CO2017008482A2 - Anticuerpos anti-transtiretina - Google Patents
Anticuerpos anti-transtiretinaInfo
- Publication number
- CO2017008482A2 CO2017008482A2 CONC2017/0008482A CO2017008482A CO2017008482A2 CO 2017008482 A2 CO2017008482 A2 CO 2017008482A2 CO 2017008482 A CO2017008482 A CO 2017008482A CO 2017008482 A2 CO2017008482 A2 CO 2017008482A2
- Authority
- CO
- Colombia
- Prior art keywords
- ttr
- antibodies
- transthyretin
- accumulation
- amyloidosis
- Prior art date
Links
- 108010071690 Prealbumin Proteins 0.000 abstract 5
- 102000009190 Transthyretin Human genes 0.000 abstract 5
- 208000034846 Familial Amyloid Neuropathies Diseases 0.000 abstract 2
- 238000009825 accumulation Methods 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000007905 transthyretin amyloidosis Diseases 0.000 abstract 2
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562109004P | 2015-01-28 | 2015-01-28 | |
| US201562266555P | 2015-12-11 | 2015-12-11 | |
| PCT/IB2016/050416 WO2016120811A1 (en) | 2015-01-28 | 2016-01-28 | Anti-transthyretin antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2017008482A2 true CO2017008482A2 (es) | 2018-01-16 |
Family
ID=55300737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2017/0008482A CO2017008482A2 (es) | 2015-01-28 | 2017-08-22 | Anticuerpos anti-transtiretina |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20160257737A1 (enExample) |
| EP (1) | EP3250593B1 (enExample) |
| JP (1) | JP7101927B2 (enExample) |
| KR (1) | KR102649788B1 (enExample) |
| CN (1) | CN107406500B (enExample) |
| AU (1) | AU2016210889C1 (enExample) |
| CA (1) | CA2974993A1 (enExample) |
| CO (1) | CO2017008482A2 (enExample) |
| CU (1) | CU20170098A7 (enExample) |
| DK (1) | DK3250593T3 (enExample) |
| EA (1) | EA036014B1 (enExample) |
| ES (1) | ES2925716T3 (enExample) |
| HR (1) | HRP20220918T1 (enExample) |
| HU (1) | HUE059592T2 (enExample) |
| MX (1) | MX389911B (enExample) |
| MY (1) | MY193701A (enExample) |
| PE (1) | PE20180218A1 (enExample) |
| PL (1) | PL3250593T3 (enExample) |
| PT (1) | PT3250593T (enExample) |
| RS (1) | RS63513B1 (enExample) |
| SA (1) | SA517381981B1 (enExample) |
| SG (2) | SG11201706126WA (enExample) |
| SI (1) | SI3250593T1 (enExample) |
| TW (2) | TWI769570B (enExample) |
| WO (1) | WO2016120811A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10633433B2 (en) | 2015-01-28 | 2020-04-28 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US9879080B2 (en) | 2015-01-28 | 2018-01-30 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10464999B2 (en) | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| WO2018007924A2 (en) * | 2016-07-02 | 2018-01-11 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| WO2019070901A1 (en) | 2017-10-04 | 2019-04-11 | Amgen Inc. | IMMUNOGLOBULIN FUSIONS OF TRANSTHYRETIN |
| WO2019071205A1 (en) * | 2017-10-06 | 2019-04-11 | Prothena Biosciences Limited | ANTI-TRANSTHYRETIN ANTIBODY |
| CN111757730A (zh) | 2017-10-06 | 2020-10-09 | 普罗塞纳生物科学有限公司 | 检测甲状腺素运载蛋白的方法 |
| BR112020010483A2 (pt) * | 2017-11-29 | 2020-10-20 | Prothena Biosciences Limited | formulação liofilizada de um anticorpo monoclonal contra transtirretina |
| WO2020003172A1 (en) | 2018-06-26 | 2020-01-02 | Mor Research Applications | Transthyretin antibodies and uses thereof |
| CN111018976B (zh) * | 2018-10-10 | 2022-04-01 | 东莞市朋志生物科技有限公司 | 一种抗人心肌肌钙蛋白i的重组抗体 |
| ES2989499T3 (es) * | 2018-11-09 | 2024-11-26 | Neurimmune Ag | Modelo de roedor de xenoinjerto de amiloide derivado de paciente |
| CN116751295A (zh) * | 2019-06-04 | 2023-09-15 | 江苏恒瑞医药股份有限公司 | 能结合胸腺基质淋巴细胞生成素的抗体及其应用 |
| CA3140208A1 (en) * | 2019-07-08 | 2021-01-14 | Amgen Inc. | Multispecific transthyretin immunoglobulin fusions |
| US20230235048A1 (en) | 2020-06-24 | 2023-07-27 | Andriani IOANNOU | Antibodies recognizing sortilin |
| CN118059229A (zh) * | 2020-10-14 | 2024-05-24 | 维里迪安治疗公司 | 用于治疗甲状腺眼病的组合物和方法 |
| CA3200767A1 (en) * | 2020-12-03 | 2022-06-09 | Zhiwan WANG | Anti-tslp antibody pharmaceutical composition and use thereof |
| CN117603360A (zh) * | 2020-12-16 | 2024-02-27 | 美勒斯公司 | 用于治疗癌症的多特异性抗体 |
| CN117916599A (zh) | 2021-09-07 | 2024-04-19 | 美国西门子医学诊断股份有限公司 | 生物标记物组合物及其使用方法 |
| CN116804186B (zh) * | 2023-07-05 | 2023-12-22 | 中国兽医药品监察所 | 一种抗鸡传染性贫血病毒单克隆抗体杂交瘤细胞株、单克隆抗体、试剂或试剂盒及其应用 |
| WO2025125544A1 (en) | 2023-12-15 | 2025-06-19 | Novo Nordisk A/S | Stable liquid formulations |
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| EP0279582A3 (en) | 1987-02-17 | 1989-10-18 | Pharming B.V. | Dna sequences to target proteins to the mammary gland for efficient secretion |
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| JP5467415B2 (ja) | 2007-03-02 | 2014-04-09 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | タンパク質製造の改良 |
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| UA118441C2 (uk) * | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
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| EP3022225B1 (en) * | 2013-07-19 | 2021-09-29 | Board Of Regents Of the University Of Texas System | Transthyretin amyloid-selective and polyreactive catabodies |
-
2016
- 2016-01-27 TW TW109138086A patent/TWI769570B/zh active
- 2016-01-27 TW TW105102532A patent/TWI711631B/zh active
- 2016-01-28 PE PE2017001289A patent/PE20180218A1/es unknown
- 2016-01-28 CU CUP2017000098A patent/CU20170098A7/es unknown
- 2016-01-28 MY MYPI2017702752A patent/MY193701A/en unknown
- 2016-01-28 DK DK16702990.9T patent/DK3250593T3/da active
- 2016-01-28 JP JP2017540250A patent/JP7101927B2/ja active Active
- 2016-01-28 CA CA2974993A patent/CA2974993A1/en active Pending
- 2016-01-28 HR HRP20220918TT patent/HRP20220918T1/hr unknown
- 2016-01-28 MX MX2017009803A patent/MX389911B/es unknown
- 2016-01-28 AU AU2016210889A patent/AU2016210889C1/en active Active
- 2016-01-28 EA EA201791710A patent/EA036014B1/ru unknown
- 2016-01-28 SG SG11201706126WA patent/SG11201706126WA/en unknown
- 2016-01-28 SG SG10201906696RA patent/SG10201906696RA/en unknown
- 2016-01-28 HU HUE16702990A patent/HUE059592T2/hu unknown
- 2016-01-28 EP EP16702990.9A patent/EP3250593B1/en active Active
- 2016-01-28 US US15/009,667 patent/US20160257737A1/en not_active Abandoned
- 2016-01-28 SI SI201631572T patent/SI3250593T1/sl unknown
- 2016-01-28 ES ES16702990T patent/ES2925716T3/es active Active
- 2016-01-28 PL PL16702990.9T patent/PL3250593T3/pl unknown
- 2016-01-28 KR KR1020177023750A patent/KR102649788B1/ko active Active
- 2016-01-28 CN CN201680015343.2A patent/CN107406500B/zh active Active
- 2016-01-28 RS RS20220788A patent/RS63513B1/sr unknown
- 2016-01-28 PT PT167029909T patent/PT3250593T/pt unknown
- 2016-01-28 WO PCT/IB2016/050416 patent/WO2016120811A1/en not_active Ceased
-
2017
- 2017-07-25 SA SA517381981A patent/SA517381981B1/ar unknown
- 2017-08-22 CO CONC2017/0008482A patent/CO2017008482A2/es unknown
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