JP2024150445A5 - - Google Patents

Info

Publication number

JP2024150445A5

JP2024150445A5 JP2024099523A JP2024099523A JP2024150445A5 JP 2024150445 A5 JP2024150445 A5 JP 2024150445A5 JP 2024099523 A JP2024099523 A JP 2024099523A JP 2024099523 A JP2024099523 A JP 2024099523A JP 2024150445 A5 JP2024150445 A5 JP 2024150445A5

Authority

JP

Japan

Prior art keywords

antigen

binding protein

seq

conjugate

antibody

Prior art date

2024-06-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 102000025171 antigen binding proteins Human genes 0.000 claims 20
• 108091000831 antigen binding proteins Proteins 0.000 claims 20
• 102000003859 Claudin-6 Human genes 0.000 claims 7
• 108090000229 Claudin-6 Proteins 0.000 claims 7
• 229940127089 cytotoxic agent Drugs 0.000 claims 6
• 239000002246 antineoplastic agent Substances 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 2
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 231100000433 cytotoxic Toxicity 0.000 claims 2
• 239000002254 cytotoxic agent Substances 0.000 claims 2
• 230000001472 cytotoxic effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 230000002927 anti-mitotic effect Effects 0.000 claims 1
• 108010044540 auristatin Proteins 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1