JP2017514461A5 - - Google Patents
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- JP2017514461A5 JP2017514461A5 JP2016559908A JP2016559908A JP2017514461A5 JP 2017514461 A5 JP2017514461 A5 JP 2017514461A5 JP 2016559908 A JP2016559908 A JP 2016559908A JP 2016559908 A JP2016559908 A JP 2016559908A JP 2017514461 A5 JP2017514461 A5 JP 2017514461A5
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- Prior art keywords
- antibody
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- cancer
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000005557 antagonist Substances 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 5
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 5
- 239000000872 buffer Substances 0.000 claims 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 5
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 102000050320 human TNFRSF4 Human genes 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 229950008882 polysorbate Drugs 0.000 claims 2
- 229920000136 polysorbate Polymers 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 239000008351 acetate buffer Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461973193P | 2014-03-31 | 2014-03-31 | |
| US61/973,193 | 2014-03-31 | ||
| US201461989448P | 2014-05-06 | 2014-05-06 | |
| US61/989,448 | 2014-05-06 | ||
| US201462073873P | 2014-10-31 | 2014-10-31 | |
| US62/073,873 | 2014-10-31 | ||
| US201462080171P | 2014-11-14 | 2014-11-14 | |
| US62/080,171 | 2014-11-14 | ||
| PCT/US2015/023432 WO2015153513A1 (en) | 2014-03-31 | 2015-03-30 | Anti-ox40 antibodies and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230794A Division JP2020072678A (ja) | 2014-03-31 | 2019-12-20 | 抗ｏｘ４０抗体及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514461A JP2017514461A (ja) | 2017-06-08 |
| JP2017514461A5 true JP2017514461A5 (enExample) | 2018-05-24 |
| JP6637439B2 JP6637439B2 (ja) | 2020-01-29 |
Family
ID=52829446
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016559908A Active JP6637439B2 (ja) | 2014-03-31 | 2015-03-30 | 抗ｏｘ４０抗体及び使用方法 |
| JP2019230794A Pending JP2020072678A (ja) | 2014-03-31 | 2019-12-20 | 抗ｏｘ４０抗体及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230794A Pending JP2020072678A (ja) | 2014-03-31 | 2019-12-20 | 抗ｏｘ４０抗体及び使用方法 |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP3126394B1 (enExample) |
| JP (2) | JP6637439B2 (enExample) |
| KR (1) | KR20160145624A (enExample) |
| CN (1) | CN106103486B (enExample) |
| AU (1) | AU2015241037B2 (enExample) |
| BR (1) | BR112016022658A2 (enExample) |
| CA (1) | CA2943262A1 (enExample) |
| CL (1) | CL2016002462A1 (enExample) |
| CR (1) | CR20160500A (enExample) |
| DK (1) | DK3126394T3 (enExample) |
| EA (1) | EA201691974A1 (enExample) |
| ES (1) | ES2763898T3 (enExample) |
| HR (1) | HRP20192285T1 (enExample) |
| HU (1) | HUE046767T2 (enExample) |
| IL (1) | IL247898A0 (enExample) |
| LT (1) | LT3126394T (enExample) |
| MA (2) | MA51552A (enExample) |
| MX (1) | MX2016012781A (enExample) |
| PE (2) | PE20161571A1 (enExample) |
| PH (1) | PH12016501894B1 (enExample) |
| PL (1) | PL3126394T3 (enExample) |
| PT (1) | PT3126394T (enExample) |
| RS (1) | RS59738B1 (enExample) |
| SG (1) | SG11201607969XA (enExample) |
| SI (1) | SI3126394T1 (enExample) |
| TW (1) | TWI680985B (enExample) |
| UA (1) | UA121112C2 (enExample) |
| WO (1) | WO2015153513A1 (enExample) |
| ZA (1) | ZA201606630B (enExample) |
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| AU2003270439B2 (en) | 2002-09-11 | 2009-09-24 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
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