JP2016505546A5 - - Google Patents

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Publication number
JP2016505546A5
JP2016505546A5 JP2015545453A JP2015545453A JP2016505546A5 JP 2016505546 A5 JP2016505546 A5 JP 2016505546A5 JP 2015545453 A JP2015545453 A JP 2015545453A JP 2015545453 A JP2015545453 A JP 2015545453A JP 2016505546 A5 JP2016505546 A5 JP 2016505546A5
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JP
Japan
Prior art keywords
kabat
cdr
vegf
seq
variant
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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JP2015545453A
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English (en)
Japanese (ja)
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JP2016505546A (ja
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Priority claimed from PCT/US2013/072335 external-priority patent/WO2014085654A1/en
Publication of JP2016505546A publication Critical patent/JP2016505546A/ja
Publication of JP2016505546A5 publication Critical patent/JP2016505546A5/ja
Ceased legal-status Critical Current

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JP2015545453A 2012-11-30 2013-11-27 抗vegf抗体及びこれらの使用 Ceased JP2016505546A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261732256P 2012-11-30 2012-11-30
US61/732,256 2012-11-30
PCT/US2013/072335 WO2014085654A1 (en) 2012-11-30 2013-11-27 Anti-vegf antibodies and their uses

Publications (2)

Publication Number Publication Date
JP2016505546A JP2016505546A (ja) 2016-02-25
JP2016505546A5 true JP2016505546A5 (enExample) 2017-01-12

Family

ID=49765713

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Application Number Title Priority Date Filing Date
JP2015545453A Ceased JP2016505546A (ja) 2012-11-30 2013-11-27 抗vegf抗体及びこれらの使用

Country Status (11)

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US (2) US20140154255A1 (enExample)
EP (1) EP2925778B1 (enExample)
JP (1) JP2016505546A (enExample)
CN (1) CN104903348A (enExample)
AU (1) AU2013352127A1 (enExample)
BR (1) BR112015012538A2 (enExample)
CA (1) CA2892164A1 (enExample)
ES (1) ES2649966T3 (enExample)
HK (1) HK1215446A1 (enExample)
MX (1) MX2015006859A (enExample)
WO (1) WO2014085654A1 (enExample)

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US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CA2957717C (en) * 2014-08-12 2021-10-19 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein
EP3353204B1 (en) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer
CN108137681B (zh) 2015-09-23 2024-06-18 豪夫迈·罗氏有限公司 抗-vegf抗体的优化的变体
BR112018013407A2 (en) 2015-12-30 2018-12-18 Kodiak Sciences Inc. antibodies and conjugates thereof
KR102293753B1 (ko) * 2016-01-06 2021-08-24 오더-메이드 메디컬 리서치 인코포레이티드 Vegf 와 nrp1 의 결합을 저해하는 항체
IL322403A (en) * 2016-04-15 2025-09-01 Univ Pennsylvania Preparations for the treatment of wet age-related macular degeneration
AU2017324983B2 (en) * 2016-09-07 2025-03-20 Saksin Lifesciences Pvt Ltd Synthetic antibodies against VEGF and their uses
KR102697394B1 (ko) 2017-02-28 2024-08-20 씨젠 인크. 컨쥬게이션을 위한 시스테인 변이된 항체
WO2018213064A1 (en) 2017-05-19 2018-11-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibody targeting tnfer2 for cancer immunotherapy
CN110003328B (zh) * 2018-01-05 2022-04-19 百奥泰生物制药股份有限公司 一种长效低毒的重组抗vegf人源化单克隆抗体及其生产方法
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CN109053895B (zh) 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
CN111363038A (zh) * 2020-03-26 2020-07-03 北京纽安博生物技术有限公司 抗VEGF单域抗体及其人源化、单域抗体和IgG1-Fc构建的融合蛋白和应用
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US20250367255A1 (en) 2021-11-08 2025-12-04 Pfizer Inc. Enhancement Of CD47 Blockade Therapy With Anti-VEGF Agents

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