PE20091163A1 - Anticuerpos para gdf8 - Google Patents
Anticuerpos para gdf8Info
- Publication number
- PE20091163A1 PE20091163A1 PE2008001853A PE2008001853A PE20091163A1 PE 20091163 A1 PE20091163 A1 PE 20091163A1 PE 2008001853 A PE2008001853 A PE 2008001853A PE 2008001853 A PE2008001853 A PE 2008001853A PE 20091163 A1 PE20091163 A1 PE 20091163A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- amino acid
- acid sequence
- heavy
- duty
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K999/00—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS dummy group
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K999/00—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS dummy group
- H05K999/99—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS dummy group dummy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
REFERIDA A UN ANTAGONISTA ESPECIFICO PARA EL FACTOR 8 DE CRECIMIENTO Y DIFERENCIACION (GDF8) Y QUE NO SE UNE ESPECIFICAMENTE A BMP11, DONDE DICHO ANTAGONISTA PUEDE SER UN ANTICUERPO POLICLONAL, MONOCLONAL, MONOESPECIFICO, POLIESPECIFICO, HUMANIZADO, TETRAMERICO, TETRAVALENTE, ENTRE OTROS, QUE COMPRENDE UNA REGION DETERMINANTE DE COMPLEMENTARIEDAD (CDR) QUE COMPRENDE UNA SECUENCIA DE AMINOACIDO TAL COMO UNA SECUENCIA DE AMINOACIDO DE LA SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:26, ENTRE OTROS Y UNA CADENA PESADA QUE COMPRENDE UNA SECUENCIA DE AMINOACIDO SELECCIONADA DE UNA SECUENCIA DE AMINOACIDO SEQ ID NO:14 Y SEQ ID NO:18. TAMBIEN ESTA REFERIDA A UN VECTOR, UN POLINUCLEOTIDO, UNA CELULA ANFITRIONA Y UNA COMPOSICION FARMACEUTICA. DICHOS ANTAGONISTAS SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS DEGENERATIVOS DEL MUSCULO, OSEOS Y DE METABOLISMO DE INSULINA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US178307P | 2007-11-01 | 2007-11-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091163A1 true PE20091163A1 (es) | 2009-08-09 |
Family
ID=40303702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001853A PE20091163A1 (es) | 2007-11-01 | 2008-10-30 | Anticuerpos para gdf8 |
Country Status (19)
Country | Link |
---|---|
US (4) | US8415459B2 (es) |
EP (2) | EP2215118B1 (es) |
JP (1) | JP5756291B2 (es) |
KR (1) | KR20100074321A (es) |
CN (1) | CN101970487A (es) |
AR (1) | AR069157A1 (es) |
AU (1) | AU2008319265A1 (es) |
CA (1) | CA2704315C (es) |
CO (1) | CO6270358A2 (es) |
ES (1) | ES2514518T3 (es) |
IL (1) | IL205448A0 (es) |
MX (1) | MX2010004915A (es) |
PA (1) | PA8802601A1 (es) |
PE (1) | PE20091163A1 (es) |
RU (1) | RU2447084C2 (es) |
SA (1) | SA08290697B1 (es) |
TW (1) | TW200934510A (es) |
WO (1) | WO2009058346A1 (es) |
ZA (1) | ZA201003876B (es) |
Families Citing this family (85)
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EP2332977B1 (en) * | 2004-07-23 | 2015-11-25 | Acceleron Pharma Inc. | ActRII receptor polypeptides |
EA026874B1 (ru) | 2005-11-23 | 2017-05-31 | Акселерон Фарма Инк. | Антагонисты активина-actriia и их применение для стимулирования роста кости |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
MY162136A (en) * | 2006-12-18 | 2017-05-31 | Acceleron Pharma Inc | Activin-actrii antagonists and uses for treating anemia |
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TW201907946A (zh) | 2007-02-02 | 2019-03-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
MX368173B (es) | 2007-02-09 | 2019-09-23 | Acceleron Pharma Inc | Una composición farmacéutica que comprende una proteína de fusión actriia-fc expresada de células cho. |
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CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
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ES2808139T3 (es) * | 2008-08-14 | 2021-02-25 | Acceleron Pharma Inc | Trampas de GDF |
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EP2440576A4 (en) | 2009-06-08 | 2013-11-20 | Acceleron Pharma Inc | PROCESS FOR INCREASING THE NUMBER OF THERMOUS ADIPOCYTES |
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- 2008-10-31 JP JP2010532058A patent/JP5756291B2/ja not_active Expired - Fee Related
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EP2805970A2 (en) | 2014-11-26 |
CO6270358A2 (es) | 2011-04-20 |
ZA201003876B (en) | 2011-04-28 |
IL205448A0 (en) | 2010-12-30 |
EP2805970A3 (en) | 2015-03-04 |
CA2704315A1 (en) | 2009-05-07 |
US8415459B2 (en) | 2013-04-09 |
EP2215118B1 (en) | 2014-08-06 |
CA2704315C (en) | 2016-05-24 |
MX2010004915A (es) | 2010-05-27 |
AU2008319265A1 (en) | 2009-05-07 |
RU2447084C2 (ru) | 2012-04-10 |
PA8802601A1 (es) | 2009-06-23 |
KR20100074321A (ko) | 2010-07-01 |
RU2010117018A (ru) | 2011-12-10 |
US20180265578A1 (en) | 2018-09-20 |
US10189896B2 (en) | 2019-01-29 |
AR069157A1 (es) | 2009-12-30 |
US9850301B2 (en) | 2017-12-26 |
TW200934510A (en) | 2009-08-16 |
US20090148436A1 (en) | 2009-06-11 |
US9409981B2 (en) | 2016-08-09 |
JP2011504096A (ja) | 2011-02-03 |
JP5756291B2 (ja) | 2015-07-29 |
US20140023638A1 (en) | 2014-01-23 |
SA08290697B1 (ar) | 2012-02-12 |
US20170145084A1 (en) | 2017-05-25 |
EP2215118A1 (en) | 2010-08-11 |
ES2514518T3 (es) | 2014-10-28 |
CN101970487A (zh) | 2011-02-09 |
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