NL301058I2 - Brolucizumab - Google Patents

Brolucizumab Download PDF

Info

Publication number
NL301058I2
NL301058I2 NL301058C NL301058C NL301058I2 NL 301058 I2 NL301058 I2 NL 301058I2 NL 301058 C NL301058 C NL 301058C NL 301058 C NL301058 C NL 301058C NL 301058 I2 NL301058 I2 NL 301058I2
Authority
NL
Netherlands
Prior art keywords
brolucizumab
Prior art date
Application number
NL301058C
Other languages
English (en)
Other versions
NL301058I1 (nl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NL301058I1 publication Critical patent/NL301058I1/nl
Publication of NL301058I2 publication Critical patent/NL301058I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
NL301058C 2008-06-25 2020-07-28 Brolucizumab NL301058I2 (nl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US13321208P 2008-06-25 2008-06-25
US15504109P 2009-02-24 2009-02-24
PCT/CH2009/000220 WO2009155724A2 (en) 2008-06-25 2009-06-25 Stable and soluble antibodies inhibiting vegf

Publications (2)

Publication Number Publication Date
NL301058I1 NL301058I1 (nl) 2020-07-31
NL301058I2 true NL301058I2 (nl) 2020-10-27

Family

ID=41209803

Family Applications (1)

Application Number Title Priority Date Filing Date
NL301058C NL301058I2 (nl) 2008-06-25 2020-07-28 Brolucizumab

Country Status (26)

Country Link
US (6) US8349322B2 (nl)
EP (3) EP3722310B1 (nl)
JP (7) JP5956752B2 (nl)
KR (8) KR102157097B1 (nl)
CN (3) CN102143976B (nl)
AU (1) AU2009264565C1 (nl)
BR (1) BRPI0914251B1 (nl)
CA (2) CA2727839C (nl)
CL (1) CL2010001544A1 (nl)
CY (3) CY1118829T1 (nl)
DK (3) DK3216803T3 (nl)
ES (3) ES2622470T3 (nl)
FI (1) FI3722310T3 (nl)
HR (3) HRP20241467T1 (nl)
HU (4) HUE032894T2 (nl)
LT (4) LT3722310T (nl)
MX (3) MX347972B (nl)
NL (1) NL301058I2 (nl)
NO (1) NO2020021I1 (nl)
PH (1) PH12015501593A1 (nl)
PL (3) PL3216803T3 (nl)
PT (3) PT2307454T (nl)
RU (6) RU2588467C3 (nl)
SI (3) SI2307454T1 (nl)
WO (1) WO2009155724A2 (nl)
ZA (1) ZA201008594B (nl)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150400A (en) 2006-04-07 2014-01-15 Aerpio Therapeutics Inc Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof
PL3444274T3 (pl) 2008-06-25 2021-06-14 Novartis Ag Stabilne i rozpuszczalne przeciwciała hamujące tnf
CN102143976B (zh) * 2008-06-25 2015-11-25 艾斯巴技术-诺华有限责任公司 抑制vegf的稳定和可溶的抗体
DK2307458T3 (en) 2008-06-25 2018-07-16 Esbatech Alcon Biomed Res Unit Humanization of rabbit antibodies using a universal antibody framework
US8637022B2 (en) 2008-06-30 2014-01-28 Esbatech, An Alcon Biomedical Research Unit Llc Functionalized polypeptides
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
AU2010217120B2 (en) 2009-02-24 2014-11-20 Novartis Ag Methods for identifying immunobinders of cell-surface antigens
EP3366692A1 (en) 2009-06-22 2018-08-29 Amgen, Inc Refolding proteins using a chemically controlled redox state
EP3660032A1 (en) 2009-06-25 2020-06-03 Amgen, Inc Capture purification processes for proteins expressed in a non-mammalian system
NZ624752A (en) * 2010-10-19 2015-11-27 Mayo Foundation Human antibodies and diagnostic and therapeutic uses thereof for the treatment of neurological disease
AR083495A1 (es) 2010-10-22 2013-02-27 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles
US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
CA2848611A1 (en) * 2011-09-16 2013-03-21 Ucb Pharma S.A. Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile
CN104039351A (zh) 2011-10-13 2014-09-10 阿尔皮奥治疗学股份有限公司 用于治疗血管渗漏综合征和癌症的方法
WO2013113820A1 (en) 2012-02-02 2013-08-08 Esbatech - A Novartis Company Llc Antibody-containing sustained-release formulation for ocular administration
SI3495387T1 (sl) 2012-07-13 2021-12-31 Roche Glycart Ag Bispecifična protitelesa proti VEGF/proti ANG-2 in njihova uporaba pri zdravljenju bolezni očesnih žil
JP2016502850A (ja) 2012-12-18 2016-02-01 ノバルティス アーゲー ヒアルロナンに結合するペプチドタグを使用する組成物及び方法
MY170528A (en) 2013-02-18 2019-08-09 Vegenics Pty Ltd Vegfr-3 ligand binding molecules and uses thereof
KR101541478B1 (ko) * 2013-05-31 2015-08-05 동아쏘시오홀딩스 주식회사 항-vegf 항체 및 이를 포함하는 암 또는 신생혈관형성관련 질환의 예방, 진단 또는 치료용 약학 조성물
IL293477B2 (en) * 2013-06-26 2024-11-01 Numab Therapeutics AG New frameworks for antibodies
MY199027A (en) 2013-07-12 2023-10-10 Ophthotech Corp Method for treating or preventing ophthalmological conditions
WO2015076425A1 (ja) * 2013-11-25 2015-05-28 リンク・ジェノミクス株式会社 新規モノクローナル抗体
KR20170003973A (ko) 2014-05-12 2017-01-10 포르미콘 아게 Ｖｅｇｆ 안타고니스트를 포함하는 사전충전형 플라스틱제 주사기
WO2015198243A2 (en) 2014-06-25 2015-12-30 Novartis Ag Compositions and methods for long acting proteins
EP3160991A2 (en) 2014-06-25 2017-05-03 Novartis AG Compositions and methods for long acting proteins
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
KR102390359B1 (ko) 2014-09-29 2022-04-22 삼성전자주식회사 폴리펩타이드, 이를 포함하는 항 VEGF 항체 및 항 c-Met/항 VEGF 이중 특이 항체
TWI761959B (zh) * 2014-11-07 2022-04-21 瑞士商諾華公司 治療眼部疾病之方法
BR112017009728A2 (pt) 2014-11-10 2018-02-06 Genentech, Inc. anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, método para produzir o anticorpo, composição, usos de um anticorpo e métodos de tratamento de um distúrbio
MX2017009759A (es) * 2015-01-28 2017-10-27 Pfizer Formulacion de anticuerpo del anti-factor de crecimiento endotelial vascular (vegf) acuosa estable.
CA2983030A1 (en) 2015-04-16 2016-10-20 Alder Biopharmaceuticals, Inc. Use of anti-pacap antibodies and antigen binding fragments thereof for treatment, prevention, or inhibition of photophobia
US10851399B2 (en) * 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
JP2018525389A (ja) 2015-08-12 2018-09-06 ノバルティス アーゲー 眼障害を治療する方法
JP6750010B2 (ja) 2015-10-30 2020-09-02 ジェネンテック， インコーポレイテッド 抗ＨｔｒＡ１抗体及びその使用方法
JP6985572B2 (ja) * 2015-11-09 2021-12-22 国立大学法人京都工芸繊維大学 単鎖抗体のスクリーニング方法及び単鎖抗体
MX382662B (es) 2015-11-18 2025-03-11 Sio2 Medical Products Inc Envase farmacéutico para formulaciones oftálmicas.
BR112018010005A2 (pt) 2015-11-18 2018-11-21 Formycon Ag seringa pré-carregada, e, kit
BR112018009953B1 (pt) 2015-11-18 2024-03-05 Formycon Ag Seringa farmacêutica pré-preenchida esterilizada, e, kit
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
JP7088454B2 (ja) 2015-12-30 2022-06-21 コディアック サイエンシーズ インコーポレイテッド 抗体および抗体複合体
CN108699141B (zh) 2016-01-06 2022-06-17 定制药品研究株式会社 高亲和性抗vegf抗体
EP3401330A4 (en) 2016-01-06 2019-09-18 Order-Made Medical Research Inc. ANTIBODY-BINDING BINDING BETWEEN VEGF AND NRP1
USD789171S1 (en) 2016-01-21 2017-06-13 Nomis Llc Right angle drive
US10576128B2 (en) 2016-01-26 2020-03-03 Formycon Ag Liquid formulation of a VEGF antagonist
SG11201806622PA (en) * 2016-02-05 2018-09-27 Univ Texas Egfl6 specific monoclonal antibodies and methods of their use
WO2017156423A2 (en) * 2016-03-11 2017-09-14 Integrated Biotherapeutics, Inc. Broadly protective antibody cocktails for treatment of filovirus hemorrhagic fever
EP3222673A1 (de) * 2016-03-23 2017-09-27 LANXESS Deutschland GmbH Metallazopigmente
SG11201808630WA (en) * 2016-04-15 2018-10-30 Alder Biopharmaceuticals Inc Humanized anti-pacap antibodies and uses thereof
GEP20217249B (en) 2016-06-30 2021-04-26 Inc Celltrion Stable liquid pharmaceutical preparation
JP7050702B2 (ja) 2016-07-08 2022-04-08 ジェネンテック， インコーポレイテッド Ｎｒｆ２及びその遺伝子の下流標的遺伝子の発現状態及び変異状態によるがんの診断及び治療方法
AU2018232883B2 (en) * 2017-03-09 2024-10-17 Mab Discovery Gmbh Antibodies specifically binding to human IL-1 R7
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
JP7282689B2 (ja) 2017-05-19 2023-05-29 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ リフォールディングした組み換えヒト化ラニビズマブの製造方法
CA3063995A1 (en) 2017-05-24 2018-11-29 Sio2 Medical Products, Inc. Sterilizable pharmaceutical package for ophthalmic formulations
WO2018215580A1 (en) 2017-05-24 2018-11-29 Formycon Ag Method for sterilizing prefilled plastic syringes containing a vegf antagonist
US20200237997A1 (en) 2017-05-24 2020-07-30 Formycon Ag Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
JP7474193B2 (ja) * 2017-06-25 2024-04-24 システィミューン， インク． 多重特異性抗体とその作製及び使用方法
WO2019020777A1 (en) 2017-07-26 2019-01-31 Formycon Ag LIQUID FORMULATION OF A VEGF ANTAGONIST
CA3083472A1 (en) * 2017-11-27 2019-05-31 4D Molecular Therapeutics Inc. Adeno-associated virus variant capsids and use for inhibiting angiogenesis
EP3731865A1 (en) 2017-12-29 2020-11-04 F. Hoffmann-La Roche AG Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody
WO2019143837A1 (en) * 2018-01-17 2019-07-25 Apexigen, Inc. Anti-pd-l1 antibodies and methods of use
EP3758737A4 (en) 2018-03-02 2022-10-12 Kodiak Sciences Inc. IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF
JP6938796B2 (ja) 2018-03-16 2021-09-22 ノバルティス アーゲー 眼疾患を治療するための方法
CN118846040A (zh) * 2018-04-06 2024-10-29 伊莱利利公司 用于治疗儿科患者中的癌症的雷莫芦单抗
AU2019328290B2 (en) 2018-08-30 2024-10-10 Immunitybio, Inc. Multi-chain chimeric polypeptides and uses thereof
IL318035A (en) 2018-08-30 2025-02-01 Immunitybio Inc Single-chain chimeric polypeptides and uses thereof
US11730762B2 (en) 2018-08-30 2023-08-22 HCW Biologics, Inc. Methods for stimulating proliferation or differentiation of an immune cell with a multi-chain chimeric polypeptide
TWI851600B (zh) * 2018-09-13 2024-08-11 美國德州系統大學評議委員會 新穎lilrb4抗體及其用途
EP3856245A4 (en) 2018-09-24 2022-10-26 EyePoint Pharmaceuticals, Inc. MULTISPECIFIC ANTIBODIES THAT TARGET HPTP - ß (VE-PTP) AND VEGF
CR20210318A (es) 2018-12-18 2021-07-14 Novartis Ag Formulación de solución de proteínas que contiene una alta concentración de un anticuerpo anti-vegf
USD907456S1 (en) 2019-05-21 2021-01-12 Nomis Llc Right angle drill attachment
USD907455S1 (en) 2019-05-21 2021-01-12 Nomis Llc Right angle drive attachment
KR20220035394A (ko) 2019-06-21 2022-03-22 에이치씨더블유 바이올로직스, 인크. 다중-사슬 키메라 폴리펩티드 및 이의 용도
CA3149706A1 (en) 2019-09-13 2021-03-18 Novartis Ag Methods for treating ocular diseases
WO2021072265A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
US12115191B2 (en) 2020-02-11 2024-10-15 Immunitybio, Inc. Methods of treating age-related and inflammatory diseases
WO2021163299A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Chromatography resin and uses thereof
IL295083A (en) 2020-02-11 2022-09-01 Hcw Biologics Inc Methods of activating regulatory t cells
US20230340112A1 (en) * 2020-02-28 2023-10-26 Apexigen, Inc. Anti-sirpa antibodies and methods of use
CA3175140A1 (en) * 2020-03-12 2021-09-16 Immune-Onc Therapeutics, Inc. Novel anti-lilrb4 antibodies and derivative products
CA3174680A1 (en) 2020-03-13 2021-09-16 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
AU2021262794A1 (en) 2020-04-29 2022-11-24 Immunitybio, Inc. Anti-CD26 proteins and uses thereof
WO2021247003A1 (en) 2020-06-01 2021-12-09 HCW Biologics, Inc. Methods of treating aging-related disorders
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
CA3184756A1 (en) 2020-06-01 2021-12-09 HCW Biologics, Inc. Methods of treating aging-related disorders
CR20230009A (es) 2020-07-16 2023-01-25 Novartis Ag Anticuerpos anti-betacelulina, fragmentos de los mismos, y moléculas de unión multiespecíficas
KR20230088749A (ko) 2020-10-15 2023-06-20 에프. 호프만-라 로슈 아게 장기 지속적 안구 전달을 위한 비공유 단백질-히알루로난 접합체
TW202237181A (zh) 2020-11-25 2022-10-01 瑞士商諾華公司 治療眼部疾病之方法
WO2022201084A1 (en) 2021-03-26 2022-09-29 Novartis Ag Methods for treating ocular diseases
EP4145456A1 (en) 2021-09-06 2023-03-08 Bayer AG Prediction of a change related to a macular fluid
KR102809807B1 (ko) 2021-12-21 2025-05-16 한림대학교 산학협력단 항-cldn18.2를 포함하는 키메릭 항원 수용체를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 및 이의 제조 방법
EP4486368A1 (en) 2022-03-02 2025-01-08 ImmunityBio, Inc. Method of treating pancreatic cancer
TW202337496A (zh) 2022-03-17 2023-10-01 瑞士商諾華公司 治療新生血管性年齡相關性黃斑點退化之方法
CN117820474A (zh) * 2023-04-25 2024-04-05 南京贝思奥生物科技有限公司 改善眼部血管新生相关疾病的药物及其应用
CN117069848B (zh) * 2023-08-02 2025-02-28 武汉爱博泰克生物科技有限公司 抗人cd146兔单克隆抗体及其应用

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
EP0623679B1 (en) 1987-05-21 2003-06-25 Micromet AG Targeted multifunctional proteins
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5147638A (en) 1988-12-30 1992-09-15 Oklahoma Medical Research Foundation Inhibition of tumor growth by blockade of the protein C system
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
OA10149A (en) 1991-03-29 1996-12-18 Genentech Inc Vascular endothelial cell growth factor antagonists
US6582959B2 (en) 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
LU91067I2 (fr) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
BR9207175A (pt) 1992-10-28 1995-12-12 Genentech Inc Composição contendo antagonista de fator de crescimento de célula endotelial vascular sequência aminoácida de anticorpo monoclonal polipeptídeo e método de tratamento de tumor em mamífero
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US5730977A (en) 1995-08-21 1998-03-24 Mitsui Toatsu Chemicals, Inc. Anti-VEGF human monoclonal antibody
CN103275221B (zh) 1996-02-09 2016-08-17 艾伯维生物技术有限公司 结合人TNFα的人抗体
JP2000516452A (ja) * 1996-07-16 2000-12-12 プリュックテュン，アンドレアス 可溶性が増大した免疫グロブリンスーパーファミリードメインおよびフラグメント
WO2000053760A2 (en) * 1999-03-12 2000-09-14 Genentech, Inc. Method of preventing the death of retinal neurons and treating ocular diseases
US6986890B1 (en) 1996-11-21 2006-01-17 Kyowa Hakko Kogyo Co., Ltd. Anti-human VEGF receptor Flt-1 monoclonal antibody
US20070059302A1 (en) 1997-04-07 2007-03-15 Genentech, Inc. Anti-vegf antibodies
DE69836729T2 (de) * 1997-04-07 2007-12-13 Genentech, Inc., South San Francisco Anti-vefg antibodies
PT1695985E (pt) * 1997-04-07 2011-06-06 Genentech Inc Métodos para formar anticorpos humanizados por mutagénese aleatória
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
WO2000034337A1 (en) * 1998-12-10 2000-06-15 Tsukuba Research Laboratory, Toagosei Co., Ltd. Humanized monoclonal antibodies against vascular endothelial cell growth factor
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
WO2000064946A2 (en) 1999-04-28 2000-11-02 Board Of Regents, The University Of Texas System Compositions and methods for cancer treatment by selectively inhibiting vegf
EP1233790A2 (en) * 1999-10-22 2002-08-28 Ludwig Institute For Cancer Research A33 antigen specific immunoglobulin products in cancer therapy
CA2396534C (en) 1999-12-28 2012-10-02 Esbatech Ag Intrabodies with defined framework that is stable in a reducing environment and applications thereof
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
US7667004B2 (en) 2001-04-17 2010-02-23 Abmaxis, Inc. Humanized antibodies against vascular endothelial growth factor
DE10201450B4 (de) 2002-01-16 2004-09-02 Infineon Technologies Ag Carry-Skip-Addierer für verschlüsselte Daten
US6576941B1 (en) 2002-02-20 2003-06-10 Samsung Electronics Co., Ltd. Ferroelectric capacitors on protruding portions of conductive plugs having a smaller cross-sectional size than base portions thereof
CN1187373C (zh) * 2002-03-20 2005-02-02 上海中信国健药业有限公司 人源化抗血管内皮生长因子单克隆抗体及其制法和药物组合物
AU2003210060B2 (en) 2002-03-22 2010-02-25 Aprogen, Inc. Humanized antibody and process for preparing same
PT2332989E (pt) * 2002-05-22 2015-08-05 Esbatech Alcon Biomed Res Unit Estruturas de imunoglobulina que demonstram estabilidade aumentada no ambiente intracelular e métodos de identificação das mesmas
US20040086979A1 (en) * 2002-08-15 2004-05-06 Dongxiao Zhang Humanized rabbit antibodies
EP2311875A1 (en) 2003-05-30 2011-04-20 Genentech, Inc. Treatment with anti-VEGF antibodies
US20050048578A1 (en) * 2003-06-26 2005-03-03 Epitomics, Inc. Methods of screening for monoclonal antibodies with desirable activity
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
WO2005044853A2 (en) * 2003-11-01 2005-05-19 Genentech, Inc. Anti-vegf antibodies
US20050033031A1 (en) 2003-08-07 2005-02-10 Couto Fernando Jose Rebelo Do Methods for humanizing rabbit monoclonal antibodies
ES2456943T3 (es) 2004-08-02 2014-04-24 Zenyth Operations Pty. Ltd. Método de tratamiento de cáncer que comprende un antagonista de VEGF-B
ES2390676T3 (es) 2004-10-21 2012-11-15 Genentech, Inc. Método para el tratamiento de enfermedades neovasculares intraoculares
US7462697B2 (en) 2004-11-08 2008-12-09 Epitomics, Inc. Methods for antibody engineering
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
WO2007019620A1 (en) * 2005-08-15 2007-02-22 Arana Therapeutics Limited Engineered antibodies with new world primate framework regions
AR059066A1 (es) 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
WO2007140534A1 (en) * 2006-06-08 2007-12-13 Csl Limited Vegf-a cross-reactive anti- vegf-b antibodies as antagonists of vegf-a and vegf-b signalling
US8936785B2 (en) 2006-07-10 2015-01-20 ESBATech, an Alcon Biomedical Research Unit, LLC scFv antibodies which pass epithelial and/or endothelial layers
CA2666709A1 (en) 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
US7553486B2 (en) 2006-11-13 2009-06-30 Paul Theodore Finger Anti-VEGF treatment for radiation-induced vasculopathy
MY183404A (en) 2006-12-19 2021-02-18 Genentech Inc Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
CN103275216B (zh) 2007-03-12 2015-05-06 艾斯巴技术-诺华有限责任公司 单链抗体的基于序列的工程改造和最优化
US8877186B2 (en) 2007-06-06 2014-11-04 Domantis Limited Polypeptides, antibody variable domains and antagonists
CA2683791A1 (en) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains & antagonists
SI2164961T1 (sl) 2007-06-25 2015-05-29 Esbatech, An Alcon Biomedical Research Unit Llc InĹľeniring na osnovi zaporedij in optimizacija mono-veriĹľnih protiteles
DK2158315T3 (en) 2007-06-25 2016-06-06 Esbatech Alcon Biomed Res Unit Methods of modifying antibodies and modified antibodies with improved functional properties
CA3053675A1 (en) * 2008-03-26 2009-10-01 Epitomics, Inc. Anti-vegf antibody
DK2307458T3 (en) * 2008-06-25 2018-07-16 Esbatech Alcon Biomed Res Unit Humanization of rabbit antibodies using a universal antibody framework
EP2307455B1 (en) 2008-06-25 2017-03-22 ESBATech, an Alcon Biomedical Research Unit LLC Solubility optimization of immunobinders
CN102143976B (zh) * 2008-06-25 2015-11-25 艾斯巴技术-诺华有限责任公司 抑制vegf的稳定和可溶的抗体
JP5579713B2 (ja) * 2008-07-10 2014-08-27 エスバテック − ア ノバルティス カンパニー エルエルシー 高分子の送達増強のための方法および組成物
CA2777527C (en) * 2009-12-23 2020-06-23 Esbatech, An Alcon Biomedical Research Unit Llc Method for decreasing immunogenicity

Also Published As

Publication number Publication date
BRPI0914251A2 (pt) 2021-01-05
CN104961828A (zh) 2015-10-07
US20180072802A1 (en) 2018-03-15
JP2014158491A (ja) 2014-09-04
LT3216803T (lt) 2020-06-10
CA2727839C (en) 2018-11-20
RU2016119152A (ru) 2017-11-21
KR20200108922A (ko) 2020-09-21
RU2019120079A (ru) 2020-12-28
RU2747735C2 (ru) 2021-05-13
JP6100199B2 (ja) 2017-03-22
LTC2307454I2 (lt) 2021-05-25
PL2307454T3 (pl) 2017-07-31
JP2019162127A (ja) 2019-09-26
CL2010001544A1 (es) 2012-02-03
JP6821612B2 (ja) 2021-01-27
JP2022020782A (ja) 2022-02-01
KR102095257B1 (ko) 2020-04-01
PT3216803T (pt) 2020-06-16
KR101817284B1 (ko) 2018-01-11
RU2531523C3 (ru) 2022-05-04
HRP20241467T1 (hr) 2025-01-03
MX2011000011A (es) 2011-09-27
CY2020026I1 (el) 2020-11-25
EP3216803A1 (en) 2017-09-13
CN102143976B (zh) 2015-11-25
KR20170057462A (ko) 2017-05-24
WO2009155724A2 (en) 2009-12-30
JP2017055774A (ja) 2017-03-23
LT2307454T (lt) 2017-05-25
EP3722310A1 (en) 2020-10-14
US20140004114A1 (en) 2014-01-02
EP2307454B1 (en) 2017-01-18
KR20110028518A (ko) 2011-03-18
HRP20170615T1 (hr) 2017-07-28
BRPI0914251B1 (pt) 2022-07-19
DK3722310T3 (da) 2024-11-18
US20200172608A1 (en) 2020-06-04
KR20180098705A (ko) 2018-09-04
KR20160128458A (ko) 2016-11-07
LTPA2020004I1 (lt) 2020-08-10
HRP20200814T1 (hr) 2020-08-07
CN104961828B (zh) 2019-03-26
CN102143976A (zh) 2011-08-03
CN110372792A (zh) 2019-10-25
KR20180005753A (ko) 2018-01-16
US20250066462A1 (en) 2025-02-27
EP3722310B1 (en) 2024-08-28
HUE050230T2 (hu) 2020-11-30
ZA201008594B (en) 2012-02-29
RU2588467C3 (ru) 2021-10-20
EP2307454A2 (en) 2011-04-13
KR102157097B1 (ko) 2020-09-18
US20150274820A1 (en) 2015-10-01
KR20190092630A (ko) 2019-08-07
CY1123028T1 (el) 2021-10-29
PT2307454T (pt) 2017-04-26
WO2009155724A3 (en) 2010-04-01
HUE068894T2 (hu) 2025-02-28
RU2648152C2 (ru) 2018-03-22
KR102296443B1 (ko) 2021-09-01
CA3020290A1 (en) 2009-12-30
RU2013133802A (ru) 2015-01-27
US10590193B2 (en) 2020-03-17
RU2696972C1 (ru) 2019-08-07
CA2727839A1 (en) 2009-12-30
KR101737466B1 (ko) 2017-05-18
FI3722310T3 (fi) 2024-11-27
RU2014132888A (ru) 2015-12-10
JP2015134792A (ja) 2015-07-27
PT3722310T (pt) 2024-11-12
KR101671886B1 (ko) 2016-11-04
KR102013220B1 (ko) 2019-08-23
ES2622470T3 (es) 2017-07-06
SI2307454T1 (sl) 2017-05-31
RU2531523C2 (ru) 2014-10-20
HUE032894T2 (hu) 2017-11-28
JP5956752B2 (ja) 2016-07-27
LT3722310T (lt) 2024-12-27
MX347972B (es) 2017-05-22
US9873737B2 (en) 2018-01-23
JP7171877B2 (ja) 2022-11-15
RU2747735C3 (ru) 2022-05-04
PL3722310T3 (pl) 2025-01-20
CY1118829T1 (el) 2018-01-10
RU2531523C9 (ru) 2015-04-10
NO2020021I1 (no) 2020-08-04
JP7171877B6 (ja) 2024-02-06
ES2998307T3 (en) 2025-02-19
ES2793008T3 (es) 2020-11-12
SI3722310T1 (sl) 2025-01-31
AU2009264565A1 (en) 2009-12-30
JP6527128B2 (ja) 2019-06-05
HK1150844A1 (en) 2012-01-13
MX392435B (es) 2025-03-19
PH12015501593A1 (en) 2015-12-14
PL3216803T3 (pl) 2020-10-19
DK2307454T3 (en) 2017-04-24
RU2011102583A (ru) 2012-07-27
JP2018108081A (ja) 2018-07-12
EP3216803B1 (en) 2020-03-11
US8349322B2 (en) 2013-01-08
US9090684B2 (en) 2015-07-28
NL301058I1 (nl) 2020-07-31
DK3216803T3 (da) 2020-06-02
RU2019120079A3 (nl) 2020-12-28
AU2009264565B2 (en) 2014-05-08
JP2011525359A (ja) 2011-09-22
KR20150132602A (ko) 2015-11-25
AU2009264565C1 (en) 2022-01-27
HUS2000028I1 (hu) 2020-08-28
JP6978468B2 (ja) 2021-12-08
SI3216803T1 (sl) 2020-07-31
US20120014958A1 (en) 2012-01-19
CY2020026I2 (el) 2020-11-25

Similar Documents

Publication Publication Date Title
NL301058I2 (nl) Brolucizumab
DK2370462T3 (da) Glucagon-analoger
DK2342317T3 (da) Hængende-dråbe-plade
BRPI0907376A2 (pt) Fotobiorretador
EP2258938A4 (en) TYPE VEHICLE TO BE PROVIDED
DK3444343T3 (da) Polypeptider
EP2368526A4 (en) INSERTION TOOL FOR AN INTRAOCULAR LENS
BRPI0914649A2 (pt) Piprazolo-quinazolinas
DE602008003972D1 (de) Sitzrücklehnungsmechanismus
EP2320913A4 (en) NUCLEIC ACID APTAMERS
DK2336132T3 (da) Morpholinpurinderivat
EP2368115A4 (en) ANALYTE DETECTION TEST
DK2379557T3 (da) Aminopyrazol-forbindelse
EP2308156A4 (en) STEP ACTUATOR
DK2271613T3 (da) Hydroxymethylcyklohexylaminer
DE602008003970D1 (de) Strahlstromkalibriersystem
EP2257170A4 (en) TETRAHYDROFUROPYRIDONE
EP2377648A4 (en) GRINDING MACHINE INNER TOOTH WHEEL
EP2344441A4 (en) 14-HYDROXY-DOCOSAHEXAENOIC ACID BASED COMPOSITIONS
EP2318641A4 (en) TOOL FOR CENTERING FOR DRILLING ENCLOSURE
BRPI0907522A2 (pt) biarlamidas
DE112009000183A5 (de) Sicherheitsvorreiber
EP2375904A4 (en) BIARYL CARBOXAMIDES
EP2339366A4 (en) DEVICE FOR OPTICAL DISTANCE MEASUREMENT
BRPI0909634A2 (pt) 2-aminoquinolinas