EA036014B1 - Антитела к транстиретину - Google Patents

Антитела к транстиретину Download PDF

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Publication number
EA036014B1
EA036014B1 EA201791710A EA201791710A EA036014B1 EA 036014 B1 EA036014 B1 EA 036014B1 EA 201791710 A EA201791710 A EA 201791710A EA 201791710 A EA201791710 A EA 201791710A EA 036014 B1 EA036014 B1 EA 036014B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
ttr
seq
transthyretin
subject
Prior art date
Application number
EA201791710A
Other languages
English (en)
Russian (ru)
Other versions
EA201791710A1 (ru
Inventor
Тарлохан С. Ниджджар
Авиджит Чакрабартти
Джеффри Н. Хигаки
Original Assignee
Протена Биосайенсис Лимитед
Юниверсити Хэлс Нетуорк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Протена Биосайенсис Лимитед, Юниверсити Хэлс Нетуорк filed Critical Протена Биосайенсис Лимитед
Publication of EA201791710A1 publication Critical patent/EA201791710A1/ru
Publication of EA036014B1 publication Critical patent/EA036014B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EA201791710A 2015-01-28 2016-01-28 Антитела к транстиретину EA036014B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109004P 2015-01-28 2015-01-28
US201562266555P 2015-12-11 2015-12-11
PCT/IB2016/050416 WO2016120811A1 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Publications (2)

Publication Number Publication Date
EA201791710A1 EA201791710A1 (ru) 2017-12-29
EA036014B1 true EA036014B1 (ru) 2020-09-14

Family

ID=55300737

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791710A EA036014B1 (ru) 2015-01-28 2016-01-28 Антитела к транстиретину

Country Status (25)

Country Link
US (1) US20160257737A1 (enExample)
EP (1) EP3250593B1 (enExample)
JP (1) JP7101927B2 (enExample)
KR (1) KR102649788B1 (enExample)
CN (1) CN107406500B (enExample)
AU (1) AU2016210889C1 (enExample)
CA (1) CA2974993A1 (enExample)
CO (1) CO2017008482A2 (enExample)
CU (1) CU20170098A7 (enExample)
DK (1) DK3250593T3 (enExample)
EA (1) EA036014B1 (enExample)
ES (1) ES2925716T3 (enExample)
HR (1) HRP20220918T1 (enExample)
HU (1) HUE059592T2 (enExample)
MX (1) MX389911B (enExample)
MY (1) MY193701A (enExample)
PE (1) PE20180218A1 (enExample)
PL (1) PL3250593T3 (enExample)
PT (1) PT3250593T (enExample)
RS (1) RS63513B1 (enExample)
SA (1) SA517381981B1 (enExample)
SG (2) SG11201706126WA (enExample)
SI (1) SI3250593T1 (enExample)
TW (2) TWI769570B (enExample)
WO (1) WO2016120811A1 (enExample)

Families Citing this family (20)

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US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
WO2018007924A2 (en) * 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
WO2019070901A1 (en) 2017-10-04 2019-04-11 Amgen Inc. IMMUNOGLOBULIN FUSIONS OF TRANSTHYRETIN
WO2019071205A1 (en) * 2017-10-06 2019-04-11 Prothena Biosciences Limited ANTI-TRANSTHYRETIN ANTIBODY
CN111757730A (zh) 2017-10-06 2020-10-09 普罗塞纳生物科学有限公司 检测甲状腺素运载蛋白的方法
BR112020010483A2 (pt) * 2017-11-29 2020-10-20 Prothena Biosciences Limited formulação liofilizada de um anticorpo monoclonal contra transtirretina
WO2020003172A1 (en) 2018-06-26 2020-01-02 Mor Research Applications Transthyretin antibodies and uses thereof
CN111018976B (zh) * 2018-10-10 2022-04-01 东莞市朋志生物科技有限公司 一种抗人心肌肌钙蛋白i的重组抗体
ES2989499T3 (es) * 2018-11-09 2024-11-26 Neurimmune Ag Modelo de roedor de xenoinjerto de amiloide derivado de paciente
CN116751295A (zh) * 2019-06-04 2023-09-15 江苏恒瑞医药股份有限公司 能结合胸腺基质淋巴细胞生成素的抗体及其应用
CA3140208A1 (en) * 2019-07-08 2021-01-14 Amgen Inc. Multispecific transthyretin immunoglobulin fusions
US20230235048A1 (en) 2020-06-24 2023-07-27 Andriani IOANNOU Antibodies recognizing sortilin
CN118059229A (zh) * 2020-10-14 2024-05-24 维里迪安治疗公司 用于治疗甲状腺眼病的组合物和方法
CA3200767A1 (en) * 2020-12-03 2022-06-09 Zhiwan WANG Anti-tslp antibody pharmaceutical composition and use thereof
CN117603360A (zh) * 2020-12-16 2024-02-27 美勒斯公司 用于治疗癌症的多特异性抗体
CN117916599A (zh) 2021-09-07 2024-04-19 美国西门子医学诊断股份有限公司 生物标记物组合物及其使用方法
CN116804186B (zh) * 2023-07-05 2023-12-22 中国兽医药品监察所 一种抗鸡传染性贫血病毒单克隆抗体杂交瘤细胞株、单克隆抗体、试剂或试剂盒及其应用
WO2025125544A1 (en) 2023-12-15 2025-06-19 Novo Nordisk A/S Stable liquid formulations

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Also Published As

Publication number Publication date
MX2017009803A (es) 2018-08-15
SG10201906696RA (en) 2019-08-27
AU2016210889C1 (en) 2022-02-10
CO2017008482A2 (es) 2018-01-16
EA201791710A1 (ru) 2017-12-29
CN107406500B (zh) 2022-02-25
AU2016210889A1 (en) 2017-08-10
HUE059592T2 (hu) 2022-11-28
ES2925716T3 (es) 2022-10-19
KR20170120608A (ko) 2017-10-31
KR102649788B1 (ko) 2024-03-20
MX389911B (es) 2025-03-04
CA2974993A1 (en) 2016-08-04
AU2016210889B2 (en) 2021-10-21
US20160257737A1 (en) 2016-09-08
CN107406500A (zh) 2017-11-28
WO2016120811A1 (en) 2016-08-04
SI3250593T1 (sl) 2022-09-30
RS63513B1 (sr) 2022-09-30
EP3250593B1 (en) 2022-06-22
SG11201706126WA (en) 2017-08-30
TW202110896A (zh) 2021-03-16
TWI769570B (zh) 2022-07-01
BR112017016345A2 (pt) 2018-03-27
DK3250593T3 (da) 2022-08-22
JP2018510617A (ja) 2018-04-19
SA517381981B1 (ar) 2022-05-17
PE20180218A1 (es) 2018-01-31
JP7101927B2 (ja) 2022-07-19
CU20170098A7 (es) 2018-03-13
PL3250593T3 (pl) 2022-09-19
HRP20220918T1 (hr) 2022-10-28
MY193701A (en) 2022-10-25
TWI711631B (zh) 2020-12-01
TW201636371A (zh) 2016-10-16
PT3250593T (pt) 2022-08-31
EP3250593A1 (en) 2017-12-06

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