|
US30985A
(en)
|
|
1860-12-18 |
|
Thomas l |
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US4968607A
(en)
|
1987-11-25 |
1990-11-06 |
Immunex Corporation |
Interleukin-1 receptors
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
AU643427B2
(en)
|
1988-10-31 |
1993-11-18 |
Immunex Corporation |
Interleukin-4 receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
WO1991010741A1
(en)
|
1990-01-12 |
1991-07-25 |
Cell Genesys, Inc. |
Generation of xenogeneic antibodies
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
WO1991018982A1
(en)
|
1990-06-05 |
1991-12-12 |
Immunex Corporation |
Type ii interleukin-1 receptors
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
EP0590076A4
(en)
|
1991-06-14 |
1997-02-12 |
Dnx Corp |
Production of human hemoglobin in transgenic pigs
|
|
DE69224906T2
(de)
|
1991-07-08 |
1998-10-29 |
Univ Massachusetts |
Thermotropes flüssig-kristallines segment-blockcopolymer
|
|
AU3178993A
(en)
|
1991-11-25 |
1993-06-28 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
AU675661B2
(en)
|
1992-07-24 |
1997-02-13 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
|
WO1997034631A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
|
DE69738539T2
(de)
|
1996-12-03 |
2009-03-26 |
Amgen Fremont Inc. |
Vollkommen humane Antikörper die EGFR binden
|
|
US6878687B1
(en)
|
1997-03-07 |
2005-04-12 |
Human Genome Sciences, Inc. |
Protein HMAAD57
|
|
WO1998039446A2
(en)
|
1997-03-07 |
1998-09-11 |
Human Genome Sciences, Inc. |
70 human secreted proteins
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
WO2000000610A2
(en)
|
1998-06-26 |
2000-01-06 |
Incyte Pharmaceuticals, Inc. |
Human signal peptide-containing proteins
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US6833268B1
(en)
|
1999-06-10 |
2004-12-21 |
Abgenix, Inc. |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
|
|
AUPQ873300A0
(en)
|
2000-07-12 |
2000-08-03 |
Medvet Science Pty. Ltd. |
A binding motif of a receptor (2)
|
|
US20020004587A1
(en)
|
2000-04-11 |
2002-01-10 |
Genentech, Inc. |
Multivalent antibodies and uses therefor
|
|
EP1351702B1
(en)
|
2000-12-08 |
2015-03-04 |
Bioprovar Corporation |
Trem-1 splice variant for use in modifying immune responses
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
CA2342376C
(en)
|
2001-03-20 |
2013-11-12 |
Marco Colonna |
A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8231878B2
(en)
|
2001-03-20 |
2012-07-31 |
Cosmo Research & Development S.P.A. |
Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8981061B2
(en)
|
2001-03-20 |
2015-03-17 |
Novo Nordisk A/S |
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US20030113316A1
(en)
|
2001-07-25 |
2003-06-19 |
Kaisheva Elizabet A. |
Stable lyophilized pharmaceutical formulation of IgG antibodies
|
|
EP2316485A1
(en)
|
2001-10-12 |
2011-05-04 |
Schering Corporation |
Use of bispecific antibodies to regulate immune responses
|
|
US20060263770A1
(en)
|
2002-03-22 |
2006-11-23 |
Marco Colonna |
Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US7556926B2
(en)
|
2002-05-24 |
2009-07-07 |
Takeda Pharmaceuticals Company Ltd. |
Methods for screening insulin-sensitizing agents
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
GB0401730D0
(en)
|
2004-01-27 |
2004-03-03 |
Bioxell Spa |
Diagnosis method
|
|
PT2314621E
(pt)
*
|
2004-05-27 |
2014-06-23 |
Crucell Holland Bv |
Moléculas de ligação capazes de neutralizar o vírus da raiva, e suas utilizações
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
US8101345B1
(en)
|
2005-03-25 |
2012-01-24 |
Isis Pharmaceuticals, Inc. |
Proinflammatory nucleic acids
|
|
KR20060135280A
(ko)
|
2005-06-24 |
2006-12-29 |
전남대학교산학협력단 |
선천성 면역에 관여하는 트렘-2의 클로닝
|
|
EP1959969A2
(en)
|
2005-07-01 |
2008-08-27 |
The Johns Hopkins University |
Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
|
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
|
CN103073639A
(zh)
|
2006-03-17 |
2013-05-01 |
比奥根艾迪克Ma公司 |
稳定的多肽组合物
|
|
DE202006007499U1
(de)
|
2006-05-11 |
2007-01-11 |
Osaka University |
Verwendung einer Zusammensetzung, die Plexin-A1-DAP12-Interaktion inhibiert, zur Behandlung von Entzündungs-, Autoimmun- oder Knochenresorptionserkrankungen
|
|
MX363905B
(es)
|
2006-06-12 |
2019-04-08 |
Aptevo Res & Development Llc |
Proteinas de union multivalentes monocatenarias con funcion efectora.
|
|
CA2551163A1
(en)
|
2006-07-17 |
2008-01-17 |
Boehringer Ingelheim International Gmbh |
Methods for treating inflammatory, autoimmune or bone resorption diseases
|
|
US7553936B2
(en)
|
2006-12-04 |
2009-06-30 |
The United States of America as represented by Secretary Department of Health and Human Services |
Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions
|
|
BRPI0806680A2
(pt)
|
2007-01-16 |
2015-06-16 |
Wyeth Corp |
Tratamento, detecção e monitoramento de inflamação via trem-1
|
|
IN2009DN05758A
(enExample)
|
2007-03-12 |
2015-07-24 |
Esbatech Ag |
|
|
US8793074B2
(en)
|
2007-06-21 |
2014-07-29 |
Saint Louis University |
Sequence covariance networks, methods and uses therefor
|
|
JP5611820B2
(ja)
|
2007-06-25 |
2014-10-22 |
エスバテック − ア ノバルティスカンパニー エルエルシー |
抗体の修飾方法並びに改善された機能特性を有する修飾された抗体
|
|
GR1007327B
(el)
|
2007-08-08 |
2011-06-27 |
Ευαγγελος Γιαμαρελλος-Μπουρμπουλης |
Ο διαλυτος υποδοχεας ενεργοποιησης των μυελοκυτταρων (strem-1) ως δεικτης αποτελεσματικοτητας της θεραπειας του πεπτικου ελκους
|
|
US20100226925A1
(en)
|
2007-09-14 |
2010-09-09 |
Amgen Inc. |
Homogeneous Antibody Populations
|
|
TW200918553A
(en)
*
|
2007-09-18 |
2009-05-01 |
Amgen Inc |
Human GM-CSF antigen binding proteins
|
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
|
KR100960684B1
(ko)
|
2008-02-22 |
2010-05-31 |
전남대학교산학협력단 |
Ｇａ733-2 발현 억제제로서의 ｔｒｅｍ-2 유전자, 및 이를포함하는 형질전환 동물 및 이의 사용방법
|
|
WO2010045479A1
(en)
|
2008-10-15 |
2010-04-22 |
The Board Of Trustees Of The University Of Illinois |
Phospholipid micellar and liposomal compositions and uses thereof
|
|
EP2424976B1
(en)
|
2009-04-28 |
2013-07-31 |
Life & Brain GmbH |
Method for obtaining human microglial precursor cells from pluripotent stem cells
|
|
WO2010132370A2
(en)
|
2009-05-11 |
2010-11-18 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Soluble tlt-1 for the treatment and diagnosis of sepsis
|
|
AU2010270979B2
(en)
|
2009-06-22 |
2015-04-23 |
Medimmune, Llc |
Engineered Fc regions for site-specific conjugation
|
|
WO2011047097A2
(en)
|
2009-10-13 |
2011-04-21 |
Sigalov Alexander B |
Inhibition of trem receptor signaling with peptide variants
|
|
CN102038698A
(zh)
|
2009-10-14 |
2011-05-04 |
山东绿叶天然药物研究开发有限公司 |
莫诺苷的新用途
|
|
JO3244B1
(ar)
*
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
|
US20120316071A1
(en)
*
|
2009-11-04 |
2012-12-13 |
Vaughn Smider |
Methods for affinity maturation-based antibody optimization
|
|
CN102127168A
(zh)
|
2010-01-19 |
2011-07-20 |
中国人民解放军第二军医大学 |
一种髓样细胞表达激发受体-1的重组融合蛋白及其应用
|
|
KR20110086460A
(ko)
|
2010-01-22 |
2011-07-28 |
한국교원대학교산학협력단 |
수용성 수용체 라이브러리 및 이를 이용한 사이토카인 발현 조절 유전자의 스크리닝 방법
|
|
AU2011237851B2
(en)
|
2010-04-08 |
2015-02-05 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Inhibiting peptides derived from TREM-Like Transcript 1 (TLT-1) and uses thereof
|
|
KR20130098161A
(ko)
|
2010-04-30 |
2013-09-04 |
알렉시온 파마슈티칼스, 인코포레이티드 |
인간에서 감소된 면역원성을 갖는 항체
|
|
WO2012016333A1
(en)
|
2010-08-06 |
2012-02-09 |
University Health Network |
Biomarkers for malaria
|
|
US20130130354A1
(en)
|
2010-09-28 |
2013-05-23 |
CTI Salud S.A. |
Novel genes and uses thereof, expression profile of colon, gastric and pancreatic cancer
|
|
UY33826A
(es)
|
2010-12-22 |
2012-07-31 |
Abbott Lab |
Proteínas de unión con dominios trivariables y sus usos
|
|
EP2654792A4
(en)
|
2010-12-22 |
2016-05-11 |
Abbvie Inc |
HALF IMMUNOGLOBULIN BINDING PROTEINS AND USES THEREOF
|
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
|
WO2012125495A2
(en)
|
2011-03-11 |
2012-09-20 |
Amgen Inc. |
Method of correlated mutational analysis to improve therapeutic antibodies
|
|
KR20120112973A
(ko)
|
2011-04-04 |
2012-10-12 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 예방 또는 치료용 조성물
|
|
US20130058947A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc |
Novel Modulators and Methods of Use
|
|
ES2682081T3
(es)
|
2011-10-11 |
2018-09-18 |
F. Hoffmann-La Roche Ag |
Ensamblaje mejorado de anticuerpos biespecíficos
|
|
KR20190077124A
(ko)
|
2011-10-21 |
2019-07-02 |
스템제닉스 인코포레이티드 |
생물학적 활성 분자의 세포내 전달을 위한 작용화 나노입자
|
|
DK2773671T3
(da)
|
2011-11-04 |
2021-11-15 |
Zymeworks Inc |
Udformning af stabilt heterodimert antistof med mutationer i fc-domænet
|
|
EP2776061B1
(en)
|
2011-11-07 |
2019-08-14 |
MedImmune, LLC |
Multispecific and multivalent binding proteins and uses thereof
|
|
WO2013093809A1
(en)
|
2011-12-23 |
2013-06-27 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
TWI450727B
(zh)
|
2011-12-29 |
2014-09-01 |
Ind Tech Res Inst |
抗人類輸鐵蛋白受體的單域抗體與其應用
|
|
CN102517287B
(zh)
|
2012-01-10 |
2013-09-11 |
广西大学 |
抑制水牛TREM1基因表达的shRNA、慢病毒表达载体及其构建方法和应用
|
|
KR20130114951A
(ko)
|
2012-04-10 |
2013-10-21 |
한양대학교 산학협력단 |
폴리감마글루탐산을 포함하는 Ｔｈ17 매개성 질환 예방 또는 치료용 조성물
|
|
CA2884121C
(en)
|
2012-09-07 |
2021-10-12 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Inhibiting peptides derived from triggering receptor expressed on myeloid cells-1 (trem-1) trem-like transcript 1 (tlt-1) and uses thereof
|
|
US9828434B2
(en)
|
2012-10-04 |
2017-11-28 |
Dana-Farber Cancer Institute, Inc. |
Human monoclonal anti-PD-L1 antibodies and methods of use
|
|
CA2887825A1
(en)
|
2012-10-23 |
2014-05-01 |
The Board Of Regents Of The University Of Texas System |
Engineered igg fc domains
|
|
WO2014074942A1
(en)
|
2012-11-08 |
2014-05-15 |
Illumina, Inc. |
Risk variants of alzheimer's disease
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
US9066928B1
(en)
*
|
2012-12-04 |
2015-06-30 |
University Of Kentucky Research Foundation |
Method, composition, and kit useful for treatment of alzheimer's disease
|
|
US9546203B2
(en)
|
2013-03-14 |
2017-01-17 |
Amgen Inc. |
Aglycosylated Fc-containing polypeptides with cysteine substitutions
|
|
AR096364A1
(es)
|
2013-05-20 |
2015-12-23 |
Genentech Inc |
Anticuerpos receptores de antitransferina y métodos de uso
|
|
KR20150010326A
(ko)
|
2013-07-19 |
2015-01-28 |
전남대학교산학협력단 |
비만 및 제 2형 당뇨 또는 지방간의 예방 또는 치료용 바이아릴아마이드를 포함한 유도체 화합물
|
|
KR101402921B1
(ko)
|
2013-08-28 |
2014-06-02 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 치료를 위한 레스베라톨 유도체의 이용
|
|
CA2825821A1
(en)
|
2013-08-28 |
2015-02-28 |
Chiesi Farmaceutici S.P.A. |
1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis
|
|
WO2015037000A1
(en)
|
2013-09-11 |
2015-03-19 |
Compugen Ltd |
Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
|
|
CN103555829B
(zh)
|
2013-10-12 |
2015-10-21 |
厦门人瑞生物医药科技有限公司 |
一种检测trem2基因r47h突变的探针、试剂盒和方法
|
|
US20160327572A1
(en)
|
2014-01-06 |
2016-11-10 |
Children's Medical Center Corporation |
Biomarkers for Dementia and Dementia Related Neurological Disorders
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
CN103866041A
(zh)
|
2014-04-04 |
2014-06-18 |
厦门大学 |
帕金森病和脑白质疏松症的突变检测试剂盒及其检测方法
|
|
ES2719584T3
(es)
|
2014-04-11 |
2019-07-11 |
Medimmune Llc |
Compuestos conjugados que comprenden anticuerpos modificados por ingeniería genética con cisteína
|
|
CN105218669A
(zh)
|
2014-06-10 |
2016-01-06 |
河北翰林生物科技有限公司 |
制备抗人r47h-trem2突变体的人单克隆抗体的方法
|
|
US20170218091A1
(en)
|
2014-07-03 |
2017-08-03 |
Abbvie Inc. |
Monovalent binding proteins
|
|
DK3172232T5
(en)
|
2014-07-17 |
2024-11-18 |
Novo Nordisk As |
Site directed mutagenesis of trem-1 antibodies for decreasing viscosity
|
|
SG11201700901SA
(en)
*
|
2014-08-08 |
2017-03-30 |
Alector Llc |
Anti-trem2 antibodies and methods of use thereof
|
|
KR101756417B1
(ko)
|
2014-08-21 |
2017-07-10 |
한국유나이티드제약 주식회사 |
금제제를 포함하는 간 섬유화 또는 간 경화의 예방 또는 치료용 약학적 조성물
|
|
KR102506663B1
(ko)
|
2014-09-28 |
2023-03-08 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
자극성 및 비자극성 골수성 세포의 조절
|
|
US20170334977A1
(en)
|
2014-10-20 |
2017-11-23 |
The Brigham And Women's Hospital, Inc. |
Targeting Apolipoprotein E (APOE) in Neurologic Disease
|
|
US10081792B2
(en)
|
2014-12-31 |
2018-09-25 |
Wisconsin Alumni Research Foundation |
Derivation of human microglia from pluripotent stem cells
|
|
CA2982246A1
(en)
|
2015-04-17 |
2016-10-20 |
Alpine Immune Sciences, Inc. |
Immunomodulatory proteins with tunable affinities
|
|
AU2016264228B2
(en)
|
2015-05-18 |
2019-06-13 |
Synaptec Development Llc |
Galantamine clearance of amyloidß
|
|
WO2016201389A2
(en)
|
2015-06-12 |
2016-12-15 |
Alector Llc |
Anti-cd33 antibodies and methods of use thereof
|
|
JP7376977B2
(ja)
|
2015-06-12 |
2023-11-09 |
アレクトル エルエルシー |
抗ｃｄ３３抗体及びその使用方法
|
|
WO2017007712A1
(en)
|
2015-07-04 |
2017-01-12 |
Emory University |
Use of trem-1 inhibitors for treatment, elimination and eradication of hiv-1 infection
|
|
WO2017011342A1
(en)
|
2015-07-10 |
2017-01-19 |
Abbvie Inc. |
Igm-or-ige-modified binding proteins and uses thereof
|
|
IL287916B2
(en)
*
|
2015-07-30 |
2023-09-01 |
Macrogenics Inc |
Molecules that bind pd-1 and methods of using them
|
|
HK1252696A1
(zh)
|
2015-08-28 |
2019-05-31 |
艾利妥 |
抗siglec-7抗体及其使用方法
|
|
WO2017058866A1
(en)
|
2015-09-28 |
2017-04-06 |
Precision Immune, Inc. |
Anti-trem2 antibodies and uses thereof
|
|
KR20180068999A
(ko)
*
|
2015-10-06 |
2018-06-22 |
알렉터 엘엘씨 |
항-trem2 항체 및 그의 사용방법
|
|
WO2017075432A2
(en)
|
2015-10-29 |
2017-05-04 |
Alector Llc |
Anti-siglec-9 antibodies and methods of use thereof
|
|
US20170218058A1
(en)
|
2016-01-28 |
2017-08-03 |
Alector, LLC |
Anti-apoe4 antigen-binding proteins and methods of use thereof
|
|
US12156890B2
(en)
|
2016-02-11 |
2024-12-03 |
The Johns Hopkins University |
Compositions and methods for neuralgenesis
|
|
US11066456B2
(en)
|
2016-02-25 |
2021-07-20 |
Washington University |
Compositions comprising TREM2 and methods of use thereof
|
|
EP3423493A2
(en)
|
2016-03-04 |
2019-01-09 |
Alector LLC |
Anti-trem1 antibodies and methods of use thereof
|
|
US10875919B2
(en)
|
2016-04-26 |
2020-12-29 |
Alector Llc |
Chimeric receptors and methods of use thereof
|
|
EP3452101A2
(en)
|
2016-05-04 |
2019-03-13 |
CureVac AG |
Rna encoding a therapeutic protein
|
|
WO2017210343A1
(en)
|
2016-06-01 |
2017-12-07 |
The University Of Virginia Patent Foundation |
Methods and compositions for modulating lymphatic vessels in the central nervous system
|
|
CA3030785A1
(en)
|
2016-07-22 |
2018-01-25 |
Deutsches Zentrum Fur Neurodegenerative Erkrankungen E.V. (Dzne) |
Trem2 cleavage modulators and uses thereof
|
|
CN106244682B
(zh)
|
2016-07-29 |
2019-11-26 |
中山大学 |
Trem-2基因在鉴别猪对蓝耳病毒易感性中的应用
|
|
CN106636330B
(zh)
|
2016-09-21 |
2017-12-15 |
郁金泰 |
阿尔茨海默病的诊断和治疗药物
|
|
CN110621774A
(zh)
|
2016-10-14 |
2019-12-27 |
儿童医疗中心有限公司 |
用于治疗中枢神经系统疾病和病症的组合物和方法
|
|
KR20240039236A
(ko)
|
2016-12-09 |
2024-03-26 |
알렉터 엘엘씨 |
항-sirp-알파 항체 및 그의 사용 방법
|
|
WO2018119018A1
(en)
|
2016-12-23 |
2018-06-28 |
Genervon Biopharmaceuticals, LLC |
Methods of using gm6 in diagnosing and treating alzheimer's disease
|
|
CN110573167A
(zh)
|
2017-01-12 |
2019-12-13 |
杜克大学 |
用于治疗脱髓鞘疾病的组合物和方法
|
|
WO2018134815A2
(en)
|
2017-01-17 |
2018-07-26 |
Yeda Research And Development Co. Ltd. |
Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells
|
|
EP3570857A1
(en)
|
2017-01-18 |
2019-11-27 |
Evelo Biosciences, Inc. |
Methods of treating cancer
|
|
US20190336615A1
(en)
|
2017-01-27 |
2019-11-07 |
Silverback Therapeutics, Inc. |
Tumor targeting conjugates and methods of use thereof
|
|
US10143187B2
(en)
|
2017-02-17 |
2018-12-04 |
Denali Therapeutics Inc. |
Transferrin receptor transgenic models
|
|
WO2018157014A1
(en)
|
2017-02-24 |
2018-08-30 |
Duke University |
Metabolic biomarkers for the identification and characterization of alzheimer's disease
|
|
JP2020513794A
(ja)
|
2017-02-28 |
2020-05-21 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用
|
|
AU2018239433B2
(en)
|
2017-03-21 |
2024-02-01 |
Indiana University Research And Technology Corporation |
A genetically modified mouse expressing human APOE4p and mouse Trem2 p.R47H and methods of use thereof
|
|
KR101936249B1
(ko)
|
2017-04-04 |
2019-01-08 |
경희대학교 산학협력단 |
쿠마타케닌을 포함하는 암의 예방, 개선 또는 치료용 조성물
|
|
JOP20190248A1
(ar)
|
2017-04-21 |
2019-10-20 |
Amgen Inc |
بروتينات ربط مولد ضد trem2 واستخداماته
|
|
US20180318379A1
(en)
|
2017-05-01 |
2018-11-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of triggering receptor expressed on myeloid cells 1 (trem1) to treat central nervous system disorders
|
|
WO2018213316A1
(en)
|
2017-05-16 |
2018-11-22 |
Alector Llc |
Anti-siglec-5 antibodies and methods of use thereof
|
|
JP7399712B2
(ja)
|
2017-05-24 |
2023-12-18 |
ナノソミックス・インコーポレイテッド |
疾病および障害の診断および予後判定のための小胞上のバイオマーカーの検出
|
|
EP3634486A4
(en)
|
2017-06-05 |
2021-03-31 |
Janssen Biotech, Inc. |
GENETICALLY PRODUCED MULTISPECIFIC ANTIBODIES AND OTHER MULTIMERIC PROTEINS WITH ASYMMETRIC MUTATIONS OF THE CH2-CH3 REGION
|
|
CN111148761B
(zh)
|
2017-06-25 |
2024-02-13 |
西雅图免疫公司 |
多特异性抗体及其制备和使用方法
|
|
US20190008812A1
(en)
|
2017-07-07 |
2019-01-10 |
Washington University |
Methods for treating microglial dysfunction
|
|
CN109206503A
(zh)
|
2017-07-07 |
2019-01-15 |
厦门大学 |
一种蛋白用于制备防治阿尔茨海默病药物的用途
|
|
WO2019016784A1
(en)
|
2017-07-21 |
2019-01-24 |
Universidade De Coimbra |
ANTI-NUCLEOLIN ANTIBODIES
|
|
CA3067509A1
(en)
|
2017-07-27 |
2019-01-31 |
Novartis Ag |
Sheddase resistant trem2 variants
|
|
AU2018310985A1
(en)
|
2017-08-03 |
2019-11-07 |
Alector Llc |
Anti-CD33 antibodies and methods of use thereof
|
|
IL270235B2
(en)
|
2017-08-03 |
2025-02-01 |
Alector Llc |
Anti-TREM2 antibodies and methods of using them
|
|
EP3664845A4
(en)
|
2017-08-08 |
2021-03-10 |
Pionyr Immunotherapeutics, Inc. |
COMPOSITIONS AND METHODS FOR DEACTIVATING MEYLOID CELLS EXPRESSING TREM1
|
|
US20200277373A1
(en)
|
2017-09-14 |
2020-09-03 |
Denali Therapeutics Inc. |
Anti-trem2 antibodies and methods of use thereof
|
|
US12276670B2
(en)
|
2017-09-29 |
2025-04-15 |
The General Hospital Corporation |
Methods for identifying and treating adrenomyeloneuropathy (AMN)
|
|
US11364303B2
(en)
|
2017-09-29 |
2022-06-21 |
Pfizer Inc. |
Cysteine engineered antibody drug conjugates
|
|
EP3692158A4
(en)
|
2017-10-03 |
2021-08-04 |
Prevail Therapeutics, Inc. |
GENE THERAPIES FOR LYSOSOMAL DISEASES
|
|
WO2019079529A1
(en)
|
2017-10-17 |
2019-04-25 |
The Translational Genomics Research Institute |
TREM2 AGONISTS FOR STIMULATING MICROGLIA AND IDENTIFICATION METHODS
|
|
US10597462B1
(en)
|
2017-11-08 |
2020-03-24 |
University Of Puerto Rico |
Anti-TLT-1 antibody and uses thereof
|
|
US11530258B2
(en)
|
2017-11-15 |
2022-12-20 |
UNIVERSITé LAVAL |
Use of SRSF3 agents for the treatment and/or prevention of neurological conditions, cancer, bacterial infections or viral infections
|
|
CN109837330A
(zh)
|
2017-11-28 |
2019-06-04 |
上海中优精准医疗科技股份有限公司 |
一种检测trem2基因多态性的探针及方法
|
|
AU2018383709B2
(en)
|
2017-12-12 |
2025-09-11 |
Pionyr Immunotherapeutics, Inc. |
Anti-TREM2 antibodies and related methods
|
|
US11470827B2
(en)
|
2017-12-12 |
2022-10-18 |
Alector Llc |
Transgenic mice expressing human TREM proteins and methods of use thereof
|
|
WO2019152715A1
(en)
|
2018-01-31 |
2019-08-08 |
Alector Llc |
Anti-ms4a4a antibodies and methods of use thereof
|
|
JP2021513969A
(ja)
|
2018-02-14 |
2021-06-03 |
イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ |
Ｔｒｅｍまたはｔｒｅｍｌタンパク質を調節するための組成物および使用方法
|
|
NL2020520B1
(en)
|
2018-03-02 |
2019-09-12 |
Labo Bio Medical Invest B V |
Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
|
|
EP3768261A1
(en)
|
2018-03-22 |
2021-01-27 |
NSC THERAPEUTICS GmbH |
Compounds and methods for use in the treatment of microglia-mediated disorders
|
|
AU2019248547B2
(en)
|
2018-04-02 |
2025-07-17 |
Bristol-Myers Squibb Company |
Anti-TREM-1 antibodies and uses thereof
|
|
KR20200143710A
(ko)
|
2018-04-09 |
2020-12-24 |
더 제너럴 하스피탈 코포레이션 |
근위축 측삭 경화증 및 관련 장애의 치료를 위한 조합 요법
|
|
BR112020023844A2
(pt)
|
2018-05-25 |
2021-04-13 |
Alector Llc |
Anticorpos, métodos de tratamento do câncer e de produção de um anticorpo, ácido nucleico, vetor, células hospedeiras e composição farmacêutica
|
|
AU2019282778A1
(en)
|
2018-06-08 |
2020-12-10 |
Alector Llc |
Anti-Siglec-7 antibodies and methods of use thereof
|
|
CN108752482B
(zh)
|
2018-06-12 |
2019-04-30 |
南京卡提医学科技有限公司 |
携带截短或未截短的髓样细胞触发性受体信号结构的嵌合抗原受体及其应用
|
|
EP3809838A4
(en)
|
2018-06-21 |
2022-03-23 |
The Jackson Laboratory |
GENETICALLY MODIFIED MOUSE MODELS OF ALZHEIMER'S DISEASE
|
|
WO2020006374A2
(en)
|
2018-06-29 |
2020-01-02 |
Alector Llc |
Anti-sirp-beta1 antibodies and methods of use thereof
|
|
KR102767594B1
(ko)
|
2018-07-12 |
2025-02-12 |
코버스 파마슈티칼스, 인크. |
아데노신 경로 활성화를 갖는 암의 검출 및 치료 방법
|
|
US11278575B2
(en)
|
2018-07-12 |
2022-03-22 |
Duke University |
Compositions and methods for the treatment of demyelinating conditions
|
|
US12352767B2
(en)
|
2018-07-16 |
2025-07-08 |
University Of Virginia Patent Foundation |
Method of treating cognitive decline associated with neurological diseases based on a decrease in FLT4 expression or activity
|
|
CN109112214A
(zh)
|
2018-07-27 |
2019-01-01 |
复旦大学附属中山医院 |
模式识别受体trem2在肝癌预后和治疗中的应用
|
|
EP3830123A1
(en)
|
2018-07-27 |
2021-06-09 |
Alector LLC |
Anti-siglec-5 antibodies and methods of use thereof
|
|
BR112021003016A2
(pt)
|
2018-08-31 |
2021-05-18 |
Alector Llc |
anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir um anticorpo e para prevenir, reduzir o risco ou tratar uma doença e composição farmacêutica
|
|
AU2019336698A1
(en)
|
2018-09-05 |
2021-03-25 |
Aztherapies, Inc. |
Methods of treating cytokine release syndrome
|
|
BR112021004316A2
(pt)
|
2018-09-11 |
2021-11-03 |
Washington University St Louis |
Anticorpos de agonistas anti-trem-2
|
|
WO2020056114A1
(en)
|
2018-09-12 |
2020-03-19 |
Board Of Regents Of The University Of Nebraska |
Antimicrobial compositions and methods
|
|
CN113164546A
(zh)
|
2018-09-28 |
2021-07-23 |
伊诺特伦公司 |
可溶的trem-1水平用于鉴定对抗炎疗法应答敏感的受试者的用途
|
|
KR102096282B1
(ko)
|
2018-10-15 |
2020-04-02 |
재단법인대구경북과학기술원 |
재조합 베큘로바이러스를 이용한 인간 ｔｒｅｍ２ 세포막 단백질의 효율적인 정제방법
|
|
UY38407A
(es)
|
2018-10-15 |
2020-05-29 |
Novartis Ag |
Anticuerpos estabilizadores de trem2
|
|
KR102156165B1
(ko)
|
2018-10-29 |
2020-09-15 |
재단법인대구경북과학기술원 |
인간 ｔｒｅｍ２ 세포막 단백질에 대한 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도
|
|
CN111135185A
(zh)
|
2018-11-02 |
2020-05-12 |
杭州星鳌生物科技有限公司 |
天然免疫激活通过调控髓系细胞触发受体trem2抑制大脑神经慢性炎症
|
|
EP3876956A4
(en)
|
2018-11-08 |
2022-12-28 |
The Regents of The University of California |
SYSTEMS AND METHODS FOR TARGETING CANCER CELLS
|
|
EP3887401A2
(en)
|
2018-11-26 |
2021-10-06 |
Denali Therapeutics Inc. |
Methods for treating dysregulated lipid metabolism
|
|
CA3122725A1
(en)
|
2018-12-10 |
2020-06-18 |
Mor Research Applications |
Trem2 antibodies and uses thereof
|
|
WO2020132230A2
(en)
|
2018-12-20 |
2020-06-25 |
Genentech, Inc. |
Modified antibody fcs and methods of use
|
|
US20220089768A1
(en)
|
2019-01-04 |
2022-03-24 |
Trio Pharmaceuticals, Inc. |
Multi-specific protein molecules and uses thereof
|
|
CN109646668B
(zh)
|
2019-01-04 |
2019-10-18 |
厦门大学 |
一种多肽用于制备防治阿尔茨海默病药物的用途
|
|
US20220119532A1
(en)
|
2019-01-14 |
2022-04-21 |
University Of Virginia Patent Foundation |
Use of integrin inhibitors for treatment or prevention of a neurological immunity disorder and/or nervous system injury
|
|
US20220104468A1
(en)
|
2019-01-22 |
2022-04-07 |
St. Jude Children's Research Hospital |
Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
|
|
WO2020154348A1
(en)
|
2019-01-23 |
2020-07-30 |
The Regents Of The University Of California |
Human genomic construct reporter cells and mouse models to screen therapeutics against microglia-expressed disease associated genes
|
|
CA3127808A1
(en)
|
2019-02-01 |
2020-08-06 |
Avrobio, Inc. |
Compositions and methods for treating neurocognitive disorders
|
|
US20220125951A1
(en)
|
2019-02-01 |
2022-04-28 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Microenvironment sensors to regulate engineered gene expression
|
|
CA3127804A1
(en)
|
2019-02-01 |
2020-08-06 |
Avrobio, Inc. |
Compositions and methods for treating neurocognitive disorders
|
|
MX2021009722A
(es)
|
2019-02-20 |
2021-09-14 |
Denali Therapeutics Inc |
Anticuerpos anti-trem2 y metodos para utilizarlos.
|
|
WO2020194317A1
(en)
|
2019-03-28 |
2020-10-01 |
Yeda Research And Development Co. Ltd. |
Method of treating lipid-related disorders
|
|
CN110320368A
(zh)
|
2019-05-30 |
2019-10-11 |
广州医科大学附属第一医院（广州呼吸中心） |
基于trem2的诊断试剂盒及其在帕金森病诊断产品上的应用
|
|
CN110241208A
(zh)
|
2019-08-02 |
2019-09-17 |
辽宁中医药大学 |
Trem2作为早期诊断冠心病的分子标志物的应用
|
|
CN110511240B
(zh)
|
2019-08-27 |
2022-03-08 |
南京医科大学 |
一种髓细胞触发受体2的内源性配体及其应用
|
|
CN110882262A
(zh)
|
2019-11-06 |
2020-03-17 |
南京医科大学 |
一种髓细胞触发受体2的激活用药及其应用
|
|
CA3159055A1
(en)
|
2019-11-22 |
2021-05-27 |
Forest Hoyt ANDREWS |
Trem2 antibodies and uses thereof
|
|
WO2021113655A1
(en)
|
2019-12-05 |
2021-06-10 |
Alector Llc |
Methods of use of anti-trem2 antibodies
|
|
CN111184742B
(zh)
|
2020-02-13 |
2022-06-24 |
中山大学附属第五医院 |
Trem-2+t细胞在制备用于治疗结核病药物中的应用
|