JP2017528476A5 - - Google Patents
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- JP2017528476A5 JP2017528476A5 JP2017513774A JP2017513774A JP2017528476A5 JP 2017528476 A5 JP2017528476 A5 JP 2017528476A5 JP 2017513774 A JP2017513774 A JP 2017513774A JP 2017513774 A JP2017513774 A JP 2017513774A JP 2017528476 A5 JP2017528476 A5 JP 2017528476A5
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- Prior art keywords
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- 108010023082 activin A Proteins 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 230000000750 progressive effect Effects 0.000 claims 1
- 102100021886 Activin receptor type-2A Human genes 0.000 description 4
- 102100027647 Activin receptor type-2B Human genes 0.000 description 4
- 101000970954 Homo sapiens Activin receptor type-2A Proteins 0.000 description 4
- 101000937269 Homo sapiens Activin receptor type-2B Proteins 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 230000011664 signaling Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049869P | 2014-09-12 | 2014-09-12 | |
| US62/049,869 | 2014-09-12 | ||
| US201562141775P | 2015-04-01 | 2015-04-01 | |
| US62/141,775 | 2015-04-01 | ||
| PCT/US2015/000100 WO2016039796A2 (en) | 2014-09-12 | 2015-09-14 | Treatment of fibrodysplasia ossificans progressiva |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528476A JP2017528476A (ja) | 2017-09-28 |
| JP2017528476A5 true JP2017528476A5 (enExample) | 2018-10-04 |
| JP6560341B2 JP6560341B2 (ja) | 2019-08-14 |
Family
ID=54207748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513774A Active JP6560341B2 (ja) | 2014-09-12 | 2015-09-14 | 進行性骨化性線維異形成症の治療 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US20160075772A1 (enExample) |
| EP (2) | EP3191512B1 (enExample) |
| JP (1) | JP6560341B2 (enExample) |
| KR (1) | KR102564079B1 (enExample) |
| CN (1) | CN107106648B (enExample) |
| AU (1) | AU2015315829B2 (enExample) |
| CA (1) | CA2960950C (enExample) |
| CL (2) | CL2017000603A1 (enExample) |
| CY (1) | CY1122188T1 (enExample) |
| DK (1) | DK3191512T3 (enExample) |
| ES (1) | ES2739605T3 (enExample) |
| HR (1) | HRP20191929T1 (enExample) |
| HU (1) | HUE046558T2 (enExample) |
| IL (1) | IL251063B (enExample) |
| LT (1) | LT3191512T (enExample) |
| MA (1) | MA40621B1 (enExample) |
| ME (1) | ME03541B (enExample) |
| MX (1) | MX382026B (enExample) |
| MY (1) | MY179654A (enExample) |
| NZ (1) | NZ730773A (enExample) |
| PL (1) | PL3191512T3 (enExample) |
| PT (1) | PT3191512T (enExample) |
| RS (1) | RS59412B1 (enExample) |
| SG (2) | SG11201701913SA (enExample) |
| SI (1) | SI3191512T1 (enExample) |
| SM (1) | SMT201900584T1 (enExample) |
| TW (1) | TWI688402B (enExample) |
| WO (1) | WO2016039796A2 (enExample) |
| ZA (1) | ZA201702112B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2780368T3 (pl) | 2011-11-14 | 2018-06-29 | Regeneron Pharmaceuticals, Inc. | Kompozycje i sposoby do zwiększania masy mięśni i siły mięśni poprzez swoiste antaganizowanie GDF8 i/lub aktywiny A |
| TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| EP3283519A1 (en) | 2015-04-15 | 2018-02-21 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| MX2017013520A (es) | 2015-04-22 | 2018-05-22 | Alivegen Usa Inc | Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular. |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| EP3415527B1 (de) * | 2017-06-14 | 2025-12-10 | Kymab Ltd. | Verwendung der extrazellulären domäne des transferrinrezeptor 2 zur diagnostik und behandlung von primär und sekundär sklerosierenden erkrankungen |
| JP7579706B2 (ja) | 2018-03-01 | 2024-11-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 体組成を変更するための方法 |
| CN111836643A (zh) * | 2018-03-05 | 2020-10-27 | 学校法人埼玉医科大学 | 用于治疗或预防异位骨化的药物组合物 |
| WO2019195796A1 (en) | 2018-04-06 | 2019-10-10 | Regeneron Pharmaceuticals, Inc. | A leptin receptor agonist antibody for use in treating a metabolic dysfunction or hypoleptinemia |
| CA3099441A1 (en) | 2018-06-13 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | A rodent model of fibrodysplasia ossificans progressiva |
| US20210214456A1 (en) | 2018-06-13 | 2021-07-15 | Kymab Limited | Antagonists and agonists of the transferrin receptor-2 for use in the treatment of diseases of the bone |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| EA202190418A1 (ru) * | 2018-08-02 | 2021-06-23 | Дайн Терапьютикс, Инк. | Мышечно-специфические комлексы и их применение в лечении прогрессирующей оссифицирующей фибродисплазии |
| JP2021533200A (ja) | 2018-08-02 | 2021-12-02 | ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. | 顔面・肩甲・上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用 |
| JP7512272B2 (ja) * | 2018-10-23 | 2024-07-08 | ケロス セラピューティクス インコーポレイテッド | Ａｌｋ２抗体及びその使用方法 |
| MX2021007394A (es) * | 2018-12-18 | 2021-07-15 | Regeneron Pharma | Composiciones y metodos para aumentar el peso corporal y la masa muscular magra mediante el uso de antagonistas contra el receptor de leptina, gdf8 y activina a. |
| EP4087652A1 (en) * | 2020-01-08 | 2022-11-16 | Regeneron Pharmaceuticals, Inc. | Treatment of fibrodysplasia ossificans progressiva |
| WO2021142260A1 (en) * | 2020-01-10 | 2021-07-15 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for modulation of acvr1 |
| US12472253B2 (en) * | 2020-06-18 | 2025-11-18 | Regeneron Pharmaceuticals, Inc. | Activin a antibody formulations and methods of use thereof |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| MX2023005565A (es) * | 2020-11-11 | 2024-02-23 | Hq Han | Antagonistas bifuncionales de activina/tgf-beta y rankl y usos de los mismos. |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| IL310810A (en) * | 2021-09-03 | 2024-04-01 | Laekna Therapeutics Shanghai Co Ltd | Anti-ACVR2A antibodies and uses thereof |
| WO2024234869A1 (en) * | 2023-05-15 | 2024-11-21 | Immunecare Biopharmaceuticals (Shanghai) Co., Ltd. | Recombinant fusion protein for treatment of pulmonary hypertension |
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| CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4634666A (en) | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US6018026A (en) | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
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| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
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| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
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| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| DE69230142T2 (de) | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
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| TW201907946A (zh) * | 2007-02-02 | 2019-03-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
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| PL2780368T3 (pl) * | 2011-11-14 | 2018-06-29 | Regeneron Pharmaceuticals, Inc. | Kompozycje i sposoby do zwiększania masy mięśni i siły mięśni poprzez swoiste antaganizowanie GDF8 i/lub aktywiny A |
| WO2014051109A1 (ja) | 2012-09-28 | 2014-04-03 | 協和発酵キリン株式会社 | 抗ヒトｂｍｐ９抗体および該抗体を有効成分とする異所性骨化疾患の治療剤 |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| JP6601687B2 (ja) | 2014-03-31 | 2019-11-06 | 大日本住友製薬株式会社 | 進行性骨化性線維異形成症の予防剤及び治療剤 |
| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| AR103675A1 (es) * | 2015-02-13 | 2017-05-24 | Sorrento Therapeutics Inc | Anticuerpos anti-ctla4 terapéuticos |
| US20160319009A1 (en) | 2015-04-29 | 2016-11-03 | Regeneron Pharmaceuticals, Inc. | Treatment of fibrodysplasia ossificans progressiva |
-
2015
- 2015-09-10 US US14/850,844 patent/US20160075772A1/en not_active Abandoned
- 2015-09-11 TW TW104130079A patent/TWI688402B/zh active
- 2015-09-14 HU HUE15775835A patent/HUE046558T2/hu unknown
- 2015-09-14 MA MA40621A patent/MA40621B1/fr unknown
- 2015-09-14 IL IL251063A patent/IL251063B/en unknown
- 2015-09-14 ES ES15775835T patent/ES2739605T3/es active Active
- 2015-09-14 DK DK15775835.0T patent/DK3191512T3/da active
- 2015-09-14 SG SG11201701913SA patent/SG11201701913SA/en unknown
- 2015-09-14 AU AU2015315829A patent/AU2015315829B2/en active Active
- 2015-09-14 WO PCT/US2015/000100 patent/WO2016039796A2/en not_active Ceased
- 2015-09-14 JP JP2017513774A patent/JP6560341B2/ja active Active
- 2015-09-14 ME MEP-2019-279A patent/ME03541B/me unknown
- 2015-09-14 SI SI201530852T patent/SI3191512T1/sl unknown
- 2015-09-14 PT PT15775835T patent/PT3191512T/pt unknown
- 2015-09-14 EP EP15775835.0A patent/EP3191512B1/en active Active
- 2015-09-14 LT LTEP15775835.0T patent/LT3191512T/lt unknown
- 2015-09-14 KR KR1020177009673A patent/KR102564079B1/ko active Active
- 2015-09-14 SM SM20190584T patent/SMT201900584T1/it unknown
- 2015-09-14 CA CA2960950A patent/CA2960950C/en active Active
- 2015-09-14 PL PL15775835T patent/PL3191512T3/pl unknown
- 2015-09-14 SG SG10201902175RA patent/SG10201902175RA/en unknown
- 2015-09-14 MY MYPI2017700819A patent/MY179654A/en unknown
- 2015-09-14 EP EP19177741.6A patent/EP3604335A1/en not_active Withdrawn
- 2015-09-14 MX MX2017003175A patent/MX382026B/es unknown
- 2015-09-14 CN CN201580049029.1A patent/CN107106648B/zh active Active
- 2015-09-14 NZ NZ730773A patent/NZ730773A/en unknown
- 2015-09-14 HR HRP20191929TT patent/HRP20191929T1/hr unknown
- 2015-09-14 RS RSP20191331 patent/RS59412B1/sr unknown
-
2017
- 2017-03-10 CL CL2017000603A patent/CL2017000603A1/es unknown
- 2017-03-27 ZA ZA2017/02112A patent/ZA201702112B/en unknown
- 2017-08-28 US US15/688,740 patent/US20180111983A1/en not_active Abandoned
-
2018
- 2018-10-17 CL CL2018002962A patent/CL2018002962A1/es unknown
-
2019
- 2019-09-17 CY CY20191100972T patent/CY1122188T1/el unknown
- 2019-09-23 US US16/579,126 patent/US11407822B2/en active Active
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