JP2020513786A5 - - Google Patents
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- JP2020513786A5 JP2020513786A5 JP2019541279A JP2019541279A JP2020513786A5 JP 2020513786 A5 JP2020513786 A5 JP 2020513786A5 JP 2019541279 A JP2019541279 A JP 2019541279A JP 2019541279 A JP2019541279 A JP 2019541279A JP 2020513786 A5 JP2020513786 A5 JP 2020513786A5
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- binding unit
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- 239000000427 antigen Substances 0.000 claims description 97
- 102000036639 antigens Human genes 0.000 claims description 97
- 108091007433 antigens Proteins 0.000 claims description 97
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 34
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 34
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 29
- 210000004027 cell Anatomy 0.000 claims description 29
- 206010028980 Neoplasm Diseases 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 21
- 201000011510 cancer Diseases 0.000 claims description 15
- 230000035931 haemagglutination Effects 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 7
- 210000003743 erythrocyte Anatomy 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 206010057249 Phagocytosis Diseases 0.000 claims description 4
- 201000005787 hematologic cancer Diseases 0.000 claims description 4
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 230000008782 phagocytosis Effects 0.000 claims description 4
- 238000000159 protein binding assay Methods 0.000 claims description 4
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims description 3
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 210000002540 macrophage Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 8
- 230000000242 pagocytic effect Effects 0.000 description 9
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2017/072738 | 2017-01-26 | ||
| CN2017072738 | 2017-01-26 | ||
| PCT/CN2018/074318 WO2018137705A1 (en) | 2017-01-26 | 2018-01-26 | Cd47 antigen binding unit and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513786A JP2020513786A (ja) | 2020-05-21 |
| JP2020513786A5 true JP2020513786A5 (enExample) | 2021-03-11 |
| JP7117311B2 JP7117311B2 (ja) | 2022-08-12 |
Family
ID=62979126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019541279A Active JP7117311B2 (ja) | 2017-01-26 | 2018-01-26 | Ｃｄ４７抗原結合単位およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11267885B2 (enExample) |
| EP (1) | EP3574009A4 (enExample) |
| JP (1) | JP7117311B2 (enExample) |
| KR (1) | KR102607101B1 (enExample) |
| CN (1) | CN110461872B (enExample) |
| AU (1) | AU2018213718B2 (enExample) |
| CA (1) | CA3051512A1 (enExample) |
| IL (1) | IL268258A (enExample) |
| WO (1) | WO2018137705A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018137705A1 (en) | 2017-01-26 | 2018-08-02 | Zai Lab (Shanghai) Co., Ltd. | Cd47 antigen binding unit and uses thereof |
| KR20200091901A (ko) | 2017-12-01 | 2020-07-31 | 시애틀 지네틱스, 인크. | 암을 치료하기 위한 cd47 항체 및 이의 용도 |
| CN108997497B (zh) * | 2018-03-30 | 2022-02-25 | 华兰基因工程有限公司 | 特异结合人质膜膜泡关联蛋白pv-1的单克隆抗体及其制备方法与应用 |
| US20220034880A1 (en) * | 2018-10-01 | 2022-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | High specificity and sensitivity immunosorbent diagnostic assays with simultaneous resolution of multiple antibody isotypes |
| JP2022506761A (ja) * | 2018-10-29 | 2022-01-17 | ティガティーエックス，インコーポレーテッド | ＩｇＡ抗体構築物を含む組成物および方法 |
| JP2022532249A (ja) * | 2019-05-16 | 2022-07-13 | アーチ オンコロジー，インコーポレイテッド | インターロイキンタンパク質の類似体と組み合わせて癌を処置するための治療用組成物及び方法 |
| US20220235131A1 (en) * | 2019-06-17 | 2022-07-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating infections by blocking pathogen mimics of cd47 |
| EP3757125A1 (en) * | 2019-06-28 | 2020-12-30 | BioArctic AB | Antibody directed against the apoe amino-terminal fragment of 12 kda |
| CA3145791A1 (en) | 2019-07-16 | 2021-01-21 | Gilead Sciences, Inc. | Hiv vaccines and methods of making and using |
| EP4001309A4 (en) * | 2019-07-16 | 2023-08-16 | Nanjing GenScript Biotech Co., Ltd. | ANTI-CD47/ANTI-CTLA-4 BISPECIFIC ANTIBODY, METHOD FOR PREPARATION AND USE |
| WO2021032174A1 (zh) * | 2019-08-21 | 2021-02-25 | 和铂医药(上海)有限责任公司 | 一种抗cd47抗原结合蛋白及其应用 |
| PH12022550489A1 (en) * | 2019-09-03 | 2022-12-12 | Akeso Biopharma Inc | Anti-cd47 monoclonal antibody and use thereof |
| MX2022004370A (es) | 2019-10-18 | 2022-05-06 | Forty Seven Inc | Terapias de combinacion para tratar sindromes mielodisplasicos y leucemia mieloide aguda. |
| AU2020372522B2 (en) | 2019-10-25 | 2024-08-15 | WuXi Biologics Ireland Limited | Novel anti-CD47 antibodies and uses thereof |
| WO2021087064A1 (en) | 2019-10-31 | 2021-05-06 | Forty Seven, Inc. | Anti-cd47 and anti-cd20 based treatment of blood cancer |
| EP4061420A1 (en) * | 2019-11-20 | 2022-09-28 | Abvision, Inc. | Monoclonal antibodies that target human cd47 protein |
| JP7369297B2 (ja) | 2019-12-17 | 2023-10-25 | ファイザー・インク | Ｃｄ４７、ｐｄ－ｌ１に特異的な抗体、およびその使用 |
| JP7711068B2 (ja) | 2019-12-24 | 2025-07-22 | カルナバイオサイエンス株式会社 | ジアシルグリセロールキナーゼ調節化合物 |
| IL295023A (en) | 2020-02-14 | 2022-09-01 | Jounce Therapeutics Inc | Antibodies and fusion proteins that bind to ccr8 and their uses |
| US20230075244A1 (en) * | 2020-02-20 | 2023-03-09 | The Feinstein Institutes For Medical Research | Agonist antibodies against endoglin and uses thereof |
| WO2021191870A1 (en) | 2020-03-27 | 2021-09-30 | Dcprime B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| CN113461817B (zh) * | 2020-03-31 | 2025-04-18 | 苏州泽璟生物制药股份有限公司 | 一种抗人cd47抗体及其抗原结合片段、制备方法和应用 |
| JP2023531537A (ja) | 2020-06-30 | 2023-07-24 | メンドゥス・ベスローテン・フェンノートシャップ | 卵巣癌ワクチンでの白血病由来細胞の使用 |
| EP4242232A4 (en) * | 2020-11-06 | 2024-09-11 | Bio-Thera Solutions, Ltd. | BISPECIFIC ANTIBODY AND ITS USE |
| JP2024503822A (ja) * | 2021-01-05 | 2024-01-29 | ナショナル インスティテュート オブ バイオロジカル サイエンシズ，ベイジン | Ｇｐｃ３及びｃｄ４７を標的とする二重特異性抗体 |
| CA3212351A1 (en) | 2021-03-12 | 2022-09-15 | Mendus B.V. | Methods of vaccination and use of cd47 blockade |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| EP4329825A4 (en) * | 2021-04-26 | 2025-03-26 | President and Fellows of Harvard College | CD47 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE EYE DISEASES |
| KR20240025616A (ko) | 2021-06-23 | 2024-02-27 | 길리애드 사이언시즈, 인코포레이티드 | 다이아실글리세롤 키나제 조절 화합물 |
| AU2022298639C1 (en) | 2021-06-23 | 2025-07-17 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| JP2024539252A (ja) | 2021-10-28 | 2024-10-28 | ギリアード サイエンシーズ， インコーポレイテッド | ピリジジン－３（２ｈ）－オン誘導体 |
| CA3235986A1 (en) | 2021-10-29 | 2023-05-04 | Gilead Science, Inc. | Cd73 compounds |
| EP4667056A1 (en) | 2021-12-22 | 2025-12-24 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| EP4452414A2 (en) | 2021-12-22 | 2024-10-30 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| WO2023165602A1 (en) * | 2022-03-04 | 2023-09-07 | Zai Lab (Us) Llc | Combinational use of anti-cd47 antibody |
| LT4245756T (lt) | 2022-03-17 | 2024-11-25 | Gilead Sciences, Inc. | Ikaros cinko pirštų šeimos skaidymo medžiagos ir jų panaudojimas |
| AU2023240346A1 (en) | 2022-03-24 | 2024-09-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| TWI876305B (zh) | 2022-04-05 | 2025-03-11 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| US20230374036A1 (en) | 2022-04-21 | 2023-11-23 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| IL317958A (en) | 2022-07-01 | 2025-02-01 | Gilead Sciences Inc | CD73 compounds |
| JP2025523043A (ja) | 2022-07-12 | 2025-07-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ免疫原性ポリペプチド及びワクチン、並びにその使用 |
| WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
| WO2024078604A1 (en) * | 2022-10-14 | 2024-04-18 | Nanjing Legend Biotech Co., Ltd. | Antibodies targeting cd47 and uses thereof |
| EP4638436A1 (en) | 2022-12-22 | 2025-10-29 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| EP4695260A1 (en) | 2023-04-11 | 2026-02-18 | Gilead Sciences, Inc. | Kras modulating compounds |
| KR20250175331A (ko) | 2023-04-21 | 2025-12-16 | 길리애드 사이언시즈, 인코포레이티드 | Prmt5 억제제 및 이의 용도 |
| AU2024306338A1 (en) | 2023-06-30 | 2026-01-08 | Gilead Sciences, Inc. | Kras modulating compounds |
| AU2024300557A1 (en) | 2023-07-26 | 2026-02-05 | Gilead Sciences, Inc. | Parp7 inhibitors |
| AU2024297978A1 (en) | 2023-07-26 | 2026-02-05 | Gilead Sciences, Inc. | Parp7 inhibitors |
| WO2025054530A1 (en) | 2023-09-08 | 2025-03-13 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
| US20250101042A1 (en) | 2023-09-08 | 2025-03-27 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| WO2025090760A1 (en) * | 2023-10-25 | 2025-05-01 | Board Of Regents, The University Of Texas System | Antibodies specific to scube3 and methods of use |
| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2026039365A1 (en) | 2024-08-12 | 2026-02-19 | Gilead Sciences, Inc. | Kras modulating compounds |
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| WO2018137705A1 (en) | 2017-01-26 | 2018-08-02 | Zai Lab (Shanghai) Co., Ltd. | Cd47 antigen binding unit and uses thereof |
-
2018
- 2018-01-26 WO PCT/CN2018/074318 patent/WO2018137705A1/en not_active Ceased
- 2018-01-26 CA CA3051512A patent/CA3051512A1/en active Pending
- 2018-01-26 EP EP18743968.2A patent/EP3574009A4/en active Pending
- 2018-01-26 US US16/481,048 patent/US11267885B2/en active Active
- 2018-01-26 KR KR1020197024767A patent/KR102607101B1/ko active Active
- 2018-01-26 CN CN201880021733.XA patent/CN110461872B/zh active Active
- 2018-01-26 JP JP2019541279A patent/JP7117311B2/ja active Active
- 2018-01-26 AU AU2018213718A patent/AU2018213718B2/en active Active
-
2019
- 2019-07-25 IL IL268258A patent/IL268258A/en unknown
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