JP2018510617A5 - - Google Patents
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- Publication number
- JP2018510617A5 JP2018510617A5 JP2017540250A JP2017540250A JP2018510617A5 JP 2018510617 A5 JP2018510617 A5 JP 2018510617A5 JP 2017540250 A JP2017540250 A JP 2017540250A JP 2017540250 A JP2017540250 A JP 2017540250A JP 2018510617 A5 JP2018510617 A5 JP 2018510617A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- heavy chain
- variable region
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010071690 Prealbumin Proteins 0.000 claims 9
- 102000009190 Transthyretin Human genes 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 206010002022 amyloidosis Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000003403 autonomic nervous system Anatomy 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000005252 bulbus oculi Anatomy 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562109004P | 2015-01-28 | 2015-01-28 | |
| US62/109,004 | 2015-01-28 | ||
| US201562266555P | 2015-12-11 | 2015-12-11 | |
| US62/266,555 | 2015-12-11 | ||
| PCT/IB2016/050416 WO2016120811A1 (en) | 2015-01-28 | 2016-01-28 | Anti-transthyretin antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510617A JP2018510617A (ja) | 2018-04-19 |
| JP2018510617A5 true JP2018510617A5 (enExample) | 2019-03-07 |
| JP7101927B2 JP7101927B2 (ja) | 2022-07-19 |
Family
ID=55300737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540250A Active JP7101927B2 (ja) | 2015-01-28 | 2016-01-28 | 抗トランスサイレチン抗体 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20160257737A1 (enExample) |
| EP (1) | EP3250593B1 (enExample) |
| JP (1) | JP7101927B2 (enExample) |
| KR (1) | KR102649788B1 (enExample) |
| CN (1) | CN107406500B (enExample) |
| AU (1) | AU2016210889C1 (enExample) |
| CA (1) | CA2974993A1 (enExample) |
| CO (1) | CO2017008482A2 (enExample) |
| CU (1) | CU20170098A7 (enExample) |
| DK (1) | DK3250593T3 (enExample) |
| EA (1) | EA036014B1 (enExample) |
| ES (1) | ES2925716T3 (enExample) |
| HR (1) | HRP20220918T1 (enExample) |
| HU (1) | HUE059592T2 (enExample) |
| MX (1) | MX389911B (enExample) |
| MY (1) | MY193701A (enExample) |
| PE (1) | PE20180218A1 (enExample) |
| PL (1) | PL3250593T3 (enExample) |
| PT (1) | PT3250593T (enExample) |
| RS (1) | RS63513B1 (enExample) |
| SA (1) | SA517381981B1 (enExample) |
| SG (2) | SG11201706126WA (enExample) |
| SI (1) | SI3250593T1 (enExample) |
| TW (2) | TWI711631B (enExample) |
| WO (1) | WO2016120811A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10464999B2 (en) | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10633433B2 (en) | 2015-01-28 | 2020-04-28 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US9879080B2 (en) | 2015-01-28 | 2018-01-30 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| EP3478716A2 (en) * | 2016-07-02 | 2019-05-08 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| MA50619A (fr) | 2017-10-04 | 2020-08-12 | Amgen Inc | Fusions d'immunoglobulines de transthyrétine |
| MX2020003043A (es) | 2017-10-06 | 2020-10-05 | Prothena Biosciences Ltd | Métodos para detectar transtiretina. |
| MX2020003041A (es) | 2017-10-06 | 2020-10-05 | Prothena Biosciences Ltd | Anticuerpos anti-transtiretina. |
| PH12020550694A1 (en) * | 2017-11-29 | 2021-04-12 | Prothena Biosciences Ltd | Lyophilized formulation of a monoclonal antibody against transthyretin |
| US12006357B2 (en) | 2018-06-26 | 2024-06-11 | Mor Research Applications Ltd. | Transthyretin antibodies and uses thereof |
| CN111018976B (zh) * | 2018-10-10 | 2022-04-01 | 东莞市朋志生物科技有限公司 | 一种抗人心肌肌钙蛋白i的重组抗体 |
| WO2020094883A1 (en) * | 2018-11-09 | 2020-05-14 | Neurimmune Ag | Patient-derived amyloid xenograft non-human animal model |
| TW202110882A (zh) * | 2019-06-04 | 2021-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 能結合胸腺基質淋巴細胞生成素的抗體及其應用 |
| SG11202112762TA (en) * | 2019-07-08 | 2021-12-30 | Amgen Inc | Multispecific transthyretin immunoglobulin fusions |
| CN116249717A (zh) | 2020-06-24 | 2023-06-09 | 普罗塞纳生物科学有限公司 | 识别分拣蛋白的抗体 |
| CN116635024A (zh) * | 2020-10-14 | 2023-08-22 | 维里迪安治疗公司 | 用于治疗甲状腺眼病的组合物和方法 |
| CN116601295A (zh) * | 2020-12-03 | 2023-08-15 | 江苏恒瑞医药股份有限公司 | 一种抗tslp抗体药物组合物及其用途 |
| US20240052050A1 (en) * | 2020-12-16 | 2024-02-15 | Merus N.V. | Multispecific antibodies for the treatment of cancer |
| JP2024535756A (ja) | 2021-09-07 | 2024-10-02 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | バイオマーカー組成物およびその使用方法 |
| CN116804186B (zh) * | 2023-07-05 | 2023-12-22 | 中国兽医药品监察所 | 一种抗鸡传染性贫血病毒单克隆抗体杂交瘤细胞株、单克隆抗体、试剂或试剂盒及其应用 |
| TW202525341A (zh) | 2023-12-15 | 2025-07-01 | 丹麥商諾佛 儂迪克股份有限公司 | 穩定的液體調配物 |
Family Cites Families (53)
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| CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US4634666A (en) | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| EP0832981A1 (en) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| JP2938569B2 (ja) | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル，インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5877218A (en) | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| DE19539493A1 (de) | 1995-10-24 | 1997-04-30 | Thomae Gmbh Dr K | Starker homologer Promotor aus Hamster |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| ATE371231T1 (de) | 1999-02-05 | 2007-09-15 | Samsung Electronics Co Ltd | Verfahren und vorrichtung zur wiederauffindung von texturbildern |
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| DE10338531A1 (de) | 2003-08-19 | 2005-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Reklonierung von Produktionszellen |
| CA2578400C (en) | 2004-11-10 | 2014-01-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of flow-cytometric analysis to optimize cell banking strategies for cho cells |
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| PT2099823E (pt) | 2006-12-01 | 2014-12-22 | Seattle Genetics Inc | Agentes de ligação ao alvo variantes e suas utilizações |
| SG182160A1 (en) | 2007-03-02 | 2012-07-30 | Boehringer Ingelheim Pharma | Improvement of protein production |
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| JP2010195710A (ja) * | 2009-02-25 | 2010-09-09 | Kumamoto Univ | アミロイド線維形成抑制剤及びその利用 |
| US9534048B2 (en) * | 2012-08-24 | 2017-01-03 | University Health Network | Antibodies to TTR and methods of use |
| UA118441C2 (uk) * | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| US9790269B2 (en) * | 2013-02-08 | 2017-10-17 | Misfolding Diagnostics, Inc. | Transthyretin antibodies and uses thereof |
| WO2015010118A2 (en) * | 2013-07-19 | 2015-01-22 | The University Of Texas | Transthyretin amyloid-selective and polyreactive catabodies |
-
2016
- 2016-01-27 TW TW105102532A patent/TWI711631B/zh active
- 2016-01-27 TW TW109138086A patent/TWI769570B/zh active
- 2016-01-28 KR KR1020177023750A patent/KR102649788B1/ko active Active
- 2016-01-28 DK DK16702990.9T patent/DK3250593T3/da active
- 2016-01-28 RS RS20220788A patent/RS63513B1/sr unknown
- 2016-01-28 MY MYPI2017702752A patent/MY193701A/en unknown
- 2016-01-28 US US15/009,667 patent/US20160257737A1/en not_active Abandoned
- 2016-01-28 EP EP16702990.9A patent/EP3250593B1/en active Active
- 2016-01-28 SI SI201631572T patent/SI3250593T1/sl unknown
- 2016-01-28 CA CA2974993A patent/CA2974993A1/en active Pending
- 2016-01-28 CN CN201680015343.2A patent/CN107406500B/zh active Active
- 2016-01-28 JP JP2017540250A patent/JP7101927B2/ja active Active
- 2016-01-28 SG SG11201706126WA patent/SG11201706126WA/en unknown
- 2016-01-28 ES ES16702990T patent/ES2925716T3/es active Active
- 2016-01-28 PE PE2017001289A patent/PE20180218A1/es unknown
- 2016-01-28 PT PT167029909T patent/PT3250593T/pt unknown
- 2016-01-28 HU HUE16702990A patent/HUE059592T2/hu unknown
- 2016-01-28 CU CUP2017000098A patent/CU20170098A7/es unknown
- 2016-01-28 AU AU2016210889A patent/AU2016210889C1/en active Active
- 2016-01-28 WO PCT/IB2016/050416 patent/WO2016120811A1/en not_active Ceased
- 2016-01-28 SG SG10201906696RA patent/SG10201906696RA/en unknown
- 2016-01-28 EA EA201791710A patent/EA036014B1/ru unknown
- 2016-01-28 MX MX2017009803A patent/MX389911B/es unknown
- 2016-01-28 HR HRP20220918TT patent/HRP20220918T1/hr unknown
- 2016-01-28 PL PL16702990.9T patent/PL3250593T3/pl unknown
-
2017
- 2017-07-25 SA SA517381981A patent/SA517381981B1/ar unknown
- 2017-08-22 CO CONC2017/0008482A patent/CO2017008482A2/es unknown