CY1111542T1 - Αντισωματα εξουδετερωσης του rsv υπερυψηλης συγγενειας - Google Patents

Αντισωματα εξουδετερωσης του rsv υπερυψηλης συγγενειας

Info

Publication number
CY1111542T1
CY1111542T1 CY20101100947T CY101100947T CY1111542T1 CY 1111542 T1 CY1111542 T1 CY 1111542T1 CY 20101100947 T CY20101100947 T CY 20101100947T CY 101100947 T CY101100947 T CY 101100947T CY 1111542 T1 CY1111542 T1 CY 1111542T1
Authority
CY
Cyprus
Prior art keywords
antibodies
disclosed
methods
high affinity
rsv
Prior art date
Application number
CY20101100947T
Other languages
English (en)
Inventor
James F Young
Scott Koenig
Leslie S Johnson
William D Huse
Herren Wu
Jeffry D Watkins
Original Assignee
Medimmune, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Llc filed Critical Medimmune, Llc
Publication of CY1111542T1 publication Critical patent/CY1111542T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Disintegrating Or Milling (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Αποκαλύπτονται αντισώματα υπερυψηλής συγγένειας με συγγένειες δέσμευσης που κυμαίνονται στα 1010 Μ-1, ακόμα και στα 1011 Μ-1. Σε αυτά τα αντισώματα περιλαμβάνονται αντισώματα που διαθέτουν καινούριες περιοχές καθορισμού της συμπληρωματικότητας (CDR) υψηλής συγγένειας, και ειδικότερα εκείνα με περιοχές πλαισίου (framework) και σταθερές περιοχές που προέρχονται είτε από ανθρώπους είτε από ποντικούς. Επίσης αποκαλύπτονται μέθοδοι για την παρασκευή και διαλογή αυτών των αντισωμάτων, καθώς και μέθοδοι για τη χρήση τους στην πρόληψη ή/και την αντιμετώπιση ασθενειών και ειδικότερα ιογενών ασθενειών.
CY20101100947T 2000-01-27 2010-10-21 Αντισωματα εξουδετερωσης του rsv υπερυψηλης συγγενειας CY1111542T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17842600P 2000-01-27 2000-01-27
EP01903352A EP1265928B1 (en) 2000-01-27 2001-01-26 Ultra high affinity rsv neutralizing antibodies

Publications (1)

Publication Number Publication Date
CY1111542T1 true CY1111542T1 (el) 2015-08-05

Family

ID=22652515

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100947T CY1111542T1 (el) 2000-01-27 2010-10-21 Αντισωματα εξουδετερωσης του rsv υπερυψηλης συγγενειας

Country Status (12)

Country Link
US (4) US6656467B2 (el)
EP (2) EP2289550A3 (el)
JP (2) JP4992068B2 (el)
AT (1) ATE474854T1 (el)
AU (2) AU785038B2 (el)
CA (1) CA2398466A1 (el)
CY (1) CY1111542T1 (el)
DE (1) DE60142614D1 (el)
DK (1) DK1265928T3 (el)
ES (1) ES2349348T3 (el)
PT (1) PT1265928E (el)
WO (1) WO2001055217A1 (el)

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JP2003528052A (ja) 2003-09-24
US20120135006A1 (en) 2012-05-31
US20040131609A1 (en) 2004-07-08
AU785038C (en) 2001-08-07
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DK1265928T3 (da) 2010-11-15
EP2289550A3 (en) 2012-02-15
EP1265928B1 (en) 2010-07-21
US20100266614A1 (en) 2010-10-21
US20020164326A1 (en) 2002-11-07
US6656467B2 (en) 2003-12-02
DE60142614D1 (de) 2010-09-02
EP2289550A2 (en) 2011-03-02
WO2001055217A1 (en) 2001-08-02
AU785038B2 (en) 2006-08-31
AU3118001A (en) 2001-08-07
PT1265928E (pt) 2010-09-30
ES2349348T3 (es) 2010-12-30
ATE474854T1 (de) 2010-08-15
US7740851B2 (en) 2010-06-22
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