JP2003528052A5 - - Google Patents
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- JP2003528052A5 JP2003528052A5 JP2001561064A JP2001561064A JP2003528052A5 JP 2003528052 A5 JP2003528052 A5 JP 2003528052A5 JP 2001561064 A JP2001561064 A JP 2001561064A JP 2001561064 A JP2001561064 A JP 2001561064A JP 2003528052 A5 JP2003528052 A5 JP 2003528052A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- immunoglobulin
- affinity neutralizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108060003951 Immunoglobulin Proteins 0.000 description 68
- 102000018358 immunoglobulin Human genes 0.000 description 68
- 125000003275 alpha amino acid group Chemical group 0.000 description 66
- 230000003472 neutralizing effect Effects 0.000 description 34
- 241000725643 Respiratory syncytial virus Species 0.000 description 10
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 239000000203 mixture Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17842600P | 2000-01-27 | 2000-01-27 | |
| US60/178,426 | 2000-01-27 | ||
| PCT/US2001/002618 WO2001055217A1 (en) | 2000-01-27 | 2001-01-26 | Ultra high affinity neutralizing antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010026299A Division JP2010180207A (ja) | 2000-01-27 | 2010-02-09 | 超高親和性中和抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003528052A JP2003528052A (ja) | 2003-09-24 |
| JP2003528052A5 true JP2003528052A5 (enExample) | 2010-04-02 |
| JP4992068B2 JP4992068B2 (ja) | 2012-08-08 |
Family
ID=22652515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561064A Expired - Fee Related JP4992068B2 (ja) | 2000-01-27 | 2001-01-26 | 超高親和性中和抗体 |
| JP2010026299A Pending JP2010180207A (ja) | 2000-01-27 | 2010-02-09 | 超高親和性中和抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010026299A Pending JP2010180207A (ja) | 2000-01-27 | 2010-02-09 | 超高親和性中和抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US6656467B2 (enExample) |
| EP (2) | EP2289550A3 (enExample) |
| JP (2) | JP4992068B2 (enExample) |
| AT (1) | ATE474854T1 (enExample) |
| AU (2) | AU785038B2 (enExample) |
| CA (1) | CA2398466A1 (enExample) |
| CY (1) | CY1111542T1 (enExample) |
| DE (1) | DE60142614D1 (enExample) |
| DK (1) | DK1265928T3 (enExample) |
| ES (1) | ES2349348T3 (enExample) |
| PT (1) | PT1265928E (enExample) |
| WO (1) | WO2001055217A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2398466A1 (en) * | 2000-01-27 | 2001-08-02 | Medimmune, Inc. | Ultra high affinity neutralizing antibodies |
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| JP2003525061A (ja) * | 2000-03-01 | 2003-08-26 | メディミューン，インコーポレイテッド | 高効力組換え抗体およびその産生法 |
| US7179900B2 (en) | 2000-11-28 | 2007-02-20 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| US6855493B2 (en) * | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| US20040096451A1 (en) * | 2002-07-25 | 2004-05-20 | Young James F. | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
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| WO2010072691A1 (en) * | 2008-12-22 | 2010-07-01 | Novo Nordisk A/S | Antibodies against tissue factor pathway inhibitor |
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| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| EP2591000B1 (en) | 2010-07-09 | 2017-05-17 | Janssen Vaccines & Prevention B.V. | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| JP2016501877A (ja) | 2012-11-28 | 2016-01-21 | シーエヌジェー ホールディングス，インコーポレイテッド | クロストリジウム・ディフィシルに対する抗体 |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| ES2950426T3 (es) | 2015-08-12 | 2023-10-09 | Univ Columbia | Procedimientos de tratamiento de la depleción de volumen y la lesión renal |
| US11161891B2 (en) | 2015-12-09 | 2021-11-02 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
| AU2017345786B2 (en) | 2016-10-21 | 2024-08-01 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US11312761B2 (en) | 2016-10-21 | 2022-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| WO2018075954A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US12655229B2 (en) | 2020-03-18 | 2026-06-16 | Memorial Sloan Kettering Cancer Center | Anti-ceramide antibodies |
| WO2021202463A1 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Anti-rsv antibodies |
| IL328264A (en) | 2023-11-14 | 2026-07-01 | Janssen Pharmaceuticals Inc | Anti-Respiratory Syncytial Virus Antibodies and Their Uses |
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-
2001
- 2001-01-26 CA CA002398466A patent/CA2398466A1/en not_active Abandoned
- 2001-01-26 DE DE60142614T patent/DE60142614D1/de not_active Expired - Lifetime
- 2001-01-26 PT PT01903352T patent/PT1265928E/pt unknown
- 2001-01-26 EP EP10007381A patent/EP2289550A3/en not_active Withdrawn
- 2001-01-26 AT AT01903352T patent/ATE474854T1/de active
- 2001-01-26 ES ES01903352T patent/ES2349348T3/es not_active Expired - Lifetime
- 2001-01-26 EP EP01903352A patent/EP1265928B1/en not_active Expired - Lifetime
- 2001-01-26 AU AU31180/01A patent/AU785038B2/en not_active Ceased
- 2001-01-26 JP JP2001561064A patent/JP4992068B2/ja not_active Expired - Fee Related
- 2001-01-26 WO PCT/US2001/002618 patent/WO2001055217A1/en not_active Ceased
- 2001-01-26 US US09/771,415 patent/US6656467B2/en not_active Expired - Fee Related
- 2001-01-26 DK DK01903352.1T patent/DK1265928T3/da active
-
2003
- 2003-09-08 US US10/657,363 patent/US7740851B2/en not_active Expired - Fee Related
-
2010
- 2010-02-09 JP JP2010026299A patent/JP2010180207A/ja active Pending
- 2010-03-19 AU AU2010201090A patent/AU2010201090B2/en not_active Ceased
- 2010-05-11 US US12/777,814 patent/US20100266614A1/en not_active Abandoned
- 2010-10-21 CY CY20101100947T patent/CY1111542T1/el unknown
-
2011
- 2011-10-24 US US13/279,592 patent/US20120135006A1/en not_active Abandoned
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