DE3878468T2 - Chimarenglykoproteine, enthaltend immunogene segmente des humanen respiratorischen synzytialvirus. - Google Patents
Chimarenglykoproteine, enthaltend immunogene segmente des humanen respiratorischen synzytialvirus.Info
- Publication number
- DE3878468T2 DE3878468T2 DE8888909879T DE3878468T DE3878468T2 DE 3878468 T2 DE3878468 T2 DE 3878468T2 DE 8888909879 T DE8888909879 T DE 8888909879T DE 3878468 T DE3878468 T DE 3878468T DE 3878468 T2 DE3878468 T2 DE 3878468T2
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- glycoprotein
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- dna
- cells
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Polypeptid, umfassend mindestens ein immunogenes
Fragment aus beiden
Humanatmungssynzytiumvirusglycoproteinen F und G.
2. Polypeptid nach Anspruch 1, zusätzlich umfassend eine
Signalsequenz.
3. Polypeptid nach Anspruch 2, bei dem es sich, beginnend
mit dem N-terminalen Ende, um die Signalsequenz von
Glycoprotein F, einem immunogenen Fragment von
Glycoprotein F und einem immunogenen Fragmenht von
Glycoprotein G handelt.
4. Polypeptid nach Anspruch 1, welches
5. Humanimpfstoff, umfassend ein Polypeptid nach einem der
vorhergehenden Ansprüche.
6. Verwendung des Vakzins nach Anspruch 5 zur Zubereitung
eines Medikaments zur Verwendung beim Schutz von
Menschen gegen Human-Atmungs-Synzytium-Virus.
7. Expressionssystem, umfassend einen geeigneten Wirt mit
einer DNA-Sequenz mit der Fähigkeit zur Expression
eines Polypeptids nach einem der Ansprüche 1 bis 4.
8. Expressionssystem nach Anspruch 7, worin der Wirt aus
Bakterienzellen, Hefezellen, Säugetierzellen und
Insektenzellen ausgewählt ist.
9. Expressionssystem nach Anspruch 8, worin der Wirt aus
E. coli-Zellen, chinesischen Hamstereierstockzellen,
Mäuse-C127-Zellen und S. frugipersa-Zellen ausgewählt
ist.
10. Expressionssystem nach einem der Ansprüche 7 bis 9,
worin der Wirt das Polypeptid abscheidet.
11. Expressionssystem nach einem der Ansprüche 7 bis 10,
worin die DNA-Sequenz in einem Plasmid enthalten ist.
12. Expressionssystem nach Anspruch 11, worin das Plasmid
unter Kontrolle eines Cytomegalovirus-Promotors steht.
13. Expressionssystem nach Anspruch 11, worin eine
Replikation des in einem geeigneten Eukaryoten-Wirt
befindlichen Plasmids unter Kontrolle von Rinder-
Papillom-Virus-DNA-Sequenzen steht.
14. Expressionssystem nach einem der Ansprüch 7 bis 10,
worin die DNA-Sequenz in einem rekombinanten Virus der
Baculovirus-Familie enthalten ist.
15. Expressionssystem nach Anspruch 14, worin der Virus
Autographa californica-kernpolyedrischer Virus ist.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13738787A | 1987-12-23 | 1987-12-23 | |
| PCT/US1988/003784 WO1989005823A1 (en) | 1987-12-23 | 1988-10-31 | Chimeric glycoproteins containing immunogenic segments of the glycoproteins of human respiratory syncytial virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3878468D1 DE3878468D1 (de) | 1993-03-25 |
| DE3878468T2 true DE3878468T2 (de) | 1993-06-09 |
Family
ID=22477194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888909879T Expired - Lifetime DE3878468T2 (de) | 1987-12-23 | 1988-10-31 | Chimarenglykoproteine, enthaltend immunogene segmente des humanen respiratorischen synzytialvirus. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5194595A (de) |
| EP (1) | EP0396563B1 (de) |
| JP (1) | JP2716503B2 (de) |
| KR (1) | KR0137963B1 (de) |
| AT (1) | ATE85622T1 (de) |
| AU (1) | AU617739B2 (de) |
| CA (1) | CA1320163C (de) |
| DE (1) | DE3878468T2 (de) |
| DK (1) | DK173175B1 (de) |
| FI (1) | FI102382B (de) |
| HK (1) | HK166295A (de) |
| MX (1) | MX9203458A (de) |
| NO (1) | NO300254B1 (de) |
| WO (1) | WO1989005823A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| US6004563A (en) * | 1990-11-07 | 1999-12-21 | American Home Products Corporation | Feline vaccine compositions and method for preventing chlamydia infections or diseases using the same |
| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
| GB9207479D0 (en) * | 1992-04-06 | 1992-05-20 | Scotgen Ltd | Novel antibodies for treatment and prevention of respiratory syncytial virus infection in animals and man |
| TW275632B (de) * | 1992-04-21 | 1996-05-11 | American Cyanamid Co | |
| KR960700271A (ko) * | 1993-01-08 | 1996-01-19 | 로렌스 티. 웰츠 | 인간 호흡계 합포체 바이러스 fg 당단백질의 정제 및 리폴딩 방법(process for the purification and refolding of human respiratory syncytial virus fg glycoprotein) |
| US5723130A (en) * | 1993-05-25 | 1998-03-03 | Hancock; Gerald E. | Adjuvants for vaccines against respiratory syncytial virus |
| US7300918B2 (en) | 1994-01-14 | 2007-11-27 | Matthias Rath | Method of producing vaccines from protein signal oligopeptides |
| ES2344643T3 (es) * | 1994-01-14 | 2010-09-02 | Matthias Dr. Med. Rath | Oligopeptidos de señal hidrofilicos y metodos de uso terapeutico. |
| FR2718452B1 (fr) * | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
| US5716821A (en) * | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
| WO1996010400A1 (en) * | 1994-09-30 | 1996-04-11 | The Uab Research Foundation | Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses |
| FR2726472B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Proteine porteuse a effet adjuvant, complexe immunogene la contenant, leur procede de preparation, sequence nucleotidique et vaccin |
| DE4442114A1 (de) * | 1994-11-25 | 1996-05-30 | Buna Sow Leuna Olefinverb Gmbh | Nitrit-, phosphat- und aminfreies Kühl- und Wärmeübertragungsmittel |
| US5811524A (en) * | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| US6015664A (en) * | 1995-11-03 | 2000-01-18 | Mcw Research Foundation | Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B |
| WO1998018819A1 (en) * | 1996-10-29 | 1998-05-07 | Smithkline Beecham Biologicals S.A. | Purification of respiratory syncytial virus antigens |
| US6103466A (en) * | 1997-07-14 | 2000-08-15 | University Of Liege | Double-muscling in mammals |
| EP1002068B1 (de) | 1997-07-14 | 2009-09-09 | University of Liège | Mutationen im myostatingen steigern muskelmasse in säugetieren |
| US20070067859A1 (en) * | 1997-07-14 | 2007-03-22 | Michel Georges | Double-muscling in mammals |
| US6699478B1 (en) * | 1997-09-19 | 2004-03-02 | Wyeth Holdings Corporation | Enhanced immune response to attachment (G) protein of Respiratory Syncytial Virus |
| GB9909077D0 (en) | 1999-04-20 | 1999-06-16 | Smithkline Beecham Biolog | Novel compositions |
| ES2349348T3 (es) * | 2000-01-27 | 2010-12-30 | Medimmune, Llc | Anticuerpos neutralizantes de rsv de ultra alta afinidad. |
| CA2401652A1 (en) * | 2000-03-01 | 2001-09-07 | Medimmune, Inc. | High potency recombinant antibodies and method for producing them |
| US7179900B2 (en) * | 2000-11-28 | 2007-02-20 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| US6855493B2 (en) | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| AU2005247091B2 (en) * | 2004-05-24 | 2010-08-12 | Polymun Scientific Immunbiologische Forschung Gmbh | Superloaded liposomes for drug delivery |
| CA2585891A1 (en) * | 2004-10-29 | 2006-05-11 | Medimmune, Inc. | Methods of preventing and treating rsv infections and related conditions |
| EP1997830A1 (de) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung |
| AU2008340949A1 (en) | 2007-12-24 | 2009-07-02 | Glaxosmithkline Biologicals S.A. | Recombinant RSV antigens |
| KR20110045008A (ko) * | 2008-07-18 | 2011-05-03 | 아이디 바이오메디컬 코포레이션 오브 퀘벡 | 키메라 호흡기 세포융합 바이러스 폴리펩티드 항원 |
| US9492531B2 (en) | 2009-06-24 | 2016-11-15 | Glaxosmithkline Biologicals Sa | Recombinant RSV vaccines |
| DK3178490T3 (da) | 2009-07-15 | 2022-06-20 | Glaxosmithkline Biologicals Sa | RSV F-proteinsammensætninger og fremgangsmåder til fremstilling af disse |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| EP3656396A1 (de) | 2012-08-01 | 2020-05-27 | Bavarian Nordic A/S | Rekombinanter modifizierter impfstoffvirus ankara (mva) gegen das respiratorische synzytialvirus (rsv) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855224A (en) * | 1984-03-09 | 1989-08-08 | Genentech, Inc. | Molecularly cloned diagnostic product and method of use |
| JPH01501357A (ja) * | 1986-01-14 | 1989-05-18 | ユニバ−シテイ・オブ・ノ−ス・カロライナ | ヒト呼吸器系ウイルス用ワクチン |
| US5223254A (en) * | 1987-09-29 | 1993-06-29 | Praxis Biologics, Inc. | Respiratory syncytial virus: vaccines |
| US5001230A (en) * | 1988-02-18 | 1991-03-19 | Schering Corporation | T cell activation markers |
| SG106639A1 (en) * | 2000-10-10 | 2004-10-29 | Gen Electric | Apparatus and method for introducing small amounts of refractory elements into a vapor deposition coating |
-
1988
- 1988-10-31 JP JP63509171A patent/JP2716503B2/ja not_active Expired - Lifetime
- 1988-10-31 US US07/543,780 patent/US5194595A/en not_active Expired - Lifetime
- 1988-10-31 KR KR1019890701589A patent/KR0137963B1/ko not_active IP Right Cessation
- 1988-10-31 WO PCT/US1988/003784 patent/WO1989005823A1/en active IP Right Grant
- 1988-10-31 AT AT88909879T patent/ATE85622T1/de not_active IP Right Cessation
- 1988-10-31 EP EP88909879A patent/EP0396563B1/de not_active Expired - Lifetime
- 1988-10-31 MX MX9203458A patent/MX9203458A/es unknown
- 1988-10-31 DE DE8888909879T patent/DE3878468T2/de not_active Expired - Lifetime
- 1988-10-31 AU AU27850/89A patent/AU617739B2/en not_active Expired
- 1988-11-07 CA CA000582378A patent/CA1320163C/en not_active Expired - Lifetime
-
1990
- 1990-06-21 FI FI903154A patent/FI102382B/fi not_active IP Right Cessation
- 1990-06-22 DK DK199001532A patent/DK173175B1/da not_active IP Right Cessation
- 1990-06-22 NO NO902802A patent/NO300254B1/no not_active IP Right Cessation
-
1992
- 1992-11-20 US US07/979,505 patent/US5288630A/en not_active Expired - Lifetime
-
1995
- 1995-10-26 HK HK166295A patent/HK166295A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK153290D0 (da) | 1990-06-22 |
| WO1989005823A1 (en) | 1989-06-29 |
| KR0137963B1 (ko) | 1998-04-30 |
| DE3878468D1 (de) | 1993-03-25 |
| FI102382B1 (fi) | 1998-11-30 |
| FI102382B (fi) | 1998-11-30 |
| KR900700508A (ko) | 1990-08-13 |
| JP2716503B2 (ja) | 1998-02-18 |
| NO902802D0 (no) | 1990-06-22 |
| DK173175B1 (da) | 2000-03-06 |
| EP0396563A1 (de) | 1990-11-14 |
| EP0396563B1 (de) | 1993-02-10 |
| AU617739B2 (en) | 1991-12-05 |
| ATE85622T1 (de) | 1993-02-15 |
| US5194595A (en) | 1993-03-16 |
| JPH03501723A (ja) | 1991-04-18 |
| NO300254B1 (no) | 1997-05-05 |
| CA1320163C (en) | 1993-07-13 |
| AU2785089A (en) | 1989-07-19 |
| HK166295A (en) | 1995-11-03 |
| US5288630A (en) | 1994-02-22 |
| FI903154A0 (fi) | 1990-06-21 |
| NO902802L (no) | 1990-06-22 |
| MX9203458A (es) | 1992-09-01 |
| DK153290A (da) | 1990-08-16 |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US |