CN112969714A - 抗cd40抗体、其抗原结合片段及其医药用途 - Google Patents
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Abstract
本公开涉及抗CD40抗体、其抗原结合片段及其医药用途。所述抗CD40抗体、其抗原结合片段的重链恒定区含有突变,所述突变使得抗CD40抗体丧失了其与FcγRIII结合的活性,同时增强了抗CD40抗体与FcγRIIB的结合,从而丧失了抗体依赖的细胞毒性(ADCC),但是增强了FcγRIIB介导的抗体交联。重链恒定区中的突变导致增强了对CD40的激活,以及增强了树突细胞对抗原的递呈。本公开的抗CD40抗体及其抗原结合片段作为抗癌药物具有治疗CD40介导的疾病或病症的用途。
Description
PCT国内申请,说明书已公开。
Claims (23)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
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CN2018114482281 | 2018-11-30 | ||
CN201811448228 | 2018-11-30 | ||
PCT/CN2019/121941 WO2020108611A1 (zh) | 2018-11-30 | 2019-11-29 | 抗cd40抗体、其抗原结合片段及其医药用途 |
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US (1) | US20220025060A1 (zh) |
EP (1) | EP3892634A4 (zh) |
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KR (1) | KR20210099027A (zh) |
CN (1) | CN112969714B (zh) |
AU (1) | AU2019389354A1 (zh) |
BR (1) | BR112021009835A2 (zh) |
CA (1) | CA3120793A1 (zh) |
MX (1) | MX2021005823A (zh) |
TW (1) | TW202039558A (zh) |
WO (1) | WO2020108611A1 (zh) |
Cited By (2)
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WO2023232036A1 (zh) * | 2022-05-31 | 2023-12-07 | 明济生物制药(北京)有限公司 | 抗cd40抗体和抗pd-l1×cd40双特异抗体及其应用 |
WO2023236951A1 (zh) * | 2022-06-06 | 2023-12-14 | 普米斯生物技术(珠海)有限公司 | 抗cd40抗体及其用途 |
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CN117616049A (zh) | 2021-08-24 | 2024-02-27 | 江苏恒瑞医药股份有限公司 | Fap/cd40结合分子及其医药用途 |
CN114573698B (zh) * | 2022-03-16 | 2023-01-06 | 沈阳三生制药有限责任公司 | 一种FcRn抗原结合蛋白及其制备方法和应用 |
WO2024076969A1 (en) * | 2022-10-04 | 2024-04-11 | Memorial Sloan-Kettering Cancer Center | Anti-cd40 antibodies and uses thereof |
WO2024179567A1 (zh) * | 2023-03-01 | 2024-09-06 | 江苏恒瑞医药股份有限公司 | Fap/4-1bb/cd40结合分子及其医药用途 |
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- 2019-11-29 CN CN201980072271.9A patent/CN112969714B/zh active Active
- 2019-11-29 TW TW108143719A patent/TW202039558A/zh unknown
- 2019-11-29 EP EP19891086.1A patent/EP3892634A4/en not_active Withdrawn
- 2019-11-29 AU AU2019389354A patent/AU2019389354A1/en not_active Abandoned
- 2019-11-29 MX MX2021005823A patent/MX2021005823A/es unknown
- 2019-11-29 JP JP2021528960A patent/JP2022509156A/ja active Pending
- 2019-11-29 KR KR1020217019296A patent/KR20210099027A/ko active Search and Examination
- 2019-11-29 WO PCT/CN2019/121941 patent/WO2020108611A1/zh unknown
- 2019-11-29 CA CA3120793A patent/CA3120793A1/en active Pending
- 2019-11-29 US US17/296,519 patent/US20220025060A1/en not_active Abandoned
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WO2020108611A1 (zh) | 2020-06-04 |
KR20210099027A (ko) | 2021-08-11 |
MX2021005823A (es) | 2021-07-15 |
AU2019389354A1 (en) | 2021-07-15 |
US20220025060A1 (en) | 2022-01-27 |
EP3892634A1 (en) | 2021-10-13 |
CA3120793A1 (en) | 2020-06-04 |
BR112021009835A2 (pt) | 2021-08-17 |
EP3892634A4 (en) | 2022-11-16 |
TW202039558A (zh) | 2020-11-01 |
CN112969714B (zh) | 2022-11-22 |
JP2022509156A (ja) | 2022-01-20 |
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