ATE474854T1 - Rsv neutralisierende antikörper mit sehr hohen affinität - Google Patents

Rsv neutralisierende antikörper mit sehr hohen affinität

Info

Publication number
ATE474854T1
ATE474854T1 AT01903352T AT01903352T ATE474854T1 AT E474854 T1 ATE474854 T1 AT E474854T1 AT 01903352 T AT01903352 T AT 01903352T AT 01903352 T AT01903352 T AT 01903352T AT E474854 T1 ATE474854 T1 AT E474854T1
Authority
AT
Austria
Prior art keywords
high affinity
antibodies
neutralizing antibodies
rsv neutralizing
disclosed
Prior art date
Application number
AT01903352T
Other languages
English (en)
Inventor
James Young
Scott Koenig
Leslie Johnson
William Huse
Herren Wu
Jeffry Watkins
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Application granted granted Critical
Publication of ATE474854T1 publication Critical patent/ATE474854T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Disintegrating Or Milling (AREA)
  • Medicinal Preparation (AREA)
AT01903352T 2000-01-27 2001-01-26 Rsv neutralisierende antikörper mit sehr hohen affinität ATE474854T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17842600P 2000-01-27 2000-01-27
PCT/US2001/002618 WO2001055217A1 (en) 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies

Publications (1)

Publication Number Publication Date
ATE474854T1 true ATE474854T1 (de) 2010-08-15

Family

ID=22652515

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01903352T ATE474854T1 (de) 2000-01-27 2001-01-26 Rsv neutralisierende antikörper mit sehr hohen affinität

Country Status (12)

Country Link
US (4) US6656467B2 (de)
EP (2) EP2289550A3 (de)
JP (2) JP4992068B2 (de)
AT (1) ATE474854T1 (de)
AU (2) AU785038B2 (de)
CA (1) CA2398466A1 (de)
CY (1) CY1111542T1 (de)
DE (1) DE60142614D1 (de)
DK (1) DK1265928T3 (de)
ES (1) ES2349348T3 (de)
PT (1) PT1265928E (de)
WO (1) WO2001055217A1 (de)

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AU785038C (en) 2001-08-07
JP4992068B2 (ja) 2012-08-08
US20020164326A1 (en) 2002-11-07
EP1265928B1 (de) 2010-07-21
AU2010201090A1 (en) 2010-04-15
EP2289550A3 (de) 2012-02-15
AU3118001A (en) 2001-08-07
AU2010201090B2 (en) 2012-05-17
EP1265928A1 (de) 2002-12-18
US6656467B2 (en) 2003-12-02
AU785038B2 (en) 2006-08-31
US7740851B2 (en) 2010-06-22
EP2289550A2 (de) 2011-03-02
CY1111542T1 (el) 2015-08-05
US20040131609A1 (en) 2004-07-08
WO2001055217A1 (en) 2001-08-02
PT1265928E (pt) 2010-09-30
US20100266614A1 (en) 2010-10-21
CA2398466A1 (en) 2001-08-02
DE60142614D1 (de) 2010-09-02
JP2010180207A (ja) 2010-08-19
US20120135006A1 (en) 2012-05-31
JP2003528052A (ja) 2003-09-24
ES2349348T3 (es) 2010-12-30
DK1265928T3 (da) 2010-11-15

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