JP2024501894A5 - - Google Patents
Info
- Publication number
- JP2024501894A5 JP2024501894A5 JP2023540678A JP2023540678A JP2024501894A5 JP 2024501894 A5 JP2024501894 A5 JP 2024501894A5 JP 2023540678 A JP2023540678 A JP 2023540678A JP 2023540678 A JP2023540678 A JP 2023540678A JP 2024501894 A5 JP2024501894 A5 JP 2024501894A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- antibody
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163133707P | 2021-01-04 | 2021-01-04 | |
| US63/133,707 | 2021-01-04 | ||
| US202163172968P | 2021-04-09 | 2021-04-09 | |
| US63/172,968 | 2021-04-09 | ||
| PCT/US2022/011119 WO2022147532A1 (en) | 2021-01-04 | 2022-01-04 | B7h4-targeted antibody-drug conjugates and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024501894A JP2024501894A (ja) | 2024-01-16 |
| JP2024501894A5 true JP2024501894A5 (enExample) | 2025-01-08 |
Family
ID=80222361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023540678A Pending JP2024501894A (ja) | 2021-01-04 | 2022-01-04 | Ｂ７ｈ４ターゲティング抗体－薬物コンジュゲートおよびその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11964024B2 (enExample) |
| EP (1) | EP4271713A1 (enExample) |
| JP (1) | JP2024501894A (enExample) |
| KR (1) | KR20230137339A (enExample) |
| AU (1) | AU2022205057A1 (enExample) |
| BR (1) | BR112023013263A2 (enExample) |
| CA (1) | CA3203721A1 (enExample) |
| CL (1) | CL2023001966A1 (enExample) |
| CO (1) | CO2023010206A2 (enExample) |
| IL (1) | IL304168A (enExample) |
| MX (1) | MX2023008000A (enExample) |
| TW (1) | TW202241954A (enExample) |
| WO (1) | WO2022147532A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3058360A1 (en) | 2017-03-29 | 2018-10-04 | Legochem Biosciences, Inc. | Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same |
| JP7843695B2 (ja) | 2019-08-02 | 2026-04-10 | メルサナ セラピューティクス インコーポレイテッド | がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物 |
| IL296901A (en) | 2020-04-02 | 2022-12-01 | Mersana Therapeutics Inc | Antibody-drug conjugates comprising sting agonists |
| MX2023008000A (es) | 2021-01-04 | 2023-07-13 | Mersana Therapeutics Inc | Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos. |
| US20240050585A1 (en) | 2022-05-17 | 2024-02-15 | Mersana Therapeutics, Inc. | B7-h4-targeted antibody-drug conjugates for the treatment of cancer |
| TW202432101A (zh) * | 2022-11-08 | 2024-08-16 | 韓商瑞嘉化學生物科學股份有限公司 | Sting促效劑 |
| WO2024186626A1 (en) * | 2023-03-03 | 2024-09-12 | Bolt Biotherapeutics, Inc. | Aza-bicyclic sting agonist immunoconjugates, and uses thereof |
| WO2025106278A1 (en) | 2023-11-17 | 2025-05-22 | Mersana Therapeutics, Inc. | Treatment of cancer using b7-h4-targeted antibody-drug conjugates |
| WO2026011052A1 (en) * | 2024-07-02 | 2026-01-08 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Car-t cell therapy for triple negative breast cancer |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| WO2004063344A2 (en) | 2003-01-10 | 2004-07-29 | Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health | CATALYTIC DOMAINS OF β/1,4)-GALACTOSYLTRANSFERASE I HAVING ALTERED DONOR AND ACCEPTOR SPECIFICITIES, DOMAINS THAT PROMOTE IN VITRO PROTEIN FOLDING, AND METHODS FOR THEIR USE |
| US8759490B2 (en) | 2005-03-24 | 2014-06-24 | Millennium Pharamaceuticals, Inc. | Antibodies that bind OV064 and methods of use therefor |
| US8323645B2 (en) | 2005-03-24 | 2012-12-04 | Millennium Pharmaceuticals, Inc. | Antibodies that bind OV064 and methods of use therefor |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| WO2007067991A2 (en) | 2005-12-08 | 2007-06-14 | Medarex, Inc. | Human monoclonal antibodies to o8e |
| US9121853B2 (en) | 2006-03-20 | 2015-09-01 | Mayo Foundation For Medical Education And Research | B7-H4 expression on tumor vasculature |
| EP2124998B8 (en) | 2006-12-27 | 2015-05-06 | The Johns Hopkins University | Methods for detecting inflammation and auto-immune diseases |
| CL2008003526A1 (es) | 2007-11-30 | 2010-01-11 | Medarex Inc | Conjugado de anticuerpo-molécula asociada que comprende un anticuerpo monoclonal humano anti b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8 humana; composición que lo comprende; método in vitro de inhibición de célula tumoral que expresa b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8; y uso para tratar cancer. |
| WO2009102820A2 (en) | 2008-02-11 | 2009-08-20 | Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services | Modified sugar substrates and methods of use |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| WO2012171020A1 (en) | 2011-06-10 | 2012-12-13 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US9676854B2 (en) | 2011-08-15 | 2017-06-13 | Medimmune, Llc | Anti-B7-H4 antibodies and their uses |
| GB201115841D0 (en) | 2011-09-13 | 2011-10-26 | Genovis Ab | Protein and method |
| US9422351B2 (en) | 2011-11-03 | 2016-08-23 | The Trustees Of The University Of Pennsylvania | Isolated B7-H4 specific compositions and methods of use thereof |
| CA2894879A1 (en) | 2012-12-19 | 2014-06-26 | Amplimmune, Inc. | B7-h4 specific antibodies, and compositions and methods of use thereof |
| JP6436965B2 (ja) | 2013-03-14 | 2018-12-12 | ジェネンテック， インコーポレイテッド | 抗ｂ７−ｈ４抗体及びイムノコンジュゲート |
| US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| KR102087850B1 (ko) | 2013-10-11 | 2020-03-12 | 메르사나 테라퓨틱스, 인코포레이티드 | 단백질-고분자-약물 접합체 |
| WO2016040724A1 (en) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anti-b7-h4 antibodies and immunoconjugates |
| US10626176B2 (en) | 2014-10-31 | 2020-04-21 | Jounce Therapeutics, Inc. | Methods of treating conditions with antibodies that bind B7-H4 |
| WO2016170186A1 (en) * | 2015-04-23 | 2016-10-27 | Synaffix B.V. | PROCESS FOR THE MODIFICATION OF A GLYCOPROTEIN USING A GLYCOSYLTRANSFERASE THAT IS OR IS DERIVED FROM A β(1,4)-N-ACETYLGALACTOSAMINYLTRANSFERASE |
| ES2972511T3 (es) | 2016-02-08 | 2024-06-13 | Synaffix Bv | Enzimas para el corte de glicoproteínas |
| CN109563503B (zh) | 2016-07-26 | 2023-09-29 | 静冈县 | 抗b7-h4抗体 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| EP3612567B1 (en) | 2017-04-19 | 2024-09-11 | Bluefin Biomedicine, Inc. | Anti-vtcn1 antibodies and antibody drug conjugates |
| US10814011B1 (en) | 2017-06-16 | 2020-10-27 | Nantbio, Inc. | Anti-B7-H4 antibodies and methods |
| US11306144B2 (en) | 2017-08-25 | 2022-04-19 | Five Prime Therapeutics, Inc. | B7-H4 antibodies and methods of use thereof |
| CN112566934B (zh) | 2018-01-23 | 2024-09-17 | 奈斯科尔公司 | B7-h4抗体及其使用方法 |
| CN116693686A (zh) | 2018-02-11 | 2023-09-05 | 江苏豪森药业集团有限公司 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
| BR112020016986A2 (pt) | 2018-02-21 | 2021-03-02 | Five Prime Therapeutics, Inc. | formulações de anticorpo contra b7-h4 |
| CA3091161A1 (en) | 2018-02-21 | 2019-08-29 | Five Prime Therapeutics, Inc. | B7-h4 antibody dosing regimens |
| CN108948204B (zh) | 2018-06-15 | 2023-01-13 | 苏州旭光科星抗体生物科技有限公司 | 抗人b7-h4单克隆抗体、鉴定方法、应用和试剂盒 |
| KR20210076025A (ko) | 2018-10-15 | 2021-06-23 | 파이브 프라임 테라퓨틱스, 인크. | 암 병용 요법 |
| CN113365664A (zh) | 2018-10-29 | 2021-09-07 | 梅尔莎纳医疗公司 | 具有含肽接头的半胱氨酸工程化的抗体-药物缀合物 |
| US20230072897A1 (en) | 2019-06-06 | 2023-03-09 | Shanghai Hansoh Biomedical Co., Ltd. | Anti-b7-h4 antibody-drug conjugate and medicinal use thereof |
| BR112022013255A2 (pt) | 2020-01-09 | 2022-09-06 | Mersana Therapeutics Inc | Conjugados anticorpo-fármaco específicos de sítio com ligantes contendo peptídeo |
| US20230112085A1 (en) | 2020-01-30 | 2023-04-13 | Apeximmune Therapeutics Inc. | Anti-b7-h4 constructs and uses thereof |
| MX2022009936A (es) | 2020-03-18 | 2022-09-12 | Genmab As | Anticuerpos que se unen al dominio v-set que contiene el inhibidor de activacion de celulas t 1 (b7h4). |
| IL296901A (en) | 2020-04-02 | 2022-12-01 | Mersana Therapeutics Inc | Antibody-drug conjugates comprising sting agonists |
| JP7726534B2 (ja) | 2020-06-30 | 2025-08-20 | 諾納生物（蘇州）有限公司 | 抗ｂ７ｈ４抗体及びその二重特異性抗体および用途 |
| MX2023008000A (es) | 2021-01-04 | 2023-07-13 | Mersana Therapeutics Inc | Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos. |
-
2022
- 2022-01-04 MX MX2023008000A patent/MX2023008000A/es unknown
- 2022-01-04 EP EP22703107.7A patent/EP4271713A1/en active Pending
- 2022-01-04 CA CA3203721A patent/CA3203721A1/en active Pending
- 2022-01-04 WO PCT/US2022/011119 patent/WO2022147532A1/en not_active Ceased
- 2022-01-04 JP JP2023540678A patent/JP2024501894A/ja active Pending
- 2022-01-04 TW TW111100248A patent/TW202241954A/zh unknown
- 2022-01-04 BR BR112023013263A patent/BR112023013263A2/pt unknown
- 2022-01-04 US US17/568,376 patent/US11964024B2/en active Active
- 2022-01-04 KR KR1020237025839A patent/KR20230137339A/ko active Pending
- 2022-01-04 AU AU2022205057A patent/AU2022205057A1/en active Pending
-
2023
- 2023-07-02 IL IL304168A patent/IL304168A/en unknown
- 2023-07-03 CL CL2023001966A patent/CL2023001966A1/es unknown
- 2023-07-31 CO CONC2023/0010206A patent/CO2023010206A2/es unknown
-
2024
- 2024-03-05 US US18/595,834 patent/US20240269306A1/en active Pending
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