JP2011518546A5 - - Google Patents
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- Publication number
- JP2011518546A5 JP2011518546A5 JP2011502087A JP2011502087A JP2011518546A5 JP 2011518546 A5 JP2011518546 A5 JP 2011518546A5 JP 2011502087 A JP2011502087 A JP 2011502087A JP 2011502087 A JP2011502087 A JP 2011502087A JP 2011518546 A5 JP2011518546 A5 JP 2011518546A5
- Authority
- JP
- Japan
- Prior art keywords
- vegf
- pdgfr
- bispecific antibody
- residues
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 12
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 12
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 12
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 4
- 230000002491 angiogenic effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 2
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 206010065630 Iris neovascularisation Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 claims 1
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000003142 neovascular glaucoma Diseases 0.000 claims 1
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000006785 proliferative vitreoretinopathy Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4006808P | 2008-03-27 | 2008-03-27 | |
| US61/040,068 | 2008-03-27 | ||
| US14454709P | 2009-01-14 | 2009-01-14 | |
| US61/144,547 | 2009-01-14 | ||
| PCT/US2009/038495 WO2009120922A2 (en) | 2008-03-27 | 2009-03-27 | Compositions and methods for inhibiting pdgfrbeta and vegf-a |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013244129A Division JP5855627B2 (ja) | 2008-03-27 | 2013-11-26 | PDGFRβおよびVEGF−Aを阻害するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518546A JP2011518546A (ja) | 2011-06-30 |
| JP2011518546A5 true JP2011518546A5 (enExample) | 2012-11-01 |
| JP5425180B2 JP5425180B2 (ja) | 2014-02-26 |
Family
ID=40793092
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502087A Expired - Fee Related JP5425180B2 (ja) | 2008-03-27 | 2009-03-27 | PDGFRβおよびVEGF−Aを阻害するための組成物および方法 |
| JP2013244129A Expired - Fee Related JP5855627B2 (ja) | 2008-03-27 | 2013-11-26 | PDGFRβおよびVEGF−Aを阻害するための組成物および方法 |
| JP2015240210A Expired - Fee Related JP6140796B2 (ja) | 2008-03-27 | 2015-12-09 | PDGFRβおよびVEGF−Aを阻害するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013244129A Expired - Fee Related JP5855627B2 (ja) | 2008-03-27 | 2013-11-26 | PDGFRβおよびVEGF−Aを阻害するための組成物および方法 |
| JP2015240210A Expired - Fee Related JP6140796B2 (ja) | 2008-03-27 | 2015-12-09 | PDGFRβおよびVEGF−Aを阻害するための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9441034B2 (enExample) |
| EP (3) | EP2274008B1 (enExample) |
| JP (3) | JP5425180B2 (enExample) |
| AU (3) | AU2009228158B2 (enExample) |
| CA (1) | CA2716882A1 (enExample) |
| CY (1) | CY1115382T1 (enExample) |
| DK (1) | DK2274008T3 (enExample) |
| ES (1) | ES2456296T3 (enExample) |
| HR (1) | HRP20140244T1 (enExample) |
| IL (3) | IL207618A (enExample) |
| PL (1) | PL2274008T3 (enExample) |
| PT (1) | PT2274008E (enExample) |
| SI (1) | SI2274008T1 (enExample) |
| WO (1) | WO2009120922A2 (enExample) |
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| BR112013001433A2 (pt) | 2010-07-19 | 2016-05-31 | Hoffmann La Roche | método de identificação de pacientes com maior probabilidade de responder a terapia anticâncer |
| CN103109189A (zh) | 2010-07-19 | 2013-05-15 | 霍夫曼-拉罗奇有限公司 | 鉴定响应抗癌疗法的可能性升高的患者的方法 |
| PT3434767T (pt) * | 2010-11-30 | 2026-01-23 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de citotoxicidade |
| US9499608B2 (en) | 2011-06-08 | 2016-11-22 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Bispecific monoclonal antibody therapeutics against West Nile virus with improved CNS penetration |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| EP2787078B1 (en) | 2011-10-31 | 2019-05-22 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
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| US10543261B2 (en) | 2012-08-31 | 2020-01-28 | Osaka University | DNA vaccine containing VEGF-specific epitope and/or angiopoietin-2-specific epitope |
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