JP2018108081A5 - - Google Patents
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- JP2018108081A5 JP2018108081A5 JP2018018375A JP2018018375A JP2018108081A5 JP 2018108081 A5 JP2018108081 A5 JP 2018108081A5 JP 2018018375 A JP2018018375 A JP 2018018375A JP 2018018375 A JP2018018375 A JP 2018018375A JP 2018108081 A5 JP2018108081 A5 JP 2018108081A5
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- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims description 7
- 102000058223 human VEGFA Human genes 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims 25
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 108091081024 Start codon Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000008728 vascular permeability Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 238000002649 immunization Methods 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 230000010799 Receptor Interactions Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019090735A JP6978468B2 (ja) | 2008-06-25 | 2019-05-13 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2021184262A JP7171877B6 (ja) | 2008-06-25 | 2021-11-11 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7569208P | 2008-06-25 | 2008-06-25 | |
| US7569708P | 2008-06-25 | 2008-06-25 | |
| US13321208P | 2008-06-25 | 2008-06-25 | |
| US61/133,212 | 2008-06-25 | ||
| US61/075,697 | 2008-06-25 | ||
| US61/075,692 | 2008-06-25 | ||
| US15504109P | 2009-02-24 | 2009-02-24 | |
| US61/155,041 | 2009-02-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016255720A Division JP6527128B2 (ja) | 2008-06-25 | 2016-12-28 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019090735A Division JP6978468B2 (ja) | 2008-06-25 | 2019-05-13 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018108081A JP2018108081A (ja) | 2018-07-12 |
| JP2018108081A5 true JP2018108081A5 (enExample) | 2019-06-20 |
| JP6821612B2 JP6821612B2 (ja) | 2021-01-27 |
Family
ID=41209803
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515049A Active JP5956752B2 (ja) | 2008-06-25 | 2009-06-25 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2014087194A Active JP6100199B2 (ja) | 2008-06-25 | 2014-04-21 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2015037794A Pending JP2015134792A (ja) | 2008-06-25 | 2015-02-27 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2016255720A Active JP6527128B2 (ja) | 2008-06-25 | 2016-12-28 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2018018375A Active JP6821612B2 (ja) | 2008-06-25 | 2018-02-05 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2019090735A Active JP6978468B2 (ja) | 2008-06-25 | 2019-05-13 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2021184262A Active JP7171877B6 (ja) | 2008-06-25 | 2021-11-11 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515049A Active JP5956752B2 (ja) | 2008-06-25 | 2009-06-25 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2014087194A Active JP6100199B2 (ja) | 2008-06-25 | 2014-04-21 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2015037794A Pending JP2015134792A (ja) | 2008-06-25 | 2015-02-27 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2016255720A Active JP6527128B2 (ja) | 2008-06-25 | 2016-12-28 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019090735A Active JP6978468B2 (ja) | 2008-06-25 | 2019-05-13 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2021184262A Active JP7171877B6 (ja) | 2008-06-25 | 2021-11-11 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US8349322B2 (enExample) |
| EP (3) | EP2307454B1 (enExample) |
| JP (7) | JP5956752B2 (enExample) |
| KR (8) | KR102095257B1 (enExample) |
| CN (3) | CN104961828B (enExample) |
| AU (1) | AU2009264565C1 (enExample) |
| BR (1) | BRPI0914251B1 (enExample) |
| CA (2) | CA2727839C (enExample) |
| CL (1) | CL2010001544A1 (enExample) |
| CY (3) | CY1118829T1 (enExample) |
| DK (3) | DK3216803T3 (enExample) |
| ES (3) | ES2998307T3 (enExample) |
| FI (1) | FI3722310T3 (enExample) |
| HR (3) | HRP20170615T1 (enExample) |
| HU (4) | HUE032894T2 (enExample) |
| LT (4) | LT2307454T (enExample) |
| MX (3) | MX347972B (enExample) |
| NL (1) | NL301058I2 (enExample) |
| NO (1) | NO2020021I1 (enExample) |
| PH (1) | PH12015501593A1 (enExample) |
| PL (3) | PL2307454T3 (enExample) |
| PT (3) | PT3216803T (enExample) |
| RU (6) | RU2531523C3 (enExample) |
| SI (3) | SI3216803T1 (enExample) |
| WO (1) | WO2009155724A2 (enExample) |
| ZA (1) | ZA201008594B (enExample) |
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| CN104004094B (zh) | 2008-06-25 | 2017-09-22 | 艾斯巴技术-诺华有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
| MX344076B (es) | 2008-06-30 | 2016-12-05 | Esbatech Alcon Biomed Res Unit | Polipeptidos funcionalizados. |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| CA2744103C (en) | 2009-02-24 | 2018-01-02 | Esbatech, An Alcon Biomedical Research Unit Llc | Methods for identifying immunobinders of cell-surface antigens |
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