CA3203721A1 - B7h4-targeted antibody-drug conjugates and methods of use thereof - Google Patents

B7h4-targeted antibody-drug conjugates and methods of use thereof

Info

Publication number
CA3203721A1
CA3203721A1 CA3203721A CA3203721A CA3203721A1 CA 3203721 A1 CA3203721 A1 CA 3203721A1 CA 3203721 A CA3203721 A CA 3203721A CA 3203721 A CA3203721 A CA 3203721A CA 3203721 A1 CA3203721 A1 CA 3203721A1
Authority
CA
Canada
Prior art keywords
amino acid
seq
acid sequence
antibody
determining region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3203721A
Other languages
English (en)
French (fr)
Inventor
Timothy B. Lowinger
Chen-Ni Chin
Marc I. DAMELIN
Dorin Toader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mersana Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3203721A1 publication Critical patent/CA3203721A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
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