JP2017523786A5 - - Google Patents
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- JP2017523786A5 JP2017523786A5 JP2017506285A JP2017506285A JP2017523786A5 JP 2017523786 A5 JP2017523786 A5 JP 2017523786A5 JP 2017506285 A JP2017506285 A JP 2017506285A JP 2017506285 A JP2017506285 A JP 2017506285A JP 2017523786 A5 JP2017523786 A5 JP 2017523786A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 110
- 239000012634 fragment Substances 0.000 claims description 81
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 46
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 46
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims description 46
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims description 46
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims description 46
- 102000008096 B7-H1 Antigen Human genes 0.000 claims description 30
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 30
- 208000015181 infectious disease Diseases 0.000 claims description 8
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- 241000894006 Bacteria Species 0.000 claims description 2
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- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
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- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
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- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims description 2
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- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 208000000728 Thymus Neoplasms Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
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- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
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- 231100000599 cytotoxic agent Toxicity 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 201000008968 osteosarcoma Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 206010038038 rectal cancer Diseases 0.000 claims description 2
- 201000001275 rectum cancer Diseases 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 230000003796 beauty Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- -1 radioisotope Substances 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/083715 | 2014-08-05 | ||
| CN2014083715 | 2014-08-05 | ||
| PCT/US2015/043723 WO2016022630A1 (en) | 2014-08-05 | 2015-08-05 | Anti-pd-l1 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020063112A Division JP7144477B2 (ja) | 2014-08-05 | 2020-03-31 | 抗ｐｄ－ｌ１抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523786A JP2017523786A (ja) | 2017-08-24 |
| JP2017523786A5 true JP2017523786A5 (enExample) | 2018-09-13 |
| JP6909153B2 JP6909153B2 (ja) | 2021-07-28 |
Family
ID=55264464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506285A Active JP6909153B2 (ja) | 2014-08-05 | 2015-08-05 | 抗ｐｄ−ｌ１抗体 |
| JP2020063112A Active JP7144477B2 (ja) | 2014-08-05 | 2020-03-31 | 抗ｐｄ－ｌ１抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020063112A Active JP7144477B2 (ja) | 2014-08-05 | 2020-03-31 | 抗ｐｄ－ｌ１抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10435470B2 (enExample) |
| EP (1) | EP3177649B1 (enExample) |
| JP (2) | JP6909153B2 (enExample) |
| KR (1) | KR102476226B1 (enExample) |
| CN (4) | CN118388646A (enExample) |
| AU (2) | AU2015301126B2 (enExample) |
| CA (1) | CA2956399A1 (enExample) |
| ES (1) | ES2987034T3 (enExample) |
| IL (1) | IL250415B (enExample) |
| MX (2) | MX390385B (enExample) |
| NZ (1) | NZ728749A (enExample) |
| RU (1) | RU2722212C9 (enExample) |
| SG (2) | SG10201901057UA (enExample) |
| WO (1) | WO2016022630A1 (enExample) |
| ZA (1) | ZA201700785B (enExample) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2376535T (pt) | 2008-12-09 | 2017-06-23 | Hoffmann La Roche | Anticorpos anti-pd-l1 e a sua utilização para a melhoria do funcionamento das células t |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| BR112017001385B1 (pt) | 2014-07-22 | 2023-12-05 | Cb Therapeutics, Inc. | Anticorpo isolado ou fragmento do mesmo que liga a pd-1, uso deste, composição, polinucleotídeo isolado e vetor de expressão |
| ES2987034T3 (es) | 2014-08-05 | 2024-11-13 | Apollomics Inc | Anticuerpos anti-PD-L1 |
| EP3268392A2 (en) | 2015-03-13 | 2018-01-17 | CytomX Therapeutics, Inc. | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| TWI886756B (zh) | 2015-07-30 | 2025-06-11 | 美商宏觀基因股份有限公司 | Pd-1結合分子和其使用方法 |
| WO2017077382A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
| MA44082A (fr) | 2015-12-14 | 2018-10-24 | Macrogenics Inc | Molécules bispécifiques présentant une immunoréactivité par rapport à pd-1 et à ctla-4 et leurs procédés d'utilisation |
| CN108883180B (zh) | 2016-02-05 | 2023-07-07 | 奥里尼斯生物科学私人有限公司 | Clec9a结合剂及其用途 |
| KR102343742B1 (ko) * | 2016-05-09 | 2021-12-24 | 아이쥐엠 바이오사이언스 인코포레이티드 | 항-pd-l1 항체 |
| CA3023883A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Targeted mutant interferon-beta and uses thereof |
| CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
| CN105968200B (zh) * | 2016-05-20 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-l1人源化单克隆抗体及其应用 |
| CN106008714B (zh) | 2016-05-24 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-1人源化单克隆抗体及其应用 |
| CN107460221B (zh) * | 2016-06-02 | 2021-01-15 | 正大天晴药业集团股份有限公司 | 一种降低抗pd-l1抗体中蛋白聚合物的细胞培养方法 |
| CN109414500B (zh) * | 2016-06-13 | 2022-02-25 | 奥美药业有限公司 | 治疗和诊断用pd-l1特异性单克隆抗体 |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
| CN109476748B (zh) * | 2016-08-08 | 2023-05-23 | 豪夫迈·罗氏有限公司 | 用于癌症的治疗和诊断方法 |
| KR20230044038A (ko) | 2016-08-09 | 2023-03-31 | 키맵 리미티드 | 항-icos 항체 |
| CN107815466B (zh) | 2016-08-31 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US11317611B2 (en) | 2016-08-31 | 2022-05-03 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric PD-L1 |
| JP7204643B2 (ja) | 2016-10-24 | 2023-01-16 | オリオニス バイオサイエンシズ ビーブイ | 標的変異インターフェロン－ガンマおよびその使用 |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN108203720A (zh) * | 2016-12-20 | 2018-06-26 | 上海生博生物医药科技有限公司 | 能靶向Her2并封闭PD-L1降低肿瘤免疫逃逸的CAR-T载体及其构建方法和应用 |
| KR102642385B1 (ko) | 2017-02-06 | 2024-03-04 | 오리오니스 바이오사이언시스 엔브이 | 표적화된 키메라 단백질 및 이의 용도 |
| US10906985B2 (en) | 2017-02-06 | 2021-02-02 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| CN108456251A (zh) * | 2017-02-21 | 2018-08-28 | 上海君实生物医药科技股份有限公司 | 抗pd-l1抗体及其应用 |
| RU2665790C1 (ru) | 2017-04-17 | 2018-09-04 | Закрытое Акционерное Общество "Биокад" | Моноклональное антитело к pd-l1 |
| CN107299110B (zh) * | 2017-05-27 | 2019-11-22 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的胰腺癌、恶性间皮瘤car-t治疗载体及其构建方法和应用 |
| CN107267555B (zh) * | 2017-05-27 | 2020-03-20 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用 |
| CN107164410B (zh) * | 2017-05-27 | 2019-09-03 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的前列腺癌car-t治疗载体及其构建方法和应用 |
| US11168144B2 (en) | 2017-06-01 | 2021-11-09 | Cytomx Therapeutics, Inc. | Activatable anti-PDL1 antibodies, and methods of use thereof |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| US12150990B2 (en) | 2017-11-02 | 2024-11-26 | Nanjing Shunxin Pharmaceutical Co., Ltd. | Pharmaceutical composition of humanized monoclonal anti-PD-L1 antibody |
| GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
| WO2019122882A1 (en) | 2017-12-19 | 2019-06-27 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
| CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| KR102311838B1 (ko) | 2017-12-27 | 2021-10-14 | 주식회사 파멥신 | 항-pd-l1 항체 및 이의 용도 |
| AU2018396964C1 (en) * | 2017-12-28 | 2024-10-03 | Nanjing Legend Biotech Co., Ltd. | Antibodies and variants thereof against PD-L1 |
| BR112020013475A2 (pt) * | 2018-01-10 | 2020-12-08 | Jiangsu Hengrui Medicine Co., Ltd. | Anticorpo de pd-l1, fragmento de ligação ao antígeno do mesmo, e uso farmacêutico do mesmo |
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| AU2019215440B2 (en) | 2018-02-05 | 2025-12-04 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
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| US11993655B2 (en) * | 2018-04-09 | 2024-05-28 | Oricell Therapeutics Co., Ltd. | Anti-PD-L1 antibody and use thereof |
| TWI822815B (zh) * | 2018-07-14 | 2023-11-21 | 財團法人生物技術開發中心 | 抗-人類ｐｄ-ｌ１之抗體及其用途 |
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| CN113365659B (zh) * | 2019-01-31 | 2023-08-18 | 正大天晴药业集团股份有限公司 | 抗pd-l1抗体治疗头颈癌的用途 |
| JP2022521800A (ja) | 2019-02-28 | 2022-04-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 皮膚がんを治療するためのｐｄ－１阻害剤の投与 |
| JP7548924B2 (ja) | 2019-03-06 | 2024-09-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | がんの処置における増強された有効性のためのｉｌ－４／ｉｌ－１３経路阻害剤 |
| CN113613674B (zh) * | 2019-03-15 | 2024-11-05 | 正大天晴药业集团股份有限公司 | 治疗小细胞肺癌的联用药物组合物 |
| CN120775051A (zh) | 2019-05-21 | 2025-10-14 | 诺华股份有限公司 | Cd19结合分子及其用途 |
| CN111973739B (zh) * | 2019-05-23 | 2024-02-13 | 正大天晴药业集团股份有限公司 | 抗pd-l1单克隆抗体治疗癌症的用途 |
| CN113939315B (zh) * | 2019-05-30 | 2024-04-02 | 正大天晴药业集团南京顺欣制药有限公司 | 治疗黑色素瘤的联用药物组合物 |
| WO2020249003A1 (en) * | 2019-06-10 | 2020-12-17 | Apollomics Inc. (Hangzhou) | Antibody-interleukin fusion protein and methods of use |
| CN113905761A (zh) * | 2019-06-10 | 2022-01-07 | 正大天晴药业集团南京顺欣制药有限公司 | 治疗驱动基因阳性肺癌的联用药物组合物 |
| CN119424632A (zh) * | 2019-07-03 | 2025-02-14 | 正大天晴药业集团南京顺欣制药有限公司 | 治疗结直肠癌的联用药物组合物 |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| EP4023679A4 (en) * | 2019-08-30 | 2023-10-04 | Nanjing Shunxin Pharmaceuticals Co., Ltd. of Chiatai Tianqing Pharmaceutical Group | FUSION PROTEIN TARGETING PD-L1 AND TGF-BETA AND USE THEREOF |
| TWI832013B (zh) * | 2019-09-30 | 2024-02-11 | 大陸商諾納生物（蘇州）有限公司 | 一種抗pd-l1抗原結合蛋白及其應用 |
| EP4056592A4 (en) * | 2019-11-08 | 2024-03-20 | Jiangsu Simcere Pharmaceutical Co., Ltd. | ANTIBODY AGAINST HUMAN PROGRAMMED CELL DEATH LIGAND 1 (PD-L1) AND USE THEREOF |
| CN120437288A (zh) * | 2019-12-24 | 2025-08-08 | 正大天晴药业集团南京顺欣制药有限公司 | 治疗卵巢癌的药物组合 |
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