|
JPS5892644A
(ja)
|
1981-11-26 |
1983-06-02 |
Taiho Yakuhin Kogyo Kk |
新規なニトロ安息香酸アミド誘導体およびそれを含有する放射線増感剤
|
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
|
US4866132A
(en)
|
1986-04-17 |
1989-09-12 |
The Research Foundation Of State University Of New York |
Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom
|
|
US5616584A
(en)
|
1986-09-25 |
1997-04-01 |
Sri International |
1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
|
|
US4921963A
(en)
|
1987-04-13 |
1990-05-01 |
British Columbia Cancer Foundation |
Platinum complexes with one radiosensitizing ligand
|
|
JPH0819111B2
(ja)
|
1987-10-22 |
1996-02-28 |
ポーラ化成工業株式会社 |
2―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
|
|
US5256334A
(en)
|
1988-09-08 |
1993-10-26 |
The Research Foundation Of The State University Of New York |
Homogeneous radiopaque polymer-organobismuth composites
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5637481A
(en)
*
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
EP0654993A1
(en)
|
1992-08-17 |
1995-05-31 |
Quadra Logic Technologies Inc. |
Method for destroying or inhibiting growth of unwanted cells or tissues
|
|
US5346981A
(en)
|
1993-01-13 |
1994-09-13 |
Miles Inc. |
Radiopaque polyurethanes
|
|
US5599796A
(en)
|
1993-12-02 |
1997-02-04 |
Emory University |
Treatment of urogenital cancer with boron neutron capture therapy
|
|
WO1996019487A1
(en)
|
1994-12-22 |
1996-06-27 |
Nissan Chemical Industries, Ltd. |
Organobismuth derivatives and process for producing the same
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5700825A
(en)
|
1995-03-31 |
1997-12-23 |
Florida State University |
Radiosensitizing diamines and their pharmaceutical preparations
|
|
GB9816575D0
(en)
|
1998-07-31 |
1998-09-30 |
Zeneca Ltd |
Novel compounds
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
ES2260570T3
(es)
|
1998-08-27 |
2006-11-01 |
Spirogen Limited |
Pirrolobenziodiazepinas dimericas.
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
AU2002368077B2
(en)
|
2001-07-12 |
2010-03-04 |
Jefferson Foote |
Super humanized antibodies
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
ES2369542T3
(es)
|
2002-07-31 |
2011-12-01 |
Seattle Genetics, Inc. |
Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
GB0416511D0
(en)
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
ES2605443T3
(es)
|
2003-11-06 |
2017-03-14 |
Seattle Genetics, Inc. |
Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
|
|
WO2005062977A2
(en)
*
|
2003-12-23 |
2005-07-14 |
The Regents Of The University Of California |
Prostate cancer specific internalizing human antibodies
|
|
EP1723152B1
(en)
|
2004-03-09 |
2015-02-11 |
Spirogen Sàrl |
Pyrrolobenzodiazepines
|
|
JP2008519863A
(ja)
|
2004-11-12 |
2008-06-12 |
シアトル ジェネティクス インコーポレイティッド |
N末端にアミノ安息香酸単位を有するオーリスタチン
|
|
ES2338696T3
(es)
|
2005-04-21 |
2010-05-11 |
Spirogen Limited |
Pirrolobenzodiazepinas.
|
|
WO2007008848A2
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
|
|
DK1813614T3
(da)
|
2006-01-25 |
2012-01-23 |
Sanofi Sa |
Cytotoksiske midler, der omfatter nye tomaymycinderivater
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
CN105837690A
(zh)
*
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
EP2148886B1
(en)
|
2007-05-10 |
2014-02-19 |
R & D Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
|
PT2019104E
(pt)
|
2007-07-19 |
2013-12-03 |
Sanofi Sa |
Agentes citotóxicos compreendendo novos derivados de tomaimicina e sua utilização terapêutica
|
|
US20090076249A1
(en)
*
|
2007-09-19 |
2009-03-19 |
Michel De Weers |
Antibodies against CD38 for treatment of multiple myeloma
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
CA3014224C
(en)
|
2009-02-05 |
2022-05-24 |
Immunogen, Inc. |
Condensed benzodiazepine-indoline derivatives and processes to prepare said derivatives
|
|
IT1394860B1
(it)
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
|
MX368648B
(es)
|
2010-04-15 |
2019-10-09 |
Seattle Genetics Inc |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
|
|
CN103068405A
(zh)
|
2010-04-15 |
2013-04-24 |
西雅图基因公司 |
靶向吡咯并苯并二氮杂卓结合物
|
|
JP2013531981A
(ja)
|
2010-06-11 |
2013-08-15 |
アンチセンス・ファーマ・ゲーエムベーハー |
選択的オリゴヌクレオチド修飾の方法
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
CN102372778B
(zh)
*
|
2010-08-19 |
2015-06-17 |
上海抗体药物国家工程研究中心有限公司 |
抗人vegf和opn双特异性抗体、其制备方法及用途
|
|
US9090629B2
(en)
|
2010-11-03 |
2015-07-28 |
Immunogen, Inc. |
Cytotoxic agents comprising new ansamitocin derivatives
|
|
WO2012177837A2
(en)
|
2011-06-21 |
2012-12-27 |
Immunogen, Inc. |
Novel maytansinoid derivatives with peptide linker and conjugates thereof
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
BR112014013526A8
(pt)
|
2011-12-05 |
2017-06-13 |
Igenica Biotherapeutics Inc |
conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados
|
|
CN104640572B
(zh)
|
2012-05-15 |
2018-04-27 |
索伦托医疗有限公司 |
药物偶联物,偶联方法,及其用途
|
|
SG10201609535TA
(en)
*
|
2012-06-05 |
2017-01-27 |
Regeneron Pharma |
Methods for making fully human bispecific antibodies using a common light chain
|
|
KR20210132742A
(ko)
|
2012-12-21 |
2021-11-04 |
알트루바이오 인코퍼레이티드 |
친수성 자기-희생 링커 및 그것의 포합체
|
|
US9701759B2
(en)
*
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
MX363787B
(es)
|
2013-03-13 |
2019-04-03 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de los mismos.
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
US20140363454A1
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Antibody-Drug Conjugates, Compositions and Methods of Use
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
AU2014337317A1
(en)
|
2013-10-15 |
2016-09-15 |
Sorrento Therapeutics Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
EP4050026A1
(en)
|
2014-04-01 |
2022-08-31 |
Adimab, LLC |
Method of obtaining or identifying one or more common light chains for use in preparing a multispecific antibody
|
|
AU2016312259B2
(en)
*
|
2015-08-26 |
2018-12-06 |
Bison Therapeutics Inc. |
Multispecific antibody platform and related methods
|
|
CN109310755A
(zh)
*
|
2016-02-02 |
2019-02-05 |
卡德门企业有限公司 |
Pd-l1和kdr的双特异性结合蛋白
|
|
CN113302207B
(zh)
|
2018-11-16 |
2025-05-13 |
维尔托索宾科公司 |
Cd38和icam1抗体及其用途
|