JP2012513214A5 - - Google Patents
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- JP2012513214A5 JP2012513214A5 JP2011543606A JP2011543606A JP2012513214A5 JP 2012513214 A5 JP2012513214 A5 JP 2012513214A5 JP 2011543606 A JP2011543606 A JP 2011543606A JP 2011543606 A JP2011543606 A JP 2011543606A JP 2012513214 A5 JP2012513214 A5 JP 2012513214A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- binding protein
- antigen binding
- group
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000025171 antigen binding proteins Human genes 0.000 claims description 93
- 108091000831 antigen binding proteins Proteins 0.000 claims description 93
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 22
- DNKYDHSONDSTNJ-XJVRLEFXSA-N chembl1910953 Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CN=CN1 DNKYDHSONDSTNJ-XJVRLEFXSA-N 0.000 claims description 16
- 238000012217 deletion Methods 0.000 claims description 16
- 230000037430 deletion Effects 0.000 claims description 16
- 238000003780 insertion Methods 0.000 claims description 16
- 230000037431 insertion Effects 0.000 claims description 16
- 102000040430 polynucleotide Human genes 0.000 claims description 16
- 108091033319 polynucleotide Proteins 0.000 claims description 16
- 238000006467 substitution reaction Methods 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 claims description 11
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 claims description 11
- 239000012634 fragment Substances 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims description 7
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims description 7
- 102100024654 Calcitonin gene-related peptide type 1 receptor Human genes 0.000 claims description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 4
- 101000760563 Homo sapiens Calcitonin gene-related peptide type 1 receptor Proteins 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 206010019233 Headaches Diseases 0.000 claims description 2
- 101000584583 Homo sapiens Receptor activity-modifying protein 1 Proteins 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 102100030697 Receptor activity-modifying protein 1 Human genes 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 2
- 231100000869 headache Toxicity 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 238000000159 protein binding assay Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102100033770 Alpha-amylase 1C Human genes 0.000 claims 1
- 101000779871 Homo sapiens Alpha-amylase 1A Proteins 0.000 claims 1
- 101000779870 Homo sapiens Alpha-amylase 1B Proteins 0.000 claims 1
- 101000779869 Homo sapiens Alpha-amylase 1C Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20356908P | 2008-12-23 | 2008-12-23 | |
| US61/203,569 | 2008-12-23 | ||
| US26462209P | 2009-11-25 | 2009-11-25 | |
| US61/264,622 | 2009-11-25 | ||
| PCT/US2009/068858 WO2010075238A1 (en) | 2008-12-23 | 2009-12-18 | Human cgrp receptor binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014164088A Division JP6261132B2 (ja) | 2008-12-23 | 2014-08-12 | ヒトｃｇｒｐ受容体結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012513214A JP2012513214A (ja) | 2012-06-14 |
| JP2012513214A5 true JP2012513214A5 (enExample) | 2013-02-07 |
| JP5761805B2 JP5761805B2 (ja) | 2015-08-12 |
Family
ID=41718325
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011543606A Active JP5761805B2 (ja) | 2008-12-23 | 2009-12-18 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2014164088A Active JP6261132B2 (ja) | 2008-12-23 | 2014-08-12 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2015219157A Withdrawn JP2016026224A (ja) | 2008-12-23 | 2015-11-09 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2018246704A Withdrawn JP2019062907A (ja) | 2008-12-23 | 2018-12-28 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2020196689A Withdrawn JP2021036912A (ja) | 2008-12-23 | 2020-11-27 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2023101810A Active JP7584577B2 (ja) | 2008-12-23 | 2023-06-21 | ヒトｃｇｒｐ受容体結合タンパク質 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014164088A Active JP6261132B2 (ja) | 2008-12-23 | 2014-08-12 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2015219157A Withdrawn JP2016026224A (ja) | 2008-12-23 | 2015-11-09 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2018246704A Withdrawn JP2019062907A (ja) | 2008-12-23 | 2018-12-28 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2020196689A Withdrawn JP2021036912A (ja) | 2008-12-23 | 2020-11-27 | ヒトｃｇｒｐ受容体結合タンパク質 |
| JP2023101810A Active JP7584577B2 (ja) | 2008-12-23 | 2023-06-21 | ヒトｃｇｒｐ受容体結合タンパク質 |
Country Status (42)
Families Citing this family (119)
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| RU2535074C2 (ru) | 2009-08-28 | 2014-12-10 | Лэйбрис Байолоджикс, Инк. | Способы лечения висцеральной боли путем введения антител-антагонистов, направленных против пептида, связанного с геном кальцитонина |
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| EP3508501B1 (en) * | 2011-05-20 | 2024-11-06 | H. Lundbeck A/S | Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
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- 2015-06-26 US US14/752,493 patent/US9862771B2/en active Active
- 2015-11-09 JP JP2015219157A patent/JP2016026224A/ja not_active Withdrawn
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2016
- 2016-01-26 IL IL243784A patent/IL243784A/en active IP Right Grant
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2017
- 2017-08-28 CY CY20171100901T patent/CY1119465T1/el unknown
- 2017-11-28 US US15/824,827 patent/US20180142029A1/en not_active Abandoned
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2018
- 2018-12-04 CY CY2018032C patent/CY2018032I1/el unknown
- 2018-12-10 HU HUS1800047C patent/HUS1800047I1/hu unknown
- 2018-12-12 NL NL300961C patent/NL300961I2/nl unknown
- 2018-12-14 LT LTPA2018017C patent/LTC2379594I2/lt unknown
- 2018-12-17 NO NO2018042C patent/NO2018042I1/no unknown
- 2018-12-20 LU LU00095C patent/LUC00095I2/fr unknown
- 2018-12-28 JP JP2018246704A patent/JP2019062907A/ja not_active Withdrawn
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2019
- 2019-02-07 JO JOP/2019/0017A patent/JOP20190017B1/ar active
- 2019-07-25 HR HRP20191341TT patent/HRP20191341T8/hr unknown
- 2019-09-19 CY CY20191100989T patent/CY1122658T1/el unknown
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2020
- 2020-11-27 JP JP2020196689A patent/JP2021036912A/ja not_active Withdrawn
- 2020-12-03 US US17/111,442 patent/US12122841B2/en active Active
- 2020-12-03 US US17/111,453 patent/US12134652B2/en active Active
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2023
- 2023-06-21 JP JP2023101810A patent/JP7584577B2/ja active Active
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2024
- 2024-10-02 US US18/904,787 patent/US20250129172A1/en active Pending
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