JP2016536020A5 - - Google Patents

Info

Publication number

JP2016536020A5

JP2016536020A5 JP2016552471A JP2016552471A JP2016536020A5 JP 2016536020 A5 JP2016536020 A5 JP 2016536020A5 JP 2016552471 A JP2016552471 A JP 2016552471A JP 2016552471 A JP2016552471 A JP 2016552471A JP 2016536020 A5 JP2016536020 A5 JP 2016536020A5

Authority

JP

Japan

Prior art keywords

seq

set forth

variable region

chain variable

region set

Prior art date

2014-11-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000611 antibody drug conjugate Substances 0.000 claims 24
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 24
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 15
• 206010028980 Neoplasm Diseases 0.000 claims 15
• 201000011510 cancer Diseases 0.000 claims 14
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 206010033128 Ovarian cancer Diseases 0.000 claims 6
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 6
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 6
• 206010014733 Endometrial cancer Diseases 0.000 claims 4
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 239000002254 cytotoxic agent Substances 0.000 claims 4
• 231100000599 cytotoxic agent Toxicity 0.000 claims 4
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical group C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 4
• 102100038449 Claudin-6 Human genes 0.000 claims 3
• 101000882898 Homo sapiens Claudin-6 Proteins 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 102000002029 Claudin Human genes 0.000 claims 2
• 108050009302 Claudin Proteins 0.000 claims 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 108010044540 auristatin Proteins 0.000 claims 2
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
• 229930195731 calicheamicin Natural products 0.000 claims 2
• 210000004907 gland Anatomy 0.000 claims 2
• 210000004072 lung Anatomy 0.000 claims 2
• 201000005202 lung cancer Diseases 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 201000002528 pancreatic cancer Diseases 0.000 claims 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
• 229910052697 platinum Inorganic materials 0.000 claims 2
• 208000016691 refractory malignant neoplasm Diseases 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
• 102100026097 Claudin-9 Human genes 0.000 claims 1
• 101000912661 Homo sapiens Claudin-9 Proteins 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 239000000562 conjugate Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 210000000130 stem cell Anatomy 0.000 claims 1
• 210000005102 tumor initiating cell Anatomy 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 description 3
• 239000013598 vector Substances 0.000 description 2
• 239000013604 expression vector Substances 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 150000007523 nucleic acids Chemical class 0.000 description 1
• 102000039446 nucleic acids Human genes 0.000 description 1
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• 230000010474 transient expression Effects 0.000 description 1