JP2018503380A5 - - Google Patents
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- JP2018503380A5 JP2018503380A5 JP2017537510A JP2017537510A JP2018503380A5 JP 2018503380 A5 JP2018503380 A5 JP 2018503380A5 JP 2017537510 A JP2017537510 A JP 2017537510A JP 2017537510 A JP2017537510 A JP 2017537510A JP 2018503380 A5 JP2018503380 A5 JP 2018503380A5
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- 150000001413 amino acids Chemical group 0.000 claims 70
- 239000012634 fragment Substances 0.000 claims 47
- 239000000427 antigen Substances 0.000 claims 34
- 102000036639 antigens Human genes 0.000 claims 34
- 108091007433 antigens Proteins 0.000 claims 34
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 10
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 7
- 102000049583 human ROR1 Human genes 0.000 claims 7
- 230000004068 intracellular signaling Effects 0.000 claims 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 4
- 102000016978 Orphan receptors Human genes 0.000 claims 4
- 108070000031 Orphan receptors Proteins 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 101100038118 Mus musculus Ror1 gene Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 208000004736 B-Cell Leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562104664P | 2015-01-16 | 2015-01-16 | |
| US62/104,664 | 2015-01-16 | ||
| PCT/US2016/013808 WO2016115559A1 (en) | 2015-01-16 | 2016-01-18 | Antibodies and chimeric antigen receptors specific for ror1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021004675A Division JP2021061857A (ja) | 2015-01-16 | 2021-01-15 | Ｒｏｒ１に特異的な抗体およびキメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503380A JP2018503380A (ja) | 2018-02-08 |
| JP2018503380A5 true JP2018503380A5 (enExample) | 2019-02-28 |
| JP6865688B2 JP6865688B2 (ja) | 2021-04-28 |
Family
ID=55272713
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017537510A Active JP6865688B2 (ja) | 2015-01-16 | 2016-01-18 | Ｒｏｒ１に特異的な抗体およびキメラ抗原受容体 |
| JP2021004675A Pending JP2021061857A (ja) | 2015-01-16 | 2021-01-15 | Ｒｏｒ１に特異的な抗体およびキメラ抗原受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021004675A Pending JP2021061857A (ja) | 2015-01-16 | 2021-01-15 | Ｒｏｒ１に特異的な抗体およびキメラ抗原受容体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20160208018A1 (enExample) |
| EP (2) | EP3245231B1 (enExample) |
| JP (2) | JP6865688B2 (enExample) |
| KR (1) | KR20170128234A (enExample) |
| CN (1) | CN107428833B (enExample) |
| AR (1) | AR103442A1 (enExample) |
| AU (1) | AU2016206457B2 (enExample) |
| CA (1) | CA2973964A1 (enExample) |
| ES (1) | ES2818103T3 (enExample) |
| MX (2) | MX2017009254A (enExample) |
| NZ (1) | NZ733841A (enExample) |
| TW (2) | TW202126682A (enExample) |
| WO (1) | WO2016115559A1 (enExample) |
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| SI3380124T1 (sl) | 2015-11-25 | 2024-10-30 | Legochem Biosciences, Inc. | Konjugati, ki obsegajo samožrtvujoče skupine in z njimi povezani postopki |
| US11167040B2 (en) | 2015-11-25 | 2021-11-09 | Legochem Biosciences, Inc. | Conjugates comprising peptide groups and methods related thereto |
| CN113599533A (zh) | 2015-11-25 | 2021-11-05 | 乐高化学生物科学股份有限公司 | 包含分支接头的抗体-药物缀合物及其相关方法 |
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| US11149073B2 (en) | 2017-04-28 | 2021-10-19 | Julius-Maximilians-Universität Würzburg | ROR1-specific chimeric antigen receptors (CAR) with humanized targeting domains |
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| JP7654240B2 (ja) | 2017-09-19 | 2025-04-01 | マサチューセッツ インスティテュート オブ テクノロジー | キメラ抗原受容体ｔ細胞治療のための組成物およびその使用 |
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-
2016
- 2016-01-18 AR ARP160100120A patent/AR103442A1/es unknown
- 2016-01-18 US US14/997,991 patent/US20160208018A1/en not_active Abandoned
- 2016-01-18 TW TW109132171A patent/TW202126682A/zh unknown
- 2016-01-18 WO PCT/US2016/013808 patent/WO2016115559A1/en not_active Ceased
- 2016-01-18 JP JP2017537510A patent/JP6865688B2/ja active Active
- 2016-01-18 KR KR1020177022796A patent/KR20170128234A/ko not_active Abandoned
- 2016-01-18 AU AU2016206457A patent/AU2016206457B2/en not_active Ceased
- 2016-01-18 EP EP16702306.8A patent/EP3245231B1/en active Active
- 2016-01-18 MX MX2017009254A patent/MX2017009254A/es unknown
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- 2016-01-18 TW TW105101422A patent/TWI718118B/zh not_active IP Right Cessation
- 2016-01-18 EP EP20178573.0A patent/EP3760644A1/en not_active Withdrawn
- 2016-01-18 CN CN201680016204.1A patent/CN107428833B/zh not_active Expired - Fee Related
- 2016-01-18 CA CA2973964A patent/CA2973964A1/en active Pending
- 2016-01-18 NZ NZ733841A patent/NZ733841A/en unknown
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2017
- 2017-07-13 MX MX2021009151A patent/MX2021009151A/es unknown
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2018
- 2018-06-04 US US15/997,635 patent/US10889652B2/en active Active
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2020
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