JP2021531254A5 - - Google Patents
Info
- Publication number
- JP2021531254A5 JP2021531254A5 JP2021500434A JP2021500434A JP2021531254A5 JP 2021531254 A5 JP2021531254 A5 JP 2021531254A5 JP 2021500434 A JP2021500434 A JP 2021500434A JP 2021500434 A JP2021500434 A JP 2021500434A JP 2021531254 A5 JP2021531254 A5 JP 2021531254A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- tgfβ1
- binding fragment
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024068880A JP7858715B2 (ja) | 2018-07-11 | 2024-04-22 | 高親和性のアイソフォーム選択的ＴＧＦβ１阻害剤、およびその使用 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696752P | 2018-07-11 | 2018-07-11 | |
| US62/696,752 | 2018-07-11 | ||
| US201862718196P | 2018-08-13 | 2018-08-13 | |
| US62/718,196 | 2018-08-13 | ||
| US201862737534P | 2018-09-27 | 2018-09-27 | |
| US62/737,534 | 2018-09-27 | ||
| US201862758180P | 2018-11-09 | 2018-11-09 | |
| US62/758,180 | 2018-11-09 | ||
| US201962810263P | 2019-02-25 | 2019-02-25 | |
| US62/810,263 | 2019-02-25 | ||
| US201962827552P | 2019-04-01 | 2019-04-01 | |
| US62/827,552 | 2019-04-01 | ||
| PCT/US2019/041373 WO2020014460A1 (en) | 2018-07-11 | 2019-07-11 | HIGH-AFFINITY, ISOFORM-SELECTIVE TGFβ1 INHIBITORS AND USE THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024068880A Division JP7858715B2 (ja) | 2018-07-11 | 2024-04-22 | 高親和性のアイソフォーム選択的ＴＧＦβ１阻害剤、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021531254A JP2021531254A (ja) | 2021-11-18 |
| JP2021531254A5 true JP2021531254A5 (enExample) | 2022-07-15 |
| JP7540994B2 JP7540994B2 (ja) | 2024-08-27 |
Family
ID=67470735
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500434A Active JP7540994B2 (ja) | 2018-07-11 | 2019-07-11 | 高親和性のアイソフォーム選択的ＴＧＦβ１阻害剤、およびその使用 |
| JP2024068880A Active JP7858715B2 (ja) | 2018-07-11 | 2024-04-22 | 高親和性のアイソフォーム選択的ＴＧＦβ１阻害剤、およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024068880A Active JP7858715B2 (ja) | 2018-07-11 | 2024-04-22 | 高親和性のアイソフォーム選択的ＴＧＦβ１阻害剤、およびその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US12252531B2 (enExample) |
| EP (1) | EP3820508A1 (enExample) |
| JP (2) | JP7540994B2 (enExample) |
| KR (1) | KR102891320B1 (enExample) |
| CN (1) | CN112996535B (enExample) |
| AU (1) | AU2019302679B2 (enExample) |
| BR (1) | BR112021000353A2 (enExample) |
| CL (1) | CL2021000073A1 (enExample) |
| CO (1) | CO2021000419A2 (enExample) |
| IL (1) | IL279914A (enExample) |
| MA (1) | MA53125A (enExample) |
| MX (1) | MX2021000347A (enExample) |
| PH (1) | PH12021550020A1 (enExample) |
| SG (1) | SG11202013231SA (enExample) |
| TW (1) | TWI923546B (enExample) |
| WO (1) | WO2020014460A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109153644B (zh) | 2016-03-16 | 2022-10-21 | H·李·莫菲特癌症中心研究有限公司 | 用以增强效应t细胞功能的针对cereblon的小分子 |
| EP3820532A4 (en) | 2018-07-11 | 2022-04-06 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | DIMERE IMMUNOMODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS |
| PT3677278T (pt) | 2018-07-11 | 2022-02-03 | Scholar Rock Inc | Inibidores seletivos da isoforma tgfbeta1 e sua utilização |
| KR102891320B1 (ko) | 2018-07-11 | 2025-11-28 | 스칼러 락, 인크. | 고친화도, 이소형-선택적 TGFβ1 억제제 및 그의 용도 |
| SG11202108099WA (en) | 2019-01-30 | 2021-08-30 | Scholar Rock Inc | LTBP COMPLEX-SPECIFIC INHIBITORS OF TGFβ AND USES THEREOF |
| CN120022360A (zh) | 2019-08-28 | 2025-05-23 | 中外制药株式会社 | 跨物种抗潜伏TGF-β1抗体和使用方法 |
| CA3166328A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| CA3167427A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgfb inhibitors and use thereof |
| AU2021239667B2 (en) * | 2020-03-19 | 2026-05-07 | Chugai Seiyaku Kabushiki Kaisha | Biomarkers for predicting the response to checkpoint inhibitors |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| EP4348260A2 (en) | 2021-06-03 | 2024-04-10 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| TW202317185A (zh) * | 2021-06-18 | 2023-05-01 | 美商健臻公司 | 抗ＴＧＦ－β抗體配製品及其用途 |
| EP4370148A1 (en) | 2021-07-14 | 2024-05-22 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgf beta1 and uses thereof |
| CN113604214B (zh) * | 2021-08-09 | 2023-07-14 | 青岛大学 | 一种高稳定性溶瘤肽荧光探针及其制备方法和应用 |
| CN116262137A (zh) * | 2021-12-14 | 2023-06-16 | 四川大学 | 一种同时杀伤肿瘤和改善免疫微环境的抗肿瘤联合用药物 |
| CN114236137A (zh) * | 2021-12-17 | 2022-03-25 | 中山大学·深圳 | 一种转化生长因子β的体外检测试剂盒及其应用 |
| CN115058440B (zh) * | 2022-06-08 | 2023-08-15 | 郑州轻工业大学 | 催化合成天然蔗糖酯的工程菌及其构建方法和应用 |
| CN120418286A (zh) | 2023-01-09 | 2025-08-01 | 北京拓界生物医药科技有限公司 | TGFβ1结合分子、GARP-TGFβ1结合分子及其医药用途 |
| EP4676954A1 (en) | 2023-03-07 | 2026-01-14 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
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| PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
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| JPH11507843A (ja) | 1996-03-28 | 1999-07-13 | ザ・ジョンズ・ホプキンス・ユニバーシティー | タンパク質の可溶性二価および多価ヘテロ二量体類縁体 |
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| JP4653660B2 (ja) | 2003-09-04 | 2011-03-16 | 独立行政法人理化学研究所 | ＴＧＦ−β活性化制御領域の切断面を認識する抗体 |
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| KR20110016959A (ko) | 2008-06-03 | 2011-02-18 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
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| JP6495884B2 (ja) | 2013-03-11 | 2019-04-03 | ジェンザイム・コーポレーション | 改変抗ｔｇｆベータ抗体および抗原結合フラグメント |
| HRP20201914T1 (hr) | 2013-05-06 | 2021-01-22 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
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| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
| EP3307772B1 (en) | 2015-06-12 | 2020-09-09 | Ludwig Institute For Cancer Research Limited | Tgf-beta 3 specific antibodies and methods and uses thereof |
| JP2018527903A (ja) | 2015-07-22 | 2018-09-27 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | Ｇｄｆ１１結合タンパク質およびその使用 |
| EA038146B1 (ru) | 2015-09-15 | 2021-07-13 | Сколар Рок, Инк. | Антитела к про-/латентному миостатину и их применения |
| RU2018131123A (ru) | 2016-02-17 | 2020-03-17 | Новартис Аг | Антитела к tgf-бета2 |
| ES2951648T3 (es) | 2016-03-11 | 2023-10-24 | Scholar Rock Inc | Inmunoglobulinas de unión a Tgfbeta1 y uso de las mismas |
| US10649198B2 (en) * | 2016-03-11 | 2020-05-12 | Battelle Memorial Institute | Sample processing and analysis methods and apparatus |
| GB201610044D0 (en) | 2016-06-08 | 2016-07-20 | Ucb Biopharma Sprl | Antibodies |
| EP3484499A4 (en) | 2016-07-14 | 2020-05-13 | Scholar Rock, Inc. | TGFB ANTIBODIES, METHODS AND USE |
| CN110382530A (zh) | 2017-01-06 | 2019-10-25 | 供石公司 | 亚型特异性、背景许可性TGFβ1抑制剂及其用途 |
| EP3571227A1 (en) | 2017-01-20 | 2019-11-27 | Sanofi | Anti-tgf-beta antibodies and their use |
| EP3658583A1 (en) | 2017-07-28 | 2020-06-03 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgf-beta 1 and uses thereof |
| PT3677278T (pt) | 2018-07-11 | 2022-02-03 | Scholar Rock Inc | Inibidores seletivos da isoforma tgfbeta1 e sua utilização |
| EP3820896A1 (en) | 2018-07-11 | 2021-05-19 | Scholar Rock, Inc. | TGFbeta1 INHIBITORS AND USE THEREOF |
| KR102891320B1 (ko) | 2018-07-11 | 2025-11-28 | 스칼러 락, 인크. | 고친화도, 이소형-선택적 TGFβ1 억제제 및 그의 용도 |
| CA3166328A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
-
2019
- 2019-07-11 KR KR1020217003926A patent/KR102891320B1/ko active Active
- 2019-07-11 SG SG11202013231SA patent/SG11202013231SA/en unknown
- 2019-07-11 EP EP19745926.6A patent/EP3820508A1/en active Pending
- 2019-07-11 AU AU2019302679A patent/AU2019302679B2/en active Active
- 2019-07-11 MX MX2021000347A patent/MX2021000347A/es unknown
- 2019-07-11 MA MA053125A patent/MA53125A/fr unknown
- 2019-07-11 TW TW108124516A patent/TWI923546B/zh active
- 2019-07-11 WO PCT/US2019/041373 patent/WO2020014460A1/en not_active Ceased
- 2019-07-11 JP JP2021500434A patent/JP7540994B2/ja active Active
- 2019-07-11 US US17/258,771 patent/US12252531B2/en active Active
- 2019-07-11 BR BR112021000353-3A patent/BR112021000353A2/pt unknown
- 2019-07-11 CN CN201980059305.0A patent/CN112996535B/zh active Active
-
2021
- 2021-01-03 IL IL279914A patent/IL279914A/en unknown
- 2021-01-04 PH PH12021550020A patent/PH12021550020A1/en unknown
- 2021-01-11 CL CL2021000073A patent/CL2021000073A1/es unknown
- 2021-01-18 CO CONC2021/0000419A patent/CO2021000419A2/es unknown
-
2024
- 2024-04-22 JP JP2024068880A patent/JP7858715B2/ja active Active
-
2025
- 2025-02-04 US US19/045,513 patent/US20250257125A1/en active Pending
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