JP2010516229A5 - - Google Patents
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- Publication number
- JP2010516229A5 JP2010516229A5 JP2009544477A JP2009544477A JP2010516229A5 JP 2010516229 A5 JP2010516229 A5 JP 2010516229A5 JP 2009544477 A JP2009544477 A JP 2009544477A JP 2009544477 A JP2009544477 A JP 2009544477A JP 2010516229 A5 JP2010516229 A5 JP 2010516229A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- antigen
- binding fragment
- hcmv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 31
- 102000036639 antigens Human genes 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 31
- 239000012634 fragment Substances 0.000 claims 30
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 13
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 3
- 238000006386 neutralization reaction Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 101100315698 Human cytomegalovirus (strain Merlin) UL131A gene Proteins 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000000066 myeloid cell Anatomy 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0700133.2 | 2007-01-04 | ||
| GBGB0700133.2A GB0700133D0 (en) | 2007-01-04 | 2007-01-04 | Human cytomegalovirus neutralising antibodies and use thereof |
| PCT/IB2008/001111 WO2008084410A2 (en) | 2007-01-04 | 2008-01-03 | Human cytomegalovirus neutralising antibodies and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043126A Division JP2014141501A (ja) | 2007-01-04 | 2014-03-05 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516229A JP2010516229A (ja) | 2010-05-20 |
| JP2010516229A5 true JP2010516229A5 (enExample) | 2011-02-24 |
| JP5710123B2 JP5710123B2 (ja) | 2015-04-30 |
Family
ID=37801734
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544477A Expired - Fee Related JP5710123B2 (ja) | 2007-01-04 | 2008-01-03 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2014043126A Pending JP2014141501A (ja) | 2007-01-04 | 2014-03-05 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043126A Pending JP2014141501A (ja) | 2007-01-04 | 2014-03-05 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US7955599B2 (enExample) |
| EP (3) | EP2487187B1 (enExample) |
| JP (2) | JP5710123B2 (enExample) |
| KR (2) | KR101541927B1 (enExample) |
| CN (1) | CN101657467B (enExample) |
| AU (1) | AU2008204258B2 (enExample) |
| BR (1) | BRPI0806185A2 (enExample) |
| CA (1) | CA2673755C (enExample) |
| CO (1) | CO6220862A2 (enExample) |
| CR (1) | CR10961A (enExample) |
| CY (1) | CY1114271T1 (enExample) |
| DK (1) | DK2118140T3 (enExample) |
| EC (1) | ECSP099547A (enExample) |
| ES (2) | ES2426987T3 (enExample) |
| GB (1) | GB0700133D0 (enExample) |
| GT (1) | GT200900188A (enExample) |
| HR (1) | HRP20130877T1 (enExample) |
| IL (1) | IL199585A (enExample) |
| MA (1) | MA31225B1 (enExample) |
| MX (1) | MX2009007320A (enExample) |
| MY (2) | MY150709A (enExample) |
| NZ (1) | NZ578844A (enExample) |
| PL (1) | PL2118140T3 (enExample) |
| PT (2) | PT2487187E (enExample) |
| RU (1) | RU2469045C2 (enExample) |
| SG (3) | SG177943A1 (enExample) |
| SI (1) | SI2118140T1 (enExample) |
| TN (1) | TN2009000285A1 (enExample) |
| UA (1) | UA100682C2 (enExample) |
| WO (1) | WO2008084410A2 (enExample) |
| ZA (1) | ZA200905408B (enExample) |
Families Citing this family (30)
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| EP3031469B1 (en) * | 2006-06-07 | 2023-08-23 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
| GB0700133D0 (en) * | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| US7947274B2 (en) * | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
| WO2009021150A2 (en) * | 2007-08-08 | 2009-02-12 | California Pacific Medical Center | Platelet derived growth factor receptor supports cytomegalovirus infectivity |
| NZ591056A (en) | 2008-07-16 | 2013-02-22 | Inst Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| WO2010007463A1 (en) * | 2008-07-16 | 2010-01-21 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| AU2012203417B2 (en) * | 2008-07-16 | 2014-07-10 | Institute For Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| AU2009275226B2 (en) | 2008-07-25 | 2015-05-14 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| CA2756889C (en) | 2009-04-01 | 2017-09-05 | Evec Incorporated | Monoclonal antibody capable of binding to specific discontinuous epitope occurring in ad1 region of human cytomegalovirus gb glycoprotein, and antigen-binding fragment thereof |
| PH12012501308A1 (en) * | 2009-12-23 | 2013-01-21 | 4 Antibody Ag | Binding members for human cytomegalovirus |
| US9017668B2 (en) | 2010-06-16 | 2015-04-28 | Trellis Bioscience, Llc | High affinity human antibodies to human cytomegalovirus (CMV) gB protein |
| SI2734545T1 (sl) | 2011-07-18 | 2019-06-28 | Institute For Research In Biomedicine | Protitelesa, ki nevtralizirajo virus influence A in njihova uporaba |
| HK1206759A1 (en) | 2012-03-28 | 2016-01-15 | F. Hoffmann-La Roche Ag | Anti-hcmv idiotypic antibodies and uses thereof |
| WO2014099908A1 (en) * | 2012-12-17 | 2014-06-26 | Genentech, Inc. | Methods for inhibiting viral infection in transplant patients |
| ES2837392T3 (es) | 2013-10-02 | 2021-06-30 | Medimmune Llc | Anticuerpos anti-influenza A neutralizantes y usos de los mismos |
| CN106573154B (zh) | 2014-07-15 | 2021-06-15 | 免疫医疗有限责任公司 | 中和抗乙型流感抗体及其用途 |
| US20160069643A1 (en) * | 2014-09-06 | 2016-03-10 | Philip Lyren | Weapon Targeting System |
| BR112017025496A2 (pt) | 2015-06-01 | 2018-08-07 | Medimmune, Llc | Moléculas de ligação neutralizantes anti- influenza e usos das mesmas |
| CA3010223A1 (en) | 2016-01-08 | 2017-07-13 | Aimm Therapeutics B.V. | Therapeutic binding compounds |
| US20190015509A1 (en) | 2016-01-13 | 2019-01-17 | Medimmune, Llc | Method of treating influenza a |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| EP3445393A4 (en) | 2016-04-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | CMV NEUTRALIZATION ANTIGEN BINDING PROTEINS |
| US12037382B2 (en) * | 2018-02-05 | 2024-07-16 | Stichting Vu | Inverse agonistic anti-US28 antibodies |
| CN109580944A (zh) * | 2018-12-07 | 2019-04-05 | 潍坊医学院 | 一种人巨细胞病毒检测试纸及其制造方法 |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| CN109738631A (zh) * | 2019-01-21 | 2019-05-10 | 潍坊医学院 | 一种人巨细胞病毒IgM抗体检测试纸的制备方法 |
| CN118465272B (zh) * | 2019-12-04 | 2025-08-19 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
| TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
| CN118772266B (zh) * | 2022-10-21 | 2025-06-17 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
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| US7947274B2 (en) * | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| US8361473B2 (en) | 2007-03-29 | 2013-01-29 | Technion Research & Development Foundation Ltd. | Antibodies and their uses for diagnosis and treatment of cytomegalovirus infection and associated diseases |
| US20080248042A1 (en) | 2007-04-05 | 2008-10-09 | Irccs Centro Di Riferimento Oncologico Di Aviano, | Monoclonal antibody cross-reactive against infective agent causing a B-cell expansion and IgG-Fc |
| WO2009024445A1 (en) | 2007-08-22 | 2009-02-26 | Ribovax Biotechnologies Sa | Antibodies against human cytomegalovirus (hcmv) |
| WO2009085383A1 (en) | 2007-12-19 | 2009-07-09 | Dcb-Usa Llc | Anti-human cytomegalovirus antibodies |
| NZ591056A (en) * | 2008-07-16 | 2013-02-22 | Inst Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| WO2010007463A1 (en) | 2008-07-16 | 2010-01-21 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
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