DE3752182T2 - Abgeschwächte herpesviren, herpesviren, die eine für aminosäuresequenzen kodierende fremd-dns enthalten, sowie impfstoffe, die diese enthalten - Google Patents

Abgeschwächte herpesviren, herpesviren, die eine für aminosäuresequenzen kodierende fremd-dns enthalten, sowie impfstoffe, die diese enthalten

Info

Publication number
DE3752182T2
DE3752182T2 DE3752182T DE3752182T DE3752182T2 DE 3752182 T2 DE3752182 T2 DE 3752182T2 DE 3752182 T DE3752182 T DE 3752182T DE 3752182 T DE3752182 T DE 3752182T DE 3752182 T2 DE3752182 T2 DE 3752182T2
Authority
DE
Germany
Prior art keywords
herpesvirus
foreign dna
herpesviren
vaccinates
weakened
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE3752182T
Other languages
English (en)
Other versions
DE3752182D1 (de
Inventor
Mark Cochran
Meng-Fu Shih
William Macconnel
Richard Macdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntro Corp
Original Assignee
Syntro Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/823,102 external-priority patent/US5068192A/en
Application filed by Syntro Corp filed Critical Syntro Corp
Priority claimed from PCT/US1987/000157 external-priority patent/WO1987004463A1/en
Publication of DE3752182D1 publication Critical patent/DE3752182D1/de
Application granted granted Critical
Publication of DE3752182T2 publication Critical patent/DE3752182T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16741—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16762—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE3752182T 1986-01-27 1987-01-23 Abgeschwächte herpesviren, herpesviren, die eine für aminosäuresequenzen kodierende fremd-dns enthalten, sowie impfstoffe, die diese enthalten Revoked DE3752182T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US06/823,102 US5068192A (en) 1986-01-27 1986-01-27 Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence
US88714086A 1986-07-17 1986-07-17
US90288786A 1986-09-02 1986-09-02
US93310786A 1986-11-20 1986-11-20
PCT/US1987/000157 WO1987004463A1 (en) 1986-01-27 1987-01-23 Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same

Publications (2)

Publication Number Publication Date
DE3752182D1 DE3752182D1 (de) 1998-05-14
DE3752182T2 true DE3752182T2 (de) 1998-08-06

Family

ID=27505864

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3752389T Expired - Lifetime DE3752389T2 (de) 1986-01-27 1987-01-23 Attenuierte Herpesviren, Herpesviren die eine Aminosäuresequenz kodierende fremde DNA enthalten, und diese enthaltende Impfstoffe
DE3752182T Revoked DE3752182T2 (de) 1986-01-27 1987-01-23 Abgeschwächte herpesviren, herpesviren, die eine für aminosäuresequenzen kodierende fremd-dns enthalten, sowie impfstoffe, die diese enthalten
DE19873752389 Pending DE122007000004I1 (de) 1986-01-27 1987-01-23 Attenuierte Herpesviren, Herpesviren die eine Aminosäuresequenz kodierende fremde DNA enthalten, unddiese enthaltende Impfstoffe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3752389T Expired - Lifetime DE3752389T2 (de) 1986-01-27 1987-01-23 Attenuierte Herpesviren, Herpesviren die eine Aminosäuresequenz kodierende fremde DNA enthalten, und diese enthaltende Impfstoffe

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19873752389 Pending DE122007000004I1 (de) 1986-01-27 1987-01-23 Attenuierte Herpesviren, Herpesviren die eine Aminosäuresequenz kodierende fremde DNA enthalten, unddiese enthaltende Impfstoffe

Country Status (5)

Country Link
EP (1) EP0794257B1 (de)
AT (2) ATE342996T1 (de)
CA (1) CA1339468C (de)
DE (3) DE3752389T2 (de)
LU (1) LU91303I2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965639A1 (de) * 1998-06-05 1999-12-22 Boehringer Ingelheim Vetmedica Gmbh Attenuierte Pestiviren
US7179473B2 (en) 1998-06-05 2007-02-20 Boehringer Ingelheim Vetmedica Gmbh Attenuated pestiviruses
US7135561B2 (en) 2001-09-06 2006-11-14 Boehringer Ingelheim Vetmedica Gmbh Infectious bovine viral diarrhea virus clone
UY31930A (es) 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
US8846054B2 (en) 2009-01-09 2014-09-30 Boehringer Ingelheim Vetmedica, Inc. Method of treating pregnant cows and/or heifers
CN103370079B (zh) 2010-10-18 2016-08-10 英特维特国际股份有限公司 针对家禽中禽流感的火鸡疱疹病毒作为载体的疫苗
BR112014009565A2 (pt) 2011-10-21 2017-04-18 Intervet Int Bv vírus da doença de marek não patogênico recombinante, ácido nucleico recombinante, vacina, e, método para ajudar na proteção de um frango contra vírus
EP2768529A1 (de) 2011-10-21 2014-08-27 Intervet International B.V. Rekombinanter nichtpathogener mdv-vektor für multivalente immunität
IL299033A (en) 2020-06-17 2023-02-01 Boehringer Ingelheim Vetmedica Gmbh Recombinant HVT vectors expressing influenza hemagglutinin and immunogenic compounds, production and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190254A4 (de) * 1984-07-05 1987-03-09 Genex Corp Kloniertes gen, verfahren zu dessen herstellung und seine verwendung.

Also Published As

Publication number Publication date
EP0794257A1 (de) 1997-09-10
LU91303I2 (fr) 2007-03-12
DE3752182D1 (de) 1998-05-14
DE3752389D1 (de) 2006-11-30
DE122007000004I1 (de) 2007-05-24
ATE342996T1 (de) 2006-11-15
EP0794257B1 (de) 2006-10-18
CA1339468C (en) 1997-09-23
DE3752389T2 (de) 2007-06-14
ATE164885T1 (de) 1998-04-15

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation