CL2023001966A1 - Conjugados de anticuerpo dirigido a b7-h4 y fármaco, y métodos de uso de los mismos - Google Patents
Conjugados de anticuerpo dirigido a b7-h4 y fármaco, y métodos de uso de los mismosInfo
- Publication number
- CL2023001966A1 CL2023001966A1 CL2023001966A CL2023001966A CL2023001966A1 CL 2023001966 A1 CL2023001966 A1 CL 2023001966A1 CL 2023001966 A CL2023001966 A CL 2023001966A CL 2023001966 A CL2023001966 A CL 2023001966A CL 2023001966 A1 CL2023001966 A1 CL 2023001966A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- drug conjugates
- antibody targeting
- conjugates
- antibody
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 abstract 1
- 239000000611 antibody drug conjugate Substances 0.000 abstract 1
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000000562 conjugate Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 102000055298 human VTCN1 Human genes 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente divulgación se refiere, en líneas generales, a conjugados anticuerpo-fármaco que comprenden anticuerpos monoclonales que se unen específicamente a B7-H4 humana en forma soluble, o unidos a la membrana (es decir, cuando se expresan sobre una superficie celular) y a métodos de uso de estos conjugados como agentes terapéuticos y/o de diagnóstico.
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US202163133707P | 2021-01-04 | 2021-01-04 | |
US202163172968P | 2021-04-09 | 2021-04-09 |
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EP (1) | EP4271713A1 (es) |
JP (1) | JP2024501894A (es) |
KR (1) | KR20230137339A (es) |
AU (1) | AU2022205057A1 (es) |
BR (1) | BR112023013263A2 (es) |
CA (1) | CA3203721A1 (es) |
CL (1) | CL2023001966A1 (es) |
CO (1) | CO2023010206A2 (es) |
IL (1) | IL304168A (es) |
MX (1) | MX2023008000A (es) |
TW (1) | TW202241954A (es) |
WO (1) | WO2022147532A1 (es) |
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BR112023013263A2 (pt) | 2021-01-04 | 2023-12-12 | Mersana Therapeutics Inc | Conjugados anticorpo-fármaco alvejados a b7h4 e métodos de uso dos mesmos |
US20240050585A1 (en) * | 2022-05-17 | 2024-02-15 | Mersana Therapeutics, Inc. | B7-h4-targeted antibody-drug conjugates for the treatment of cancer |
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2022
- 2022-01-04 BR BR112023013263A patent/BR112023013263A2/pt unknown
- 2022-01-04 JP JP2023540678A patent/JP2024501894A/ja active Pending
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EP4271713A1 (en) | 2023-11-08 |
KR20230137339A (ko) | 2023-10-04 |
CO2023010206A2 (es) | 2023-08-09 |
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TW202241954A (zh) | 2022-11-01 |
WO2022147532A1 (en) | 2022-07-07 |
BR112023013263A2 (pt) | 2023-12-12 |
US11964024B2 (en) | 2024-04-23 |
IL304168A (en) | 2023-09-01 |
MX2023008000A (es) | 2023-07-13 |
AU2022205057A1 (en) | 2023-07-13 |
CA3203721A1 (en) | 2022-07-07 |
JP2024501894A (ja) | 2024-01-16 |
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