12-23 2005-12-23
PCT/US2006/062397 WO2007076391A1 (en) 2005-12-23 2006-12-20 Tgf-beta binding compositions

Publications (2)

Publication Number Publication Date
JP2009521496A JP2009521496A (ja) 2009-06-04
JP2009521496A5 true JP2009521496A5 (enExample) 2010-02-12

Family

ID=37898733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547744A Ceased JP2009521496A (ja) 2005-12-23 2006-12-20 TGF−β結合組成物

Country Status (10)

Country Link
US (3) US7494651B2 (enExample)
EP (1) EP1966243B1 (enExample)
JP (1) JP2009521496A (enExample)
CN (1) CN101346394B (enExample)
AT (1) ATE545657T1 (enExample)
AU (1) AU2006330542B2 (enExample)
BR (1) BRPI0620240A2 (enExample)
CA (1) CA2632799A1 (enExample)
ES (1) ES2379194T3 (enExample)
WO (1) WO2007076391A1 (enExample)

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RU2386638C2 (ru) * 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
WO2007076391A1 (en) * 2005-12-23 2007-07-05 Eli Lilly And Company Tgf-beta binding compositions
US8350006B2 (en) * 2008-10-24 2013-01-08 Mead Johnson Nutrition Company Methods for determining the bioactivity of TGF-β in a composition
EP2894226B1 (en) * 2009-01-08 2021-04-14 Bio-Rad Laboratories, Inc. Methods and compositions for improving efficiency of nucleic acids amplification reactions
ES2702049T3 (es) * 2009-04-24 2019-02-27 Univ Vanderbilt Inducción anti-TGF-beta de crecimiento óseo
EP3954704A1 (en) 2011-06-03 2022-02-16 XOMA Technology Ltd. Antibodies specific for tgf-beta
WO2013134365A1 (en) 2012-03-08 2013-09-12 Ludwig Institute For Cancer Research Ltd TGF-β1 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF
EP2822871A4 (en) 2012-03-08 2015-12-09 Selig Sealing Products Inc TANK SEALING ELEMENT WITH A PROTECTED SAFETY COMPONENT AND A REMOVAL BAG
EA032327B1 (ru) * 2013-03-20 2019-05-31 Джензим Корпорейшн Способы лечения несовершенного остеогенеза
WO2016024628A1 (ja) * 2014-08-14 2016-02-18 学校法人東京医科大学 樹状細胞の抗癌免疫賦活能の促進方法およびその用途
CA2973978A1 (en) 2015-01-14 2016-07-21 The Brigham And Women's Hospital, Inc. Treatment of cancer with anti-lap monoclonal antibodies
TWI733661B (zh) 2015-03-04 2021-07-21 美商健臻公司 以高親合性、結合性及特異性結合轉化生長因子-β1的經修飾IgG抗體
TWI726870B (zh) 2015-03-04 2021-05-11 美商健臻公司 具有高親和性、結合性及專一性之結合轉形生長因子-β1的scFv-Fc二聚體
CN116327915A (zh) 2015-04-03 2023-06-27 佐马技术有限公司 使用TGF-β抑制剂和PD-1抑制剂治疗癌症
WO2016201282A2 (en) 2015-06-12 2016-12-15 Ludwig Institute For Cancer Research Ltd TGF-β3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF
JP7359547B2 (ja) 2016-05-17 2023-10-11 ジェネンテック, インコーポレイテッド 免疫療法における診断及び使用のための間質遺伝子シグネチャー
GB201610044D0 (en) 2016-06-08 2016-07-20 Ucb Biopharma Sprl Antibodies
CN109071656B (zh) 2017-01-05 2021-05-18 璟尚生物制药公司 检查点调节物拮抗剂
AR110755A1 (es) * 2017-01-20 2019-05-02 Genzyme Corp Anticuerpos dirigidos a hueso
WO2019090263A1 (en) 2017-11-06 2019-05-09 Genentech, Inc. Diagnostic and therapeutic methods for cancer
EP3813864A4 (en) 2018-06-29 2022-07-20 Gensun Biopharma Inc. Antitumor antagonists
WO2020095113A1 (en) 2018-11-05 2020-05-14 Ludwig Institute For Cancer Research Ltd Humanized and variant tgf-beta1 specific antibodies and methods and uses thereof
WO2020095104A1 (en) 2018-11-05 2020-05-14 Ludwig Institute For Cancer Research Ltd. HUMANIZED AND VARIANT TGF-β3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF
WO2020263312A1 (en) 2019-06-28 2020-12-30 Gensun Biopharma, Inc. ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFβ1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
CA3152371A1 (en) 2019-08-01 2021-02-04 Vaccinex, Inc. Combined inhibition of semaphorin-4d and tgf.beta. and compositions therefor
CN115243724B (zh) 2020-02-19 2025-10-21 纳米医疗有限公司 可用于治疗癌症的经调配和/或共调配的含有TFGβ拮抗剂前药的脂质体组合物和其方法
CN113563473A (zh) 2020-04-29 2021-10-29 三生国健药业(上海)股份有限公司 四价双特异性抗体、其制备方法和用途
US20240002479A1 (en) * 2020-11-23 2024-01-04 The Regents Of The University Of Michigan Single-chain antibody against flavivirus ns1 protein
WO2022115611A1 (en) 2020-11-25 2022-06-02 Catamaran Bio, Inc. Cellular therapeutics engineered with signal modulators and methods of use thereof
CN112940119B (zh) * 2021-04-26 2022-05-20 北京芳渟阳生生物科技有限公司 一种单克隆抗体及其与间充质干细胞外泌体的联合应用
CN115707716A (zh) * 2021-08-18 2023-02-21 丹生医药技术(上海)有限公司 一种TGF-β/VEGF双功能抗体融合蛋白
WO2023080900A1 (en) 2021-11-05 2023-05-11 Genentech, Inc. Methods and compositions for classifying and treating kidney cancer
EP4527857A1 (en) 2022-05-17 2025-03-26 Suzhou Transcenta Therapeutics Co., Ltd. Bifunctional protein, and preparation thereof and use thereof
WO2024077166A1 (en) 2022-10-05 2024-04-11 Genentech, Inc. Methods and compositions for classifying and treating lung cancer
EP4599089A1 (en) 2022-10-05 2025-08-13 Genentech, Inc. Methods and compositions for classifying and treating bladder cancer
JP2026504831A (ja) * 2023-01-09 2026-02-10 北京拓界生物医薬科技有限公司 TGFβ1結合分子、GARP-TGFβ1結合分子及びそれらの医薬的使用

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US5571714A (en) 1988-12-22 1996-11-05 Celtrix Pharmaceuticals, Inc. Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
EP1646655A2 (en) * 2003-07-09 2006-04-19 Eli Lilly And Company Tgf-beta1 ligands
RU2386638C2 (ru) * 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
WO2007076391A1 (en) * 2005-12-23 2007-07-05 Eli Lilly And Company Tgf-beta binding compositions

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