JP2014158469A5 - - Google Patents
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- JP2014158469A5 JP2014158469A5 JP2014043403A JP2014043403A JP2014158469A5 JP 2014158469 A5 JP2014158469 A5 JP 2014158469A5 JP 2014043403 A JP2014043403 A JP 2014043403A JP 2014043403 A JP2014043403 A JP 2014043403A JP 2014158469 A5 JP2014158469 A5 JP 2014158469A5
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- Prior art keywords
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- variable region
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- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 102000044457 human DLL4 Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 230000004614 tumor growth Effects 0.000 claims 4
- 108700041286 delta Proteins 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101100499372 Homo sapiens DLL1 gene Proteins 0.000 claims 1
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 101100387419 Mus musculus Dll4 gene Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000053255 human DLL3 Human genes 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004898 n-terminal fragment Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84790406P | 2006-09-29 | 2006-09-29 | |
| US60/847,904 | 2006-09-29 | ||
| US88626007P | 2007-01-23 | 2007-01-23 | |
| US60/886,260 | 2007-01-23 | ||
| US94254207P | 2007-06-07 | 2007-06-07 | |
| US60/942,542 | 2007-06-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530419A Division JP5535633B2 (ja) | 2006-09-29 | 2007-09-28 | 癌の診断および処置のための組成物および方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016164264A Division JP2017002076A (ja) | 2006-09-29 | 2016-08-25 | 癌の診断および処置のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014158469A JP2014158469A (ja) | 2014-09-04 |
| JP2014158469A5 true JP2014158469A5 (enExample) | 2014-10-16 |
| JP5997194B2 JP5997194B2 (ja) | 2016-09-28 |
Family
ID=39268983
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530419A Expired - Fee Related JP5535633B2 (ja) | 2006-09-29 | 2007-09-28 | 癌の診断および処置のための組成物および方法 |
| JP2014043403A Expired - Fee Related JP5997194B2 (ja) | 2006-09-29 | 2014-03-06 | 癌の診断および処置のための組成物および方法 |
| JP2016164264A Pending JP2017002076A (ja) | 2006-09-29 | 2016-08-25 | 癌の診断および処置のための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530419A Expired - Fee Related JP5535633B2 (ja) | 2006-09-29 | 2007-09-28 | 癌の診断および処置のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016164264A Pending JP2017002076A (ja) | 2006-09-29 | 2016-08-25 | 癌の診断および処置のための組成物および方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US7750124B2 (enExample) |
| EP (3) | EP2066694B1 (enExample) |
| JP (3) | JP5535633B2 (enExample) |
| KR (1) | KR101477824B1 (enExample) |
| AU (1) | AU2007305443B2 (enExample) |
| BR (1) | BRPI0717431A2 (enExample) |
| CA (1) | CA2664738C (enExample) |
| CO (1) | CO6180466A2 (enExample) |
| CR (1) | CR10667A (enExample) |
| CY (1) | CY1117154T1 (enExample) |
| DK (1) | DK2066694T3 (enExample) |
| EA (1) | EA018260B1 (enExample) |
| ES (1) | ES2557953T3 (enExample) |
| HR (1) | HRP20160082T1 (enExample) |
| HU (1) | HUE028379T2 (enExample) |
| IL (1) | IL197721A (enExample) |
| MA (1) | MA30808B1 (enExample) |
| ME (1) | ME02371B (enExample) |
| MX (1) | MX2009003229A (enExample) |
| NO (1) | NO20091635L (enExample) |
| NZ (1) | NZ576404A (enExample) |
| PL (1) | PL2066694T3 (enExample) |
| PT (1) | PT2066694E (enExample) |
| RS (1) | RS54452B1 (enExample) |
| SI (1) | SI2066694T1 (enExample) |
| WO (1) | WO2008042236A2 (enExample) |
| ZA (1) | ZA200901615B (enExample) |
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| NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
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| GB0709333D0 (en) * | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
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